| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Santosh Pothula, Taro Kato, Rong-Jian Liu, Min Wu, Danielle Gerhard, Ryota Shinohara, Alexa-Nicole Sliby, Golam M I Chowdhury, Kevin L Behar, Gerard Sanacora, Pradeep Banerjee, Ronald S Duma. Cell-type specific modulation of NMDA receptors triggers antidepressant actions. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32488125. |
we demonstrate that rapastinel directly enhances nmdar activity on principal glutamatergic neurons in medial prefrontal cortex (mpfc) without any effect on glutamate efflux, while ketamine blocks nmdar on gaba interneurons to cause glutamate efflux and indirect activation of excitatory synapses. |
2021-11-15 |
2023-08-13 |
human |
| Alessandro Piva, Lucia Caffino, Francesca Mottarlini, Nicholas Pintori, Fernando Castillo Díaz, Fabio Fumagalli, Cristiano Chiamuler. Metaplastic Effects of Ketamine and MK-801 on Glutamate Receptors Expression in Rat Medial Prefrontal Cortex and Hippocampus. Molecular neurobiology. vol 58. issue 7. 2021-11-03. PMID:33723767. |
the aim of the present study was to investigate the molecular changes occurring at glutamatergic synapses 24 h after ketamine or mk-801 treatment in the rat medial prefrontal cortex (mpfc) and hippocampus (hipp). |
2021-11-03 |
2023-08-13 |
rat |
| Barbara Ziółkowsk. The Role of Mesostriatal Dopamine System and Corticostriatal Glutamatergic Transmission in Chronic Pain. Brain sciences. vol 11. issue 10. 2021-10-26. PMID:34679376. |
the second part of this article focuses on the glutamatergic inputs from the medial prefrontal cortex to the nac, their activity changes in chronic pain, and their role in pain modulation. |
2021-10-26 |
2023-08-13 |
Not clear |
| Zixiu Xiang, Xiaohui Lv, Xin Lin, Daniel E O'Brien, Molly K Altman, Craig W Lindsley, Jonathan A Javitch, Colleen M Niswender, P Jeffrey Con. Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu Science signaling. vol 14. issue 677. 2021-10-08. PMID:33824180. |
input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mglu metabotropic glutamate receptors (mglurs) are g protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. |
2021-10-08 |
2023-08-13 |
Not clear |
| Leonardo A Guercio, Mathieu E Wimmer, Heath D Schmidt, Sarah E Swinford-Jackson, R Christopher Pierce, Fair M Vassole. Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking. Brain research. vol 1746. 2021-10-01. PMID:32652146. |
the present study investigated the effects of dbs in brain regions that send major glutamatergic projections to the nucleus accumbens including the basolateral amygdala (bla) and ventral hippocampus (vhipp) as well as subregions of the medial prefrontal cortex (mpfc) including the anterior cingulate, infralimbic and prelimbic cortices. |
2021-10-01 |
2023-08-13 |
rat |
| Jae Soon Kang, Ji Hyeong Baek, Soonwoong Jung, Hye Jin Chung, Dong Kun Lee, Hyun Joon Ki. Ingestion of Bis(2-ethylhexyl) phthalate (DEHP) during adolescence causes depressive-like behaviors through hypoactive glutamatergic signaling in the medial prefrontal cortex. Environmental pollution (Barking, Essex : 1987). vol 289. 2021-09-29. PMID:34426190. |
ingestion of bis(2-ethylhexyl) phthalate (dehp) during adolescence causes depressive-like behaviors through hypoactive glutamatergic signaling in the medial prefrontal cortex. |
2021-09-29 |
2023-08-13 |
mouse |
| Jae Soon Kang, Ji Hyeong Baek, Soonwoong Jung, Hye Jin Chung, Dong Kun Lee, Hyun Joon Ki. Ingestion of Bis(2-ethylhexyl) phthalate (DEHP) during adolescence causes depressive-like behaviors through hypoactive glutamatergic signaling in the medial prefrontal cortex. Environmental pollution (Barking, Essex : 1987). vol 289. 2021-09-29. PMID:34426190. |
in the medial prefrontal cortex (mpfc), glutamate and glutamine were decreased, and glutamine synthetase showed lower activity compared to the control group, suggesting imbalanced glutamatergic signaling. |
