| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongping Wang, Arjun Stokes, Zhijian Duan, Jordan Hui, Ying Xu, YiPing Chen, Hong-Wu Chen, Kit Lam, Chengji J Zho. LDL Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic Dysplasia. Journal of the American Society of Nephrology : JASN. vol 27. issue 2. 2016-06-07. PMID:26047795. |
the expression of ret proto-oncogene (ret), a critical receptor for the growth factor glial cell line-derived neurotrophic factor (gdnf), which is required for early nephrogenesis, was dramatically diminished in the mutant renal primordia. |
2016-06-07 |
2023-08-13 |
mouse |
| Edgar R Kramer, Birgit Lis. GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. FEBS letters. vol 589. issue 24 Pt A. 2016-04-29. PMID:26555190. |
glial cell line-derived neurotrophic factor (gdnf) and its canonical receptor ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (da) system. |
2016-04-29 |
2023-08-13 |
Not clear |
| Edgar R Kramer, Birgit Lis. GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. FEBS letters. vol 589. issue 24 Pt A. 2016-04-29. PMID:26555190. |
here, we review the current knowledge of gdnf and ret signaling and function in the midbrain da system, and their crosstalk with proteins and signaling pathways associated with pd. |
2016-04-29 |
2023-08-13 |
Not clear |
| Hyun-Jung Park, Eric C Bolto. Glial cell line-derived neurotrophic factor induces cell proliferation in the mouse urogenital sinus. Molecular endocrinology (Baltimore, Md.). vol 29. issue 2. 2016-02-29. PMID:25549043. |
glial cell line-derived neurotrophic factor (gdnf) is a tgfβ family member, and gdnf signals through a glycosyl-phosphatidylinositol-linked cell surface receptor (gfrα1) and ret receptor tyrosine kinase. |
2016-02-29 |
2023-08-13 |
mouse |
| M Curcio, I L Salazar, A R Inácio, E P Duarte, L M T Canzoniero, C B Duart. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell death & disease. vol 6. 2016-01-25. PMID:25675305. |
the glial cell line-derived neurotrophic factor (gdnf) has an important role in neuronal survival through binding to the gfrα1 (gdnf family receptor alpha-1) receptor and activation of the receptor tyrosine kinase ret. |
2016-01-25 |
2023-08-13 |
mouse |
| Agnes W Wong, James K P Yeung, Sophie C Payne, Janet R Keast, Peregrine B Osborn. Neurite outgrowth in normal and injured primary sensory neurons reveals different regulation by nerve growth factor (NGF) and artemin. Molecular and cellular neurosciences. vol 65. 2016-01-11. PMID:25752731. |
artemin is a member of the glial cell line-derived neurotrophic factor (gdnf) family of ligands (gfls) that forms a signalling complex with gfrα3 and the tyrosine kinase ret. |
2016-01-11 |
2023-08-13 |
rat |
| Cynthia C Tsui, Nicole A Gabreski, Sarah J Hein, Brian A Pierchal. Lipid Rafts Are Physiologic Membrane Microdomains Necessary for the Morphogenic and Developmental Functions of Glial Cell Line-Derived Neurotrophic Factor In Vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 38. 2015-12-29. PMID:26400951. |
glial cell line-derived neurotrophic factor (gdnf) promotes pns development and kidney morphogenesis via a receptor complex consisting of the glycerophosphatidylinositol (gpi)-anchored, ligand binding receptor gdnf family receptor α1 (gfrα1) and the receptor tyrosine kinase ret. |
2015-12-29 |
2023-08-13 |
mouse |
