| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abhro Jyoti Roy, P Stanely Mainzen Princ. Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteins in experimentally induced myocardial infarcted rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol 60 issue 2014 23669407 |
thus, p-coumaric acid prevented cardiac hypertrophy and alterations in lipids, lipoproteins, and electrocardiogram, by virtue of its antihypertrophic, antilipidemic, and free radical scavenging effects in isoproterenol induced myocardial infarcted rats. |
2014-05-05 |
2023-01-25 |
rat |
| Rishi K Somvanshi, Shenglong Zou, Xiaofan Qiu, Ujendra Kuma. Somatostatin receptor-2 negatively regulates \\xce\\xb2-adrenergic receptor mediated Ca(2+) dependent signaling pathways in H9c2 cells. Biochimica et biophysica acta vol 1843 issue 4 2014 24412308 |
sstr2 selective agonist abrogates isoproterenol mediated increase in cell size and protein content (an index of hypertrophy). |
2014-04-25 |
2023-01-25 |
Not clear |
| Valeria Krandycheva, Sergey Kharin, Marina Strelkova, Konstantin Shumikhin, Aleksey Sobolev, Dmitry Shmako. Ventricular repolarization in a rat model of global heart failure. Clinical and experimental pharmacology & physiology vol 40 issue 7 2014 23647125 |
myocardial damage and haemodynamic changes in heart failure induced by isoproterenol were accompanied by significant changes in ventricular repolarization, which were not associated with myocardial hypertrophy. |
2014-04-24 |
2023-01-25 |
rat |
| Rishi K Somvanshi, Xiaofan Qiu, Ujendra Kuma. Isoproterenol induced hypertrophy and associated signaling pathways are modulated by somatostatin in H9c2 cells. International journal of cardiology vol 167 issue 3 2014 22465343 |
isoproterenol induced hypertrophy and associated signaling pathways are modulated by somatostatin in h9c2 cells. |
2014-04-02 |
2023-01-25 |
rat |
| Xingxu Wang, Li Ni, Lei Yang, Quanlu Duan, Chen Chen, Matthew L Edin, Darryl C Zeldin, Dao Wen Wan. CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. Molecular pharmacology vol 85 issue 1 2014 24145329 |
chronic infusion of isoproterenol (iso) or angiotensin ii (angii) by osmotic mini-pump induced cardiac hypertrophy and heart failure in mice as evaluated by hemodynamic measurements and echocardiography. |
2014-03-03 |
2023-01-25 |
mouse |
| Fanghao Lu, Jun Xing, Xinying Zhang, Shiyun Dong, Yajun Zhao, Lina Wang, Hulun Li, Fan Yang, Changqing Xu, Weihua Zhan. Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol. Molecular and cellular biochemistry vol 381 issue 1-2 2014 23660955 |
exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol. |
2014-02-12 |
2023-01-25 |
Not clear |
| Fanghao Lu, Jun Xing, Xinying Zhang, Shiyun Dong, Yajun Zhao, Lina Wang, Hulun Li, Fan Yang, Changqing Xu, Weihua Zhan. Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol. Molecular and cellular biochemistry vol 381 issue 1-2 2014 23660955 |
the cardiac hypertrophy model was obtained by injecting a high dose of isoproterenol (iso) subcutaneously, and the hemodynamic parameters were measured in groups that received either iso or iso with the treatment of nahs. |
2014-02-12 |
2023-01-25 |
Not clear |
| Cui-cui Lu, Ying-qi Xu, Ji-chao Wu, Peng-zhou Hang, Yan Wang, Chen Wang, Jian-wei Wu, Jian-cui Qi, Yong Zhang, Zhi-min D. Vitexin protects against cardiac hypertrophy via inhibiting calcineurin and CaMKII signaling pathways. Naunyn-Schmiedeberg's archives of pharmacology vol 386 issue 8 2014 23624753 |
in the present study, we aimed to determine whether vitexin prevents cardiac hypertrophy induced by isoproterenol (iso) in cultured neonatal rat ventricular myocytes in vitro and pressure overload-induced cardiac hypertrophy in mice in vivo. |
2014-01-28 |
2023-01-25 |
rat |
| Debabrata Chowdhury, Anjana Devi Tangutur, Tarak Nath Khatua, Priyanka Saxena, Sanjay K Banerjee, Manika Pal Bhadr. A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. Journal of translational medicine vol 11 issue 2013 23706090 |
a proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. |
2013-12-31 |
2023-01-25 |
rat |
| Debabrata Chowdhury, Anjana Devi Tangutur, Tarak Nath Khatua, Priyanka Saxena, Sanjay K Banerjee, Manika Pal Bhadr. A proteomic view of isoproterenol induced cardiac hypertrophy: prohibitin identified as a potential biomarker in rats. Journal of translational medicine vol 11 issue 2013 23706090 |
the present study aimed at using a proteomics based approach to: a) analyze and contrast the proteome of the healthy and isoproterenol induced hypertrophied hearts and b) identify potential biomarkers for diagnosis of cardiac hypertrophy. |
2013-12-31 |
2023-01-25 |
rat |
