| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jens Benninghoff, Angela Gritti, Matteo Rizzi, Giuseppe Lamorte, Robert J Schloesser, Angelika Schmitt, Stefanie Robel, Just Genius, Rainald Moessner, Peter Riederer, Husseini K Manji, Heinz Grunze, Dan Rujescu, Hans-Juergen Moeller, Klaus-Peter Lesch, Angelo Luigi Vescov. Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 4. 2010-04-28. PMID:20010549. |
blocking tph function by para-chlorophenylalanine (pcpa) reduced ansc proliferation, which was rescued by exogenous 5-ht. |
2010-04-28 |
2023-08-12 |
mouse |
| Mireille Basselin, Meredith A Fox, Lisa Chang, Jane M Bell, Dede Greenstein, Mei Chen, Dennis L Murphy, Stanley I Rapopor. Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19145225. |
pretreatment with para-chlorophenylalanine, a 5-ht synthesis inhibitor, restored head twitches in 5-htt(-/-) mice to levels in 5-htt(+/+) mice. |
2009-08-03 |
2023-08-12 |
mouse |
| Franck Chenu, Mostafa El Mansari, Pierre Blie. Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area. The international journal of neuropsychopharmacology. vol 12. issue 4. 2009-06-26. PMID:18700056. |
da firing was restored in clorgyline-treated rats by inhibiting 5-ht synthesis using para-chlorophenylalanine (p-cpa; 300 mg/kg. |
2009-06-26 |
2023-08-12 |
rat |
| Rakesh Kumar Sinha, Yogender Aggarwa. Neural network detects the effects of p-CPA pre-treatment on brain electrophysiology in a rat model of focal brain injury. Journal of clinical monitoring and computing. vol 23. issue 2. 2009-06-23. PMID:19301131. |
to examine the performance of artificial neural network (ann) in evaluation of the effects of pretreatment of para-chlorophenylalanine (p-cpa), a serotonin blocker, in experimental brain injury. |
2009-06-23 |
2023-08-12 |
rat |
| Rajeev Rajendran, Shanker Jha, Kimberly A Fernandes, Sunayana B Banerjee, Farhan Mohammad, Brian G Dias, Vidita A Vaidy. Monoaminergic regulation of Sonic hedgehog signaling cascade expression in the adult rat hippocampus. Neuroscience letters. vol 453. issue 3. 2009-06-22. PMID:19429033. |
combined depletion of both serotonin and norepinephrine with para-chlorophenylalanine (pcpa) resulted in a significant decrease in smo and ptc mrna within the dentate gyrus subfield of the hippocampus. |
2009-06-22 |
2023-08-12 |
rat |
| Kristina Annerbrink, Marie Olsson, Lydia K Melchior, Jan Hedner, Elias Eriksso. Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder. The international journal of neuropsychopharmacology. vol 6. issue 1. 2009-04-06. PMID:12899736. |
to elucidate if serotonergic transmission affects respiratory variability, a parameter consistently found increased in patients with panic disorder, we studied the effect of a serotonin synthesis inhibitor, para-chlorophenylalanine (pcpa), on respiratory variability at baseline and during co2-induced hyperventilation in awake and unrestrained rats. |
2009-04-06 |
2023-08-12 |
rat |
| Janel M Boyce-Rustay, Benjamin Palachick, Kathryn Hefner, Yi-Chyan Chen, Rose-Marie Karlsson, Rachel A Millstein, Judith Harvey-White, Andrew Holme. Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18625256. |
desipramine potentiation of ethanol's depressant effects was assessed following depletion of brain norepinephrine via n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine hydrochloride (dsp-4) treatment, or depletion of brain 5-ht via para-chlorophenylalanine methyl ester hydrochloride (pcpa) treatment. |
2009-01-15 |
2023-08-12 |
Not clear |
| Ludmila A Vataeva, Vladimir S Kudrin, Elena A Vershinina, Vjacheslav M Mosin, Ekaterina I Tiul'kova, Vladimir A Otelli. Maternal para-chlorophenylalanine exposure modifies central monoamines and behaviors in the adult offspring. Brain research. vol 1234. 2008-12-08. PMID:18718452. |
we reported a perspective animal model of neurodevelopmental disorders using rats prenatally exposed to an inhibitor of serotonin (5ht) synthesis, para-chlorophenylalanine (pcpa). |
2008-12-08 |
2023-08-12 |
rat |
| Brian A Hoshaw, Tiffany I Hill, James J Crowley, Jessica E Malberg, Xavier Khawaja, Sharon Rosenzweig-Lipson, Lee E Schechter, Irwin Luck. Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18675266. |
depletion of serotonin, by the tryptophan hydroxylase inhibitor para-chlorophenylalanine, blocked the antidepressant-like effects of igf-i. |
2008-11-25 |
2023-08-12 |
rat |
| Prem Prakash Tripathi, Luca Giovanni Di Giovannantonio, Alessandro Viegi, Wolfgang Wurst, Antonio Simeone, Yuri Bozz. Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784307. |
indeed, prolonged pretreatment of en1(cre/+); otx2(flox/flox) mice with the 5-ht synthesis inhibitor para-chlorophenylalanine (pcpa) restored brain 5-ht content to control levels, fully reestablishing ka seizure susceptibility. |
2008-11-03 |
2023-08-12 |
mouse |
| E S Petrova, V A Otelli. [Study of effect of serotonin on histogenesis of rat embryonal neocortex at model of ectopic neurotransplantation]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 43. issue 6. 2008-06-10. PMID:18265561. |
