| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mosaad A Soltan, Ramdan S Shewita, Omaima A Matroud, Lamya Ahmed Alkeridis, Samy Sayed, Mustafa Shukry, Set A El-Shoboksh. Lignocellulose and probiotic supplementation in broiler chicken diet: effect on growth performance, digestive health, litter quality, and genes expression. Poultry science. vol 103. issue 6. 2024-04-23. PMID:38652957. |
dietary inclusion of lc and or b. subtilis supplementation significantly (p < 0.001) up-regulated hepatic growth-related genes (growth hormone receptor (ghr) and insulin growth factor1 (igf-1)) and antioxidant-related genes (superoxide dismutase 1 (sod1), glutathione peroxidase (gpx1) and uncoupling protein (ucp) and down-regulated (p < 0.001) splenic toll-like receptor 4 (tlrp) gene expression while had no significant effect on splenic interleukin 8 (il8) and tumor necrosis factor (tnf) with the best-obtained results with 1.0% followed by 0.5% lc with b. subtilis supplementation. |
2024-04-23 |
2024-04-26 |
chicken |
| Rashmi Patil, Urmila Aswar, Nishant Vya. Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling. Hormones and behavior. vol 161. 2024-02-14. PMID:38354494. |
insulin resistance, lipid profile, antioxidant enzyme, inflammatory cytokines (nf-κb, il-6, tnf α) and cortisol levels were mitigated by pte. |
2024-02-14 |
2024-02-17 |
mouse |
| Yu Wang, Hidekatsu Ih. The Novel Link between Gene Expression Profiles of Adult T-Cell Leukemia/Lymphoma Patients' Peripheral Blood Lymphocytes and Ferroptosis Susceptibility. Genes. vol 14. issue 11. 2023-11-25. PMID:38002949. |
autophagy-related degs are linked to autophagy, apoptosis, nod-like receptor signaling, tnf signaling, and the insulin resistance pathway. |
2023-11-25 |
2023-11-28 |
Not clear |
| Zeping Zhang, Boyan Zhang, Xianzhe Jiang, Yue Yu, Yimeng Cui, Hailing Luo, Bing Wan. Hyocholic acid retards renal fibrosis by regulating lipid metabolism and inflammatory response in a sheep model. International immunopharmacology. vol 122. 2023-07-23. PMID:37481851. |
the kegg pathways including non-alcoholic fatty liver disease, insulin resistance, tnf signaling pathway, and th17 cell differentiation were enriched and nf-κb, il-6, and tgf-β were identified as the core interconnected genes. |
2023-07-23 |
2023-08-14 |
Not clear |
| Axel de Baat, Beckey Trinh, Helga Ellingsgaard, Marc Y Donat. Physiological role of cytokines in the regulation of mammalian metabolism. Trends in immunology. 2023-07-09. PMID:37423882. |
tnf induces insulin resistance and prevents ketogenesis. |
2023-07-09 |
2023-08-14 |
Not clear |
| Xia Deng, Chang Guo, Huijuan Qin, Li Zhao, Yanyan Li, Zhicong Zhao, Haoxiang Li, Ling Yang, Dong Wang, Guoyue Yua. Association between Circulating Ectodysplasin A and Diabetic Kidney Disease. Journal of diabetes research. vol 2023. 2023-04-24. PMID:37091044. |
ectodysplasin a (eda), a member of the tnf family, plays important roles in ectodermal development, while recent studies expanded its regulatory effects on insulin resistance and lipid metabolism. |
2023-04-24 |
2023-08-14 |
Not clear |
| Shruti Jain, Ayodeji Olalekan Sala. Novel predictive model of cell survival/death related effects of Extracellular Signal-Regulated kinase protein. Artificial cells, nanomedicine, and biotechnology. vol 51. issue 1. 2023-03-27. PMID:36971398. |
three hundred erk samples were examined using ten different concentrations of three input proteins: egf, tnf, and insulin. |
2023-03-27 |
2023-08-14 |
Not clear |
| Shruti Jain, Ayodeji Olalekan Sala. Novel predictive model of cell survival/death related effects of Extracellular Signal-Regulated kinase protein. Artificial cells, nanomedicine, and biotechnology. vol 51. issue 1. 2023-03-27. PMID:36971398. |
