| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaakko Kopra, Marian Villarta-Aguilera, Mari Savolainen, Samo Weingerl, Timo T Myöhänen, Saara Rannanpää, Michael F Salvatore, Jaan-Olle Andressoo, T Petteri Pieppone. Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine. Neuropharmacology. vol 128. 2018-07-13. PMID:29031851. |
together, our results suggest that downstream components of gdnf signaling, in this case ret, may mediate persistent drug-seeking behavior through increased th expression and dopamine levels in the mesolimbic dopamine neurons. |
2018-07-13 |
2023-08-13 |
mouse |
| Zhijiang Chen, Christopher R Donnelly, Bertha Dominguez, Yoshinobu Harada, Weichun Lin, Alan S Halim, Tasha G Bengoechea, Brian A Pierchala, Kuo-Fen Le. p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell reports. vol 21. issue 3. 2018-06-13. PMID:29045838. |
here, we show that the p75 neurotrophin receptor interacts with ret and its gfrα co-receptor upon stimulation with glial cell line-derived neurotrophic factor (gdnf). |
2018-06-13 |
2023-08-13 |
mouse |
| Li Li, Haijing Song, Peipei Mu, Ming Xu, Chaoxia Liu, Ying Wang, Yingsong Qin, Shen Sun, Jin Gao, Ting Wang, Dianshuai Ga. The Actin Cytoskeleton Is Involved in Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Induced Ret Translocation into Lipid Rafts in Dopaminergic Neuronal Cells. International journal of molecular sciences. vol 18. issue 9. 2018-05-14. PMID:28880247. |
the actin cytoskeleton is involved in glial cell line-derived neurotrophic factor (gdnf)-induced ret translocation into lipid rafts in dopaminergic neuronal cells. |
2018-05-14 |
2023-08-13 |
Not clear |
| Li Li, Haijing Song, Peipei Mu, Ming Xu, Chaoxia Liu, Ying Wang, Yingsong Qin, Shen Sun, Jin Gao, Ting Wang, Dianshuai Ga. The Actin Cytoskeleton Is Involved in Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Induced Ret Translocation into Lipid Rafts in Dopaminergic Neuronal Cells. International journal of molecular sciences. vol 18. issue 9. 2018-05-14. PMID:28880247. |
glial cell line-derived neurotrophic factor (gdnf), a potential therapeutic factor for parkinson's disease (pd), exerts its biological effects through the ret receptor tyrosine kinase. |
2018-05-14 |
2023-08-13 |
Not clear |
| Paolo Ria, Antonia Fabris, Alessandra Dalla Gassa, Gianluigi Zaza, Antonio Lupo, Giovanni Gambar. New non-renal congenital disorders associated with medullary sponge kidney (MSK) support the pathogenic role of GDNF and point to the diagnosis of MSK in recurrent stone formers. Urolithiasis. vol 45. issue 4. 2018-04-19. PMID:27573101. |
it has been suggested that the rearranged during transfection (ret) proto-oncogene and the glial cell line-derived neurotrophic factor (gdnf) gene are defective in patients with msk, and both ret and gdnf are known to have a role in the development of the central nervous system, heart, and craniofacial skeleton. |
2018-04-19 |
2023-08-13 |
Not clear |
| Logan Myers, Hiran Perera, Michael G Alvarado, Thomas Kid. The Development (Cambridge, England). vol 145. issue 3. 2018-04-09. PMID:29361562. |
the the ret receptor tyrosine kinase is crucial for the development of the enteric nervous system (ens), acting as a receptor for glial cell line-derived neurotrophic factor (gdnf) via gfr co-receptors. |
2018-04-09 |
2023-08-13 |
Not clear |
| Maria Christina Sergaki, Juan Carlos López-Ramos, Stefanos Stagkourakis, Agnès Gruart, Christian Broberger, José María Delgado-García, Carlos F Ibáñe. Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning. Cell reports. vol 19. issue 10. 2018-03-09. PMID:28591570. |
compromised survival of cerebellar molecular layer interneurons lacking gdnf receptors gfrα1 or ret impairs normal cerebellar motor learning. |
2018-03-09 |
2023-08-13 |
mouse |
| Maria Christina Sergaki, Juan Carlos López-Ramos, Stefanos Stagkourakis, Agnès Gruart, Christian Broberger, José María Delgado-García, Carlos F Ibáñe. Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning. Cell reports. vol 19. issue 10. 2018-03-09. PMID:28591570. |
here, we show that purkinje cells (pcs), the target of mlis, express the neurotrophic factor gdnf during mli development and survival of mlis depends on gdnf receptors gfrα1 and ret. |
2018-03-09 |
2023-08-13 |
mouse |
| Hongfeng Ruan, Huan Luo, Jirong Wang, Xing Ji, Zhongmiao Zhang, Junsong Wu, Xianning Zhang, Ximei W. Smoothened-independent activation of hedgehog signaling by rearranged during transfection promotes neuroblastoma cell proliferation and tumor growth. Biochimica et biophysica acta. vol 1860. issue 9. 2017-10-26. PMID:27316313. |
rearranged during transfection (ret) proto-oncogene encodes a receptor tyrosine kinase for glial cell line-derived neurotrophic factor (gdnf) signaling, and high ret expression is closely related to the tumorigenesis and malignancy of neuroblastoma(nb). |
2017-10-26 |
2023-08-13 |
Not clear |
| Anja Drinkut, Karsten Tillack, Durga P Meka, Jorg B Schulz, Sebastian Kügler, Edgar R Krame. Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell death & disease. vol 7. issue 9. 2017-10-25. PMID:27607574. |
