| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Berthold, J R Fozard, G Enge. 5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice. European journal of pharmacology. vol 162. issue 1. 1989-07-06. PMID:2566495. |
inhibition of 5-ht synthesis with para-chlorophenylalanine (pcpa) had only minimal effects on withdrawal jumping per se; the attenuating effects of 8-oh-dpat and ru 24969 were not altered in pcpa-pretreated animals. |
1989-07-06 |
2023-08-11 |
mouse |
| B Söderpalm, J A Enge. Does the PCPA induced anticonflict effect involve activation of the GABAA/benzodiazepine chloride ionophore receptor complex? Journal of neural transmission. vol 76. issue 2. 1989-06-06. PMID:2540262. |
pretreatment with para-chlorophenylalanine (pcpa; 300 mg/kg/day for three days, last injection - 24 h) markedly decreased brain 5-ht levels and produced clearcut anticonflict effects. |
1989-06-06 |
2023-08-11 |
Not clear |
| F Gilbert, C T Dourish, C Brazell, S McClue, S M Stah. Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology. vol 13. issue 6. 1989-05-05. PMID:2907164. |
plasma acth also was measured in rats pretreated with the serotonin synthesis inhibitor, para-chlorophenylalanine (pcpa) for three days (150 mg/kg, i.p. |
1989-05-05 |
2023-08-11 |
rat |
| L J Mille. Serotoninergic activity stimulates melanin dispersion within dermal melanophores of newts. Life sciences. vol 44. issue 5. 1989-03-17. PMID:2521686. |
injections of para-chlorophenylalanine (pcpa), an inhibitor of serotonin synthesis, inhibited melanin dispersion, and hence darkening of the skin, when newts were transferred to a dark background. |
1989-03-17 |
2023-08-11 |
Not clear |
| J M Barnes, N M Barnes, B Costall, R J Naylor, F D Tattersal. Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret. Neuropharmacology. vol 27. issue 8. 1989-03-03. PMID:2905784. |
the involvement of 5-hydroxytryptamine (5-ht) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine. |
1989-03-03 |
2023-08-11 |
Not clear |
| J M Barnes, N M Barnes, B Costall, R J Naylor, F D Tattersal. Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret. Neuropharmacology. vol 27. issue 8. 1989-03-03. PMID:2905784. |
all treatments reduced the levels of 5-ht in the area postrema and at other cerebral sites, but whilst this action was relatively selective for small doses of para-chlorophenylalanine [only modest effects on noradrenaline (na) and no change in the content of dopamine (da) in the area postrema], other treatments reduced levels of dopamine and noradrenaline. |
1989-03-03 |
2023-08-11 |
Not clear |
| E Jørum, B C Shy. Course and mode of action of descending system conveying nucleus raphe magnus induced inhibition of flexion reflex in rats. Acta physiologica Scandinavica. vol 131. issue 4. 1988-04-18. PMID:2964771. |
the antinociceptive effect of 20 microa nrm stimulation was partly reduced by pretreatment with the serotonin synthesis inhibitor para-chlorophenylalanine (pcpa) or the opiate naloxone (1 mg kg-1 i.v.). |
1988-04-18 |
2023-08-11 |
rat |
| F Passarelli, A M Galzin, S Z Lange. Interaction between neuronal uptake inhibitors and presynaptic serotonin autoreceptors in rat hypothalamic slices: comparison of K+ and electrical depolarization. The Journal of pharmacology and experimental therapeutics. vol 242. issue 3. 1987-11-05. PMID:2958618. |
this effect of citalopram on transmitter release was potentiated when the endogenous stores of 5-ht were depleted by pretreatment with para-chlorophenylalanine methyl ester (300 mg/kg i.p.). |
1987-11-05 |
2023-08-11 |
rat |
| G A Jahn, R P Dei. A possible dual regulation of prolactin release by the serotoninergic system in rats at pro-oestrus and during late pregnancy: role of ovarian hormones. The Journal of endocrinology. vol 112. issue 3. 1987-05-08. PMID:2951475. |
the effect of para-chlorophenylalanine (pcpa), an inhibitor of serotonin synthesis, on prolactin release was studied in rats on the day of pro-oestrus and at the end of pregnancy (day 19). |
1987-05-08 |
2023-08-11 |
rat |
