| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Ramos, P Tagliaferro, E M López, J Pecci Saavedra, A Brusc. Neuroglial interactions in a model of para-chlorophenylalanine-induced serotonin depletion. Brain research. vol 883. issue 1. 2001-02-01. PMID:11063982. |
we present in this paper the effects upon neurons and glia of a 5ht depletion induced by 14 days of treatment with para-chlorophenylalanine (pcpa) in adult rats. |
2001-02-01 |
2023-08-12 |
rat |
| N Murakami, R Kono, K Nakahara, T Ida, H Kurod. Induction of unseasonable hibernation and involvement of serotonin in entrance into and maintenance of its hibernation of chipmunks T. asiaticus. The Journal of veterinary medical science. vol 62. issue 7. 2000-12-07. PMID:10945297. |
subcutaneous infusion of a serotonin antagonist, para-chlorophenylalanine (pcpa), facilitated entrance into and interrupted hibernation in aroused and hibernating chipmunks in summer, respectively. |
2000-12-07 |
2023-08-12 |
Not clear |
| C L Tsai, L H Wang, C F Chang, C C Ka. Effects of gonadal steroids on brain serotonergic and aromatase activity during the critical period of sexual differentiation in tilapia, Oreochromis mossambicus. Journal of neuroendocrinology. vol 12. issue 9. 2000-10-02. PMID:10971814. |
since the 5-ht system may influence sexual differentiation, we examined the effects of para-chlorophenylalanine (p-cpa), a 5-ht synthesis inhibitor. |
2000-10-02 |
2023-08-12 |
Not clear |
| J Gervais, C Rouillar. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657038. |
depletion of endogenous 5-ht by the neurotoxin, 5,7-dihydroxytryptamine (5,7-dht), and the 5-ht synthesis inhibitor para-chlorophenylalanine (pcpa), almost completely eliminated the inhibition-excitation response in both snpc and vta da cells, without changing the percentage of da cells initially excited. |
2000-03-13 |
2023-08-12 |
rat |
| S D Hadley, P D Walker, H G Goshgaria. Effects of serotonin inhibition on neuronal and astrocyte plasticity in the phrenic nucleus 4 h following C2 spinal cord hemisection. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619560. |
as part of our ongoing analysis of the neurotransmitters involved, the present study investigated the effects of systemic administration of para-chlorophenylalanine (p-cpa), a serotonin (5-ht) synthesis inhibitor, on plasticity in the rat phrenic nucleus 4 h following c2 hemisection. |
2000-01-14 |
2023-08-12 |
rat |
| L Givalois, H Becq, P Siaud, G Ixart, I Assenmacher, G Barbane. Serotoninergic and suprachiasmatic nucleus involvement in the corticotropic response to systemic endotoxin challenge in rats. Journal of neuroendocrinology. vol 11. issue 8. 1999-09-20. PMID:10447801. |
depletion of hypothalamic 5-ht (-93%) by pretreatment of the animals with para-chlorophenylalanine (p-cpa), resulted in a halved acth response to lps, despite an overall unchanged secretory pattern. |
1999-09-20 |
2023-08-12 |
rat |
| J A Rudd, C H Cheng, R J Naylo. Serotonin-independent model of cisplatin-induced emesis in the ferret. Japanese journal of pharmacology. vol 78. issue 3. 1999-03-03. PMID:9869258. |
para-chlorophenylalanine (pcpa, 100-200 mg/kg) was used as a pharmacological tool to characterize the 5-hydroxytryptamine (5-ht) involvement in the emesis occurring 24 hr after the administration of cisplatin (10 mg/kg) in the ferret. |
1999-03-03 |
2023-08-12 |
Not clear |
| P De Deurwaerdère, L Stinus, U Spampinat. Opposite change of in vivo dopamine release in the rat nucleus accumbens and striatum that follows electrical stimulation of dorsal raphe nucleus: role of 5-HT3 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 16. 1998-09-09. PMID:9698340. |
the 5-ht synthesis inhibitor para-chlorophenylalanine (3 x 400 mg/kg, i.p., for 3 d), although preventing the effect on da release, failed to modify significantly the effect of 20 hz drn stimulation on dopac and 5-hiaa outflow in both structures. |
1998-09-09 |
2023-08-12 |
rat |
| A K Pani, R P Crol. Pharmacological analysis of monoamine synthesis and catabolism in the scallop, Placopecten magellanicus. General pharmacology. vol 31. issue 1. 1998-08-05. PMID:9595282. |
central ganglia, labial palps and feet from scallops incubated in 10(-5) m or 10(-4) m para-chlorophenylalanine for 1 day followed by a 3-6 day wash in artificial sea water had significantly reduced concentrations of 5-hydroxytryptophan, 5-hydroxytryptamine and 5-hydroxy-3-indoleacetic acid. |
1998-08-05 |
2023-08-12 |
Not clear |
| J Revelis, A M Thompson, B H Britton, G C Thompso. Effects of para-chlorophenylalanine (pCPA) on the bush baby auditory brainstem response. Hearing research. vol 116. issue 1-2. 1998-04-21. PMID:9508035. |
click-evoked auditory brainstem responses were recorded in a prosimian primate, the bush baby (otolemur garnettii), before and after depletion of serotonin (by systemic injection of para-chlorophenylalanine; pcpa) and up to 20 days after discontinuing pcpa injections (during the recovery of serotonin). |
