| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenjun Peng, Yuan Xie, Chongzheng Liao, Yunxia Bai, Huimin Wang, Chunxia L. Spatiotemporal patterns of gliosis and neuroinflammation in presenilin 1/2 conditional double knockout mice. Frontiers in aging neuroscience. vol 14. 2022-10-03. PMID:36185485. |
over time, both astrocyte and microglial activation were found in the whole cortex, and age-related increases in gliosis activation were more pronounced in the cortex compared to hippocampus. |
2022-10-03 |
2023-08-14 |
mouse |
| Miika Vuorimaa, Ilona Kareinen, Petri Toivanen, Stefan Karlsson, Saku Ruohone. Deep Learning-Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure. Toxicologic pathology. 2022-09-20. PMID:36125102. |
the astrocyte algorithm was created using a commercial supervised deep learning platform and the used training set consisted of 940 astrocytes manually annotated from hippocampus and cortex. |
2022-09-20 |
2023-08-14 |
rat |
| Rafael Y S Hirata, Roberto N Oliveira, Mariana S C F Silva, Adam Armada-Moreira, Sandra H Vaz, Filipa F Ribeiro, Ana Maria Sebastião, Jéssica A Lemes, José S de Andrade, Bárbara A Rosário, Isabel C Céspedes, Milena B Vian. Platinum Nanoparticle-Based Microreactors Protect Against the Behavioral and Neurobiological Consequences of Chronic Stress Exposure. Brain research bulletin. 2022-09-11. PMID:36089164. |
rats were either unstressed or exposed for 2 weeks to an unpredictable chronic mild stress paradigm (ucms), administered intra-ventral hippocampus with the microreactors (with or without the blockage of astrocyte functioning), and seven days later tested in the elevated t-maze (etm; experiment 1). |
2022-09-11 |
2023-08-14 |
rat |
| Runan Yang, Jingjian Yang, Zijing Li, Ruichen Su, Lifang Zou, Lin Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Shangdong Liang, Changshui X. Pinocembrin Inhibits P2X4 Receptor-Mediated Pyroptosis in Hippocampus to Alleviate the Behaviours of Chronic Pain and Depression Comorbidity in Rats. Molecular neurobiology. 2022-09-10. PMID:36088500. |
in the model rats, the mrna and protein levels of the p2x4 receptor in the hippocampus were increased, and the coexpression of p2x4 and the astrocyte marker glial fibrillary acidic protein (gfap) in the hippocampus was increased. |
2022-09-10 |
2023-08-14 |
rat |
| Maryvonne Ardourel, Arnaud Pâris, Chloé Felgerolle, Fabien Lesne, Isabelle Ranchon-Cole, Sylvain Briault, Olivier Perch. FMRP-related retinal phenotypes: Evidence of glutamate-glutamine metabolic cycle impairment. Experimental eye research. 2022-09-06. PMID:36067823. |
indeed, glutamate homeostasis deficit has been observed in absence of fmrp in-vivo in cortex and hippocampus structures as well as in vitro on astroglial cell culture. |
2022-09-06 |
2023-08-14 |
human |
| Lílian Juliana Lissner, Krista Minéia Wartchow, Leticia Rodrigues, Larissa Daniele Bobermin, Ederson Borba, Vitor Gayger Dias, Fernanda Hansen, André Quincozes-Santos, Carlos-Alberto Gonçalve. Acute Methylglyoxal-Induced Damage in Blood-Brain Barrier and Hippocampal Tissue. Neurotoxicity research. 2022-09-03. PMID:36057040. |
we investigated the integrity of the blood-brain barrier (bbb) and astrocyte response in the hippocampus to acute insult induced by mg when it was intracerebroventricularly administered to rats. |
2022-09-03 |
2023-08-14 |
rat |
| Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zha. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-09. PMID:35944999. |