2021-09-29 |
2023-08-13 |
mouse |
| Dong-Dong Shi, Ying-Dan Zhang, Yan-Yan Ren, Shi-Yu Peng, Ti-Fei Yuan, Zhen Wan. Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats. Molecular psychiatry. 2021-09-25. PMID:34561611. |
we demonstrate that structural and functional impairments occur in glutamatergic synapses in pyramidal neurons of the medial prefrontal cortex (mpfc) in rats with unpredictable ms but not in rats with predictable ms. then, we used differentially expressed gene (deg) analysis of rna sequencing data from the adult male pfc to identify a hub gene that is responsible for stress resilience. |
2021-09-25 |
2023-08-13 |
rat |
| Claudia Rangel-Barajas, Israel Coronel, Yanping Zhang, Maribel Hernández, Stephen L Boehm I. Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression. Neuropharmacology. vol 181. 2021-09-23. PMID:33010299. |
because pb exposure is associated with increased glutamatergic tone, we also studied the effects on the expression of synaptic and non-synaptic glutamate transporters in brain regions associated with drug addiction such as the nucleus accumbens (nac), dorsomedial striatum (dms), dorsolateral striatum (dls), and medial prefrontal cortex (mpfc). |
2021-09-23 |
2023-08-13 |
mouse |
| Gela V Beselia, Nino C Chkhikvishvili, Maia A Burjanadze, Revaz O Solomonia, Maia Meparishvili, Barbare Nozadze, Sulkhan Asanidze, Aleksandre Nemsitsveridze, Manana G Dashnian. Modulation of prefrontal cortex function by basal forebrain cholinergic and GABAergic neurons at the behavioral and molecular level. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029291. |
the present research aimed to study the effects of selective immunolesions of cholinergic or gamma-aminobutyric acid (gaba)ergic neurons in the nucleus basalis magnocellularis (nbm) on memory function as well as cholinergic activity and the level of expression of glutamatergic [nr2b subunit of n-methyl-d-aspartate(nmda)] receptors in the medial prefrontal cortex (mpfc) and hippocampus of behaviorally characterized rats. |
2021-09-20 |
2023-08-13 |
rat |
| Daisuke Yamada, Junpei Takahashi, Keita Iio, Hiroshi Nagase, Akiyoshi Saito. Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice. Biochemical and biophysical research communications. vol 560. 2021-08-26. PMID:34000468. |
modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice. |
2021-08-26 |
2023-08-13 |
mouse |
| Li Yang, Ming Chen, Qianqian Ma, Huan Sheng, Dongyang Cui, Da Shao, Bin Lai, Ping Zhen. Morphine selectively disinhibits glutamatergic input from mPFC onto dopamine neurons of VTA, inducing reward. Neuropharmacology. vol 176. 2021-08-13. PMID:32679049. |
using optogenetic strategy combined with whole-cell patch-clamp, qrt-pcr, immunofluorescence and chemical genetic approach combined with behavioral methods, our results show that: 1) morphine promotes glutamate release from glutamatergic terminals of medial prefrontal cortex (mpfc) neurons projecting to vta-da neurons but does not on those from glutamatergic terminals of the lateral hypothalamus (lh) neurons projecting to vta-da neurons; 2) different response of glutamatergic neurons projecting to vta-da neurons from the mpfc or the lh to morphine is related to the expression of gaba |
2021-08-13 |
2023-08-13 |
Not clear |
| João P T Brufatto, Davi C Lagatta, Daniela L Uliana, Egidi M S Firmino, Anna B Borges-Assis, Leonardo B M Resste. Ventromedial prefrontal cortex CRF1 receptors modulate the tachycardic activity of baroreflex. Pflugers Archiv : European journal of physiology. vol 473. issue 4. 2021-08-13. PMID:33839941. |
ventral medial prefrontal cortex (vmpfc) glutamatergic neurotransmission has a facilitatory role on cardiac baroreflex activity which is mediated by nmda receptors activation. |
