| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jea Eun Park, Eunji Kang, Ji Sook Ha. HM-chromanone attenuates TNF-α-mediated inflammation and insulin resistance by controlling JNK activation and NF-κB pathway in 3T3-L1 adipocytes. European journal of pharmacology. 2022-03-15. PMID:35288193. |
we investigated the ability of (e)-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone (hm-chromanone) isolated from portulaca oleracea to attenuate the activation of inflammatory cytokines and signaling pathways associated with tumor necrosis factor (tnf)-α-mediated inflammation and insulin resistance in 3t3-l1 adipocytes. |
2022-03-15 |
2023-08-13 |
Not clear |
| Jia-Luo Cai, Xiao-Ping Li, Yi-Lin Zhu, Gui-Ming Deng, Lei Yang, Xin-Hua Xia, Gang-Qiang Yi, Xin-Yu Che. [Mechanism of Huangjing Qianshi Decoction in treatment of prediabetes based on network pharmacology and molecular docking]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 4. 2022-03-14. PMID:35285205. |
the hub genes mainly involved the go terms of tricarboxylic acid cycle, peptide binding, amide binding, hydrolase activity, and kinase activity regulation, and the kegg pathways of age-rage signaling pathway, tnf signaling pathway, ampk signaling pathway, il-17 signaling pathway, and insulin signaling pathway. |
2022-03-14 |
2023-08-13 |
Not clear |
| Musashi Kawamura, Naoki Goda, Natsuyo Hariya, Mayu Kimura, Shiori Ishiyama, Takeo Kubota, Kazuki Mochizuk. Medium-chain fatty acids enhance expression and histone acetylation of genes related to lipid metabolism in insulin-resistant adipocytes. Biochemistry and biophysics reports. vol 29. 2022-01-14. PMID:35028437. |
in this study, we examined the effects of fatty acids on the reduced expressions and histone acetylation of lipid metabolism-related genes in 3t3-l1 adipocytes treated with insulin resistance induced by tumor necrosis factor (tnf)-α. |
2022-01-14 |
2023-08-13 |
Not clear |
| Lale A Ertuglu, Fernando Elijovich, Cheryl L Laffer, Annet Kirab. Salt-Sensitivity of Blood Pressure and Insulin Resistance. Frontiers in physiology. vol 12. 2021-12-30. PMID:34966295. |
another common denominator in the pathogenesis of insulin resistance, hypertension, and salt sensitivity (ss) is immune activation involving pro-inflammatory cytokines like tumor necrosis factor (tnf)-α, il-1β, and il-6. |
2021-12-30 |
2023-08-13 |
Not clear |
| Carmem Peres Valgas da Silva, Fabiano Calmasini, Eduardo Costa Alexandre, Helena Fonseca Raposo, Maria Andreia Delbin, Fabiola Zakia Monica, Angelina Zanesc. The effects of mirabegron on obesity-induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue. Clinical and experimental pharmacology & physiology. vol 48. issue 11. 2021-11-18. PMID:34343353. |
blood glucose, insulin, glycerol, free fatty acids (ffa), thiobarbituric acid reactive substance (tbar), and tumour necrosis factor (tnf)-α levels were also assessed, and the homa index was determined. |
2021-11-18 |
2023-08-13 |
mouse |
| Sule Cilekar, Selvihan Beysel, Savas Karatas, Aydin Balci, Kursad Akaslan, Ali Unc. Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome. Scientific reports. vol 11. issue 1. 2021-11-18. PMID:34764367. |
circulating soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (stweak) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. |
2021-11-18 |
2023-08-13 |
Not clear |
| Tereza C M Fontes-Cal, Rafael T Mattos, Nayara I Medeiros, Bruna F Pinto, Mayara Belchior-Bezerra, Bruna Roque-Souza, Walderez O Dutra, Teresa C A Ferrari, Paula V T Vidigal, Luciana C Faria, Cláudia A Couto, Juliana A S Gome. Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression. Frontiers in immunology. vol 12. 2021-11-09. PMID:34447378. |
these data suggest that il-6 and il-10 might act in chronic inflammation and insulin resistance whereas il-12 and tnf may be involved in promoting liver damage and nafld progression. |
2021-11-09 |
2023-08-13 |
Not clear |
| Pawel A Kolodziejski, Natalia Leciejewska, Agata Chmurzynska, Maciej Sassek, Aleksandra Szczepankiewicz, Dawid Szczepankiewicz, Emilian Malek, Mathias Z Strowski, Zuzanna Checinska-Maciejewska, Krzysztof W Nowak, Ewa Pruszynska-Oszmale. 30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status. Molecular and cellular endocrinology. vol 536. 2021-09-16. PMID:34384849. |
