| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A B Alfieri, L X Cubedd. Treatment with para-chlorophenylalanine antagonises the emetic response and the serotonin-releasing actions of cisplatin in cancer patients. British journal of cancer. vol 71. issue 3. 1995-04-12. PMID:7533519. |
to test the role of serotonin in chemotherapy-induced nausea and emesis, ten cancer patients were pretreated with the serotonin synthesis inhibitor para-chlorophenylalanine (pcpa). |
1995-04-12 |
2023-08-12 |
Not clear |
| C P Buchanan, E M Shrier, W L Hil. Time-dependent effects of PCPA on social aggression in chicks. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862698. |
we investigated the effects of para-chlorophenylalanine (pcpa), a serotonin (5-ht) antagonist, on social aggression and brain neurochemistry in young domestic chickens (gallus domesticus). |
1995-03-22 |
2023-08-12 |
Not clear |
| H Hardin, A Bernard, F Rajas, M Fevre-Montange, E Derrington, M F Belin, M Didier-Baze. Modifications of glial metabolism of glutamate after serotonergic neuron degeneration in the hippocampus of the rat. Brain research. Molecular brain research. vol 26. issue 1-2. 1995-03-16. PMID:7854035. |
the inhibition of serotonin synthesis (by para-chlorophenylalanine (p-cpa) administration) produced no significant increase of gdh level. |
1995-03-16 |
2023-08-12 |
rat |
| E L Gibson, A J Kennedy, G Curzo. d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors. European journal of pharmacology. vol 242. issue 1. 1993-12-16. PMID:8223940. |
severe depletion of 5-hydroxytryptamine (5-ht) by para-chlorophenylalanine (pcpa, 150 mg/kg per day x3) did not alter the hypophagic effect of d-fenfluramine (1-3 mg/kg i.p.) |
1993-12-16 |
2023-08-12 |
rat |
| L A Riley, G M Jonakait, R P Har. Serotonin modulates the levels of mRNAS coding for thyrotropin-releasing hormone and preprotachykinin by different mechanisms in medullary raphe neurons. Brain research. Molecular brain research. vol 17. issue 3-4. 1993-07-15. PMID:8389958. |
just like the mrna coding for the precursor of sp (preprotachykinin, ppt), levels of trh mrna are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pcpa) and decreased when serotonin reuptake is blocked by zimelidine. |
1993-07-15 |
2023-08-12 |
Not clear |
| S A Signs, D E Dluzen, A J Carrill. Para-chlorophenylalanine treatment inhibits the expression of vasoactive intestinal peptide messenger RNA in rat anterior pituitary. Brain research. Molecular brain research. vol 17. issue 1-2. 1993-03-16. PMID:8381907. |
adult male sprague-dawley rats were treated with para-chlorophenylalanine (pcpa) or alpha-methyl tyrosine (alpha-mt) to study the effect of serotonin or catecholamine depletion on the expression of vasoactive intestinal peptide (vip) messenger rna in the anterior pituitary. |
1993-03-16 |
2023-08-12 |
rat |
| P Navarra, M Martire, R del Carmine, G Pozzoli, P Prezios. A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon. Toxicology letters. vol 64-65 Spec No. 1993-01-25. PMID:1471230. |
a serotonergic mechanism appears to be involved in both cisplatin- and 5-ht3 receptor antagonist-induced emesis, since pretreatment with an inhibitor of 5-ht synthesis, para-chlorophenylalanine (300 mg/kg x 3 days), is able to hamper vomiting induced by either cisplatin or 5-ht3 receptor antagonists. |
1993-01-25 |
2023-08-11 |
pigeon |
| E Meller, M Chalfin, K Bohmake. Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance. Pharmacology, biochemistry, and behavior. vol 43. issue 2. 1992-12-22. PMID:1359573. |
attempts to identify the synaptic locus of the receptor were unsuccessful because depletion of central serotonin (5-ht) by treatment with para-chlorophenylalanine (pcpa; 3 x 150 mg/kg) did not alter the hypothermic response to 8-oh-dpat. |
1992-12-22 |
2023-08-11 |
mouse |
| P Preziosi, M D'Amato, R Del Carmine, M Martire, G Pozzoli, P Navarr. The effects of 5-HT3 receptor antagonists on cisplatin-induced emesis in the pigeon. European journal of pharmacology. vol 221. issue 2-3. 1992-12-22. PMID:1426010. |
a serotonergic mechanism appears to be involved in both cisplatin- and 5-ht3 receptor antagonist-induced emesis, since pretreatment with an inhibitor of 5-ht synthesis, para-chlorophenylalanine (pcpa), prevented vomiting induced by either cisplatin or 5-ht3 receptor antagonists. |
1992-12-22 |
2023-08-11 |
pigeon |
| H Fukui, M Yamamoto, S Sat. Vagal afferent fibers and peripheral 5-HT3 receptors mediate cisplatin-induced emesis in dogs. Japanese journal of pharmacology. vol 59. issue 2. 1992-12-04. PMID:1434118. |
