| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin E Johansson, Ivan Toni, Roy P C Kessels, Bastiaan R Bloem, Rick C Helmic. Clinical severity in Parkinson's disease is determined by decline in cortical compensation. Brain : a journal of neurology. 2023-09-27. PMID:37757883. |
dopaminergic dysfunction in the basal ganglia, particularly in the posterior putamen, is often viewed as the primary pathological mechanism behind motor slowing (i.e., bradykinesia) in parkinson's disease. |
2023-09-27 |
2023-10-07 |
Not clear |
| Victor Pando-Naude, Tomas Edward Matthews, Andreas Højlund, Sebastian Jakobsen, Karen Østergaard, Erik Johnsen, Eduardo A Garza-Villarreal, Maria A G Witek, Virginia Penhune, Peter Vuus. Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms. The European journal of neuroscience. 2023-09-19. PMID:37724707. |
dopamine in motor and limbic networks is implicated in beat-based timing and music-induced pleasure, suggesting a central role of basal ganglia (bg) dopaminergic systems in plumm. |
2023-09-19 |
2023-10-07 |
human |
| Fernando Falkenburger Melleu, Newton Sabino Cantera. Pathways from the Superior Colliculus to the Basal Ganglia. Current neuropharmacology. 2023-09-13. PMID:37702174. |
moreover, we discuss how information from the sc might also be relayed to the basal ganglia through midbrain tectonigral and tectotegmental projections directed at the substantia nigra compacta and ventrotegmental area, respectively, influencing the dopaminergic outflow to the dorsal and ventral striatum. |
2023-09-13 |
2023-10-07 |
Not clear |
| Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
in this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal's repertoire in which the brainstem is strongly involved. |
2023-08-18 |
2023-09-07 |
Not clear |
| Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
we consider what is known about how these structures are related to the basal ganglia, focusing on their projections toward the striatum, dopaminergic neurons and subthalamic nucleus, and explore the functional consequences of those interactions. |
2023-08-18 |
2023-09-07 |
Not clear |
| Chayaporn Reakkamnuan, Ekkasit Kumarnsit, Dania Cheah. Local field potential (LFP) power and phase-amplitude coupling (PAC) changes in the striatum and motor cortex reflect neural mechanisms associated with bradykinesia and rigidity during D2R suppression in an animal model. Progress in neuro-psychopharmacology & biological psychiatry. 2023-08-09. PMID:37557945. |
impairments in motor control are the primary feature of parkinson's disease, which is caused by dopaminergic imbalance in the basal ganglia. |
2023-08-09 |
2023-08-16 |
mouse |
| Emil Wärnberg, Arvind Kuma. Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 32. 2023-08-01. PMID:37527344. |
it is well established that midbrain dopaminergic neurons support reinforcement learning (rl) in the basal ganglia by transmitting a reward prediction error (rpe) to the striatum. |
2023-08-01 |
2023-08-14 |
Not clear |
| Pooja Mittal, Sanchit Dhankhar, Samrat Chauhan, Nitika Garg, Tanima Bhattacharya, Maksood Ali, Anis Ahmad Chaudhary, Hassan Ahmad Rudayni, Mohammed Al-Zharani, Wasim Ahmad, Salah Ud-Din Khan, Thakur Gurjeet Singh, Somdutt Mujwa. A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513820. |
the neurodegenerative condition known as parkinson's disease (pd) is brought on by the depletion of dopaminergic neurons in the basal ganglia, which is the brain region that controls body movement. |
2023-07-29 |
2023-08-14 |
Not clear |
| Alejandro G Rey Hipolito, Meike E van der Heijden, Roy V Sillito. Physiology of Dystonia: Animal Studies. International review of neurobiology. vol 169. 2023-07-23. PMID:37482392. |
in the basal ganglia, changes in dopaminergic, serotonergic, noradrenergic, and cholinergic signaling are found across different animal models. |
2023-07-23 |
2023-08-14 |
Not clear |
| Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiell. Perturbation of serine enantiomers homeostasis in the striatum of MPTP-lesioned monkeys and mice reflects the extent of dopaminergic midbrain degeneration. Neurobiology of disease. 2023-07-14. PMID:37451474. |
here, through high-performance liquid chromatography (hplc), we measured the levels of these amino acids in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated monkeys and mptp-plus-probenecid (mptpp)-treated mice to determine whether and how dopaminergic midbrain degeneration affects the levels of serine enantiomers in various basal ganglia subregions. |
2023-07-14 |
2023-08-14 |
mouse |
