| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Han-Jun Wang, Wei Wang, Kurtis G Cornish, George J Rozanski, Irving H Zucke. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension (Dallas, Tex. : 1979). vol 64. issue 4. 2014-11-21. PMID:24980663. |
most importantly, we found that epicardial application of resiniferatoxin largely prevented the elevated left ventricle end-diastolic pressure, lung edema, and cardiac hypertrophy, partially reduced left ventricular dimensions in the failing heart, and increased cardiac contractile reserve in response to β-adrenergic receptor stimulation with isoproterenol in chf rats. |
2014-11-21 |
2023-08-13 |
rat |
| Enrico Patrucco, Katrin Domes, Mauro Sbroggió, Anne Blaich, Jens Schlossmann, Matthias Desch, Sergei D Rybalkin, Joseph A Beavo, Robert Lukowski, Franz Hofman. Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 35. 2014-11-12. PMID:25139994. |
in particular, βrm mice developed the same hypertrophy as wt controls when subjected to thoracic aortic constriction or isoproterenol infusion. |
2014-11-12 |
2023-08-13 |
mouse |
| Hassan N Althurwi, Osama H Elshenawy, Ayman O S El-Kad. Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. Journal of cardiovascular pharmacology. vol 63. issue 2. 2014-10-06. PMID:24157956. |
furthermore, fenofibrate significantly decreased the hypertrophic markers and the increase in heart-to-body weight ratio induced by isoproterenol. |
2014-10-06 |
2023-08-12 |
rat |
| Jason H Yang, Renata K Polanowska-Grabowska, Jeffrey S Smith, Charles W Shields, Jeffrey J Saucerma. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling. Journal of molecular and cellular cardiology. vol 66. 2014-08-18. PMID:24225179. |
ca(2+) and cell hypertrophy measurements validated these predictions and identified higher isoproterenol sensitivity for contractile enhancements (ec50=1.84 nmol/l) over cell hypertrophy (ec50=85.9 nmol/l). |
2014-08-18 |
2023-08-12 |
Not clear |
| Yang Wu, Yu-qin Wang, Bao-xia Wan. [MicroRNA-133a attenuates isoproterenol-induced neonatal rat cardiomyocyte hypertrophy by downregulating L-type calcium channel α1C subunit gene expression]. Zhonghua xin xue guan bing za zhi. vol 41. issue 6. 2014-08-14. PMID:24113045. |
to investigate the effects of microrna-133a on isoproterenol (iso)-induced neonatal rat cardiomyocyte hypertrophy and related molecular mechanism focusing on the changes of l-type calcium channel α1c subunit. |
2014-08-14 |
2023-08-12 |
rat |
| Hae Jin Kee, Sangha Park, Wanseok Kang, Kyung Seob Lim, Jung Ha Kim, Youngkeun Ahn, Myung Ho Jeon. Piceatannol attenuates cardiac hypertrophy in an animal model through regulation of the expression and binding of the transcription factor GATA binding factor 6. FEBS letters. vol 588. issue 9. 2014-06-27. PMID:24662306. |
piceatannol pretreatment suppresses cardiac hypertrophy induced by isoproterenol as assessed by heart weight/body weight ratio, cross-sectional area, and expression of hypertrophic markers. |
2014-06-27 |
2023-08-12 |
rat |
| Jia-Xi Xu, Man Si, Hui-Ran Zhang, Xing-Juan Chen, Xi-Dong Zhang, Chuan Wang, Xiao-Na Du, Hai-Lin Zhan. Phosphoinositide kinases play key roles in norepinephrine- and angiotensin II-induced increase in phosphatidylinositol 4,5-bisphosphate and modulation of cardiac function. The Journal of biological chemistry. vol 289. issue 10. 2014-06-24. PMID:24448808. |
in two animal models of cardiac hypertrophy, pip2 levels were significantly reduced in hypertrophic hearts induced by isoprenaline but not in those induced by swimming exercise. |
2014-06-24 |
2023-08-12 |
rat |
| Inbal Rachmin, Sagi Tshori, Yoav Smith, Amit Oppenheim, Sylvie Marchetto, Gillian Kay, Roger S-Y Foo, Noa Dagan, Eliahu Golomb, Dan Gilon, Jean-Paul Borg, Ehud Razi. Erbin is a negative modulator of cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 16. 2014-06-17. PMID:24711380. |
cardiac hypertrophy was induced in mice either by isoproterenol administration or by aortic constriction. |
2014-06-17 |
2023-08-13 |
mouse |
| Carmen C Sucharov, Jamie G Hijmans, Rebecca D Sobus, William F A Melhado, Shelley D Miyamoto, Brian L Stauffe. β-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. Journal of applied physiology (Bethesda, Md. : 1985). vol 115. issue 7. 2014-06-03. PMID:23887897. |
we found that isoproterenol treatment (through osmotic minipump implantation) of young and adult mice produced similar degrees of cardiac hypertrophy and recapitulated several age-related molecular abnormalities in human heart failure, including phospholamban phosphorylation and β-ar expression. |
2014-06-03 |
2023-08-12 |
mouse |
| Abhro Jyoti Roy, P Stanely Mainzen Princ. Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteins in experimentally induced myocardial infarcted rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 60. 2014-05-05. PMID:23669407. |