| A Planavila, I Redondo, E Hondares, M Vinciguerra, C Munts, R Iglesias, L A Gabrielli, M Sitges, M Giralt, M van Bilsen, F Villarroy. Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. Nature communications vol 4 issue 2013 23771152 |
here we show that fgf21(-/-) mice exhibit an increased relative heart weight and develop enhanced signs of dilatation and cardiac dysfunction in response to isoproterenol infusion, indicating eccentric hypertrophy development. |
2013-12-30 |
2023-01-25 |
mouse |
| Mandy M Y Tse, Mona E Aboutabl, Hassan N Althurwi, Osama H Elshenawy, Ghada Abdelhamid, Ayman O S El-Kad. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular pharmacology vol 58 issue 5-6 2013 23466634 |
therefore, in this study, we examined the effect of isoproterenol in h9c2 cells, and the protective effects of 14,15-eet against isoproterenol-induced cellular hypertrophy. |
2013-12-10 |
2023-01-25 |
rat |
| Mandy M Y Tse, Mona E Aboutabl, Hassan N Althurwi, Osama H Elshenawy, Ghada Abdelhamid, Ayman O S El-Kad. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular pharmacology vol 58 issue 5-6 2013 23466634 |
our results demonstrated that isoproterenol significantly increased the expression of hypertrophic marker, atrial natriuretic peptide (anp) and brain natriuretic peptide (bnp), parallel to a significant increase in cell surface area. |
2013-12-10 |
2023-01-25 |
rat |
| Mandy M Y Tse, Mona E Aboutabl, Hassan N Althurwi, Osama H Elshenawy, Ghada Abdelhamid, Ayman O S El-Kad. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular pharmacology vol 58 issue 5-6 2013 23466634 |
interestingly, 20-hydroxyeicosatetraenoic acid (20-hete) treatment caused similar effects to that of isoproterenol treatment and induced cellular hypertrophy in h9c2 cells. |
2013-12-10 |
2023-01-25 |
rat |
| Mandy M Y Tse, Mona E Aboutabl, Hassan N Althurwi, Osama H Elshenawy, Ghada Abdelhamid, Ayman O S El-Kad. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular pharmacology vol 58 issue 5-6 2013 23466634 |
in conclusion, isoproterenol induces cellular hypertrophy and modulates the expression of cyps and ephx2 in h9c2 cells. |
2013-12-10 |
2023-01-25 |
rat |
| Liang Yang, Xiangyu Cai, Jie Liu, Zhe Jia, Jinjin Jiao, Jincai Zhang, Changlin Li, Jing Li, Xiang D Tan. CpG-ODN attenuates pathological cardiac hypertrophy and heart failure by activation of PI3K\\xce\\xb1-Akt signaling. PloS one vol 8 issue 4 2013 23638055 |
in vitro studies indicated that c274 could blunt reactivation of fetal cardiac genes and cell enlargement induced by a hypertrophic agent, isoproterenol. |
2013-11-26 |
2023-01-25 |
mouse |
| J\\xc3\\xb8rgen Gravning, M Shakil Ahmed, Eirik Qvigstad, Kurt Krobert, Thor Edvardsen, Ingvild Tronstad Moe, Else Marie V Hagelin, Julia Sagave, Guro Valen, Finn Olav Levy, Jan-Bj\\xc3\\xb8rn Osnes, Tor Skomedal, H\\xc3\\xa5vard Attramada. Connective tissue growth factor/CCN2 attenuates \\xce\\xb2-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes. Molecular pharmacology vol 84 issue 3 2013 23778361 |
finally, tg-ctgf mice subjected to chronic exposure (14 days) to isoproterenol revealed blunted myocardial hypertrophy and preserved cardiac function versus nlc mice. |
2013-11-26 |
2023-01-25 |
mouse |
| Shouting Liu, Canguo Zhao, Changshan Yang, Xiaofen Li, Hongbiao Huang, Ningning Liu, Shujue Li, Xuejun Wang, Jinbao Li. Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. American journal of cardiovascular disease vol 3 issue 4 2013 24224134 |
in the present study, we examined the effect of ga on pressure overload or isoproterenol infusion induced cardiac hypertrophy and fibrosis, and changes in myocardial nf-\xce\xbab signaling. |
2013-11-13 |
2023-01-25 |
rat |
| Shouting Liu, Canguo Zhao, Changshan Yang, Xiaofen Li, Hongbiao Huang, Ningning Liu, Shujue Li, Xuejun Wang, Jinbao Li. Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. American journal of cardiovascular disease vol 3 issue 4 2013 24224134 |
in conclusion, ga treatment can suppress cardiac hypertrophy and fibrosis induced by pressure overload or isoproterenol possibly through the inhibition of the proteasome and the nf-\xce\xbab pathway, suggesting that ga treatment may provide a new strategy to treat cardiac hypertrophy. |
2013-11-13 |
2023-01-25 |
rat |
| Weiping Wang, Man Zhang, Pingping Li, Hui Yuan, Nan Feng, Ying Peng, Ling Wang, Xiaoliang Wan. An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy. Journal of cardiovascular pharmacology vol 61 issue 4 2013 23232841 |
to elucidate the expression and identify the functional changes of 2 pore domain potassium channel trek-1 during cardiac hypertrophy in rats, left ventricular hypertrophy was induced by subcutaneous injection with isoproterenol. |
2013-11-11 |
2023-01-25 |
rat |