| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wolfgang Liedtk. Molecular mechanisms of TRPV4-mediated neural signaling. Annals of the New York Academy of Sciences. vol 1144. 2009-02-19. PMID:19076362. |
here, recent findings pertaining to trpv4's mechano- and osmosensory function in endothelia, in the alveolar unit of the lung, and in intestinal sensory innervation are reviewed, namely, transduction of mechanical shear stress in endothelia, maintenance of alveolar integrity on the endothelial side, and intestinal mechanosensation of noxious stimuli by dorsal root ganglion sensory neurons, which can be potently sensitized to mechanical stimuli by activation of the proteinase-activated receptor 2 (par-2), in a strictly trpv4-dependent manner. |
2009-02-19 |
2023-08-12 |
caenorhabditis_elegans |
| Yang Zhang, Yong-Hui Wang, Hong-You Ge, Lars Arendt-Nielsen, Rong Wang, Shou-Wei Yu. A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats. Neuroscience letters. vol 432. issue 3. 2008-06-12. PMID:18206306. |
the aim of the present study was to investigate the role of transient receptor potential vanilloid 4 (trpv4) in mediating mechanical allodynia in rodent models of chronic compression of the dorsal root ganglion (ccd). |
2008-06-12 |
2023-08-12 |
rat |
| Yang Zhang, Yong-Hui Wang, Hong-You Ge, Lars Arendt-Nielsen, Rong Wang, Shou-Wei Yu. A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats. Neuroscience letters. vol 432. issue 3. 2008-06-12. PMID:18206306. |
first, the levels of trpv4 mrna and protein expression in the dorsal root ganglion (drg) were assessed using real-time rt-pcr and western blotting analysis respectively at 7, 14, and 28 days post-ccd. |
2008-06-12 |
2023-08-12 |
rat |
| J Frederick, M E Buck, D J Matson, D N Cortrigh. Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury. Biochemical and biophysical research communications. vol 358. issue 4. 2007-08-09. PMID:17517374. |
we developed a multiplex ribonuclease protection assay (rpa) to quantify rat trpv1, trpv2, trpv3, trpv4, trpa1, and trpm8 rna levels in drg. |
2007-08-09 |
2023-08-12 |
rat |
| Andrew D Grant, Graeme S Cottrell, Silvia Amadesi, Marcello Trevisani, Paola Nicoletti, Serena Materazzi, Christophe Altier, Nicolas Cenac, Gerald W Zamponi, Francisco Bautista-Cruz, Carlos Barajas Lopez, Elizabeth K Joseph, Jon D Levine, Wolfgang Liedtke, Stephen Vanner, Nathalie Vergnolle, Pierangelo Geppetti, Nigel W Bunnet. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. The Journal of physiology. vol 578. issue Pt 3. 2007-04-26. PMID:17124270. |
immunoreactive trpv4 was coexpressed by rat dorsal root ganglia (drg) neurons with par2, substance p (sp) and calcitonin gene-related peptide (cgrp), mediators of pain transmission. |
2007-04-26 |
2023-08-12 |
mouse |
| Andrew D Grant, Graeme S Cottrell, Silvia Amadesi, Marcello Trevisani, Paola Nicoletti, Serena Materazzi, Christophe Altier, Nicolas Cenac, Gerald W Zamponi, Francisco Bautista-Cruz, Carlos Barajas Lopez, Elizabeth K Joseph, Jon D Levine, Wolfgang Liedtke, Stephen Vanner, Nathalie Vergnolle, Pierangelo Geppetti, Nigel W Bunnet. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. The Journal of physiology. vol 578. issue Pt 3. 2007-04-26. PMID:17124270. |
par2-agonist similarly sensitized trpv4 ca2+ signals and currents in drg neurons. |
2007-04-26 |
2023-08-12 |
mouse |