| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Mauk, S J Peroutka, J D Kocsi. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339401. |
the actions of 5-hydroxytryptamine (5-ht) and buspirone, an anxiolytic agent that displays high and selective affinity for 5-ht1a receptor sites, on synaptic activation of hippocampal ca1 pyramidal cells were studied in vitro. |
1988-03-08 |
2023-08-11 |
Not clear |
| M D Mauk, S J Peroutka, J D Kocsi. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339401. |
whereas 5-ht application leads to a rapid hyperpolarization and decreased input resistance in pyramidal cells, buspirone has no measurable effects on membrane potential and input resistance. |
1988-03-08 |
2023-08-11 |
Not clear |
| M D Mauk, S J Peroutka, J D Kocsi. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339401. |
however, unlike 5-ht, buspirone application leads to a gradual and reversible reduction in excitatory postsynaptic potentials (epsps) elicited by stimulation of afferents in the stratum radiatum. |
1988-03-08 |
2023-08-11 |
Not clear |
| M D Mauk, S J Peroutka, J D Kocsi. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339401. |
the attenuation of the epsps and the decrease in afferent fiber excitability appear to be independent of 5-ht receptors as 5-ht neither shares nor antagonizes the effects of buspirone. |
1988-03-08 |
2023-08-11 |
Not clear |
| M D Mauk, S J Peroutka, J D Kocsi. Buspirone attenuates synaptic activation of hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 8. issue 1. 1988-03-08. PMID:3339401. |
thus, both 5-ht and buspirone can contribute to reduced spike activity in pyramidal cells, but they do so via different mechanisms: 5-ht hyperpolarizes pyramidal cells whereas buspirone attenuates their synaptic activation, possibly via action on the presynaptic fibers in the stratum radiatum. |
1988-03-08 |
2023-08-11 |
Not clear |
| F Gilbert, C T Douris. Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology. vol 93. issue 3. 1988-03-03. PMID:2893412. |
these results indicate that gepirone is a very efficacious appetite stimulant in rats and suggest that gepirone, buspirone and ipsapirone act as 5-ht autoreceptor agonists in the feeding model. |
1988-03-03 |
2023-08-11 |
rat |
| J R Ieni, L R Meyerso. The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. Life sciences. vol 42. issue 3. 1988-02-23. PMID:2961966. |
for example, 8-oh-dpat 5ht1a had an ic50 of 117 nm; tfmpp 5ht1b (2.3 microm0 and papp 1a + 5ht2 (9 microm); ipsapirone 5ht1a (21.1 microm) and buspirone 5ht1a (greater than 100 microm); ketanserin 5ht2 (greater than 100 microm); 5-ht uptake inhibitors: paroxetine (13 nm); chlorimipramine (73 nm) and fluoxetine (653 nm). |
1988-02-23 |
2023-08-11 |
human |
| J M Witkin, R S Mansbach, J E Barrett, G T Bolger, P Skolnick, B Weissma. Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2891840. |
interactions of the nonbenzodiazepine anxiolytic, buspirone, with serotonin (5-ht) were studied using behavioral and neurochemical procedures. |
1988-02-02 |
2023-08-11 |
rat |
| J M Witkin, R S Mansbach, J E Barrett, G T Bolger, P Skolnick, B Weissma. Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2891840. |
a serotonin agonist, mk-212 (0.01 mg/kg), antagonized whereas the 5-ht antagonist, cyproheptadine (0.01 mg/kg), potentiated the effects of buspirone without having behavioral effects of their own. |
1988-02-02 |
2023-08-11 |
rat |
| J M Witkin, R S Mansbach, J E Barrett, G T Bolger, P Skolnick, B Weissma. Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons. The Journal of pharmacology and experimental therapeutics. vol 243. issue 3. 1988-02-02. PMID:2891840. |
hill coefficients significantly less than unity for all drugs except 5-ht suggested multiple serotonergic binding sites for buspirone and analogs. |