the effects of 30 days spx treatment of mice with experimentally induced obesity (dio) or type 2 diabetes (t2dm) on serum glucose and lipid levels, insulin sensitivity and hormonal profile (insulin, glucagon, adiponectin, leptin, tnf alpha, il-6 and il-1β) are characterized. |
2021-09-16 |
2023-08-13 |
mouse |
| Shing-Hwa Liu, Shih-An Feng, Chen-Yuan Chiu, Meng-Tsan Chian. Influence of Dietary Chitosan Feeding Duration on Glucose and Lipid Metabolism in a Diabetic Rat Model. Molecules (Basel, Switzerland). vol 26. issue 16. 2021-09-07. PMID:34443619. |
however, chitosan supplementation decreased plasma tumor necrosis factor (tnf)-α, insulin levels, alanine aminotransferase (alt) activity, insulin resistance (homa-ir), and adipose tissue lipoprotein lipase activity. |
2021-09-07 |
2023-08-13 |
rat |
| Mingmin Wang, Shuangjie Yang, Mingyan Shao, Qian Zhang, Xiaoping Wang, Linghui Lu, Sheng Gao, Yong Wang, Wei Wan. Identification of Potential Bioactive Ingredients and Mechanisms of the Guanxin Suhe Pill on Angina Pectoris by Integrating Network Pharmacology and Molecular Docking. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-08-24. PMID:34422068. |
protein-protein interaction identified vegfa (vascular endothelial growth factor a), tnf (tumor necrosis factor), ccl2 (c-c motif chemokine ligand 2), fn1 (fibronectin 1), mmp9 (matrix metallopeptidase 9), ptgs2 (prostaglandin-endoperoxide synthase 2), il10 (interleukin 10), cxcl8 (c-x-c motif chemokine ligand 8), il6 (interleukin 6), and ins (insulin) as hub targets for gsp, which were involved in the inflammatory process, ecm proteolysis, glucose metabolism, and lipid metabolism. |
2021-08-24 |
2023-08-13 |
Not clear |
| Yuting Hao, Xiaoshan Liao, Xiangdong Wang, Shenghui Lao, Wenzhen Lia. The biological regulatory activities of Flammulina velutipes polysaccharide in mice intestinal microbiota, immune repertoire and heart transcriptome. International journal of biological macromolecules. vol 185. 2021-08-18. PMID:34216660. |
kegg annotation indicated that the up-regulated mrna was enriched in 17 pathways including adherens junction, mtor signaling pathway, insulin signaling pathway, mitophagy, tight junction, ppar signaling pathway and tnf signaling pathway, etc. |
2021-08-18 |
2023-08-13 |
mouse |
| Rebecca Roy, Caitlyn Nguyen-Ngo, Martha Lappa. Short-chain fatty acids as novel therapeutics for gestational diabetes. Journal of molecular endocrinology. vol 65. issue 2. 2021-08-05. PMID:32580157. |
primary human cells isolated from skeletal muscle were stimulated with tnf to assess the effect of scfas on inflammation-induced defects in the insulin signalling pathway. |
2021-08-05 |
2023-08-13 |
human |
| Raushan Kumar, Farhan Akhtar, Syed Ibrahim Rizv. Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat. Clinical and experimental pharmacology & physiology. vol 47. issue 4. 2021-07-12. PMID:31793010. |
the present study reports reactive oxygen species (ros) production, oxidative stress parameters: malondialdehyde (mda), protein carbonyl (pco), oxidation of plasma protein (aopp), and advance glycation end products (ages); antioxidant defence parameters: ferric reducing ability of plasma (frap), reduced glutathione (gsh), paraoxonase-1 (pon-1), plasma membrane redox system (pmrs); general biochemical parameters: triglyceride, cholesterol, serum glutamic oxaloacetic transaminase (sgot), and serum glutamic pyruvic transaminase (sgpt), fasting insulin, fasting glucose, homeostatic model assessment-insulin resistance (homa-ir) index, and inflammatory biomarkers: interleukin (il)-6 and tumour necrosis factor (tnf)-α. |
2021-07-12 |
2023-08-13 |
rat |
| Bide Duan, Yuan Li, Kun Dong, Yuan Sun, Airong Ma, Xiuzhi Yan. Regulative effect of maternal serum fatty acid-binding protein 4 on insulin resistance and the development of gestational diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids. vol 163. 2021-06-02. PMID:33260074. |
we firstly confirmed the positive correlations between serum fabp4, insulin resistance and inflammation cytokines, including tumor necrosis factor-α (tnf) and interleukin-6 (il-6), in gdm patients. |
