| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tong Zhang, Junko Yanagida, Hironori Kamii, Shintaro Wada, Masaki Domoto, Hitoki Sasase, Satoshi Deyama, Takeshi Takarada, Eiichi Hinoi, Kenji Sakimura, Akihiro Yamanaka, Takashi Maejima, Michihiro Mieda, Takeshi Sakurai, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Masabumi Minami, Katsuyuki Kaned. Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. Addiction biology. vol 25. issue 1. 2021-02-10. PMID:30734456. |
glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. |
2021-02-10 |
2023-08-13 |
mouse |
| Samuel Rupprechter, Liana Romaniuk, Peggy Series, Yoriko Hirose, Emma Hawkins, Anca-Larisa Sandu, Gordon D Waiter, Christopher J McNeil, Xueyi Shen, Mathew A Harris, Archie Campbell, David Porteous, Jennifer A Macfarlane, Stephen M Lawrie, Alison D Murray, Mauricio R Delgado, Andrew M McIntosh, Heather C Whalley, J Douglas Steel. Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32385498. |
the functional anatomy of the medial prefrontal cortex and basal ganglia has been extensively studied and the former has excitatory glutamatergic projections to the latter. |
2021-01-19 |
2023-08-13 |
human |
| Sheng-Tzung Tsai, Shin-Yuan Chen, Shinn-Zong Lin, Guo-Fang Tsen. Rostral intralaminar thalamic deep brain stimulation ameliorates memory deficits and dendritic regression in β-amyloid-infused rats. Brain structure & function. vol 225. issue 2. 2020-11-20. PMID:32036422. |
spatial memory was tested in the morris water maze (mwm), while structural synaptic plasticity and glutamatergic transmission strength were estimated by measuring dendritic spine densities in dye-injected neurons and tissue expression levels of postsynaptic density protein 95 (psd-95) in medial prefrontal cortex (mpfc) and hippocampus. |
2020-11-20 |
2023-08-13 |
rat |
| Patricia Oliveros-Matus, Nelson Perez-Urrutia, Nathalie Alvarez-Ricartes, Florencia Echeverria, George E Barreto, James Elliott, Alexandre Iarkov, Valentina Echeverri. Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32300297. |
cotinine facilitates fe in rodents, in part due to its inhibitory effect on the amygdala by the glutamatergic projections from the medial prefrontal cortex (mpfc). |
2020-09-28 |
2023-08-13 |
mouse |
| Peter Koppensteiner, Richard Von Itter, Riccardo Melani, Christopher Galvin, Francis S Lee, Ipe Nina. Diminished Fear Extinction in Adolescents Is Associated With an Altered Somatostatin Interneuron-Mediated Inhibition in the Infralimbic Cortex. Biological psychiatry. vol 86. issue 9. 2020-09-24. PMID:31235076. |
although the ethological relevance and the underlying mechanism are largely unknown, the suppression of fear extinction during adolescence is associated with a diminished plasticity in the glutamatergic neurons of the infralimbic medial prefrontal cortex, a brain region critical for fear extinction. |
2020-09-24 |
2023-08-13 |
Not clear |
| Laura Domingo-Rodriguez, Inigo Ruiz de Azua, Eduardo Dominguez, Eric Senabre, Irene Serra, Sami Kummer, Mohit Navandar, Sarah Baddenhausen, Clementine Hofmann, Raul Andero, Susanne Gerber, Marta Navarrete, Mara Dierssen, Beat Lutz, Elena Martín-García, Rafael Maldonad. A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nature communications. vol 11. issue 1. 2020-05-18. PMID:32034128. |
here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mpfc) and in the nucleus accumbens (nac). |
2020-05-18 |
2023-08-13 |
mouse |
| Priscila Medeiros, Sylmara Esther Negrini-Ferrari, Enza Palazzo, Sabatino Maione, Sérgio Henrique Ferreira, Renato Leonardo de Freitas, Norberto Cysne Coimbr. N-methyl-D-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain. Neurochemical research. vol 44. issue 9. 2020-01-20. PMID:31317507. |