| Erin M Radcliffe, Alexander J Baumgartner, Drew S Kern, Mazen Al Borno, Steven Ojemann, Daniel R Kramer, John A Thompso. Oscillatory beta dynamics inform biomarker-driven treatment optimization for Parkinson's disease. Journal of neurophysiology. 2023-05-17. PMID:37198135. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons and dysregulation of the basal ganglia. |
2023-05-17 |
2023-08-14 |
Not clear |
| Alireza Rouzitalab, Chadwick B Boulay, Adam J Sach. Volitional Control of Beta Activities in Parkinson's Disease Patients. Brain research. 2023-05-08. PMID:37156320. |
patients diagnosed with parkinson's disease (pd) have difficulty initiating and executing movements due to an acquired imbalance of the basal ganglia thalamocortical circuit secondary to loss of dopaminergic input into the striatum. |
2023-05-08 |
2023-08-14 |
Not clear |
| Emily C Mahoney-Rafferty, Heidi R Tucker, Kainat Akhtar, Rachael Herlihy, Aliyah Audil, Dia Shah, Megan Gupta, Eliyahu M Kochman, Paul J Feustel, Eric S Molho, Julie G Pilitsis, Damian S Shi. Assessing the Location, Relative Expression and Subclass of Dopamine Receptors in the Cerebellum of Hemi-Parkinsonian Rats. Neuroscience. 2023-04-28. PMID:37116741. |
parkinson's disease (pd) is a neurodegenerative disease with loss of dopaminergic neurons in the nigrostriatal pathway resulting in basal ganglia (bg) dysfunction. |
2023-04-28 |
2023-08-14 |
rat |
| Elijah A Petter, Isabella P Fallon, Ryan N Hughes, Glenn D R Watson, Warren H Meck, Francesco Paolo Ulloa Severino, Henry H Yi. Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement. eLife. vol 12. 2023-04-21. PMID:37083584. |
while previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, little is known about the role of the hippocampus. |
2023-04-21 |
2023-08-14 |
mouse |
| Jeong Pyo Seo, Dong Kyun Ko. Degeneration of nigrostriatal pathway in patients with middle cerebral infarct: A diffusion tensor imaging study. Medicine. vol 102. issue 14. 2023-04-07. PMID:37026940. |
the nigrostriatal tract (nst) is a dopaminergic pathway that runs from the substantia nigra pars compacta in the midbrain to the dorsal striatum (caudate nucleus and putamen) and regulates voluntary movement via the basal ganglia motor loops. |
2023-04-07 |
2023-08-14 |
human |
| Hyeon-Man Bae. Diffusion Measures of Subcortical Structures Using High-Field MRI. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979201. |
the pathology of parkinson's disease (pd) involves the death of dopaminergic neurons in the substantia nigra (sn), which slowly influences downstream basal ganglia pathways as dopamine transport diminishes. |
2023-03-29 |
2023-08-14 |
human |
| Karam Chamoun, Lucie Chevillard, Aline Hajj, Jacques Callebert, Bruno Mégarban. Mechanisms of Neurorespiratory Toxicity Induced by Fentanyl Analogs-Lessons from Animal Studies. Pharmaceuticals (Basel, Switzerland). vol 16. issue 3. 2023-03-29. PMID:36986482. |
various mechanisms have been proposed to explain this particularity associated with fentanyl analogs, including the activation of noradrenergic and glutamatergic coerulospinal neurons and dopaminergic basal ganglia neurons. |
2023-03-29 |
2023-08-14 |
human |
| Jeyaram Bharathi J, Nagarjuna Palathoti, Muralikrishnan Dhanasekaran, R Sivasamy, Sivasankaran Ponnusankar, S P Dhanabal, V Sankar, Antony Justi. Neurotrophin mimetics and tropomyosin kinase receptors: a futuristic pharmacological tool for Parkinson's. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2023-03-04. PMID:36870001. |
while the motor symptoms and its clinical manifestations are attributed to the nigral dopaminergic neuronal death and basal ganglia dysfunction, studies have subsequently proven that the non-dopaminergic neurons in various brain regions are also additionally involved with the disease progression. |
2023-03-04 |
2023-08-14 |
Not clear |
| Sanghoon Kim, Edward Pajarillo, Ivan Nyarko-Danquah, Michael Aschner, Eunsook Le. Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants. Cells. vol 12. issue 4. 2023-02-25. PMID:36831289. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the aggregation of lewy bodies in the basal ganglia, resulting in movement impairment referred to as parkinsonism. |
2023-02-25 |
2023-08-14 |
Not clear |
| Sanghoon Kim, Edward Pajarillo, Ivan Nyarko-Danquah, Michael Aschner, Eunsook Le. Role of Astrocytes in Parkinson's Disease Associated with Genetic Mutations and Neurotoxicants. Cells. vol 12. issue 4. 2023-02-25. PMID:36831289. |
in the pd brain, dopaminergic neurons degenerate mainly in the basal ganglia, but recently emerging evidence has shown that astrocytes also significantly contribute to dopaminergic neuronal death. |
2023-02-25 |
2023-08-14 |
Not clear |