here, we demonstrate that ptbp1 downregulation using an astrocyte specific aav-mediated shrna system fails to convert hippocampal astrocytes into neurons in both male and female wt, and β-amyloid (5×fad) and tau (ps19) alzheimer's disease (ad) mouse models, and fails to reverse synaptic/cognitive deficits and ad-associated pathology in male mice. |
2022-08-09 |
2023-08-14 |
mouse |
| Diana J Zajac, Benjamin C Shaw, David J Braun, Stefan J Green, Joshua M Morganti, Steven Estu. Exogenous Short Chain Fatty Acid Effects in APP/PS1 Mice. Frontiers in neuroscience. vol 16. 2022-07-21. PMID:35860296. |
similarly, scfas did not affect cortical or hippocampal astrocyte activation observed in the app/ps1 mice. |
2022-07-21 |
2023-08-14 |
mouse |
| Jin Xing, Li Ren, Hao Xu, Liang Zhao, Zhi-Han Wang, Guang-Dong Hu, Zi-Long We. Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With Traumatic Brain Injury. Frontiers in genetics. vol 13. 2022-07-18. PMID:35846152. |
specifically, we found that oligodendrocytes were the most abundant cell type in mouse hippocampus, and detected an expanded astrocyte population, which was significantly activated in tbi. |
2022-07-18 |
2023-08-14 |
mouse |
| Tianhai Wang, Guiping Xu, Xue Zhang, Yanghao Ren, Tianyu Yang, Cheng Xiao, Chunyi Zho. Malfunction of astrocyte and cholinergic inputs is involved in postoperative impairment of hippocampal synaptic plasticity and cognitive function. Neuropharmacology. 2022-07-14. PMID:35835213. |
malfunction of astrocyte and cholinergic inputs is involved in postoperative impairment of hippocampal synaptic plasticity and cognitive function. |
2022-07-14 |
2023-08-14 |
mouse |
| Ghazal Naseri Kouzehgarani, Mikhail E Kandel, Masayoshi Sakakura, Joshua S Dupaty, Gabriel Popescu, Martha U Gillett. Circadian Volume Changes in Hippocampal Glia Studied by Label-Free Interferometric Imaging. Cells. vol 11. issue 13. 2022-07-09. PMID:35805157. |
we hypothesize that the dynamic nature of astrocyte morphology plays an important role in the functional circuitry of hippocampal learning and memory, specifically in the dg. |
2022-07-09 |
2023-08-14 |
Not clear |
| Ying Wei, Li Xiao, Weihao Fan, Jing Zou, Hong Yang, Bo Liu, Yi Ye, Di Wen, Linchuan Lia. Astrocyte Activation, but not Microglia, Is Associated with the Experimental Mouse Model of Schizophrenia Induced by Chronic Ketamine. Journal of molecular neuroscience : MN. 2022-07-08. PMID:35802289. |
meanwhile, immunofluorescence was used to evaluate the expression levels of iba-1 (a microglial marker) and gfap (an astrocyte marker) in the mouse hippocampus for any change. |
2022-07-08 |
2023-08-14 |
mouse |
| Sydney Aten, Yixing Du, Olivia Taylor, Courtney Dye, Kelsey Collins, Matthew Thomas, Conrad Kiyoshi, Min Zho. Chronic Stress Impairs the Structure and Function of Astrocyte Networks in an Animal Model of Depression. Neurochemical research. 2022-07-07. PMID:35796915. |
additionally, in astrocyte syncytial isopotentiality measurement, we found that ucms impairs the syncytial coupling strength of astrocytes within the hippocampus and prefrontal cortex-two brain regions that have been implicated in the regulation of mood. |
2022-07-07 |
2023-08-14 |
mouse |
| Marika Cordaro, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Tiziana Genovese, Livia Interdonato, Gianluca Franco, Alessia Arangia, Enrico Gugliandolo, Rosalia Crupi, Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzer. Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion. Biomedicines. vol 10. issue 6. 2022-06-24. PMID:35740470. |