| P J Conn, E Sanders-Bus. Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:3025382. |
depletion of 5-ht levels with para-chlorophenylalanine or chemical denervation of serotonergic neurons with 5,7-dihydroxytryptamine had no significant effect upon 5-ht-2 receptor density or upon the phosphoinositide response to 5-ht. |
1987-02-10 |
2023-08-11 |
Not clear |
| C T Dourish, P H Hutson, G Curzo. Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Psychopharmacology. vol 89. issue 4. 1986-10-01. PMID:2428076. |
para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat). |
1986-10-01 |
2023-08-11 |
rat |
| C T Dourish, P H Hutson, G Curzo. Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Psychopharmacology. vol 89. issue 4. 1986-10-01. PMID:2428076. |
the effects of para-chlorophenylalanine pre-treatment (pcpa, 150 mg/kg ip daily for 3 days) on feeding and stereotyped behaviour elicited by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) in rats were investigated. |
1986-10-01 |
2023-08-11 |
rat |
| C T Dourish, P H Hutson, G A Kennett, G Curzo. 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite. vol 7 Suppl. 1986-09-18. PMID:2943219. |
feeding elicited by peripheral injection of the drug was attenuated by pretreatment with the serotonin synthesis inhibitor para-chlorophenylalanine. |
1986-09-18 |
2023-08-11 |
rat |
| P S Blum, J A Spat. Interaction between naloxone and serotonin in the control of the cardiovascular system in hemorrhaged cats. European journal of pharmacology. vol 123. issue 1. 1986-07-10. PMID:3709664. |
two other groups of hemorrhaged animals were depleted of serotonin by pretreatment with para-chlorophenylalanine 40-48 h before the experiment. |
1986-07-10 |
2023-08-11 |
Not clear |
| H S Sharma, P K De. Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. Neuropharmacology. vol 25. issue 2. 1986-05-23. PMID:2939361. |
this increased permeability of the blood-brain barrier and the increased level of 5-ht were prevented by pretreatment with para-chlorophenylalanine (p-cpa), indomethacin and diazepam. |
1986-05-23 |
2023-08-11 |
rat |
| A M Galzin, C Moret, B Verzier, S Z Lange. Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:2864432. |
after depletion of endogenous stores of 5-ht by pretreatment with para-chlorophenylalanine (300 mg/kg i.p. |
1985-11-08 |
2023-08-11 |
rat |
| T Sakumoto, K Sakai, D Salvert, H Sasaki, H Kimura, T Maeda, M Jouve. Possible role of serotonin in the secretory activity of the subcommissural organ of the cat. Neuroscience research. vol 1. issue 3. 1985-09-11. PMID:6536894. |
administration of para-chlorophenylalanine, a potent inhibitor of 5-ht synthesis, was found to produce a marked decrease in both 5-ht-immunoreactive materials and secretory granules in the sco. |
1985-09-11 |
2023-08-12 |
cat |
| T Sakumoto, K Sakai, D Salvert, H Sasaki, H Kimura, T Maeda, M Jouve. Possible role of serotonin in the secretory activity of the subcommissural organ of the cat. Neuroscience research. vol 1. issue 3. 1985-09-11. PMID:6536894. |
in contrast, administration of 5-hydroxytryptophan, an immediate precursor of 5-ht, to animals pretreated with para-chlorophenylalanine resulted in an increase in the amount of both secretory granules and 5-ht immunoreactivities in this circumventricular organ. |
1985-09-11 |
2023-08-12 |
cat |
| F Petitjean, C Buda, M Janin, M Sallanon, M Jouve. [Insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin]. Sleep. vol 8. issue 1. 1985-06-05. PMID:3158060. |
[insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin]. |
1985-06-05 |
2023-08-11 |
cat |
| J C Jackson, R J Cross, R F Walker, W R Markesbery, W H Brooks, T L Roszma. Influence of serotonin on the immune response. Immunology. vol 54. issue 3. 1985-04-19. PMID:3156091. |
conversely, para-chlorophenylalanine (pcpa, 250 mg/kg), which inhibits the rate-limiting enzyme (tryptophan hydroxylase) in 5-ht biosynthesis, markedly enhanced igm and igg antibody production when injected 48 hr prior to antigen. |
1985-04-19 |
2023-08-11 |
mouse |