the medial prefrontal cortex (mpfc) seems to participate in pain chronification, and glutamatergic neurotransmission may be involved in this process. |
2020-01-20 |
2023-08-13 |
rat |
| Luis A Natividad, Michael Q Steinman, Sarah A Laredo, Cristina Irimia, Ilham Y Polis, Robert Lintz, Matthew W Buczynski, Rémi Martin-Fardon, Marisa Roberto, Loren H Parson. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility. Addiction biology. vol 23. issue 5. 2019-10-22. PMID:28940879. |
repeated cycles of alcohol [ethanol (etoh)] intoxication and withdrawal dysregulate excitatory glutamatergic systems in the brain and induce neuroadaptations in the medial prefrontal cortex (mpfc) that contribute to cognitive dysfunction. |
2019-10-22 |
2023-08-13 |
rat |
| Yoshikage Muroi, Toshiaki Ishi. Glutamatergic Signals in the Dorsal Raphe Nucleus Regulate Maternal Aggression and Care in an Opposing Manner in Mice. Neuroscience. vol 400. 2019-06-21. PMID:30605702. |
we first examined neuronal activity in the medial prefrontal cortex (mpfc) and lateral habenula (lhb), which send glutamatergic input to the drn, in dams by injecting fluorogold, a retrograde tracer, into the drn. |
2019-06-21 |
2023-08-13 |
mouse |
| Hyeonwi Son, Ji Hyeong Baek, Bok Soon Go, Doo-Hyuk Jung, Sneha B Sontakke, Hye Jin Chung, Dong Hoon Lee, Gu Seob Roh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Dong Kun Lee, Hyun Joon Ki. Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. Neuropharmacology. vol 143. 2019-02-25. PMID:30266598. |
glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. |
2019-02-25 |
2023-08-13 |
mouse |
| Hyeonwi Son, Ji Hyeong Baek, Bok Soon Go, Doo-Hyuk Jung, Sneha B Sontakke, Hye Jin Chung, Dong Hoon Lee, Gu Seob Roh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Dong Kun Lee, Hyun Joon Ki. Glutamine has antidepressive effects through increments of glutamate and glutamine levels and glutamatergic activity in the medial prefrontal cortex. Neuropharmacology. vol 143. 2019-02-25. PMID:30266598. |
here, we found low glu and gln levels and low frequency of spontaneous excitatory postsynaptic current (sepsc) of glutamatergic neurons in the medial prefrontal cortex (mpfc) of chronic immobilization stress (cis)-induced depressed mice. |
2019-02-25 |
2023-08-13 |
mouse |
| b' J\\xc3\\xbalia Gasull-Cam\\xc3\\xb3s, Sara Mart\\xc3\\xadnez-Torres, Mireia Tarr\\xc3\\xa9s-Gatius, Andr\\xc3\\xa9s Ozaita, Francesc Artigas, Anna Casta\\xc3\\xb1\\xc3\\xa. Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex. Neuropharmacology. vol 139. 2019-02-20. PMID:29940206.' |
novel fast-acting antidepressant strategies, such as ketamine and deep brain stimulation, enhance glutamatergic neurotransmission in medial prefrontal cortex (mpfc) regions via ampa receptor (ampa-r) activation. |
2019-02-20 |
2023-08-13 |
rat |
| Betina González, Subramaniam Jayanthi, Natalia Gomez, Oscar V Torres, Máximo H Sosa, Alejandra Bernardi, Francisco J Urbano, Edgar García-Rill, Jean-Lud Cadet, Verónica Bisagn. Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 82. 2019-01-22. PMID:29247759. |
we evaluated total h3ac, h4ac and 5-mc levels in the medial prefrontal cortex (mpfc), h3ac and h4ac promotor enrichment (chip) and mrna expression (rt-pcr) of neurotransmitter systems involved in arousal, wakefulness and cognitive control, like dopaminergic (drd1 and drd2), α-adrenergic (adra1a and adra1b), orexinergic (hcrtr1 and hcrtr2), histaminergic (hrh1 and hrh3) and glutamatergic (ampa gria1 and nmda grin1) receptors. |
