| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology vol issue 2023 36870407 |
the triggering receptor expressed on myeloid cells 2 (trem2) is revealed to be implicated in a range of microglia functions. |
2023-03-04 |
2023-03-06 |
rat |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology vol issue 2023 36870407 |
trem2 overexpression partly ameliorated microglia dysfunction and autistic-like behaviors in prenatal vpa-exposed rats. |
2023-03-04 |
2023-03-06 |
rat |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology vol issue 2023 36870407 |
our findings demonstrated that prenatally vpa exposure is likely to cause autistic-like behavior in the rat offspring via trem2 down-regulation to affect the microglial activation, microglial polarization and synaptic pruning of microglia for the first time. |
2023-03-04 |
2023-03-06 |
rat |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine vol 15 issue 1 2023 36805764 |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-03-06 |
mouse |
| Na Zhao, Guojun B. A TREM2 antibody energizes microglia. Nature neuroscience vol issue 2023 36765163 |
a trem2 antibody energizes microglia. |
2023-02-10 |
2023-03-06 |
Not clear |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation vol 20 issue 1 2023 36755323 |
genetic models of cleavage-reduced and soluble trem2 reveal distinct effects on myelination and microglia function in the cuprizone model. |
2023-02-09 |
2023-03-06 |
mouse |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation vol 20 issue 1 2023 36755323 |
triggering receptor expressed on myeloid cells 2 (trem2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. |
2023-02-09 |
2023-03-06 |
mouse |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation vol 20 issue 1 2023 36755323 |
taken together, our data suggest that sustained microglia activation led to increased remyelination, whereas microglia without plasma membrane trem2 and only soluble trem2 had reduced phagocytic activity despite efficient lysosomal function, as observed in bone marrow-derived macrophages, leading to a dysfunctional phenotype with improper myelin debris removal, lack of remyelination and axonal pathology following cuprizone intoxication. |
2023-02-09 |
2023-03-06 |
mouse |
| Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zen. Frontiers in immunology vol 13 issue 2023 36713360 |
single-cell analysis and multiple immunohistochemical staining results showed that microglia and macrophage cells expressed trem2. |
2023-01-30 |
2023-01-31 |
Not clear |
| Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zen. Frontiers in immunology vol 13 issue 2023 36713360 |
in conclusion, our findings revealed that trem2 was significantly expressed in microglia and macrophage cells and was intimately associated with the tumor immune microenvironment. |
2023-01-30 |
2023-01-31 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol issue 2023 36683512 |
untangling the role of trem2 in conjugation with microglia in neuronal dysfunction: a hypothesis on a novel pathway in the pathophysiology of alzheimer's disease. |
2023-01-23 |
2023-01-31 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD vol issue 2023 36683512 |
disease associated microglia (dam), a novel state of microglia with unique transcriptional and functional signatures reported in neurodegenerative conditions, also depend on the trem2 pathway for its differentiation. |
2023-01-23 |
2023-01-31 |
Not clear |
| Zhiyun Qiu, Huilin Wang, Mengdi Qu, Shuainan Zhu, Hao Zhang, Qingwu Liao, Changhong Mia. Consecutive Injection of High-Dose Lipopolysaccharide Modulates Microglia Polarization via TREM2 to Alter Status of Septic Mice. Brain sciences vol 13 issue 1 2023 36672106 |
consecutive injection of high-dose lipopolysaccharide modulates microglia polarization via trem2 to alter status of septic mice. |
2023-01-21 |
2023-01-30 |
mouse |
| Ivonne Jeric\\xc3\\xb3, Janire Vicu\\xc3\\xb1a-Urriza, Idoia Blanco-Luquin, M\\xc3\\xb3nica Macias, Leyre Martinez-Merino, Miren Rold\\xc3\\xa1n, Ricard Rojas-Garcia, Inmaculada Pagola-Lorz, Alvaro Carbayo, Noemi De Luna, Victoria Zelaya, Maite Mendioro. Profiling TREM2 expression in amyotrophic lateral sclerosis. Brain, behavior, and immunity vol issue 2023 36681358 |
trem2 gene plays a crucial role in shaping microglia in neurodegenerative conditions. |
2023-01-21 |
2023-01-30 |
Not clear |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3\\xce\\xb2 Signaling Pathway In vivo and In vitro. Molecular neurobiology vol issue 2023 36662361 |
triggering receptor expressed on myeloid cells-2 (trem2), a cell surface receptor mainly expressed on microglia, has been shown to play a critical role in alzheimer's disease (ad) pathogenesis and progression. |
2023-01-20 |
2023-01-30 |
mouse |
| Yingyue Zhou, Mari Tada, Zhangying Cai, Prabhakar S Andhey, Amanda Swain, Kelly R Miller, Susan Gilfillan, Maxim N Artyomov, Masaki Takao, Akiyoshi Kakita, Marco Colonn. Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. Nature immunology vol issue 2023 36658241 |
heterozygous hypofunctional trem2 variants impair microglia, accelerating late-onset alzheimer's disease. |
2023-01-19 |
2023-01-30 |
mouse |
| Gunel Ayyubov. TREM2-signaling as a multifaceted player in brain homeostasis and a potential target for Alzheimer's Disease treatment. The European journal of neuroscience vol issue 2023 36637116 |
trem2 also ameliorates the pathological effects of activated microglia on neuronal tau pathology, demonstrating its protective anti-inflammatory effects. |
2023-01-13 |
2023-01-30 |
mouse |
| Gunel Ayyubov. TREM2-signaling as a multifaceted player in brain homeostasis and a potential target for Alzheimer's Disease treatment. The European journal of neuroscience vol issue 2023 36637116 |
however, since the excessive activation of trem2 signaling can inhibit pro-inflammatory reactions and suppress the role of microglia in immune surveillance, at the late stages of the disease it might promote immune tolerance, which is detrimental. |
2023-01-13 |
2023-01-30 |
mouse |
| Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gn\\xc3\\xb6rich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea H Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pes\\xc3\\xa4maa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monro. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience vol issue 2023 36635496 |
in human induced pluripotent stem cell (ipsc)-derived microglia, atv:trem2 induced proliferation and improved mitochondrial metabolism. |
2023-01-12 |
2023-01-30 |
mouse |
| Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gn\\xc3\\xb6rich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea H Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pes\\xc3\\xa4maa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monro. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience vol issue 2023 36635496 |
single-cell rna sequencing and morphometry revealed that atv:trem2 shifted microglia to metabolically responsive states, which were distinct from those induced by amyloid pathology. |
2023-01-12 |
2023-01-30 |
mouse |