| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T A Mangylev. [Activity of Vegetative Nervous System and Levels of Inflammatory Cytokines During Glucose Tolerance Test in Subjects With Optimal and High Normal Blood Pressure]. Kardiologiia. vol 55. issue 3. 2019-11-20. PMID:28294840. |
fasting and postprandial (60 and 120 min after oral intake of glucose) levels of glucose, insulin, interleukin (il)-1, tumor necrosis factor (tnf)-, and c-reactive protein were measured. |
2019-11-20 |
2023-08-13 |
human |
| Shan Huang, Yong Xu, Wen-Fang Peng, Jie Cheng, Hui-Hua Li, Li-Sha Shen, Li-Li Xi. Asymmetric dimethylarginine targets MAPK pathway to regulate insulin resistance in liver by activating inflammation factors. Journal of cellular biochemistry. 2019-11-20. PMID:30506883. |
our results demonstrated that adma inhibits insulin sensitivity in a concentration-dependent manner by activating inflammation factors tumor necrosis factor (tnf)-α, interleukin (il)-1, and il-6 in primary hepatocytes. |
2019-11-20 |
2023-08-13 |
Not clear |
| I A Clark, B Visse. Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases. British journal of pharmacology. vol 175. issue 20. 2019-11-04. PMID:30097997. |
therapeutic implications of how tnf links apolipoprotein e, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases. |
2019-11-04 |
2023-08-13 |
Not clear |
| Sufang Chen, Wei Wei, Minjie Chen, Xiaobo Qin, Lianglin Qiu, Li Zhang, Yuhao Zhang, Qi Cao, Zhekang Yin. TNF Signaling Impacts Glucagon-Like Peptide-1 Expression and Secretion. Journal of molecular endocrinology. vol 61. issue 4. 2019-10-25. PMID:30021757. |
these data collectively suggest that physiological tnf signaling regulates glucose metabolism primarily through effects on glp-1 expression and secretion and subsequently insulin secretion. |
2019-10-25 |
2023-08-13 |
mouse |
| Seisuke Sato, Hitomi Imachi, Jingya Lyu, Yumi Miyai, Kensaku Fukunaga, Tao Dong, Tomohiro Ibata, Toshihiro Kobayashi, Takuo Yoshimoto, Fumi Kikuchi, Kazuko Yonezaki, Nao Yamaji, Hisakazu Iwama, Koji Mura. Effect of TNF-α on the expression of ABCA1 in pancreatic β-cells. Journal of molecular endocrinology. vol 61. issue 4. 2019-10-25. PMID:30131353. |
tumor necrosis factor (tnf)-α is a pleiotropic cytokine that elicits a wide spectrum of physiological events, including cell proliferation, differentiation, and apoptosis, and is also known to decrease glucose-dependent insulin secretion in pancreatic islets. |
2019-10-25 |
2023-08-13 |
rat |
| Laís Bhering Martins, Marina Chaves de Oliveira, Zélia Menezes-Garcia, Débora Fernandes Rodrigues, Jaqueline Pereira Lana, Leda Quercia Vieira, Mauro Martins Teixeira, Adaliene Versiani Matos Ferreir. Paradoxical role of tumor necrosis factor on metabolic dysfunction and adipose tissue expansion in mice. Nutrition (Burbank, Los Angeles County, Calif.). vol 50. 2019-10-16. PMID:29510322. |
tumor necrosis factor (tnf) is a well-known cytokine that triggers insulin resistance during obesity development. |
2019-10-16 |
2023-08-13 |
mouse |
| Laís Bhering Martins, Marina Chaves de Oliveira, Zélia Menezes-Garcia, Débora Fernandes Rodrigues, Jaqueline Pereira Lana, Leda Quercia Vieira, Mauro Martins Teixeira, Adaliene Versiani Matos Ferreir. Paradoxical role of tumor necrosis factor on metabolic dysfunction and adipose tissue expansion in mice. Nutrition (Burbank, Los Angeles County, Calif.). vol 50. 2019-10-16. PMID:29510322. |
the aim of this study was to evaluate whether the ablation of tnf receptor 1 (tnfr1) alters fat mass and insulin resistance induced by a highly refined carbohydrate-containing (hc) diet. |