| Shuyong Zhu, Chengjiang Zhao, Yingying Wu, Qiaoqiao Yang, Aiyun Shao, Tiepeng Wang, Jianfu Wu, Yanqing Yin, Yandong Li, Jincan Hou, Xinhua Zhang, Guomin Zhou, Xiaosong Gu, Xiaomin Wang, Xosé R Bustelo, Jiawei Zho. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nature neuroscience. vol 18. issue 8. 2015-10-21. PMID:26147533. |
here we show that the rho-family guanine nucleotide exchange factor protein vav2 is required for dat cell surface expression and transporter activity modulated by glial cell line-derived neurotrophic factor (gdnf) and its cognate receptor ret. |
2015-10-21 |
2023-08-13 |
mouse |
| M J Luesma, I Cantarero, J M Álvarez-Dotu, S Santander, C Junquer. New insights into c-Ret signalling pathway in the enteric nervous system and its relationship with ALS. BioMed research international. vol 2014. 2015-09-30. PMID:24868525. |
the receptor tyrosine kinase ret (c-ret) transduces the glial cell line-derived neurotrophic factor (gdnf) signal, one of the neurotrophic factors related to the degeneration process or the regeneration activity of motor neurons in amyotrophic lateral sclerosis (als). |
2015-09-30 |
2023-08-13 |
human |
| Uta Rickert, Steffen Grampp, Henrik Wilms, Jessica Spreu, Friederike Knerlich-Lukoschus, Janka Held-Feindt, Ralph Luciu. Glial Cell Line-Derived Neurotrophic Factor Family Members Reduce Microglial Activation via Inhibiting p38MAPKs-Mediated Inflammatory Responses. Journal of neurodegenerative diseases. vol 2014. 2015-08-28. PMID:26317008. |
using rt-pcr and immunohistochemistrym we investigated the expression of the gdnf family receptor alpha 1 (gfr alpha) and the coreceptor transmembrane receptor tyrosine kinase (ret) in rat microglia in vitro as well as the effect of gfl on the expression of proinflammatory molecules in lps activated microglia. |
2015-08-28 |
2023-08-13 |
rat |
| Durga Praveen Meka, Anne Kathrin Müller-Rischart, Prakash Nidadavolu, Behnam Mohammadi, Elisa Motori, Srinivas Kumar Ponna, Helia Aboutalebi, Mahmoud Bassal, Anil Annamneedi, Barbara Finckh, Margit Miesbauer, Natalie Rotermund, Christian Lohr, Jörg Tatzelt, Konstanze F Winklhofer, Edgar R Krame. Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25822020. |
parkin and the glial cell line-derived neurotrophic factor (gdnf) receptor ret have both been independently linked to the dopaminergic neuron degeneration that underlies parkinson's disease (pd). |
2015-08-17 |
2023-08-13 |
mouse |
| Guoqing Hou, Victoria Wu, Gulmohar Singh, Lawrence B Holzman, Cynthia C Tsu. Ret is critical for podocyte survival following glomerular injury in vivo. American journal of physiology. Renal physiology. vol 308. issue 7. 2015-06-09. PMID:25587123. |
glial cell line-derived neurotrophic factor (gdnf) and its receptor tyrosine kinase, ret, are upregulated in both nonimmune and immune-mediated in vitro and in vivo models of glomerular diseases. |
2015-06-09 |
2023-08-13 |
mouse |
| Shelley L Forrest, Sophie C Payne, Janet R Keast, Peregrine B Osborn. Peripheral injury of pelvic visceral sensory nerves alters GFRα (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord. Frontiers in neuroanatomy. vol 9. 2015-04-27. PMID:25914629. |
gdnf (glial cell line-derived neurotrophic factor), neurturin and artemin use their co-receptors (gfrα1, gfrα2 and gfrα3, respectively) and the tyrosine kinase ret for downstream signaling. |
2015-04-27 |
2023-08-13 |
Not clear |
| Jussi Kupari, Matti S Airaksine. Different requirements for GFRα2-signaling in three populations of cutaneous sensory neurons. PloS one. vol 9. issue 8. 2015-04-17. PMID:25111710. |