1998-04-21 |
2023-08-12 |
Not clear |
| L Imeri, S Bianchi, M Manci. Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis. The American journal of physiology. vol 273. issue 5. 1997-12-16. PMID:9374807. |
to this purpose, mdp and il-1 were injected intracerebroventricularly at dark onset into freely moving rats pretreated twice intraperitoneally with para-chlorophenylalanine (pcpa) (300 mg/kg), which depletes brain 5-ht and causes insomnia. |
1997-12-16 |
2023-08-12 |
rat |
| V Dupouy, J M Zaja. Neuropeptide FF receptors control morphine-induced analgesia in the parafascicular nucleus and the dorsal raphe nucleus. European journal of pharmacology. vol 330. issue 2-3. 1997-09-22. PMID:9253945. |
similarly, the serotonin (5-ht) depletion induced by a systemic administration of para-chlorophenylalanine did not modify morphine analgesia microinjected into the nucleus raphe dorsalis and the parafascicular nucleus but blocked the ability of (1dme)y8fa to reverse morphine effects in both nuclei. |
1997-09-22 |
2023-08-12 |
rat |
| Y H Chang, M T Hsieh, J T Chen. Increase of locomotor activity by acupuncture on Bai-Hui point in rats. Neuroscience letters. vol 211. issue 2. 1997-01-23. PMID:8830859. |
otherwise, action of acupuncture was enhanced by para-chlorophenylalanine, the depleter of endogenous 5-hydroxytryptamine (5-ht), and eliminated by 5-hydroxytryptophan, the precursor of 5-ht, in the initial stage of insertion. |
1997-01-23 |
2023-08-12 |
rat |
| I Korzeniewska, A Płaźni. Influence of serotonergic drugs on restraint stress induced analgesia. Polish journal of pharmacology. vol 47. issue 5. 1996-11-27. PMID:8868128. |
it was found that pretreatment of rats with para-chlorophenylalanine (p-cpa), an inhibitor of serotonin synthesis, significantly attenuated sia, measured immediately after stress session. |
1996-11-27 |
2023-08-12 |
rat |
| Y Minabe, K Emori, C R Ashb. The depletion of brain serotonin levels by para-chlorophenylalanine administration significantly alters the activity of midbrain dopamine cells in rats: an extracellular single cell recording study. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822477. |
the depletion of brain serotonin levels by para-chlorophenylalanine administration significantly alters the activity of midbrain dopamine cells in rats: an extracellular single cell recording study. |
1996-11-08 |
2023-08-12 |
rat |
| Y Minabe, K Emori, C R Ashb. The depletion of brain serotonin levels by para-chlorophenylalanine administration significantly alters the activity of midbrain dopamine cells in rats: an extracellular single cell recording study. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822477. |
in this study, we examined the effect of 5-ht depletion produced by the acute administration of para-chlorophenylalanine (pcpa) on the number of spontaneously active dopamine (da) cells in the ventral tegmental area (vta or a10) and substantia nigra pars compacta (snc or a9) in the rat. |
1996-11-08 |
2023-08-12 |
rat |
| C L Chang, J C Lee, C C Tseng, Y H Chang, J T Chen. Decrease of anesthetics activity by electroacupuncture on Jen-Chung point in rabbits. Neuroscience letters. vol 202. issue 1-2. 1996-10-23. PMID:8787839. |
moreover, pretreatment with para-chlorophenylalanine at a dose sufficient to deplete endogenous 5-hydroxytryptamine (5-ht) failed to influence the action of ea. |
1996-10-23 |
2023-08-12 |
Not clear |
| Y Ueta, A Levy, H S Chowdrey, S L Lightma. Inhibition of hypothalamic nitric oxide synthase gene expression in the rat paraventricular nucleus by food deprivation is independent of serotonin depletion. Journal of neuroendocrinology. vol 7. issue 11. 1996-10-11. PMID:8748123. |
since there is considerable evidence for an important role of 5-ht in feeding behaviour, we then examined the effect of food deprivation on nos gene expression in the pvn following para-chlorophenylalanine (pcpa)-induced hypothalamic 5-ht depletion. |
1996-10-11 |
2023-08-12 |
rat |
| E C Azmitia, V J Rubinstein, J A Strafaci, J C Rios, P M Whitaker-Azmiti. 5-HT1A agonist and dexamethasone reversal of para-chloroamphetamine induced loss of MAP-2 and synaptophysin immunoreactivity in adult rat brain. Brain research. vol 677. issue 2. 1995-11-14. PMID:7552242. |
reducing circulating adrenal steroids or central 5-ht levels via adrenalectomy (adx) or the tryptophan hydroxylase inhibitor, para-chlorophenylalanine (pcpa), respectively, has been shown to have de-differentiating effects in the adult brain. |
1995-11-14 |
2023-08-12 |
rat |
| H C Dringenberg, E L Hargreaves, G B Baker, R K Cooley, C H Vanderwol. p-chlorophenylalanine-induced serotonin depletion: reduction in exploratory locomotion but no obvious sensory-motor deficits. Behavioural brain research. vol 68. issue 2. 1995-10-05. PMID:7544584. |
para-chlorophenylalanine (pcpa) depletes central serotonin (5-hydroxytryptamine, 5-ht) by inhibiting tryptophan hydroxylase, an enzyme necessary for the synthesis of 5-ht. |
1995-10-05 |
2023-08-12 |
rat |