| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emma Connolly, David J Morgan, Miriam Franklin, Angela Simpson, Rajesh Shah, Oliver J Brand, Christopher P Jagger, Joshua Casulli, Karishma Mohamed, Aleksander M Grabiec, Tracy Hussel. Neurturin regulates the lung-resident macrophage inflammatory response to viral infection. Life science alliance. vol 3. issue 12. 2021-07-13. PMID:33020210. |
this circuit involves type 1 interferon-induced up-regulation of ret that when combined with the glial cell line-derived neurotrophic factor (gdnf) receptor α2 (gfrα2) allows binding to epithelial-derived nrtn. |
2021-07-13 |
2023-08-13 |
human |
| Arun Kumar Mahato, Yulia A Sidorov. Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinson's disease. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32556722. |
rearranged during transfection (ret), in complex with glial cell line-derived (gdnf) family receptor alpha (gfrα), is the canonical signaling receptor for gdnf family ligands (gfls) expressed in both central and peripheral parts of the nervous system and also in non-neuronal tissues. |
2021-06-23 |
2023-08-13 |
Not clear |
| Kumi Kawai, Masahide Takahash. Intracellular RET signaling pathways activated by GDNF. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32816064. |
physiologically, ret is activated by glial cell line-derived neurotrophic factor (gdnf) ligands that bind to coreceptor gdnf family receptor alphas (gfrαs), leading to ret dimerization. |
2021-06-23 |
2023-08-13 |
human |
| James A Conway, Selvi Ince, Stephanie Black, Edgar R Krame. GDNF/RET signaling in dopamine neurons in vivo. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32870383. |
the glial cell line-derived neurotrophic factor (gdnf) and its canonical receptor ret can signal both in tandem and separately to exert many vital functions in the midbrain dopamine system. |
2021-06-23 |
2023-08-13 |
Not clear |
| James A Conway, Selvi Ince, Stephanie Black, Edgar R Krame. GDNF/RET signaling in dopamine neurons in vivo. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32870383. |
it is known that ret has effects on maintenance, physiology, protection and regeneration in the midbrain dopamine system, with the physiological functions of gdnf still somewhat unclear. |
2021-06-23 |
2023-08-13 |
Not clear |
| Juho-Matti Renko, Merja H Voutilainen, Tanel Visnapuu, Yulia A Sidorova, Mart Saarma, Raimo K Tuomine. GDNF Receptor Agonist Alleviates Motor Imbalance in Unilateral 6-Hydroxydopamine Model of Parkinson's Disease. Frontiers in neurology and neuroscience research. vol 1. 2021-03-26. PMID:33479704. |
ret is the signalling receptor for a known survival factor for dopamine neurons called glial cell line-derived neurotrophic factor (gdnf). |
2021-03-26 |
2023-08-13 |
rat |
| Niloofar Nickaeen, Jafar Ghaisari, Shiva Moein, Yousof Gheisar. Bifurcation analysis of a modular model of embryonic kidney development. Bio Systems. vol 189. 2020-11-18. PMID:31935434. |
our findings also indicate that glial cell-derived neurotrophic factor (gdnf), a known potent regulator of kidney development, exerts its fate-determination function on cell placement through destruction of saddle node bifurcation points in ret steady states and confining ret activity level to high activity in ureteric bud tip. |
2020-11-18 |
2023-08-13 |
Not clear |
| Huiling Chen, Tiyun Han, Liping Gao, Bin Xiong, Xiaoli Li, Guoqing Qi, Pengyun Zeng, Ye Chai, Dekui Zhan. [IL-1β and TNF-α up-regulate the expression of glial cell line-derived neurotrophic factor (GDNF) and down-regulate its receptors in rat intestinal smooth muscle cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696749. |
the relative mrna expression of gdnf, receptor tyrosine kinase (ret) and gdnf family receptor alpha-1 (gfrα1) were measured by real-time quantitative pcr. |
2020-10-30 |
2023-08-13 |
rat |
| Liliane Tenenbaum, Marie Humbert-Claud. Glial Cell Line-Derived Neurotrophic Factor Gene Delivery in Parkinson's Disease: A Delicate Balance between Neuroprotection, Trophic Effects, and Unwanted Compensatory Mechanisms. Frontiers in neuroanatomy. vol 11. 2020-10-01. PMID:28442998. |
glial cell line-derived neurotrophic factor (gdnf) and neurturin (nrtn) bind to a receptor complex consisting of a member of the gdnf family receptor (gfr)-α and the ret tyrosine kinase. |
2020-10-01 |
2023-08-13 |
human |
| Wenxian Li, Di Wei, Jiaxing Lin, Jianye Liang, Xiaomei Xie, Kangping Song, Li'an Huan. Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31456664. |
glial cell line-derived neurotrophic factor (gdnf)/gdnf family receptor alpha-1 (gfrα1)/receptor tyrosine kinase (ret) signaling is altered in the hippocampus of cch rats; however, nbp treatment improved cognitive function, protected against hippocampal neuron apoptosis |
2020-09-29 |
2023-08-13 |
rat |
| Sean Jmaeff, Yulia Sidorova, Hayley Lippiatt, Pablo F Barcelona, Hinyu Nedev, Lucia M Saragovi, Mark A Hancock, Mart Saarma, H Uri Saragov. Small-Molecule Ligands that Bind the RET Receptor Activate Neuroprotective Signals Independent of but Modulated by Coreceptor GFR Molecular pharmacology. vol 98. issue 1. 2020-07-30. PMID:32362584. |