many primary sensory neurons in mouse dorsal root ganglia (drg) express one or several gfrα's, the ligand-binding receptors of the gdnf family, and their common signaling receptor ret. |
2015-04-17 |
2023-08-13 |
mouse |
| Tao Xu, Wenjie Li, Yiqun Liang, Zhonghua Yang, Jingdong Liu, Yejun Wang, Nailun S. Neuroprotective effects of electro acupuncture on hypoxic-ischemic encephalopathy in newborn rats Ass. Pakistan journal of pharmaceutical sciences. vol 27. issue 6 Suppl. 2015-02-12. PMID:25410062. |
this was accompanied by gradually increased expression of gdnf family receptor ret at the mrna level and its downstream signaling akt at the protein level in the ischemic cortex. |
2015-02-12 |
2023-08-13 |
rat |
| Esther Diaz-Rodriguez, Angela R Garcia-Rendueles, Alejandro Ibáñez-Costa, Ester Gutierrez-Pascual, Montserrat Garcia-Lavandeira, Alfonso Leal, Miguel A Japon, Alfonso Soto, Eva Venegas, Francisco J Tinahones, Juan A Garcia-Arnes, Pedro Benito, Maria Angeles Galvez, Luis Jimenez-Reina, Ignacio Bernabeu, Carlos Dieguez, Raul M Luque, Justo P Castaño, Clara V Alvare. Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF. Endocrinology. vol 155. issue 11. 2014-12-31. PMID:25137025. |
in rodents, when normal somatotrophs are deprived of the ret ligand, gdnf (glial cell derived neurotrophic factor), ret is processed intracellularly to induce overexpression of pit1 [transcription factor (gene : pouf1) essential for transcription of pituitary hormones gh, prl and tshb], which in turn leads to p19arf/p53-dependent apoptosis. |
2014-12-31 |
2023-08-13 |
mouse |
| Xuefeng Tan, Lei Zhang, Huixia Zhu, Jianbing Qin, Meiling Tian, Chuanming Dong, Haoming Li, Guohua Ji. Brn4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons. Neuroscience letters. vol 571. 2014-12-03. PMID:24769320. |
furthermore, brn4 significantly induced the expression of glial cell line-derived neurotrophic factor (gdnf) with its receptors gfrα-1 and ret, which may contribute to the maturation and survival of differentiated da neurons. |
2014-12-03 |
2023-08-13 |
Not clear |
| Marta Rusmini, Paola Griseri, Ivana Matera, Elena Pontarini, Roberto Ravazzolo, Domenico Mavilio, Isabella Ceccherin. Expression variability and function of the RET gene in adult peripheral blood mononuclear cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24777754. |
moreover, we investigated the ret-associated inflammatory pathways in pbmcs from healthy donors both in resting conditions and upon glial cell derived neurotrophic factor (gdnf) and gpi-linked co-receptors alpha 1 (gfrα1) mediated ret activation. |
2014-10-20 |
2023-08-13 |
human |
| T Keefe Davis, Masato Hoshi, Sanjay Jai. To bud or not to bud: the RET perspective in CAKUT. Pediatric nephrology (Berlin, Germany). vol 29. issue 4. 2014-10-14. PMID:24022366. |
in the kidneys, ret is activated by interaction with the ligand glial cell line-derived neurotrophic factor (gdnf) and coreceptor gfrα1. |
2014-10-14 |
2023-08-12 |
mouse |
| Yatsuka Hibi, Tamae Ohye, Kimio Ogawa, Yoshimi Shimizu, Masahiro Shibata, Chikara Kagawa, Yutaka Mizuno, Hiroki Kurahashi, Katsumi Iwas. A MEN2A family with two asymptomatic carriers affected by unilateral renal agenesis. Endocrine journal. vol 61. issue 1. 2014-10-14. PMID:24152999. |
genetic analysis detected c618r ret mutation in the proband and her 3 sons, and no other mutations were found in ret as well as glial cell line-derived neurotrophic factor (gdnf). |
2014-10-14 |
2023-08-12 |
mouse |