| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Merve Kasap, Donard S Dwye. Na Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 6. 2021-10-15. PMID:33961117. |
na parkinson's disease (pd) is a debilitating movement disorder often accompanied by neuropsychiatric symptoms that stem from the loss of dopaminergic function in the basal ganglia and altered neurotransmission more generally. |
2021-10-15 |
2023-08-13 |
Not clear |
| Alexander N Rodichkin, Melissa K Edler, Jennifer L McGlothan, Tomás R Guilart. Behavioral and neurochemical studies of inherited manganese-induced dystonia-parkinsonism in Slc39a14-knockout mice. Neurobiology of disease. vol 158. 2021-10-14. PMID:34358615. |
the pathophysiology of this disease is unknown, but the nigrostriatal dopaminergic system of the basal ganglia has been implicated. |
2021-10-14 |
2023-08-13 |
mouse |
| Shivam Kumar, Lav Goyal, Shamsher Sing. Tremor and Rigidity in Patients with Parkinson's Disease: Emphasis on Epidemiology, Pathophysiology and Contributing Factors. CNS & neurological disorders drug targets. 2021-10-08. PMID:34620070. |
this is mainly triggered by the depletion of dopaminergic neurons located in substantia nigra pars compacta (snpc) in the region of basal ganglia. |
2021-10-08 |
2023-08-13 |
Not clear |
| Robert A McCutcheon, Kate Merritt, Oliver D Howe. Dopamine and glutamate in individuals at high risk for psychosis: a meta-analysis of in vivo imaging findings and their variability compared to controls. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 20. issue 3. 2021-09-23. PMID:34505389. |
there were no significant differences between high-risk individuals and controls in striatal presynaptic dopaminergic function, striatal d2/d3 receptor availability, prefrontal cortex glutamate or glx, hippocampal glutamate or glx, or basal ganglia glx. |
2021-09-23 |
2023-08-13 |
Not clear |
| Peter A Kempster, Laura Perju-Dumbrav. The Thermodynamic Consequences of Parkinson's Disease. Frontiers in neurology. vol 12. 2021-09-14. PMID:34512508. |
that the dopaminergic deficit of pd creates a problem with energy efficiency highlights the role played by the basal ganglia, and by dopamine, in thermodynamic governance. |
2021-09-14 |
2023-08-13 |
Not clear |
| Owen M Peters, Alexandra Weiss, Jake Metterville, Lina Song, Robert Logan, Gaynor A Smith, Michael A Schwarzschild, Christian Mueller, Robert H Brown, Marc Freema. Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease. Neurobiology of disease. vol 155. 2021-09-03. PMID:33892050. |
parkinson's disease (pd) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. |
2021-09-03 |
2023-08-13 |
mouse |
| Jie Zhao, Manish Kumar, Jeevan Sharma, Zhihai Yua. Arbutin effectively ameliorates the symptoms of Parkinson's disease: the role of adenosine receptors and cyclic adenosine monophosphate. Neural regeneration research. vol 16. issue 10. 2021-08-21. PMID:33642391. |
an antagonistic communication exists between adenosinergic and dopaminergic signaling in the basal ganglia, which suggests that the suppression of adenosine a |
2021-08-21 |
2023-08-13 |
Not clear |
| Florence Véronneau-Veilleux, Mauro Ursino, Philippe Robaey, Daniel Lévesque, Fahima Nekk. Nonlinear pharmacodynamics of levodopa through Parkinson's disease progression. Chaos (Woodbury, N.Y.). vol 30. issue 9. 2021-08-18. PMID:33003902. |
this can be attributed to different compensation mechanisms taking place in the basal ganglia where the dopaminergic neurons are progressively lost. |
2021-08-18 |
2023-08-13 |
Not clear |
| Huma Ikram, Shoaib Ahmed, Darakhshan Jabeen Halee. Restraint-induced behavioral deficits are attenuated or impaired by pre- or post-injection of apomorphine: A context-based study. Pakistan journal of pharmaceutical sciences. vol 33. issue 3. 2021-08-03. PMID:33191219. |
this dopaminergic dysfunction is more pre-dominant in basal ganglia and prefrontal cortex. |
2021-08-03 |
2023-08-13 |
rat |
| Anna Maria Szota, Jørgen Scheel-Krüge. The role of glutamate receptors and their interactions with dopamine and other neurotransmitters in the development of tardive dyskinesia: preclinical and clinical results. Behavioural pharmacology. vol 31. issue 6. 2021-08-02. PMID:32459694. |
the leading preclinical hypothesis of tardive dyskinesia development includes dopaminergic imbalance in the direct and indirect pathways of the basal ganglia, cholinergic deficiency, serotonin receptor disturbances, neurotoxicity, oxidative stress, and changes in synaptic plasticity. |
2021-08-02 |
2023-08-13 |
Not clear |
| Yadan Zhao, Zichen Zhang, Siru Qin, Wen Fan, Wei Li, Jingyi Liu, Songtao Wang, Zhifang Xu, Meidan Zha. Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit. Neural plasticity. vol 2021. 2021-07-29. PMID:34221005. |
it has also been found that acupuncture can protect dopaminergic neurons from degeneration via antioxidative stress, anti-inflammatory, and antiapoptotic pathways as well as modulating the neurotransmitter balance in the basal ganglia circuit. |
2021-07-29 |
2023-08-13 |
Not clear |