thus, p-coumaric acid prevented cardiac hypertrophy and alterations in lipids, lipoproteins, and electrocardiogram, by virtue of its antihypertrophic, antilipidemic, and free radical scavenging effects in isoproterenol induced myocardial infarcted rats. |
2014-05-05 |
2023-08-12 |
rat |
| Rishi K Somvanshi, Shenglong Zou, Xiaofan Qiu, Ujendra Kuma. Somatostatin receptor-2 negatively regulates β-adrenergic receptor mediated Ca(2+) dependent signaling pathways in H9c2 cells. Biochimica et biophysica acta. vol 1843. issue 4. 2014-04-25. PMID:24412308. |
sstr2 selective agonist abrogates isoproterenol mediated increase in cell size and protein content (an index of hypertrophy). |
2014-04-25 |
2023-08-12 |
Not clear |
| Valeria Krandycheva, Sergey Kharin, Marina Strelkova, Konstantin Shumikhin, Aleksey Sobolev, Dmitry Shmako. Ventricular repolarization in a rat model of global heart failure. Clinical and experimental pharmacology & physiology. vol 40. issue 7. 2014-04-24. PMID:23647125. |
myocardial damage and haemodynamic changes in heart failure induced by isoproterenol were accompanied by significant changes in ventricular repolarization, which were not associated with myocardial hypertrophy. |
2014-04-24 |
2023-08-12 |
rat |
| Rishi K Somvanshi, Xiaofan Qiu, Ujendra Kuma. Isoproterenol induced hypertrophy and associated signaling pathways are modulated by somatostatin in H9c2 cells. International journal of cardiology. vol 167. issue 3. 2014-04-02. PMID:22465343. |
isoproterenol induced hypertrophy and associated signaling pathways are modulated by somatostatin in h9c2 cells. |
2014-04-02 |
2023-08-12 |
rat |
| Xingxu Wang, Li Ni, Lei Yang, Quanlu Duan, Chen Chen, Matthew L Edin, Darryl C Zeldin, Dao Wen Wan. CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. Molecular pharmacology. vol 85. issue 1. 2014-03-03. PMID:24145329. |
chronic infusion of isoproterenol (iso) or angiotensin ii (angii) by osmotic mini-pump induced cardiac hypertrophy and heart failure in mice as evaluated by hemodynamic measurements and echocardiography. |
2014-03-03 |
2023-08-12 |
mouse |
| Fanghao Lu, Jun Xing, Xinying Zhang, Shiyun Dong, Yajun Zhao, Lina Wang, Hulun Li, Fan Yang, Changqing Xu, Weihua Zhan. Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol. Molecular and cellular biochemistry. vol 381. issue 1-2. 2014-02-12. PMID:23660955. |
exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol. |
2014-02-12 |
2023-08-12 |
Not clear |
| Fanghao Lu, Jun Xing, Xinying Zhang, Shiyun Dong, Yajun Zhao, Lina Wang, Hulun Li, Fan Yang, Changqing Xu, Weihua Zhan. Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol. Molecular and cellular biochemistry. vol 381. issue 1-2. 2014-02-12. PMID:23660955. |
the cardiac hypertrophy model was obtained by injecting a high dose of isoproterenol (iso) subcutaneously, and the hemodynamic parameters were measured in groups that received either iso or iso with the treatment of nahs. |
2014-02-12 |
2023-08-12 |
Not clear |
| Cui-cui Lu, Ying-qi Xu, Ji-chao Wu, Peng-zhou Hang, Yan Wang, Chen Wang, Jian-wei Wu, Jian-cui Qi, Yong Zhang, Zhi-min D. Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology. vol 386. issue 8. 2014-01-28. PMID:23624753. |
in the present study, we aimed to determine whether vitexin prevents cardiac hypertrophy induced by isoproterenol (iso) in cultured neonatal rat ventricular myocytes in vitro and pressure overload-induced cardiac hypertrophy in mice in vivo. |
2014-01-28 |
2023-08-12 |
mouse |
| Debabrata Chowdhury, Anjana Devi Tangutur, Tarak Nath Khatua, Priyanka Saxena, Sanjay K Banerjee, Manika Pal Bhadr. A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. Journal of translational medicine. vol 11. 2013-12-31. PMID:23706090. |
a proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. |
2013-12-31 |
2023-08-12 |
rat |
| Debabrata Chowdhury, Anjana Devi Tangutur, Tarak Nath Khatua, Priyanka Saxena, Sanjay K Banerjee, Manika Pal Bhadr. A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. Journal of translational medicine. vol 11. 2013-12-31. PMID:23706090. |
the present study aimed at using a proteomics based approach to: a) analyze and contrast the proteome of the healthy and isoproterenol induced hypertrophied hearts and b) identify potential biomarkers for diagnosis of cardiac hypertrophy. |
2013-12-31 |
2023-08-12 |
rat |
| A Planavila, I Redondo, E Hondares, M Vinciguerra, C Munts, R Iglesias, L A Gabrielli, M Sitges, M Giralt, M van Bilsen, F Villarroy. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. Nature communications. vol 4. 2013-12-30. PMID:23771152. |
here we show that fgf21(-/-) mice exhibit an increased relative heart weight and develop enhanced signs of dilatation and cardiac dysfunction in response to isoproterenol infusion, indicating eccentric hypertrophy development. |
2013-12-30 |
2023-08-12 |
mouse |