| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' L I Khozha\\xc4\\xa. [Astroglia formation in the neocortex of mice after temporary prenatal serotonin depletion]. Morfologiia (Saint Petersburg, Russia). vol 127. issue 1. 2005-09-19. PMID:16080341.' |
to suppress serotonin synthesis, para-chlorophenylalanine was administered to females once at the early postimplantation stage of gestation. |
2005-09-19 |
2023-08-12 |
mouse |
| Irina Pavlovna Butkevich, Victor Anatol'evich Mikhailenko, Elena Andreevna Vershinina, Ludmila Ivanovna Khozhai, Igor'Pavlovich Grigorev, Vladimir Alexandrovich Otelli. Reduced serotonin synthesis during early embryogeny changes effect of subsequent prenatal stress on persistent pain in the formalin test in adult male and female rats. Brain research. vol 1042. issue 2. 2005-07-15. PMID:15854586. |
pregnant dams were injected with para-chlorophenylalanine (pcpa, 400 mg/kg/2 ml, ip), producing 5-ht depletion during the early period of fetal serotonergic system development. |
2005-07-15 |
2023-08-12 |
rat |
| David A Slattery, Sandrine Desrayaud, John F Crya. GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent. The Journal of pharmacology and experimental therapeutics. vol 312. issue 1. 2005-04-13. PMID:15333677. |
to further assess the possible interaction between gaba(b) receptor antagonism and serotonin, rats were pretreated with the tryptophan hydroxylase inhibitor para-chlorophenylalanine. |
2005-04-13 |
2023-08-12 |
rat |
| Irina P Butkevich, Ludmila I Khozhai, Victor A Mikhailenko, Vladimir A Otelli. Decreased serotonin level during pregnancy alters morphological and functional characteristics of tonic nociceptive system in juvenile offspring of the rat. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:14614772. |
of the 5-ht synthesis inhibitor, para-chlorophenylalanine (pcpa), given to pregnant rats during the critical period fetal serotonin development. |
2004-09-08 |
2023-08-12 |
rat |
| Kelvin K W Kan, Robert L Jones, Man-P Ngan, John A Rudd, Man-K Wa. Emetic action of the prostanoid TP receptor agonist, U46619, in Suncus murinus (house musk shrew). European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660035. |
however, fenfluramine (5 mg/kg, repeated treatment) and para-chlorophenylalanine (100-400 mg/kg) and ondansetron (0.3-3 mg/kg) were inactive (p>0.05) to reduce u46619-induced emesis precluding a role of 5-ht and 5-ht(3) receptors in the mechanism. |
2004-08-16 |
2023-08-12 |
Not clear |
| Minoru Fujiki, Hidenori Kobayashi, Ryo Inoue, Keisuke Ishi. Immediate plasticity in the motor pathways after spinal cord hemisection: implications for transcranial magnetic motor-evoked potentials. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144873. |
both electrophysiological and neurological facilitations were significantly attenuated by the selective serotonin synthesis inhibitor para-chlorophenylalanine (p-cpa). |
2004-06-30 |
2023-08-12 |
rat |
| Sandrine M Géranton, David J Heal, S Clare Stanfor. 5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamine, and the reuptake inhibitor, BTS 54 354. Neuropharmacology. vol 46. issue 4. 2004-05-28. PMID:14975675. |
we studied the effects of the 5-ht synthesis inhibitor, para-chlorophenylalanine (pcpa; which depleted 5-ht stores in both the frontal cortex and the hypothalamus), on spontaneous efflux of noradrenaline and on the noradrenergic responses to d-amphetamine, and the monoamine reuptake inhibitor, bts 54 354. pcpa pretreatment alone did not affect spontaneous noradrenaline efflux in either brain region, whether or not alpha2-autoreceptors were inactivated by administration of the alpha2-antagonist, atipamezole (1 mg/kg i.p). |
2004-05-28 |
2023-08-12 |
rat |
| Naceur A Boughattas, Mossadok Ben Attia, Guy Ixart, Guy Lemaigre, Mohamed Mechkouri, Alain Reinber. Pharmacological blockage of serotonin biosynthesis and circadian changes in oxaliplatin toxicity in rats. Chronobiology international. vol 19. issue 6. 2003-12-05. PMID:12511030. |
four groups of female rats (120 in total) synchronized with light-dark (12 h:12 h) were treated with: (i) saline, (ii) para-chlorophenylalanine (pcpa, an inhibitor of serotonin biosynthesis: 300 mg/kg/d, i.p. |
2003-12-05 |
2023-08-12 |
rat |
| H B Lebsanft, A Mayerhofer, K-A Kovar, W J Schmid. Is the Ecstasy-induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats dopamine independent? Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 7. 2003-10-14. PMID:12811632. |
mdma induced rotations were attenuated by the selective serotonin reuptake inhibitor citalopram but were only slightly reduced by pre-treatment with the selective serotonin synthesis inhibitor pcpa (para-chlorophenylalanine). |
2003-10-14 |
2023-08-12 |
rat |
| A Harkin, T J Connor, M Walsh, N St John, J P Kell. Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668047. |