| Talita Glaser, Roberta Andrejew, Ágatha Oliveira-Giacomelli, Deidiane Elisa Ribeiro, Lucas Bonfim Marques, Qing Ye, Wen-Jing Ren, Alexey Semyanov, Peter Illes, Yong Tang, Henning Ulric. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington's and Parkinson's Disease. Neuroscience bulletin. vol 36. issue 11. 2021-07-28. PMID:33026587. |
huntington's (hd) and parkinson's diseases (pd) are neurodegenerative disorders caused by the death of gabaergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms, respectively. |
2021-07-28 |
2023-08-13 |
Not clear |
| Yiqiu Liu, Junyu Deng, Ye Liu, Wei Li, Xuqiang Ni. FGF, Mechanism of Action, Role in Parkinson's Disease, and Therapeutics. Frontiers in pharmacology. vol 12. 2021-07-09. PMID:34234672. |
the death or dysfunction of dopaminergic neurons in the dense part of the substantia nigra leads to dopamine deficiency in the basal ganglia and motor dysfunction. |
2021-07-09 |
2023-08-13 |
Not clear |
| Simon Moskowitz, David W Russ, Leatha A Clark, Nathan P Wages, Dustin R Grooms, Adam J Woods, Julie Suhr, Janet E Simon, Andrew O'Shea, Cody R Criss, Paolo Fadda, Brian C Clar. Is impaired dopaminergic function associated with mobility capacity in older adults? GeroScience. vol 43. issue 3. 2021-07-01. PMID:33236263. |
in this article, we report four pieces of complementary evidence from behavioral, genetic, and neuroimaging experiments that, we believe, provide theoretical support for the assertion that the basal ganglia and its dopaminergic function are responsible, in part, for age-related reductions in mobility. |
2021-07-01 |
2023-08-13 |
Not clear |
| Simon Moskowitz, David W Russ, Leatha A Clark, Nathan P Wages, Dustin R Grooms, Adam J Woods, Julie Suhr, Janet E Simon, Andrew O'Shea, Cody R Criss, Paolo Fadda, Brian C Clar. Is impaired dopaminergic function associated with mobility capacity in older adults? GeroScience. vol 43. issue 3. 2021-07-01. PMID:33236263. |
these findings align with recent basic and clinical science work suggesting that the basal ganglia and its dopaminergic function are mechanistically linked to age-related reductions in mobility capacity. |
2021-07-01 |
2023-08-13 |
Not clear |
| Christopher R Kelley, Jeffrey L Kauffma. Optimal Control Perspective on Parkinson's Disease: Increased Delay Between State Estimator and Controller Produces Tremor. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. vol 28. issue 10. 2021-06-24. PMID:32822299. |
contextualization of the optimal control model with physiological models and clinical observations provides insight into the potential role of the basal ganglia and cerebello-thalamo-cortical circuit and how treatments like dopaminergic medications and deep brain stimulation reduce tremor. |
2021-06-24 |
2023-08-13 |
human |
| Beatrice Orso, Dario Arnaldi, Francesco Famà, Nicola Girtler, Andrea Brugnolo, Elisa Doglione, Laura Filippi, Federico Massa, Enrico Peira, Matteo Bauckneht, Silvia Morbelli, Flavio Nobili, Matteo Pardin. Anatomical and neurochemical bases of theory of mind in de novo Parkinson's Disease. Cortex; a journal devoted to the study of the nervous system and behavior. vol 130. 2021-06-21. PMID:32755727. |
we acquired fdg-pet images (as a marker of regional neurodegeneration), i-123 ioflupane single photon emission computed tomography (123 i-fp-cit-spect, as a marker of dopaminergic impairment in the basal ganglia and in the cortex and as a proxy marker of serotoninergic deafferentation in the thalamus), and qeeg recordings (using the theta/alpha power ratio as marker of cholinergic deafferentation). |
2021-06-21 |
2023-08-13 |
human |
| E Hill, R Gowers, M J E Richardson, M J Wal. α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide. eNeuro. vol 8. issue 1. 2021-06-18. PMID:33229413. |
dopaminergic neurons (dns) in the substantia nigra pars compacta (snpc) form an important part of the basal ganglia circuitry, playing key roles in movement initiation and coordination. |
2021-06-18 |
2023-08-13 |
Not clear |
| Kristen N Hirter, Elaine N Miller, Cheryl D Stimpson, Kimberley A Phillips, William D Hopkins, Patrick R Hof, Chet C Sherwood, C Owen Lovejoy, Mary Ann Raghant. The nucleus accumbens and ventral pallidum exhibit greater dopaminergic innervation in humans compared to other primates. Brain structure & function. vol 226. issue 6. 2021-06-15. PMID:34032910. |
our data show that humans have a significantly greater dopaminergic innervation in both structures, supporting the hypothesis that selection for a prosocial neurochemistry in the human basal ganglia may have contributed to the evolution of our uniquely social behavior profile. |
2021-06-15 |
2023-08-13 |
human |
| Roberto Limongi, Michael Mackinley, Kara Dempster, Ali R Khan, Joseph S Gati, Lena Palaniyappa. Frontal-striatal connectivity and positive symptoms of schizophrenia: implications for the mechanistic basis of prefrontal rTMS. European archives of psychiatry and clinical neuroscience. vol 271. issue 1. 2021-06-06. PMID:32683527. |
it has been hypothesized that high-frequency rtms of the ldlpfc might increase the dopaminergic neurotransmission by driving the activity of the left striatum in the basal ganglia (lstr)-increasing striatal dopaminergic activity. |
2021-06-06 |
2023-08-13 |
human |