the results reveal that utilising different concentrations and samples, values such as 7.55 ad and 18.4 ad were obtained using the weibull distribution function for 0 ng/ml of tnf, 100 ng/ml of egf, and 0 ng/ml of insulin concentrations. |
2023-03-27 |
2023-08-14 |
Not clear |
| Ming-Han Li, Ming-Hui Jin, Rui-Yi Hu, Shan Tang, Ke-Ke Li, Xiao-Jie Gong, Yin-Shi Sun, Ying-Ping Wang, Zi Wang, Wei L. Exploring the mechanism of active components from ginseng to manage diabetes mellitus based on network pharmacology and molecular docking. Scientific reports. vol 13. issue 1. 2023-01-16. PMID:36646777. |
kyoto encyclopedia of genes and genomes and gene ontology enrichment analysis showed that the management of diabetes mellitus by ginsenosides may be related to the positive regulation of reactive oxygen metabolic processes, associated with the insulin signaling pathway, tnf signaling pathway, and ampk signaling pathway. |
2023-01-16 |
2023-08-14 |
Not clear |
| Hao Gu, Mailin Gan, Linghui Wang, Yiting Yang, Jinyong Wang, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Dongmei Jiang, Yiwu Chen, Anan Jiang, Linyuan Shen, Li Zh. Differential Expression Analysis of tRNA-Derived Small RNAs from Subcutaneous Adipose Tissue of Obese and Lean Pigs. Animals : an open access journal from MDPI. vol 12. issue 24. 2022-12-23. PMID:36552481. |
functional enrichment analysis revealed that differential tsrnas indirectly participated in mapk, ampk, insulin resistance, the tnf signaling pathway, adipocytokine signaling pathway, and other signaling pathways by interacting with target genes. |
2022-12-23 |
2023-08-14 |
Not clear |
| Keith Taverner, Yousif Murad, Adam B Yasunaga, Christine Furrer, Jonathan Little, Isaac T S L. The effect of type-2 diabetes conditions on neutrophil rolling adhesion. BMC research notes. vol 15. issue 1. 2022-12-03. PMID:36463286. |
type 2 diabetes mellitus (t2d) is the result of a dysregulation of insulin production and signalling, leading to an increase in both glucose concentration and pro-inflammatory cytokines such as interleukin (il)-6 and tumour necrosis factor (tnf)-α. |
2022-12-03 |
2023-08-14 |
Not clear |
| Ximena Hildebrandt, Mohamed Ibrahim, Nieves Peltze. Cell death and inflammation during obesity: "Know my methods, WAT(son)". Cell death and differentiation. 2022-09-29. PMID:36175539. |
during obesity, signalling via cytokines of the tnf family mediate cell death and inflammation within the adipose tissue, eventually resulting in lipid spill-over, glucotoxicity and insulin resistance. |
2022-09-29 |
2023-08-14 |
Not clear |
| Tianjiao Gao, Shaotao Chen, Yiran Han, Dongmei Zhang, Yi Tan, Yutao He, Mingjun Li. Ameliorating Inflammation in Insulin-resistant Rat Adipose Tissue with Abdominal Massage Regulates SIRT1/NF-κB Signaling. Cell biochemistry and biophysics. 2022-07-30. PMID:35907080. |
the model rat adipose tissue showed significant improvements in obesity, glucose intolerance, and the accumulation of lipid in the body [the total cholesterol level (tc), triglycerides (tg), high-density lipoprotein cholesterol (hdl-c), and low-density lipoprotein cholesterol (ldl-c)], metabolic effects of glucose [the fasting blood glucose (fbg), fasting insulin levels (fins)], inflammatory status [interleukin-6 (il-6) and tumor necrosis factor (tnf)-α, c-reactive protein (crp)], and macrophage polarization after am or rsv treatment. |
2022-07-30 |
2023-08-14 |
rat |
| Stepheny C de Campos Zani, Myoungjin Son, Khushwant S Bhullar, Catherine B Chan, Jianping W. IRW (Isoleucine-Arginine-Tryptophan) Improves Glucose Tolerance in High Fat Diet Fed C57BL/6 Mice via Activation of Insulin Signaling and AMPK Pathways in Skeletal Muscle. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740257. |