2019-10-16 |
2023-08-13 |
mouse |
| Jessica A Breznik, Avee Naidoo, Kevin P Foley, Christian Schulz, Trevor C Lau, Dessi Loukov, Deborah M Sloboda, Dawn M E Bowdish, Jonathan D Schertze. TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice. Physiological reports. vol 6. issue 23. 2019-09-17. PMID:30548217. |
tnf, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice. |
2019-09-17 |
2023-08-13 |
mouse |
| Jessica A Breznik, Avee Naidoo, Kevin P Foley, Christian Schulz, Trevor C Lau, Dessi Loukov, Deborah M Sloboda, Dawn M E Bowdish, Jonathan D Schertze. TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice. Physiological reports. vol 6. issue 23. 2019-09-17. PMID:30548217. |
inflammatory cytokines such as tumor necrosis factor (tnf) can contribute to insulin resistance. |
2019-09-17 |
2023-08-13 |
mouse |
| Piero Ruscitti, Francesco Ursini, Paola Cipriani, Marta Greco, Saverio Alvaro, Liakouli Vasiliki, Paola Di Benedetto, Francesco Carubbi, Onorina Berardicurti, Elio Gulletta, Giovambattista De Sarro, Roberto Giacomell. IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study. Medicine. vol 98. issue 7. 2019-03-14. PMID:30762811. |
recently, it has been shown that some well-known pathogenic mediators in rheumatoid arthritis (ra), such as interleukin-1β (il-1β) and tumor necrosis factor (tnf), could play a pathogenic role in insulin resistance and (ir) and type 2 diabetes (t2d).in this 6-month longitudinal study, we aimed at investigating if the inhibition of il-1 or tnf is associated with an improvement of ir in ra patients with comorbid t2d and the possible effects on selected serum adipokines. |
2019-03-14 |
2023-08-13 |
Not clear |
| V Lopreiato, A Hosseini, F Rosa, Z Zhou, A Alharthi, E Trevisi, J J Loo. Dietary energy level affects adipose depot mass but does not impair in vitro subcutaneous adipose tissue response to short-term insulin and tumor necrosis factor-α challenge in nonlactating, nonpregnant Holstein cows. Journal of dairy science. vol 101. issue 11. 2019-01-25. PMID:30146294. |
subcutaneous adipose tissue was collected from the tail-head region and was used as follows: control, bovine insulin (ins) at 1 µmol/l, tumor necrosis factor-α at 5 ng/ml (tnf), and their combination. |
2019-01-25 |
2023-08-13 |
cattle |
| Dan Liu, Yiyi Zhang, Yunhui Liu, Liqiong Hou, Sheyu Li, Haoming Tian, Tieyun Zha. Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 126. issue 8. 2018-12-17. PMID:29365334. |
we investigated the effects of berberine on obesity and insulin resistance by examining the lipopolysaccharide (lps)/toll-like receptor 4 (tlr4)/tumor necrosis factor (tnf)-α signaling pathway in livers of hfd-fed obese rats. |
2018-12-17 |
2023-08-13 |
rat |
| Rodrigo Martins Dos Santos, Fernando Marani, Fernando Yamamoto Chiba, Maria Sara de Lima Coutinho Mattera, Thais Verônica Saori Tsosura, Gestter Willian Lattari Tessarin, Renato Felipe Pereira, Bianca Elvira Belardi, Beatriz Costa E Silva Pinheiro, Doris Hissako Sumid. Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease. Life sciences. vol 213. 2018-12-11. PMID:30321542. |
melatonin promotes reduction in tnf levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease. |
2018-12-11 |
2023-08-13 |
rat |
| Loqmane Seridi, Gregory C Leo, G Lynis Dohm, Walter J Pories, James Lenhar. Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome. PloS one. vol 13. issue 5. 2018-11-26. PMID:29851973. |