depletion of endogenous serotonin using para-chlorophenylalanine (pcpa; 3 x 150 mg/kg, i.p.) |
2003-06-23 |
2023-08-12 |
rat |
| K V S Nemmani, J S Mogi. Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia. Neuropharmacology. vol 44. issue 3. 2003-05-02. PMID:12604090. |
the benzodiazepine receptor agonist, diazepam, the serotonin synthesis inhibitor, para-chlorophenylalanine (p-cpa), and the 5-ht(1a) receptor agonist, 8-oh-dpat, were all found to attenuate morphine and u50,488 analgesia. |
2003-05-02 |
2023-08-12 |
mouse |
| B R Tuladhar, B Costall, R J Naylo. Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine. British journal of pharmacology. vol 136. issue 1. 2002-08-15. PMID:11976280. |
fluoxetine (10 microm) also failed to prevent the relaxation due to exogenous 5-ht and the 5-ht4 receptor agonist 5-methoxytryptamine in tissues taken from the rats treated with para-chlorophenylalanine (300 mg kg-1) for 3 and 6 days, which reduced the 5-ht level in the mucosa by 88 and 97.5% respectively. |
2002-08-15 |
2023-08-12 |
rat |
| C L Tsai, L H Wang, L S Fan. Estradiol and para-chlorophenylalanine downregulate the expression of brain aromatase and estrogen receptor-alpha mRNA during the critical period of feminization in tilapia (Oreochromis mossambicus). Neuroendocrinology. vol 74. issue 5. 2001-12-28. PMID:11694764. |
the effect of e(2) at this time is mimicked by para-chlorophenylalanine (p-cpa), a serotonin (5-hydroxytryptamine; 5-ht) synthesis inhibitor. |
2001-12-28 |
2023-08-12 |
Not clear |
| L T Tran-Nguyen, J G Bellew, K A Grote, J L Neisewande. Serotonin depletion attenuates cocaine seeking but enhances sucrose seeking and the effects of cocaine priming on reinstatement of cocaine seeking in rats. Psychopharmacology. vol 157. issue 4. 2001-12-19. PMID:11605092. |
acute serotonin (5-ht) depletion by the tryptophan hydroxylase inhibitor, para-chlorophenylalanine, attenuates cocaine seeking in rats. |
2001-12-19 |
2023-08-12 |
rat |
| T J Connor, M C Dennedy, A Harkin, J P Kell. Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin. European journal of pharmacology. vol 418. issue 1-2. 2001-09-27. PMID:11334877. |
we examined the effect of pretreatment with the selective serotonin reuptake inhibitor paroxetine, and the tryptophan hydroxylase inhibitor para-chlorophenylalanine on mdma-induced suppression of interleukin-1beta and tumour necrosis factor (tnf)-alpha secretion following an in vivo lipopolysaccharide challenge. |
2001-09-27 |
2023-08-12 |
rat |
| T J Connor, M C Dennedy, A Harkin, J P Kell. Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin. European journal of pharmacology. vol 418. issue 1-2. 2001-09-27. PMID:11334877. |
similarly, although para-chlorophenylalanine caused a 90% depletion in cortical and hypothalamic serotonin content, it failed to alter the suppressive effect of mdma on lipopolysaccharide-induced interleukin-1beta or tnf-alpha secretion. |
2001-09-27 |
2023-08-12 |
rat |
| A J Mayorga, A Dalvi, M E Page, S Zimov-Levinson, R Hen, I Luck. Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice. The Journal of pharmacology and experimental therapeutics. vol 298. issue 3. 2001-09-13. PMID:11504807. |
the decreased baseline immobility in 5-ht(1a) receptor mutant mice was reversed by pretreatment with alpha-methyl-para-tyrosine, but not by para-chlorophenylalanine, suggesting mediation by enhanced catecholamine function. |
2001-09-13 |
2023-08-12 |
mouse |
| J C Ehlen, G H Grossman, J D Glas. In vivo resetting of the hamster circadian clock by 5-HT7 receptors in the suprachiasmatic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 14. 2001-07-26. PMID:11438611. |
phase shifts induced by 8-oh-dpat were enhanced more than threefold by pretreatment with the 5-ht synthesis inhibitor para-chlorophenylalanine. |
2001-07-26 |
2023-08-12 |
Not clear |
| A Laalaoui, S Ahboucha, M Didier-Bazes, M Fèvre-Montange, A Meiniel, H Gamran. Postnatal secretion of the subcommissural organ of the Meriones shawi: control of serotonin innervation. Brain research. Developmental brain research. vol 126. issue 1. 2001-05-17. PMID:11172888. |
neurotoxic destruction with 5,7-dihydroxytryptamine of the sco serotonin input in the adult or the inhibition of serotonin synthesis by para-chlorophenylalanine at different postnatal ages, resulted in a decrease of the intensity of sco reissner's fiber immunolabelling suggesting a reduction in the sco secretory material. |
2001-05-17 |
2023-08-12 |
Not clear |
| F Shutoh, S Hamada, M Shibata, M Narita, T Shiga, E C Azmitia, N Okad. Long term depletion of serotonin leads to selective changes in glutamate receptor subunits. Neuroscience research. vol 38. issue 4. 2001-04-26. PMID:11164563. |
5-ht was depleted by a 5-ht metabolite blocker (para-chlorophenylalanine; pcpa) for a week. |
2001-04-26 |
2023-08-12 |
rat |