irw (isoleucine-arginine-tryptophan), has antihypertensive and anti-inflammatory properties in cells and animal models and prevents angiotensin-ii- and tumor necrosis factor (tnf)-α-induced insulin resistance (ir) in vitro. |
2022-06-24 |
2023-08-14 |
mouse |
| Hui Jiang, Tangyou Mao, Yuyue Liu, Xiang Tan, Zhongmei Sun, Yuan Cheng, Xiao Han, Yang Zhang, Jiali Wang, Lei Shi, Yi Guo, Junxiang Li, Haixiao Ha. Protective Effects and Mechanisms of Yinchen Linggui Zhugan Decoction in HFD-Induced Nonalcoholic Fatty Liver Disease Rats Based on Network Pharmacology and Experimental Verification. Frontiers in pharmacology. vol 13. 2022-06-20. PMID:35721171. |
kegg enrichment analysis revealed fundamental roles of tnf, pi3k/akt, hif-1α, and insulin resistance signaling pathways in the treatment of nafld by ylzd. |
2022-06-20 |
2023-08-14 |
rat |
| Shuang Wei, Ji Li, Dong-Wei Han, Qiang Fu, Feng Ha. [Mechanism of Astragali Radix-Puerariae Lobatae Radix combination in regulating type 2 diabetes mellitus through AMPK signaling pathway: based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718494. |
after 4 weeks of intragastric administration, serum fasting blood glucose(fbg), fasting insulin(fins), aspartate aminotransferase(ast), alanine aminotransferase(alt), triglyceride(tg), total cholesterol(tc), low-density lipoprotein cholesterol(ldl-c), high-density lipoprotein cholesterol(hdl-c), interleukin(il)-6, and tumor necrosis factor(tnf)-α of rats in each group were measured. |
2022-06-19 |
2023-08-14 |
rat |
| Yiwen Wang, Ping Che. Combination of HPLC-Q-TOF-MS/MS, Network Pharmacology, and Molecular Docking to Reveal the Mechanism of Apple Pollen in the Treatment of Type 2 Diabetes Mellitus. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-06-03. PMID:35656465. |
moreover, akt1, pparg, src, egfr, casp3, esr1, and the other potential core targets might be involved in the treatment of t2dm by modulating the following pathways, containing insulin resistance, hepatitis c, pancreatic cancer, insulin signaling pathway, tnf signaling pathway, and pi3k-akt signaling pathway. |
2022-06-03 |
2023-08-14 |
Not clear |
| Muhammad M Hossain, Sunanda Paul, Manisha Das, Trissa Saha, Md O Faruque, Zahid Hassa. Tumour necrosis factor-α -308G/A polymorphism is associated with insulin secretory defects in Bangladeshi prediabetic/diabetic subjects. Journal of Taibah University Medical Sciences. vol 17. issue 2. 2022-05-20. PMID:35592794. |
tumour necrosis factor (tnf)-α, an adipocytokine, is closely linked to impaired glucose tolerance (igt) and insulin resistance (ir) in type 2 diabetes (t2d) subjects. |
2022-05-20 |
2023-08-13 |
human |
| Landon Deru, Cali Warren, Braxton Wright, Jacob Coleman, Austin Duersch, Hi'ilei Chan, Katelynn Hales, Bruce Bailey, Benjamin Bikma. Understanding the endocrine response to macronutrients in the context of a ketogenic diet. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552192. |
thirteen analytes were measured including amylin, c-peptide, ghrelin, gastric inhibitory peptide (gip), glucagon, glucagon-like peptide 1 (glp-1), interleukin 6 (il-6), insulin, leptin, pancreatic polypeptide (pp), polypeptide yy (pyy), and tumor necrosis factor alpha (tnf). |
2022-05-13 |
2023-08-13 |
human |
| Dongjuan Wang, Kun Liu, Jinyan Zhong, Xin Li, Jie Zhang, Gongxin Wang, Ni Li, Tianwen Li, Harvey Davis, Ibrahim El-Gaby, Guoliang Hao, Honghua Ye, Dan L. Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets. Oxidative medicine and cellular longevity. vol 2022. 2022-04-25. PMID:35464763. |
rna-sequencing analysis of ventricular tissue revealed a differential transcriptome profile and abnormal activation of pathways involved in fatty acid metabolism, oxidative phosphorylation, cardiac structure and function, insulin resistance, calcium signalling, apoptosis, and tnf signalling. |
2022-04-25 |
2023-08-13 |
human |