2021-08-13 |
2023-08-13 |
rat |
| Bing Zhang, Xili Yang, Luyu Ye, Rui Liu, Binglu Ye, Weijia Du, Fuyi Shen, Qian Li, Fan Guo, Jinqi Liu, Fei Guo, Yang Li, Zhendong Xu, Zhiqiang Li. Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex. Neuropharmacology. vol 194. 2021-07-28. PMID:33144117. |
ketamine activated glutamatergic neurotransmission by gabaergic disinhibition in the medial prefrontal cortex. |
2021-07-28 |
2023-08-13 |
Not clear |
| Santosh Pothula, Rong-Jian Liu, Min Wu, Alexa-Nicole Sliby, Marina R Picciotto, Pradeep Banerjee, Ronald S Duma. Positive modulation of NMDA receptors by AGN-241751 exerts rapid antidepressant-like effects via excitatory neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 4. 2021-06-23. PMID:33059355. |
dysregulation of the glutamatergic system and its receptors in medial prefrontal cortex (mpfc) has been implicated in major depressive disorder. |
2021-06-23 |
2023-08-13 |
mouse |
| Yong-Yu Yin, Yun-Hui Wang, Wen-Gang Liu, Jun-Qi Yao, Jin Yuan, Ze-Han Li, Yu-Hua Ran, Li-Ming Zhang, Yun-Feng L. The role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants. Neuropharmacology. vol 191. 2021-06-23. PMID:33945826. |
the balance between excitatory glutamatergic pyramidal neurons and inhibitory γ-aminobutyric acid (gaba) interneurons, i.e., the excitation:inhibition functional (e:i) balance, in the medial prefrontal cortex (mpfc) is critical in regulating several behaviors and might play an important mediating role in the mechanism of rapid antidepressant-like action reported by several studies. |
2021-06-23 |
2023-08-13 |
rat |
| Danilo De Gregorio, Jelena Popic, Justine P Enns, Antonio Inserra, Agnieszka Skalecka, Athanasios Markopoulos, Luca Posa, Martha Lopez-Canul, He Qianzi, Christopher K Lafferty, Jonathan P Britt, Stefano Comai, Argel Aguilar-Valles, Nahum Sonenberg, Gabriella Gobb. Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 5. 2021-06-15. PMID:33495318. |
using a multidisciplinary approach including in vivo electrophysiology, optogenetics, behavioral paradigms, and molecular biology, the effects of lsd on sb and glutamatergic neurotransmission in the medial prefrontal cortex (mpfc) were studied in male mice. |
2021-06-15 |
2023-08-13 |
mouse |
| Jessica A Cooper, Makiah R Nuutinen, Victoria M Lawlor, Brittany A M DeVries, Elyssa M Barrick, Shabnam Hossein, Daniel J Cole, Chelsea V Leonard, Emma C Hahn, Andrew P Teer, Grant S Shields, George M Slavich, Dost Ongur, J Eric Jensen, Fei Du, Diego A Pizzagalli, Michael T Treadwa. Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression. Nature communications. vol 12. issue 1. 2021-06-09. PMID:34039978. |
preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mpfc). |
2021-06-09 |
2023-08-13 |
human |
| Rebecca S Hofford, Tanner J Euston, Rashaun S Wilson, Katherine R Meckel, Emily G Peck, Arthur Godino, Joseph A Landry, Erin S Calipari, TuKiet T Lam, Drew D Kiral. Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 7. 2021-04-29. PMID:33361463. |
granulocyte-colony stimulating factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex. |
2021-04-29 |
2023-08-13 |
rat |
| Simeon O A Helgers, Svilen Angelov, Marc A N Muschler, Alexander Glahn, Shadi Al-Afif, Yazeed Al Krinawe, Elvis J Hermann, Joachim K Krauss, Helge Frieling, Kerstin Schwabe, Mathias Rhei. Epigenetic Regulation of Neural Transmission after Cerebellar Fastigial Nucleus Lesions in Juvenile Rats. Cerebellum (London, England). 2021-04-09. PMID:33834423. |
dna methylation was investigated for target genes of the gabaergic, dopaminergic, glutamatergic and oxytocinergic systems in brain regions with anatomic connections to the fastigial nucleus, i.e., medial prefrontal cortex, nucleus accumbens, striatum, thalamus, and sensorimotor cortex. |
2021-04-09 |
2023-08-13 |
rat |