a comparative study has been performed of dynamics of development of ectopic transplants of embryonal (e14) neocortex anlages obtained from intact rats and from the rats administered with serotonin inhibitor para-chlorophenylalanine (pcpa) at the 11th day of pregnancy as well as after incubation of such anlages in the serotonin-containing medium. |
2008-06-10 |
2023-08-12 |
rat |
| E S Petrova, V A Otelli. Serotonin is involved in the regulation of histogenetic processes in rat embryonic neocortex. Bulletin of experimental biology and medicine. vol 143. issue 3. 2008-02-27. PMID:18225767. |
we compared the dynamics of the development of ectopic transplants of embryonic (day 14) primordial neocortex from rats injected with serotonin inhibitor (para-chlorophenylalanine; 400 mg/kg) on day 11 of pregnancy and transplants of similar primordial neocortex incubated before transplantation in a medium with serotonin (3 microg/ml). |
2008-02-27 |
2023-08-12 |
rat |
| Ludmila A Vataeva, Vladimir S Kudrin, Elena A Vershinina, Vjacheslav M Mosin, Ekaterina I Tiul'kova, Vladimir A Otelli. Behavioral alteration in the adult rats prenatally exposed to para-chlorophenylalanine. Brain research. vol 1169. 2007-12-14. PMID:17698045. |
in the present work, effects of maternal administration of para-chlorophenylalanine (pcpa), a serotonin synthesis inhibitor, on behavior of adult offspring were studied. |
2007-12-14 |
2023-08-12 |
rat |
| H G Ruhé, N S Mason, A H Schen. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Molecular psychiatry. vol 12. issue 4. 2007-06-01. PMID:17389902. |
acute tryptophan depletion (atd) or para-chlorophenylalanine (pcpa) deplete 5-ht, acute phenylalanine/tyrosine depletion (aptd) or alpha-methyl-para-tyrosine (ampt) deplete ne/da. |
2007-06-01 |
2023-08-12 |
human |
| Brian George Dias, David Crew. Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens. Hormones and behavior. vol 50. issue 3. 2006-10-24. PMID:16793042. |
treatment with para-chlorophenylalanine (an inhibitor of tryptophan hydroxylase) facilitated male-like pseudosexual behavior depending on the circulating hormonal milieu and decreased serotonin levels in the preoptic area. |
2006-10-24 |
2023-08-12 |
Not clear |
| Arturo Zazpe, Inés Artaiz, Ana Innerárity, Elena Del Olmo, Elena Castro, Luis Labeaga, Angel Pazos, Aurelio Orjale. In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties. Neuropharmacology. vol 51. issue 1. 2006-09-11. PMID:16643965. |
the 5-ht depleting agent para-chlorophenylalanine (pcpa) partially attenuated tacrine-induced tjm but did not block the suppressive effect of 5-ht(1a) agonists. |
2006-09-11 |
2023-08-12 |
rat |
| Chloé Alexandre, Daniela Popa, Véronique Fabre, Saoussen Bouali, Patrice Venault, Klaus-Peter Lesch, Michel Hamon, Joëlle Adrie. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 20. 2006-06-08. PMID:16707806. |
we found that treatments initiated at postnatal day 5 and continued for 2 weeks with the 5-ht synthesis inhibitor para-chlorophenylalanine, or for 4 weeks with the 5-ht(1a) receptor (5-ht(1a)r) antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexane carboxamide (way 100635), induced total or partial recovery of rems, respectively, in 5-htt-/- mutants. |
2006-06-08 |
2023-08-12 |
mouse |
| György Csaba, Péter Kovács, Eva Pállinge. Hormones in the nucleus. Immunologically demonstrable biogenic amines (serotonin, histamine) in the nucleus of rat peritoneal mast cells. Life sciences. vol 78. issue 16. 2006-04-11. PMID:16332378. |
the tryptophan hydroxylase inhibitor, para-chlorophenylalanine (pcpa), and the mast cell degranulator, compound 48/80, reduced cytoplasmic serotonin content without influencing nuclear content. |
2006-04-11 |
2023-08-12 |
rat |
| Eric Dailly, Franck Chenu, Benoit Petit-Demoulière, Michel Bouri. Specificity and efficacy of noradrenaline, serotonin depletion in discrete brain areas of Swiss mice by neurotoxins. Journal of neuroscience methods. vol 150. issue 1. 2006-04-03. PMID:16098600. |
the aim of this work is to define neurotoxins doses to have efficient and specific depletion of noradrenaline (na), serotonin (5-ht) neurotransmission in cortex, striatum, hippocampus and hypothalamus of swiss mice after intraperitoneal administration of, respectively, n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine hydrochloride (dsp-4) and para-chlorophenylalanine methyl ester hydrochloride (pcpa). |
2006-04-03 |
2023-08-12 |
mouse |
| Daniel O Kellett, S Clare Stanford, Benedito H Machado, David Jordan, Andrew G Ramag. Effect of 5-HT depletion on cardiovascular vagal reflex sensitivity in awake and anesthetized rats. Brain research. vol 1054. issue 1. 2005-11-14. PMID:16054601. |
the present experiments examined the effect of 5-ht depletion with para-chlorophenylalanine (p-cpa) on the cardiac vagal baroreflex and cardiopulmonary reflex in awake and anesthetized rats. |
2005-11-14 |
2023-08-12 |
rat |