| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saroj Kumar Das, Kalpana Barhwal, Sunil Kumar Hota, Mahendra Kumar Thakur, Ravi Bihari Srivastav. Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats. BMC neuroscience. vol 16. 2016-01-12. PMID:25880744. |
serotonin was depleted by administering para-chlorophenylalanine (pcpa) to a separate ph group (phpcpa), phno group (phnopcpa) and shno group (shnopcpa) to determine the role of serotonin in mediating monotony induced emotional mal-adaptations. |
2016-01-12 |
2023-08-13 |
rat |
| Shyamshree S S Manna, Sudhir N Umath. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behavioural pharmacology. vol 26. issue 3. 2015-12-08. PMID:25340977. |
swiss mice (20-22 g) were subjected to forced swim, tail suspension, or marble-burying tests after an injection of paracetamol either alone or in the presence of am251 (a cb1 antagonist), fenclonine (pcpa: a 5-ht synthesis inhibitor), am404 (anandamide uptake inhibitor) or fluoxetine. |
2015-12-08 |
2023-08-13 |
mouse |
| Chonlawan Saengjaroentham, Weera Supornsilpchai, Wilawan Ji-Au, Anan Srikiatkhachorn, Supang Maneesri-le Gran. Serotonin depletion can enhance the cerebrovascular responses induced by cortical spreading depression via the nitric oxide pathway. The International journal of neuroscience. vol 125. issue 2. 2015-08-19. PMID:24670256. |
5-ht depletion was induced by intraperitoneal injection with para-chlorophenylalanine (pcpa) 3 days before the experiment. |
2015-08-19 |
2023-08-12 |
rat |
| L I Khozha. [Distribution of GABAergic neurons in pneumotaxic center nuclei in the early postnatal period in norm and in prenatal deficiency of serotoninergic system in rats]. Morfologiia (Saint Petersburg, Russia). vol 147. issue 1. 2015-06-12. PMID:25958722. |
reduction of endogenous serotonin levels in fetal rats was achieved by tryptophan hydroxylase inhibition with para-chlorophenylalanine (pcpa), which was administered to female rats on day 16 of gestation. |
2015-06-12 |
2023-08-13 |
rat |
| Gordon F Buchanan, Nicholas M Murray, Michael A Hajek, George B Richerso. Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality. The Journal of physiology. vol 592. issue 19. 2015-06-10. PMID:25107926. |
in c57bl/6n mice, reduction of 5-ht synthesis with para-chlorophenylalanine increased mes-induced seizure severity but not mortality. |
2015-06-10 |
2023-08-13 |
mouse |
| Erwan Le Maître, Nathalie Dourmap, Catherine Vilpoux, Romain Leborgne, François Janin, Jean-Jacques Bonnet, Jean Costentin, Isabelle Leroux-Nicolle. Acute and subchronic treatments with selective serotonin reuptake inhibitors increase Nociceptin/Orphanin FQ (NOP) receptor density in the rat dorsal raphe nucleus; interactions between nociceptin/NOP system and serotonin. Brain research. vol 1520. 2014-04-11. PMID:23669068. |
this effect was also observed with other ssris (sertraline, fluoxetine), but not with two tricyclic antidepressants (imipramine, clomipramine) and was abolished by pre-treatment with para-chlorophenylalanine, an inhibitor of serotonin synthesis. |
2014-04-11 |
2023-08-12 |
rat |
| Morteza Zendehdel, Kasra Mokhtarpouriani, Vahab Babapour, Ali Baghbanzadeh, Maryam Pourrahimi, Shahin Hassanpou. The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken. The journal of physiological sciences : JPS. vol 63. issue 4. 2014-01-23. PMID:23615894. |
the present study was designed to examine the effects of intracerebroventricular injection of para-chlorophenylalanine (pcpa) (cerebral serotonin depletive), fluoxetine (selective serotonin reuptake inhibitor), 8-oh-dpat (5-ht1a autoreceptor agonist) and sb 242084 (5-ht2c receptor antagonist) on nociceptin/orphanin fq (n/ofq) induced feeding response in chickens. |
2014-01-23 |
2023-08-12 |
chicken |
| Caio Maximino, Bruna Puty, Rancés Benzecry, Juliana Araújo, Monica Gomes Lima, Evander de Jesus Oliveira Batista, Karen Renata de Matos Oliveira, Maria Elena Crespo-Lopez, Anderson Manoel Herculan. Role of serotonin in zebrafish (Danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine (pCPA) in two behavioral models. Neuropharmacology. vol 71. 2014-01-10. PMID:23541719. |
role of serotonin in zebrafish (danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, way 100635, sb 224289, fluoxetine and para-chlorophenylalanine (pcpa) in two behavioral models. |
2014-01-10 |
2023-08-12 |
zebrafish |
| Ryan E O'Leary, Jean C Shih, Keith Hyland, Nancy Kramer, Y Jane Tavyev Asher, John M Graha. De novo microdeletion of Xp11.3 exclusively encompassing the monoamine oxidase A and B genes in a male infant with episodic hypotonia: a genomics approach to personalized medicine. European journal of medical genetics. vol 55. issue 5. 2012-10-17. PMID:22365943. |
serotonin biosynthesis inhibitors like para-chlorophenylalanine and p-ethynylphenylalanine may be needed to lower serotonin levels in patients with absent monoamine oxidase enzymes. |
2012-10-17 |
2023-08-12 |
mouse |
| R Cespuglio, E Walker, M E Gomez, R Musolin. Cooling of the nucleus raphe dorsalis induces sleep in the cat. Neuroscience letters. vol 3. issue 4. 2012-10-02. PMID:19604890. |