here, we found that vad caused brain injury, lipid peroxidation, and neuronal death in the hippocampus, as well as astrocyte and microglial activation, and reduced bdnf neurotrophic factor expression together with behavioral alterations. |
2022-06-24 |
2023-08-14 |
mouse |
| Marcela K Preininger, Daniela Kaufe. Blood-Brain Barrier Dysfunction and Astrocyte Senescence as Reciprocal Drivers of Neuropathology in Aging. International journal of molecular sciences. vol 23. issue 11. 2022-06-10. PMID:35682895. |
over time, bbbd-associated astrocyte dysfunction results in hippocampal and cortical neural hyperexcitability and cognitive deficits. |
2022-06-10 |
2023-08-14 |
Not clear |
| Wilfred Fonseca-Ferrer, Cristina Suárez-Gomez, Lubriel Sambolin-Escobales, Kimberly Santos-Avilés, Maria Colón-Romero, Anixa Hernández-López, Adariana Feliciano-Quiñones, Lizmarie Tirado-Castro, James Porte. Infusion of C20 ceramide induces depressive-like behavior, increases microglia but not astrocyte expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555658. |
because of this, we hypothesize that the infusion of long-chain ceramides (c20) in the ventral hippocampus will increase the development of depressive-like behavior, will cause an increase in the level of microglia expression but not astrocyte expression. |
2022-05-13 |
2023-08-13 |
rat |
| Jessica Zilli, Anne Schänzer, Kathrin Büttner, Monika Kressin, Martin J Schmid. Quantitative and qualitative evaluation of the hippocampal cytoarchitecture in adult cats with regard to the pathological diagnosis of hippocampal sclerosis. PloS one. vol 17. issue 5. 2022-05-13. PMID:35560321. |
significant differences in neuronal density (in ca2-ca4 and the granule cell layer) and layer thickness (in ca1-ca3 and the granule cell layer) were evidenced throughout the longitudinal hippocampal axis (p<0.05); on the other hand, the astrocyte density did not differ. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kazuki Hatayama, Sydney Riddick, Fares Awa, Xiaodi Chen, Daniela Virgintino, Barbara S Stonestree. Time Course of Changes in the Neurovascular Unit after Hypoxic-Ischemic Injury in Neonatal Rats. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35456999. |
the right hi and left hypoxic alone sides of the brains were examined by quantitative immunohistochemistry for vascular density (laminin), pericyte vascular coverage (pdgfrβ), astrocyte vascular coverage (gfap), and claudin-5 expression in the microvasculature of the cerebral cortex, white matter, and hippocampus. |
2022-04-23 |
2023-08-13 |
rat |
| Julia Schneider, Johannes Weigel, Marie-Theres Wittmann, Pavel Svehla, Sebastian Ehrt, Fang Zheng, Tarek Elmzzahi, Julian Karpf, Lucía Paniagua-Herranz, Onur Basak, Arif Ekici, Andre Reis, Christian Alzheimer, Felipe Ortega de la O, Sabine Liebscher, Ruth Beckervordersandfort. Astrogenesis in the murine dentate gyrus is a life-long and dynamic process. The EMBO journal. 2022-04-22. PMID:35451150. |
our study establishes astrocytes as enduring plastic elements in dg circuits, implicating a vital contribution of astrocyte dynamics to hippocampal plasticity. |
2022-04-22 |
2023-08-13 |
mouse |
| Saki Watanabe, Alzahra Al Omran, Amy S Shao, Chen Xue, Zeyu Zhang, Jifeng Zhang, Daryl L Davies, Xuesi M Shao, Junji Watanabe, Jing Lian. Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice. Scientific reports. vol 12. issue 1. 2022-04-08. PMID:35393483. |
social isolation also increased astrocyte density, reduced astrocyte size with shorter branches, and reduced morphological complexity in the hippocampus. |
2022-04-08 |
2023-08-13 |
mouse |