small-molecule ligands that bind the ret receptor activate neuroprotective signals independent of but modulated by coreceptor gfr glial cell line-derived neurotrophic factor (gdnf) binds the gfr |
2020-07-30 |
2023-08-13 |
Not clear |
| C R Donnelly, A A Shah, E B Suh, B A Pierchal. Ret Signaling Is Required for Tooth Pulp Innervation during Organogenesis. Journal of dental research. vol 98. issue 6. 2020-07-14. PMID:30958726. |
in this study, we analyzed the expression and function of glial cell line-derived neurotrophic factor (gdnf) and its receptor tyrosine kinase, ret, in the regulation of innervation of the mouse tooth pulp by dental pulpal afferent (dpa) neurons of the trigeminal ganglion (tg). |
2020-07-14 |
2023-08-13 |
mouse |
| Zhenghu Chen, Yanling Zhao, Yang Yu, Jonathan C Pang, Sarah E Woodfield, Ling Tao, Shan Guan, Huiyuan Zhang, Shayahati Bieerkehazhi, Yan Shi, Roma Patel, Sanjeev A Vasudevan, Joanna S Yi, Jodi A Muscal, Guo-Tong Xu, Jianhua Yan. Small molecule inhibitor regorafenib inhibits RET signaling in neuroblastoma cells and effectively suppresses tumor growth Oncotarget. vol 8. issue 61. 2020-03-09. PMID:29262623. |
herein we report that ret is required for nb cell proliferation and that the small molecule inhibitor regorafenib (bay 73-4506) blocks glial cell derived neurotrophic factor (gdnf)-induced ret signaling in nb cells and inhibits nb growth both |
2020-03-09 |
2023-08-13 |
human |
| Anja Drinkut, Karsten Tillack, Durga P Meka, Jorg B Schulz, Sebastian Kügler, Edgar R Krame. Correction to: Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell death & disease. vol 9. issue 6. 2019-11-20. PMID:29802278. |
correction to: ret is essential to mediate gdnf's neuroprotective and neuroregenerative effect in a parkinson disease mouse model. |
2019-11-20 |
2023-08-13 |
mouse |
| L Lauriina Porokuokka, Heikki T Virtanen, Jere Lindén, Yulia Sidorova, Tatiana Danilova, Maria Lindahl, Mart Saarma, Jaan-Olle Andresso. Gfra1 Underexpression Causes Hirschsprung's Disease and Associated Enterocolitis in Mice. Cellular and molecular gastroenterology and hepatology. vol 7. issue 3. 2019-06-04. PMID:30594740. |
ret, the receptor for the glial cell line-derived neurotrophic factor (gdnf) family ligands, is the most frequently mutated gene in congenital aganglionic megacolon or hirschsprung's disease (hscr). |
2019-06-04 |
2023-08-13 |
mouse |
| Muhammad Usman Janjua, Xiao-Dan Long, Zhao-Hui Mo, Chang-Sheng Dong, Ping Ji. Association of medullary sponge kidney and hyperparathyroidism with RET G691S/S904S polymorphism: a case report. Journal of medical case reports. vol 12. issue 1. 2019-04-09. PMID:29983117. |
given the key role of the interaction of glial cell line-derived neurotrophic factor gene, gdnf, and the "rearranged during transfection" proto-oncogene, ret, in kidney and urinary tract development, variations in these genes are proposed to be candidates for medullary sponge kidney. |
2019-04-09 |
2023-08-13 |
Not clear |
| Xi-Bin Hu, Shu-Hua Fu, Q I Luo, Jian-Zhong He, Yan-Fei Qiu, Wei Lai, Min Zhon. Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury Journal of biosciences. vol 43. issue 5. 2019-01-29. PMID:30541958. |
this study aims to elucidate the role of mir-216a in yttrium aluminium garnet (yag) laser-induced retinal injury by targeting glial cell line-derived neurotrophic factor (gdnf) via gdnf/gdnf family neurotrophic factor receptor α1 (gfrα1)/rearranged during transfection (ret) signalling pathway. |
2019-01-29 |
2023-08-13 |
rat |
| Xi-Bin Hu, Shu-Hua Fu, Q I Luo, Jian-Zhong He, Yan-Fei Qiu, Wei Lai, Min Zhon. Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury Journal of biosciences. vol 43. issue 5. 2019-01-29. PMID:30541958. |
compared with the blank and nc groups, the mir-216a mimic and sirna-gdnf groups had higher mrna and protein levels of c-fos, vegf and bax, cell number in the g1 phase and increased cell apoptosis but reduced bdnf, gdnf, gfrα1, ret and bcl-2 expression, cell proliferation and cell numbers in the s phase, while the opposite trend was observed in the mir-216a inhibitor group. |
2019-01-29 |
2023-08-13 |
rat |
| Kamal Hezam, Jiahao Jiang, Fumou Sun, Xinrong Zhang, Juan Zhan. Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. Reviews in the neurosciences. vol 29. issue 1. 2018-10-30. PMID:28937965. |
artemin (artn) is a member of glial cell line-derived neurotrophic factor (gdnf) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored gdnf family receptors a (gfra1, gfra3) and ret receptor tyrosine kinase. |
2018-10-30 |
2023-08-13 |
Not clear |
| Christopher R Donnelly, Amol A Shah, Charlotte M Mistretta, Robert M Bradley, Brian A Pierchal. Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 3. 2018-07-17. PMID:29282324. |
gdnf, acting through the receptor tyrosine kinase ret, regulates the expression of the chemosensory fate determinant phox2b early in gg development. |
2018-07-17 |
2023-08-13 |
Not clear |