after depletion of brain 5-hydroxytryptamine (5-ht) by para-chlorophenylalanine, cooling the raphe dorsalis resulted in muscle atonia and bursts of high frequency pgo waves but not in cortical synchronization. |
2012-10-02 |
2023-08-12 |
cat |
| Shyamshree S S Manna, Sudhir N Umath. A possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine. European journal of pharmacology. vol 685. issue 1-3. 2012-09-28. PMID:22542657. |
the present study investigated the influence of transient receptor vanilloid type 1 (trpv1) channel agonist (capsaicin) and antagonist (capsazepine) either alone or in combination with traditional antidepressant drug, fluoxetine; or a serotonin hydroxylase inhibitor, para-chlorophenylalanine; or a glutamate n-methyl-d-aspartate (nmda) receptor agonist, nmda on the forced swim test and tail suspension test using male swiss mice. |
2012-09-28 |
2023-08-12 |
mouse |
| Angela C Robert. The importance of serotonin for orbitofrontal function. Biological psychiatry. vol 69. issue 12. 2011-09-29. PMID:21353665. |
a consensus is emerging that reductions in orbitofrontal 5-ht, whether the result of localized infusions of 5,7-dihydroxytryptamine (5,7-dht), peripheral treatment with parachloroamphetamine (pca) or para-chlorophenylalanine (pcpa), or chronic cold stress impairs this ability. |
2011-09-29 |
2023-08-12 |
Not clear |
| Emily Steed, Caitlin A Jones, Andrew C McCrear. Serotonergic involvement in methamphetamine-induced locomotor activity: a detailed pharmacological study. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21262272. |
in the present study, the ability of the serotonin reuptake inhibitor fluvoxamine, 5-ht(1a), 5-ht(1b), 5-ht(2a) and 5-ht(2c) receptor antagonists way100635, gr127935, m100907 and sb242084, and the 5-ht(2c) receptor agonists way163909 and ro 60-0175 or the 5-ht synthesis inhibitor para-chlorophenylalanine (pcpa) to alter meth-induced hyperactivity was analysed. |
2011-07-15 |
2023-08-12 |
Not clear |
| Francesco Cresp. Further Electrochemical and Behavioural Evidence of a Direct Relationship Between Central 5-HT and Cytoskeleton in the Control of Mood. The open neurology journal. vol 4. 2011-07-14. PMID:20802812. |
moreover, treatment with para-chlorophenylalanine (pcpa, compound that specifically depletes brain serotonin) but not alpha-methyl para tyrosine (alpha-mpt, compound that blocks synthesis of catechols: chemicals also implicated in depression) significantly reduced tyrosinated alpha-tubulin. |
2011-07-14 |
2023-08-12 |
rat |
| K Raghuveer, C C Sudhakumari, B Senthilkumaran, H Kagawa, A Dutta-Gupta, Y Nagaham. Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and 5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation. General and comparative endocrinology. vol 171. issue 1. 2011-07-05. PMID:21156177. |
changes in tph2 mrna expression, 5-htp, and 5-ht levels in the poa-hyp+oct region of brains of methyltestosterone and para-chlorophenylalanine treated fishes during development further endorse our results. |
2011-07-05 |
2023-08-12 |
Not clear |
| Anders Ettrup, Birgitte R Kornum, Pia Weikop, Gitte M Knudse. An approach for serotonin depletion in pigs: effects on serotonin receptor binding. Synapse (New York, N.Y.). vol 65. issue 2. 2011-04-01. PMID:20560131. |
central serotonin depletion in danish landrace pigs was achieved following 4 days treatment with para-chlorophenylalanine (pcpa). |
2011-04-01 |
2023-08-12 |
human |
| Jonathan L Brigman, Poonam Mathur, Judith Harvey-White, Alicia Izquierdo, Lisa M Saksida, Timothy J Bussey, Stephanie Fox, Evan Deneris, Dennis L Murphy, Andrew Holme. Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 8. 2011-02-18. PMID:20032063. |
effects of constitutive genetic loss or acute pharmacological depletion of 5-ht were assessed by testing pet-1 null mice and para-chlorophenylalanine (pcpa)-treated c57bl/6j mice, respectively. |
2011-02-18 |
2023-08-12 |
mouse |
| S Tejada, R V Rial, A Gamundí, S Esteba. Effects of serotonergic drugs on locomotor activity and vigilance states in ring doves. Behavioural brain research. vol 216. issue 1. 2011-02-18. PMID:20699107. |
the role of the neurotransmitter serotonin on vigilance states was studied in ring doves intraperitoneally treated with the 5-ht(1a) agonist 8-oh-dpat, the 5-ht(1a) antagonist way100635 and the inhibitor of serotonin synthesis para-chlorophenylalanine (pcpa) by means of behavioural, electrophysiological and infrared actimetry criteria. |
2011-02-18 |
2023-08-12 |
human |
| Güner Ulak, Oguz Mutlu, Pelin Tanyeri, F Ipek Komsuoglu, Füruzan Yildiz Akar, B Faruk Erde. Involvement of serotonin receptor subtypes in the antidepressant-like effect of TRIM in the rat forced swimming test. Pharmacology, biochemistry, and behavior. vol 95. issue 3. 2010-11-01. PMID:20171242. |
depletion of endogenous serotonin using para-chlorophenylalanine (pcpa; 3x150mg/kg, i.p.) |
2010-11-01 |
2023-08-12 |
rat |
| Agnieszka Pałucha-Poniewiera, Piotr Brański, Tomasz Lenda, Andrzej Pil. The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent. The Journal of pharmacology and experimental therapeutics. vol 334. issue 3. 2010-09-23. PMID:20562216. |
did not induce an antidepressant-like effect after depletion of serotonin (5-ht) with para-chlorophenylalanine. |
2010-09-23 |
2023-08-12 |
mouse |