1988-02-02 |
2023-08-11 |
rat |
| H Francè. Analysis of the nature of antagonism of the reserpine-induced hypothermia by imipramine. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 3. 1988-01-11. PMID:2891045. |
none of the serotonin (5-ht) receptor antagonists, methysergide, metergoline, ritanserin and buspirone, impaired the effect of imipramine. |
1988-01-11 |
2023-08-11 |
Not clear |
| R Andrade, R A Nicol. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 1. 1987-10-22. PMID:2888027. |
bath administration of buspirone elicited a long lasting hyperpolarization which was mediated by an increase in potassium conductance and resembled the hyperpolarizing component of the response to 5-ht (5-hydroxytryptamine). |
1987-10-22 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 1. 1987-10-22. PMID:2888027. |
buspirone, however, failed to mimic the depolarizing action of 5-ht or to reduce the calcium-activated after hyperpolarization. |
1987-10-22 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 1. 1987-10-22. PMID:2888027. |
quantitative comparisons of the hyperpolarizing responses of 5-ht and buspirone revealed that the maximal hyperpolarization induced by buspirone was significantly smaller than that induced by 5-ht. |
1987-10-22 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 1. 1987-10-22. PMID:2888027. |
since the buspirone induced hyperpolarization was also accompanied by a surmountable antagonism of 5-ht responses, these results indicate that buspirone behaves as a partial agonist at a subpopulation of 5-ht receptors in the ca1 region of the hippocampus. |
1987-10-22 |
2023-08-11 |
rat |
| R Andrade, R A Nicol. Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 336. issue 1. 1987-10-22. PMID:2888027. |
administration of the buspirone congeners gepirone and isapirone also elicited a hyperpolarization and reduced 5-ht responses, although they lack antidopaminergic activity, indicating that the effects observed with buspirone are unlikely to be mediated through dopamine receptors. |
1987-10-22 |
2023-08-11 |
rat |
| M Joëls, P Shinnick-Gallagher, J P Gallaghe. Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro. Brain research. vol 417. issue 1. 1987-10-13. PMID:2957026. |
two other 5-ht1a analogues, tvx q 7821 and buspirone, could also mimick the effect of 5-ht. |
1987-10-13 |
2023-08-11 |
rat |
| B A McMillen, S M Scott, H L Williams, M K Sangher. Effects of gepirone, an aryl-piperazine anxiolytic drug, on aggressive behavior and brain monoaminergic neurotransmission. Naunyn-Schmiedeberg's archives of pharmacology. vol 335. issue 4. 1987-07-30. PMID:2439924. |
gepirone had variable effects on dopamine metabolism and reduced 5-hydroxytryptamine (5ht) metabolism about one third after a dose of 2.5 mg/kg. |
1987-07-30 |
2023-08-11 |
mouse |
| B A McMillen, S M Scott, H L Williams, M K Sangher. Effects of gepirone, an aryl-piperazine anxiolytic drug, on aggressive behavior and brain monoaminergic neurotransmission. Naunyn-Schmiedeberg's archives of pharmacology. vol 335. issue 4. 1987-07-30. PMID:2439924. |
thus, although gepirone may be a weak postsynaptic 5ht agonist, its primary effect is to decrease 5ht neurotransmission. |
1987-07-30 |
2023-08-11 |
mouse |
| B A McMillen, S M Scott, H L Williams, M K Sangher. Effects of gepirone, an aryl-piperazine anxiolytic drug, on aggressive behavior and brain monoaminergic neurotransmission. Naunyn-Schmiedeberg's archives of pharmacology. vol 335. issue 4. 1987-07-30. PMID:2439924. |
in support of this conclusion was the observed potentiation of antiaggressive effects by blocking 5ht receptors wit small doses of methiothepin or methysergide, which would exacerbate the decreased release of 5ht caused by gepirone. |
1987-07-30 |
2023-08-11 |
mouse |