| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A S Eison, M S Eison, M Stanley, L A Rible. Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 24. issue 3. 1986-06-17. PMID:2871564. |
a shift in the gepirone dose-response curve to the left in serotonin lesioned rats suggests that this may be 5-ht-receptor mediated. |
1986-06-17 |
2023-08-11 |
rat |
| A S Eison, M S Eison, M Stanley, L A Rible. Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 24. issue 3. 1986-06-17. PMID:2871564. |
both buspirone and gepirone enhance the acoustic startle response and gepirone's effect is attenuated in serotonin lesioned animals. |
1986-06-17 |
2023-08-11 |
rat |
| A S Eison, M S Eison, M Stanley, L A Rible. Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 24. issue 3. 1986-06-17. PMID:2871564. |
while other components of buspirone's mechanism of action may suppress the behavioral expression of its serotonergic interactions, results from these studies suggest that serotonin agonist-like activity may be an important mechanism in the actions of a clinically proven nonbenzodiazepine anxiolytic (buspirone), and anxiolytic candidate (gepirone). |
1986-06-17 |
2023-08-11 |
rat |
| T Mennini, M Gobbi, F Ponzio, S Garattin. Neurochemical effects of buspirone in rat hippocampus: evidence for selective activation of 5HT neurons. Archives internationales de pharmacodynamie et de therapie. vol 279. issue 1. 1986-05-22. PMID:2421657. |
neurochemical effects of buspirone in rat hippocampus: evidence for selective activation of 5ht neurons. |
1986-05-22 |
2023-08-11 |
rat |
| T Mennini, M Gobbi, F Ponzio, S Garattin. Neurochemical effects of buspirone in rat hippocampus: evidence for selective activation of 5HT neurons. Archives internationales de pharmacodynamie et de therapie. vol 279. issue 1. 1986-05-22. PMID:2421657. |
the in vitro and in vivo data suggest that buspirone specifically activates 5ht neurons in hippocampus, and are compared with those obtained with diazepam. |
1986-05-22 |
2023-08-11 |
rat |
| P Skolnick, B A Weissman, M B Youdi. Monoaminergic involvement in the pharmacological actions of buspirone. British journal of pharmacology. vol 86. issue 3. 1986-01-09. PMID:2933109. |
buspirone, mj-13805 and mj-13653 did not produce a '5-hydroxytryptamine (5-ht) syndrome' in rats at doses up to 20 mg kg-1. |
1986-01-09 |
2023-08-11 |
rat |
| P Skolnick, B A Weissman, M B Youdi. Monoaminergic involvement in the pharmacological actions of buspirone. British journal of pharmacology. vol 86. issue 3. 1986-01-09. PMID:2933109. |
parenterally administered buspirone blocked apomorphine-induced stereotypy, inhibited the 5-ht syndrome elicited by 5-methoxy-n,n-dimethyltryptamine, and delayed the onset of p-chloroamphetamine induced behaviours. |
1986-01-09 |
2023-08-11 |
rat |
| D P Taylor, M S Eison, L A Riblet, C P Vandermaele. Pharmacological and clinical effects of buspirone. Pharmacology, biochemistry, and behavior. vol 23. issue 4. 1986-01-07. PMID:2866549. |
pharmacologic studies on the molecular level indicate that buspirone interacts with dopamine and serotonin receptors. |
1986-01-07 |
2023-08-11 |
Not clear |
| D P Taylor, M S Eison, L A Riblet, C P Vandermaele. Pharmacological and clinical effects of buspirone. Pharmacology, biochemistry, and behavior. vol 23. issue 4. 1986-01-07. PMID:2866549. |
recent evidence indicates that other neurotransmitter systems (serotonin, norepinephrine, acetylcholine) mediate buspirone's effects. |
1986-01-07 |
2023-08-11 |
Not clear |
| S J Peroutk. Selective labeling of 5-HT1A and 5-HT1B binding sites in bovine brain. Brain research. vol 344. issue 1. 1985-11-12. PMID:4041865. |
by contrast, 8-oh-dpat, tvx q 7821 and buspirone were significantly more potent at [3h]8-oh-dpat binding sites in bovine hippocampus than at [3h]5-ht binding sites in bovine striatum. |
1985-11-12 |
2023-08-11 |
cattle |
| A S Eison, F D Yocc. Reduction in cortical 5HT2 receptor sensitivity after continuous gepirone treatment. European journal of pharmacology. vol 111. issue 3. 1985-09-16. PMID:2862051. |
continuous administration (28 days) of gepirone, a potential anxiolytic, decreased rat cortical serotonin type 2 (5ht2) receptor density by 17 percent and reduced the frequency of head shakes induced by the serotonin agonist quipazine. |
1985-09-16 |
2023-08-11 |
rat |
| A S Eison, F D Yocc. Reduction in cortical 5HT2 receptor sensitivity after continuous gepirone treatment. European journal of pharmacology. vol 111. issue 3. 1985-09-16. PMID:2862051. |
these data support the results of previous studies confirming gepirone's involvement with brain serotonin systems, and suggest that in addition to its preclinical anxiolytic profile, gepirone exhibits pharmacological properties common to clinically effective antidepressants. |
1985-09-16 |
2023-08-11 |
rat |
| T Glaser, J Trabe. Buspirone: action on serotonin receptors in calf hippocampus. European journal of pharmacology. vol 88. issue 1. 1983-07-29. PMID:6133764. |
buspirone: action on serotonin receptors in calf hippocampus. |
1983-07-29 |
2023-08-12 |
Not clear |