2019-01-22 |
2023-08-13 |
mouse |
| José I Pena-Bravo, Carmela M Reichel, Antonieta Lavi. Abstinence from Cocaine-Induced Conditioned Place Preference Produces Discrete Changes in Glutamatergic Synapses onto Deep Layer 5/6 Neurons from Prelimbic and Infralimbic Cortices. eNeuro. vol 4. issue 6. 2018-08-07. PMID:29242822. |
glutamatergic signaling in the medial prefrontal cortex (mpfc) plays a critical role in drug addiction and relapse. |
2018-08-07 |
2023-08-13 |
rat |
| Bing Xue, Li-Min Mao, Dao-Zhong Jin, John Q Wan. Pharmacological modulation of AMPA receptor phosphorylation by dopamine and muscarinic receptor agents in the rat medial prefrontal cortex. European journal of pharmacology. vol 820. 2018-08-06. PMID:29242119. |
two key transmitters in the medial prefrontal cortex (mpfc), dopamine and acetylcholine, are believed to interact with each other to modulate local glutamatergic transmission, although molecular mechanisms underlying their crosstalk are poorly understood. |
2018-08-06 |
2023-08-13 |
rat |
| Tengfei Ma, Britton Barbee, Xuehua Wang, Jun Wan. Alcohol induces input-specific aberrant synaptic plasticity in the rat dorsomedial striatum. Neuropharmacology. vol 123. 2018-05-09. PMID:28526611. |
here, we used optogenetics to selectively activate the rat medial prefrontal cortex (mpfc) and basolateral amygdala (bla) inputs in dms slices, and measured the effects of alcohol consumption on glutamatergic transmission in these corticostriatal and amygdalostriatal circuits. |
2018-05-09 |
2023-08-13 |
rat |
| Haley E Carpenter, Kyle B Kelly, Jennifer L Bizon, Charles J Frazie. Age-related changes in tonic activation of presynaptic versus extrasynaptic γ-amniobutyric acid type B receptors in rat medial prefrontal cortex. Neurobiology of aging. vol 45. 2017-10-17. PMID:27459929. |
the present study examined the effect of age on both glutamatergic and γ-aminobutyric acid mediated (gabaergic) signaling in the rodent medial prefrontal cortex (mpfc), with an emphasis on revealing novel changes contributing to increased inhibition in age. |
2017-10-17 |
2023-08-13 |
rat |
| Luis Prado, Jorge Luis-Islas, Osvaldo I Sandoval, Liliana Puron, Moreno M Gil, Alvaro Luna, Mario A Arias-García, Elvira Galarraga, Sidney A Simon, Ranier Gutierre. Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 50. 2017-07-24. PMID:27974611. |
activation of glutamatergic fibers in the anterior nac shell modulates reward activity in the anacsh, the lateral hypothalamus, and medial prefrontal cortex and transiently stops feeding. |
2017-07-24 |
2023-08-13 |
mouse |
| Luis Prado, Jorge Luis-Islas, Osvaldo I Sandoval, Liliana Puron, Moreno M Gil, Alvaro Luna, Mario A Arias-García, Elvira Galarraga, Sidney A Simon, Ranier Gutierre. Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 50. 2017-07-24. PMID:27974611. |
one important component of this network is the anterior nucleus accumbens shell (anacsh), which sends gabaergic projections into the lateral hypothalamus (lh) and receives extensive glutamatergic inputs from, among others, the medial prefrontal cortex (mpfc). |
2017-07-24 |
2023-08-13 |
mouse |
| Daniela Laricchiuta, Luana Saba, Paola De Bartolo, Silvia Caioli, Cristina Zona, Laura Petrosin. Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit. Scientific reports. vol 6. 2016-12-14. PMID:26875790. |
the two non-extinguishing phenotypes exhibited potentiated glutamatergic neurotransmission (spontaneous excitatory postsynaptic currents/spinogenesis) of pyramidal neurons of medial prefrontal cortex and basolateral amygdala. |
2016-12-14 |
2023-08-13 |
mouse |