we analyzed the metabolome in association to five hormones (adiponectin, insulin, ghrelin, leptin, and resistin), four peptide hormones (gip, glucagon, glp1, and pyy), and two cytokines (il-6 and tnf). |
2018-11-26 |
2023-08-13 |
human |
| Akira Takagur. [Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 138. issue 11. 2018-11-20. PMID:30381640. |
in this review, we describe the current understanding of the effects of 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) reductase inhibitors (statins) and tumor necrosis factor (tnf)-α on insulin signal transduction in adipocytes. |
2018-11-20 |
2023-08-13 |
Not clear |
| Qi Ge, Liang Chen, Min Tang, Shu Zhang, Lanlan Liu, Lu Gao, Shangshang Ma, Ming Kong, Qin Yao, Fan Feng, Keping Che. Analysis of mulberry leaf components in the treatment of diabetes using network pharmacology. European journal of pharmacology. vol 833. 2018-10-29. PMID:29782863. |
the results showed that mulberry leaf powder contains tricetin, gallic acid, chlorogenic acid, and other drug components that can regulate tumor necrosis factor (tnf), peroxisome proliferator-activated receptor gamma (pparg), glycogen synthase kinase-3 beta (gsk3b), insulin receptor substrate 1 (irs1), interleukin 6 (il-6) and other proteins, which are related to the insulin and inflammatory signaling pathways, glucose metabolism and other related pathways, chronic inflammatory diseases, obesity, diabetic nephropathy, non-insulin-dependent diabetes mellitus and other diseases. |
2018-10-29 |
2023-08-13 |
Not clear |
| Subhadeep Chakrabarti, Forough Jahandideh, Sandra T Davidge, Jianping W. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. Journal of agricultural and food chemistry. vol 66. issue 39. 2018-10-15. PMID:30160110. |
our results suggested both peptides enhanced insulin signaling and contributed toward the prevention of insulin resistance in the presence of tumor necrosis factor (tnf). |
2018-10-15 |
2023-08-13 |
Not clear |
| Subhadeep Chakrabarti, Forough Jahandideh, Sandra T Davidge, Jianping W. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. Journal of agricultural and food chemistry. vol 66. issue 39. 2018-10-15. PMID:30160110. |
inhibition of inflammatory mediator nf-kb under tnf stimulation was a likely contributor to the prevention of insulin resistance. |
2018-10-15 |
2023-08-13 |
Not clear |
| Jing Gao, Jiajia Song, Min Du, Xueying Ma. Bovine α-Lactalbumin Hydrolysates (α-LAH) Ameliorate Adipose Insulin Resistance and Inflammation in High-Fat Diet-Fed C57BL/6J Mice. Nutrients. vol 10. issue 2. 2018-10-10. PMID:29473848. |
results showed that bovine α-lah significantly reduced body weight, blood glucose, serum insulin, and homa-ir (homeostatic model assessment of insulin resistance) levels, lowered the area-under-the-curve (auc) during ogtt and ipitt, and downregulated inflammation-related gene [tumor necrosis factor (tnf)-α, interleukin (il)-6, monocyte chemoattractant protein (mcp)-1] expression in adipose tissues of hfd-fed c57bl/6j mice. |
2018-10-10 |
2023-08-13 |
mouse |
| Errol M Thomson, Shinjini Pilon, Josée Guénette, Andrew Williams, Alison C Hollowa. Ozone modifies the metabolic and endocrine response to glucose: Reproduction of effects with the stress hormone corticosterone. Toxicology and applied pharmacology. vol 342. 2018-08-27. PMID:29391239. |
we assessed acute effects of ozone, and stress axis involvement, on glucose tolerance and on the metabolic (triglyceride), endocrine/energy regulation (insulin, glucagon, glp-1, leptin, ghrelin, corticosterone), and inflammatory/endothelial (tnf, il-6, vegf, pai-1) response to exogenous glucose. |
2018-08-27 |
2023-08-13 |
human |