ret is essential to mediate gdnf's neuroprotective and neuroregenerative effect in a parkinson disease mouse model. |
2017-10-25 |
2023-08-13 |
mouse |
| Anja Drinkut, Karsten Tillack, Durga P Meka, Jorg B Schulz, Sebastian Kügler, Edgar R Krame. Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell death & disease. vol 7. issue 9. 2017-10-25. PMID:27607574. |
to address this question we overexpressed gdnf in the striatum of mice deficient for ret in dopaminergic neurons and subsequently challenged these mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2017-10-25 |
2023-08-13 |
mouse |
| Anja Drinkut, Karsten Tillack, Durga P Meka, Jorg B Schulz, Sebastian Kügler, Edgar R Krame. Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell death & disease. vol 7. issue 9. 2017-10-25. PMID:27607574. |
strikingly, in this established pd mouse model, the absence of ret completely abolished gdnf's neuroprotective and regenerative effect on the midbrain dopaminergic system. |
2017-10-25 |
2023-08-13 |
mouse |
| Anja Drinkut, Karsten Tillack, Durga P Meka, Jorg B Schulz, Sebastian Kügler, Edgar R Krame. Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model. Cell death & disease. vol 7. issue 9. 2017-10-25. PMID:27607574. |
this establishes ret signaling as absolutely required for gdnf's effects to prevent and compensate dopaminergic system degeneration and suggests ret activation as the primary target of gdnf therapy in pd. |
2017-10-25 |
2023-08-13 |
mouse |
| Hyun-Jung Park, Eric C Bolto. RET-mediated glial cell line-derived neurotrophic factor signaling inhibits mouse prostate development. Development (Cambridge, England). vol 144. issue 12. 2017-09-21. PMID:28506996. |
glial cell line-derived neurotrophic factor (gdnf) binds gdnf family receptor α1 (gfrα1) and signals through activation of ret tyrosine kinase. |
2017-09-21 |
2023-08-13 |
mouse |
| Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldma. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one. vol 12. issue 5. 2017-09-18. PMID:28467503. |
zebrafish gdnf and its co-receptor gfrα1 activate the human ret receptor and promote the survival of dopaminergic neurons in vitro. |
2017-09-18 |
2023-08-13 |
mouse |
| Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldma. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one. vol 12. issue 5. 2017-09-18. PMID:28467503. |
glial cell line-derived neurotrophic factor (gdnf) is a ligand that activates, through co-receptor gdnf family receptor alpha-1 (gfrα1) and receptor tyrosine kinase "ret", several signaling pathways crucial in the development and sustainment of multiple neuronal populations. |
2017-09-18 |
2023-08-13 |
mouse |
| Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldma. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one. vol 12. issue 5. 2017-09-18. PMID:28467503. |
surprisingly, we also found that zebrafish gdnf as well as zebrafish gfrα1 robustly activated human ret signaling and promoted the survival of cultured mouse dopaminergic neurons with comparable efficiency to mammalian gdnf, unlike e. coli-produced human proteins. |
2017-09-18 |
2023-08-13 |
mouse |
| Mariusz Kaczmarczyk, Beata Loniewska, Anna Kuprjanowicz, Agnieszka Binczak-Kuleta, Iwona Goracy, Malgorzata Ryder, Olga Taryma-Lesniak, Andrzej Ciechanowic. Association Between RET (rs1800860) and GFRA1 (rs45568534, rs8192663, rs181595401, rs7090693, and rs2694770) Variants and Kidney Size in Healthy Newborns. Genetic testing and molecular biomarkers. vol 20. issue 10. 2017-03-06. PMID:27533506. |
the glial cell-derived neurotrophic factor (gdnf) family receptor alpha 1 (gfra1) is a component of the ret receptor complex, and three alternatively spliced gfra1 transcripts (with or without exon 5) have been identified. |
2017-03-06 |
2023-08-13 |
rat |
| Tao Xu, Neng-Gui Xu, Zhong-Hua Yang, Yan-Zhen Wan, Qing-Long Wu, Kang-Bai Huan. Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats are associated with increased expression of GDNF-RET and protein kinase B. Chinese journal of integrative medicine. vol 22. issue 6. 2017-02-22. PMID:26033318. |
to explore the neuroprotective effects of electroacupuncture (ea) on hypoxic-ischemic encephalopathy (hie) and to further investigate the role of glial cell line-derived neurotrophic factor (gdnf) family receptor member ret (rearranged during transfection) and its key downstream phosphatidylinositol 3 kinase (pi-3k)/protein kinase b (akt) pathway in the process. |
2017-02-22 |
2023-08-13 |
rat |
| Mathieu J F Crupi, Piriya Yoganathan, Leslie N Bone, Eric Lian, Andrew Fetz, Costin N Antonescu, Lois M Mulliga. Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2. Traffic (Copenhagen, Denmark). vol 16. issue 11. 2016-08-15. PMID:26304132. |
ret isoforms are internalized from the cell surface into endosomal compartments in response to glial cell line-derived neurotropic factor (gdnf) ligand stimulation but the specific mechanisms of ret trafficking remain to be elucidated. |
2016-08-15 |
2023-08-13 |
human |