2021-06-02 |
2023-08-13 |
mouse |
| V V Sathibabu Uddandrao, P Rameshreddy, P Brahmanaidu, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, Ravindar Naik Ramavat, K Swapna, Suresh Pothani, Harishankar Nemani, Balaji Meriga, S Vadivukkarasi, Nivedha P R, Saravanan Ganapath. Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats. Archives of physiology and biochemistry. vol 126. issue 5. 2021-05-31. PMID:30739501. |
changes in body composition, glucose, insulin resistance (ir) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (ppar-γ) and its target genes fatty-acid synthase (fas), adipocyte protein-2 (ap2) and uncoupling protein-2 (ucp-2) and pro-inflammatory factor tumor necrosis factor (tnf)-α were observed in experimental rats. |
2021-05-31 |
2023-08-13 |
rat |
| Shao-Hua Xie, Sirus Rabbani, Eivind Ness-Jensen, Jesper Lagergre. Circulating Levels of Inflammatory and Metabolic Biomarkers and Risk of Esophageal Adenocarcinoma and Barrett Esophagus: Systematic Review and Meta-analysis. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 29. issue 11. 2021-05-31. PMID:32855267. |
comparing the highest versus lowest categories of circulating biomarker levels, the pooled ors were increased for leptin (or, 1.68; 95% ci, 0.95-2.97 for barrett esophagus), glucose (or, 1.12; 95% ci, 1.03-1.22 for esophageal adenocarcinoma), insulin (or, 1.47; 95% ci, 1.06-2.00 for barrett esophagus), c-reactive protein (crp; or, 2.06; 95% ci, 1.28-3.31 for esophageal adenocarcinoma), il6 (or, 1.50; 95% ci, 1.03-2.19 for esophageal adenocarcinoma), and soluble tnf receptor 2 (stnfr-2; or, 3.16; 95% ci, 1.76-5.65 for esophageal adenocarcinoma). |
2021-05-31 |
2023-08-13 |
Not clear |
| Mohammad Hossein Esmaeili, Mohsen Enayati, Farhad Khabbaz Abkenar, Fereshte Ebrahimian, Ali-Akbar Salar. Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease. Behavioural brain research. vol 379. 2021-05-03. PMID:31733313. |
we measured glucose and insulin levels in the blood, and inflammatory cytokines such as tumor necrosis factor (tnf)-α and interleukin (il)-6 in the hippocampus of animals. |
2021-05-03 |
2023-08-13 |
rat |
| Nihal AlMuraikhi, Hanouf Alaskar, Sarah Binhamdan, Amal Alotaibi, Moustapha Kassem, Musaad Alfaye. JAK2 Inhibition by Fedratinib Reduces Osteoblast Differentiation and Mineralisation of Human Mesenchymal Stem Cells. Molecules (Basel, Switzerland). vol 26. issue 3. 2021-04-15. PMID:33503825. |
fedratinib inhibited the expression of lif, socs3, rrad, notch3, tnf, comp, thbs2, and il6, which are associated with various signalling pathways, including tgfβ signalling, insulin signalling, focal adhesion, notch signalling, il-6 signalling, endochondral ossification, tnf-α, and cytokines and inflammatory response. |
2021-04-15 |
2023-08-13 |
human |
| Fatema Al-Rashed, Sardar Sindhu, Hossein Arefanian, Ashraf Al Madhoun, Shihab Kochumon, Reeby Thomas, Sarah Al-Kandari, Abdulwahab Alghaith, Texy Jacob, Fahd Al-Mulla, Rasheed Ahma. Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway. Cells. vol 9. issue 8. 2021-03-19. PMID:32806763. |
the data show that adipose irf5 gene expression was higher in t2d than nondiabetic counterparts (p = 0.006), which correlated with glycated hemoglobin (hba1c) (r = 0.47/p < 0.001), homeostatic model assessment of insulin resistance (homa-ir) (r = 0.23/p = 0.03), tumor necrosis factor (tnf)-α (r = 0.56/p < 0.0001), interleukin (il)-1β (r = 0.40/p = 0.0009), and c-c motif chemokine receptor (ccr)-2 (r = 0.49/p < 0.001) expression. |
2021-03-19 |
2023-08-13 |
Not clear |
| Alisson S P Caldeira, Ulrich C Mbiakop, Rodrigo M Pádua, Maryna van de Venter, Motlalepula G Matsabisa, Priscilla R V Campana, Steyner F Cortes, Fernão C Brag. Bioguided chemical characterization of pequi (Caryocar brasiliense) fruit peels towards an anti-diabetic activity. Food chemistry. vol 345. 2021-03-11. PMID:33310563. |
the extract and fractions thereof inhibited the release of cytokines involved in insulin resistance - tnf, il-1β, and ccl2 - by lipopolysaccharide-stimulated thp-1 cells. |
2021-03-11 |
2023-08-13 |
Not clear |