| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L O Wilkinson, E D Abercrombie, K Rasmussen, B L Jacob. Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats. European journal of pharmacology. vol 136. issue 1. 1987-07-24. PMID:3595712. |
the effects of administration of the non-benzodiazepine anxiolytic buspirone on the spontaneous and sensory evoked single unit activity of serotonergic (5-ht) neurons in the dorsal raphe nucleus and noradrenergic (ne) neurons in the locus coeruleus were examined in freely moving cats. |
1987-07-24 |
2023-08-11 |
Not clear |
| L O Wilkinson, E D Abercrombie, K Rasmussen, B L Jacob. Effect of buspirone on single unit activity in locus coeruleus and dorsal raphe nucleus in behaving cats. European journal of pharmacology. vol 136. issue 1. 1987-07-24. PMID:3595712. |
it is suggested that the anxiolytic effects of buspirone administration are not achieved through an action of ne neurons, but may be mediated in part by actions on 5-ht neurons in the dorsal raphe. |
1987-07-24 |
2023-08-11 |
Not clear |
| S J Peroutka, M D Mauk, J D Kocsi. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1A selective drugs. Neuropharmacology. vol 26. issue 2-3. 1987-06-29. PMID:2884586. |
the interactions between 5-hydroxytryptamine (5-ht), 8-hydroxy-2-(n,n-dipropylamino)-tetralin (8-oh-dpat), buspirone, 2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1,2-benzisothiazol-3- (2h)one-1, 1-dioxide-hydrochloride (tvx q 7821) and ketanserin, and putative 5-ht receptors were analyzed using both radioligand techniques and an in vitro hippocampal slice preparation. |
1987-06-29 |
2023-08-11 |
rat |
| S J Peroutka, M D Mauk, J D Kocsi. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1A selective drugs. Neuropharmacology. vol 26. issue 2-3. 1987-06-29. PMID:2884586. |
the binding site had similar affinity for 5-ht, 8-oh-dpat, buspirone and tvx q 7821, whereas ketanserin was essentially inactive. |
1987-06-29 |
2023-08-11 |
rat |
| S J Peroutka, M D Mauk, J D Kocsi. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1A selective drugs. Neuropharmacology. vol 26. issue 2-3. 1987-06-29. PMID:2884586. |
ketanserin did not affect the amplitude of the population spike and it did not antagonize the effects of 5-ht, buspirone or tvx q 7821. |
1987-06-29 |
2023-08-11 |
rat |
| S J Peroutka, M D Mauk, J D Kocsi. Modulation of neuronal activity in the hippocampus by 5-hydroxytryptamine and 5-hydroxytryptamine1A selective drugs. Neuropharmacology. vol 26. issue 2-3. 1987-06-29. PMID:2884586. |
neither buspirone nor 8-oh-dpat altered the initial increase in population spike induced by 5-ht. |
1987-06-29 |
2023-08-11 |
rat |
| G A Kennett, C T Dourish, G Curzo. Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression. European journal of pharmacology. vol 134. issue 3. 1987-05-28. PMID:2883013. |
however, the 5-ht1a agonists buspirone and tvxq 7821 (ipsapirone) and the non-specific 5-ht agonist quipazine all possess similar properties to 8-oh-dpat in this test. |
1987-05-28 |
2023-08-11 |
rat |
| T J Wander, A Nelson, H Okazaki, E Richelso. Antagonism by antidepressants of serotonin S1 and S2 receptors of normal human brain in vitro. European journal of pharmacology. vol 132. issue 2-3. 1987-04-07. PMID:3816971. |
buspirone, a new anxiolytic agent, possessed high affinity for the serotonin s1 receptor (kd = 3.8 nm). |
1987-04-07 |
2023-08-11 |
human |
| M J Rowan, R Anwy. Neurophysiological effects of buspirone and isapirone in the hippocampus: comparison with 5-hydroxytryptamine. European journal of pharmacology. vol 132. issue 1. 1987-04-01. PMID:2880731. |
neurophysiological effects of buspirone and isapirone in the hippocampus: comparison with 5-hydroxytryptamine. |
1987-04-01 |
2023-08-11 |
rat |
| M J Rowan, R Anwy. Neurophysiological effects of buspirone and isapirone in the hippocampus: comparison with 5-hydroxytryptamine. European journal of pharmacology. vol 132. issue 1. 1987-04-01. PMID:2880731. |
the neurophysiological effects of two novel anxiolytic compounds, buspirone and isapirone (tvx q 7821), were compared with those of 5-hydroxytryptamine (5-ht) on the population spike in the ca1 region of the rat hippocampal slice. |
1987-04-01 |
2023-08-11 |
rat |