the cisplatin-induced emesis was also suppressed by the intravenous administration of para-chlorophenylalanine (300 mg/kg/day for 3 days), an inhibitor of 5-ht synthesis. |
1992-12-04 |
2023-08-11 |
Not clear |
| M D Schechte. Effect of serotonin depletion by p-chlorophenylalanine upon discriminative behaviours. General pharmacology. vol 22. issue 5. 1992-02-13. PMID:1684770. |
para-chlorophenylalanine (p-cpa), a competitive inhibitor of the serotonin (5-ht) synthesis enzyme tryptophan hydroxylase, was administered to rats at a dosage (100 mg/kg daily for 3 days) that depletes 5-ht. |
1992-02-13 |
2023-08-11 |
rat |
| O C Ikonomov, A G Stoynev, I I Goranova-Stoyneva, A Popov, V A Minkov. Nephrotoxic effect of the specific brain serotonin depletor para-chlorophenylalanine. Acta physiologica Hungarica. vol 76. issue 3. 1991-08-14. PMID:2151605. |
nephrotoxic effect of the specific brain serotonin depletor para-chlorophenylalanine. |
1991-08-14 |
2023-08-11 |
rat |
| M F Anderson, D J Mokler, B J Winterso. Inhibition of chronic hindlimb flexion in rat: evidence for mediation by 5-hydroxytryptamine. Brain research. vol 541. issue 2. 1991-08-01. PMID:1711397. |
pretreatment with para-chlorophenylalanine (pcpa) to deplete 5-ht, or the administration of metergoline, a non-specific 5-ht antagonist, had no significant effect on flexion at 72 h in the intact rat but abolished rebound. |
1991-08-01 |
2023-08-11 |
rat |
| W Wang, R C M. [Serotonin mediated synaptic transmission of inferior mesenteric ganglion of the guinea pig]. Sheng li xue bao : [Acta physiologica Sinica]. vol 43. issue 1. 1991-06-28. PMID:1645476. |
(4) pretreating the guinea pigs with para-chlorophenylalanine (pcpa), a 5-ht biosynthesis inhibitor, markedly reduced the occurrence rate and amplitude of ls-epsp. |
1991-06-28 |
2023-08-11 |
Not clear |
| H O Kalkma. Discriminative stimulus properties of 8-OH-DPAT in rats are not altered by pretreatment with para-chlorophenylalanine. Psychopharmacology. vol 101. issue 1. 1990-06-27. PMID:1971447. |
drug lever appropriate responding to 8-oh-dpat (0.1 mg/kg, sc) and ipsapirone (3 mg/kg, sc) was measured before and after treatment with para-chlorophenylalanine (pcpa) at a dose (150 mg/kg ip, -3 and -2 days) which causes severe depletion of brain 5-ht stores. |
1990-06-27 |
2023-08-11 |
rat |
| M D Kelland, A S Freeman, L A Chiod. Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 253. issue 2. 1990-06-21. PMID:1971022. |
depletion of brain 5-ht (greater than 80%) by either para-chlorophenylalanine or 5,7-dihydroxytryptamine eliminated the rate-dependent nature of quinpirole-induced inhibition of nigrostriatal da neurons, while having limited effects on the basal electrophysiological activity of these cells. |
1990-06-21 |
2023-08-11 |
rat |
| J W Smythe, B A Pappa. Noradrenergic and serotonergic mediation of the locomotor and antinociceptive effects of clonidine in infant and adult rats. Pharmacology, biochemistry, and behavior. vol 34. issue 2. 1990-03-27. PMID:2533689. |
newborn rats were administered systemically 6-hydroxydopamine (100 micrograms/g; 12 and 24 hours after birth) to deplete norepinephrine (ne), and at 10 or 100 days they were injected with para-chlorophenylalanine (300 mg/kg pcpa; 5 and 24 hours before testing) to deplete serotonin (5-ht). |
1990-03-27 |
2023-08-11 |
rat |
| A Mistry, J L Voog. Role of serotonin in nocturnal and diurnal surges of prolactin in the pregnant rat. Endocrinology. vol 125. issue 6. 1990-01-09. PMID:2479530. |
pretreatment 24 h earlier with para-chlorophenylalanine (pcpa; 250 mg/kg bw), an inhibitor of 5-ht biosynthesis, did not affect the n prl surge, although the hypothalamic concentrations of 5-ht and its metabolite 5-hydroxyindole acetic acid were greatly reduced. |
1990-01-09 |
2023-08-11 |
rat |
| M Denoyer, M Sallanon, K Kitahama, C Aubert, M Jouve. Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan. Neuroscience. vol 28. issue 1. 1989-09-18. PMID:2527339. |
para-chlorophenylalanine, a blocker of serotonin biosynthesis by inhibiting tryptophan hydroxylase, induced total insomnia which was accompanied in cat by a permanent discharge of ponto-geniculo-occipital activity. |
1989-09-18 |
2023-08-11 |
cat |
| L Ugedo, J Grenhoff, T H Svensso. Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition. Psychopharmacology. vol 98. issue 1. 1989-07-07. PMID:2524859. |
these effects were prevented by endogenous 5-ht depletion through pretreatment with the 5-ht synthesis inhibitor para-chlorophenylalanine (pcpa, 300 mg/kg, ip, x3), which did not significantly alter the firing characteristics of the midbrain da cells when given alone. |
1989-07-07 |
2023-08-11 |
rat |