| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B N Kang, K S Jeong, S J Park, S J Kim, T H Kim, H J Kim, S Y Ry. Regulation of apoptosis by somatostatin and substance P in peritoneal macrophages. Regulatory peptides. vol 101. issue 1-3. 2002-02-07. PMID:11495678. |
to define the mechanism of the cytokine production enhancements and inhibitions by som and sp, we examined the expression of apoptosis modulator, p53, bcl-2, bax, inducible nitric oxide synthase (inos), fas, caspase-8 and nitric oxide (no) in thioglycolate-elicited peritoneal macrophages. |
2002-02-07 |
2023-08-12 |
Not clear |
| D Quaglino, I P Ronchett. Cell death in the rat thymus: a minireview. Apoptosis : an international journal on programmed cell death. vol 6. issue 5. 2001-12-10. PMID:11483863. |
finally, a brief overview has been devoted to the contribution of mitochondria, nitric oxide, glutathione and intracellular levels of cations in addition to the activity of genes as cdk2, p53, fas and members' of the bcl2 family in modulating rat thymus cell death. |
2001-12-10 |
2023-08-12 |
rat |
| K Kawahara, T Gotoh, S Oyadomari, A Kuniyasu, S Kohsaka, M Mori, H Nakayam. Nitric oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic guanosine monophosphate. Neuroscience letters. vol 310. issue 2-3. 2001-12-04. PMID:11585574. |
nitric oxide inhibits the proliferation of murine microglial mg5 cells by a mechanism involving p21 but independent of p53 and cyclic guanosine monophosphate. |
2001-12-04 |
2023-08-12 |
mouse |
| A Rajnakova, S Moochhala, P M Goh, S Ngo. Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer. Cancer letters. vol 172. issue 2. 2001-11-01. PMID:11566494. |
we conclude, that tumor-associated nitric oxide production, as well as cox-2 overexpression, may promote gastric cancer progression by providing a selective growth advantage to tumor cells with non-functioning p53. |
2001-11-01 |
2023-08-12 |
human |
| B Brüne, A von Knethen, K B Sanda. Transcription factors p53 and HIF-1alpha as targets of nitric oxide. Cellular signalling. vol 13. issue 8. 2001-09-27. PMID:11483405. |
transcription factors p53 and hif-1alpha as targets of nitric oxide. |
2001-09-27 |
2023-08-12 |
Not clear |
| A Yamaguchi, M Tamatani, H Matsuzaki, K Namikawa, H Kiyama, M P Vitek, N Mitsuda, M Tohyam. Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11054421. |
to investigate the molecular mechanism underlying activated akt's ability to protect neurons from hypoxia or nitric oxide (no) toxicity, we focused on the apoptosis-related functions of p53 and caspases. |
2001-06-28 |
2023-08-12 |
Not clear |
| L Chazotte-Aubert, O Pluquet, P Hainaut, H Ohshim. Nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells. Biochemical and biophysical research communications. vol 281. issue 3. 2001-04-19. PMID:11237724. |
nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in mcf-7 cells. |
2001-04-19 |
2023-08-12 |
Not clear |
| L Chazotte-Aubert, O Pluquet, P Hainaut, H Ohshim. Nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells. Biochemical and biophysical research communications. vol 281. issue 3. 2001-04-19. PMID:11237724. |
we previously reported that nitric oxide (no) released from s-nitrosoglutathione induces conformational change of the p53 tumor-suppressor protein that impairs its dna-binding activity in vitro. |
2001-04-19 |
2023-08-12 |
Not clear |
| G Martinez-Mier, L H Toledo-Pereyra, S Bussell, J Gauvin, G Vercruysse, A Arab, J R Harkema, J A Jordan, P A War. Nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion injury. Transplantation. vol 70. issue 10. 2001-01-11. PMID:11118085. |
nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion injury. |
2001-01-11 |
2023-08-12 |
Not clear |
| G Martinez-Mier, L H Toledo-Pereyra, S Bussell, J Gauvin, G Vercruysse, A Arab, J R Harkema, J A Jordan, P A War. Nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion injury. Transplantation. vol 70. issue 10. 2001-01-11. PMID:11118085. |
the aim of this study was to reevaluate the beneficial effect of exogenous nitric oxide and define its effects as regulator of gene p53 expression and apoptosis in the ischemic renal injury. |
2001-01-11 |
2023-08-12 |
Not clear |
| F Yang, A von Knethen, B Brün. Modulation of nitric oxide-evoked apoptosis by the p53-downstream target p21(WAF1/CIP1). Journal of leukocyte biology. vol 68. issue 6. 2001-01-11. PMID:11129661. |
when produced in excess, the inflammatory mediator nitric oxide (no) attenuates cell-cycle progression at the g1 phase in tight correlation with p21(waf1/cip1) expression, provokes accumulation of the tumor suppressor p53, and initiates apoptosis/necrosis as judged on cell accumulation in the sub-g1 phase. |