| R S Mansbach, J E Barret. Discriminative stimulus properties of buspirone in the pigeon. The Journal of pharmacology and experimental therapeutics. vol 240. issue 2. 1987-03-26. PMID:3806400. |
these findings support recent behavioral and receptor binding studies suggesting that serotonin receptors, and 5-hydroxytryptamine-1a receptors in particular, may be responsible for mediating the anticonflict effects of buspirone and other atypical anxiolytics. |
1987-03-26 |
2023-08-11 |
human |
| R W Ransom, K B Asarch, J C Shi. Photoaffinity labeling of the 5-hydroxytryptamine 1A receptor in rat hippocampus. Journal of neurochemistry. vol 47. issue 4. 1986-10-15. PMID:3746296. |
this incorporation could be blocked when membranes were incubated with 1 microm of several agents that have high affinity for 5-ht1a sites [5-ht, 8-hydroxy-2-(di-n-propylamino)tetraline, tvx q 7821, spiperone, buspirone, d-lysergic acid diethylamide, metergoline]. |
1986-10-15 |
2023-08-11 |
rat |
| J S New, J P Yevich, M S Eison, D P Taylor, A S Eison, L A Riblet, C P VanderMaelen, D L Templ. Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives. Journal of medicinal chemistry. vol 29. issue 8. 1986-09-17. PMID:2874226. |
the pharmacology of buspirone and 32 is contrasted, and the potent serotonin agonist properties of 32 are discussed with reference to its potential contribution to the anxioselective mechanism of this compound. |
1986-09-17 |
2023-08-11 |
Not clear |
| L M Smith, S J Peroutk. Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome. Pharmacology, biochemistry, and behavior. vol 24. issue 6. 1986-09-17. PMID:2942947. |
the effects of 8-hydroxy-2-(di-n-propyl-amino) tetralin (8-oh-dpat), 5-methoxy-n,n-dimethyltryptamine (5-meodmt), buspirone and isapirone were examined at 5-hydroxytryptamine1a (5-ht1a) binding sites and on the 5-ht behavioral syndrome in the rat. |
1986-09-17 |
2023-08-11 |
rat |
| E M Pich, R Samani. Disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: possible role of dopamine. Psychopharmacology. vol 89. issue 1. 1986-09-16. PMID:2874581. |
it is suggested that buspirone and sulpiride produce these disinhibitory effects by blocking particular dopamine receptors in the brain, possibly those located in the nerve terminals, but it is likely that other mechanisms, particularly serotonin, are involved in the effects of buspirone in anxious states. |
1986-09-16 |
2023-08-11 |
rat |
| M De Vivo, S Maayan. Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. The Journal of pharmacology and experimental therapeutics. vol 238. issue 1. 1986-08-20. PMID:2941565. |
in guinea pig hippocampal membranes 8-hydroxy-2-(di-n-propylamino)tetralin, d-lysergic acid diethylamide, 5-ht and buspirone were potent in inhibiting forskolin-stimulated adenylate cyclase activity, with ec50 values of 18, 24, 53 and 146 nm, respectively. |
1986-08-20 |
2023-08-11 |
rat |
| M De Vivo, S Maayan. Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. The Journal of pharmacology and experimental therapeutics. vol 238. issue 1. 1986-08-20. PMID:2941565. |
in rat hippocampal membranes, 8-hydroxy-2-(di-n-propylamino)tetralin, d-lysergic acid diethylamide, 5-ht and buspirone were potent agonists and exhibited the same rank order of potency as in guinea pig hippocampal membranes. |
1986-08-20 |
2023-08-11 |
rat |
| M De Vivo, S Maayan. Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. The Journal of pharmacology and experimental therapeutics. vol 238. issue 1. 1986-08-20. PMID:2941565. |
the maximal percentage of inhibition by buspirone was significantly less than the maximal percentage of inhibition by 5-ht in rat membranes, suggesting that it is a partial agonist at this receptor, with an intrinsic activity relative to 5-ht of 0.5. |
1986-08-20 |
2023-08-11 |
rat |
| A S Eison, M S Eison, M Stanley, L A Rible. Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 24. issue 3. 1986-06-17. PMID:2871564. |
serotonergic involvement in the mechanism of action of two nonbenzodiazepine anxiolytics, buspirone and gepirone, supports a role for serotonin in anxiety. |
1986-06-17 |
2023-08-11 |
rat |
| A S Eison, M S Eison, M Stanley, L A Rible. Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 24. issue 3. 1986-06-17. PMID:2871564. |
the anticonflict effect of both drugs is blocked by serotonin lesions, and gepirone induces the serotonin syndrome. |
1986-06-17 |
2023-08-11 |
rat |