2001-01-11 |
2023-08-12 |
Not clear |
| C Nucci, S Piccirilli, P Rodinò, R Nisticò, M Grandinetti, L Cerulli, M Leist, P Nicotera, G Bagett. Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation. Biochemical and biophysical research communications. vol 278. issue 2. 2001-01-04. PMID:11097843. |
here we report that monocular deprivation for 2, 7, and 14 consecutive days causes p53 accumulation, cell death, and progressive loss of neurones in the dorsal lateral geniculate nucleus (dlgn) of newborn rats and these are prevented by nmda and non-nmda glutamate receptor antagonists, and by l-name, an inhibitor of nitric oxide synthesis. |
2001-01-04 |
2023-08-12 |
mouse |
| D W Davis, D A Weidner, A Holian, D J McConke. Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung. The Journal of experimental medicine. vol 192. issue 6. 2000-10-30. PMID:10993916. |
experiments with a thiol antioxidant (n-acetylcysteine) in vivo and nitric oxide (no) donors in vitro confirmed that reactive oxygen species were required for p53 activation. |
2000-10-30 |
2023-08-12 |
mouse |
| M R Kibbe, J Li, S Nie, S C Watkins, A Lizonova, I Kovesdi, R L Simmons, T R Billiar, E Tzen. Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate. Journal of vascular surgery. vol 31. issue 6. 2000-07-27. PMID:10842159. |
the purpose of this study was to examine the mechanism by which nitric oxide (no) inhibits vascular smooth muscle cell (vsmc) proliferation, specifically focusing on signaling pathways known to be activated by no, including cyclic guanosine monophosphate (cgmp), p53, and p42/44 mitogen-activated protein kinase (mapk). |
2000-07-27 |
2023-08-12 |
Not clear |
| J G Shen, X S Quo, B Jiang, M Li, W Xin, B L Zha. Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation. Biochimica et biophysica acta. vol 1500. issue 2. 2000-06-26. PMID:10657591. |
the results suggest that chinonin has preventive effects against apoptotic and necrotic cell death and its protective mechanisms are related to the antioxidant properties of scavenging nitric oxide and oxygen free radicals, and the modulating effects on the expression levels of bcl-2 and p53 proteins. |
2000-06-26 |
2023-08-12 |
rat |
| L A Applegate, C Scaletta, R Panizzon, E Frenk, P Hohlfeld, S Schwarzkop. Induction of the putative protective protein ferritin by infrared radiation: implications in skin repair. International journal of molecular medicine. vol 5. issue 3. 2000-04-07. PMID:10677564. |
in addition, we observed that ir-a is not capable of inducing frank damage to dna (pyrimidine dimers, p53), induction of oxidative stress proteins (heme oxygenase, nitric oxide, superoxide dismutase, heat shock proteins) or proteases (collagenase, stromelysin, gelatinase) involved in carcinogenesis and photoaging of the skin. |
2000-04-07 |
2023-08-12 |
human |
| A C Souici, J Mirkovitch, P Hausel, L K Keefer, E Felley-Bosc. Transition mutation in codon 248 of the p53 tumor suppressor gene induced by reactive oxygen species and a nitric oxide-releasing compound. Carcinogenesis. vol 21. issue 2. 2000-04-03. PMID:10657969. |
exposing the human bronchial epithelial cell line beas-2b to the nitric oxide (no) donor sodium 1-(n,n-diethylamino)diazen-1-ium-1, 2-diolate (dea/no) at an initial concentration of 0.6 mm while generating superoxide ion at the rate of 1 microm/min with the hypoxanthine/xanthine oxidase (hx/xo) system induced c:g-->t:a transition mutations in codon 248 of the p53 gene. |
2000-04-03 |
2023-08-12 |
human |
| L Chazotte-Aubert, P Hainaut, H Ohshim. Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells. Biochemical and biophysical research communications. vol 267. issue 2. 2000-02-23. PMID:10631110. |
nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in mcf-7 cells. |
2000-02-23 |
2023-08-12 |
Not clear |
| L Chazotte-Aubert, P Hainaut, H Ohshim. Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells. Biochemical and biophysical research communications. vol 267. issue 2. 2000-02-23. PMID:10631110. |
it has been reported that mammalian cells incubated with excess nitric oxide (no) accumulate p53 protein but concomitantly this p53 loses its capacity for binding to its dna consensus sequence. |
2000-02-23 |
2023-08-12 |
Not clear |
| S Ambs, S P Hussain, A J Marrogi, C C Harri. Cancer-prone oxyradical overload disease. IARC scientific publications. issue 150. 2000-02-17. PMID:10626229. |
in this brief review, we focus on the possible interactive effects of nitric oxide and the p53 tumour suppressor gene in human carcinogenesis. |
2000-02-17 |
2023-08-12 |
human |