| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harald Neumann, Kazuya Takahash. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. Journal of neuroimmunology. vol 184. issue 1-2. 2007-06-01. PMID:17239445. |
indeed, trem2 of microglia fulfils important function of tissue debris clearance and resolution of latent inflammatory reactions. |
2007-06-01 |
2023-08-12 |
Not clear |
| Harald Neumann, Kazuya Takahash. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. Journal of neuroimmunology. vol 184. issue 1-2. 2007-06-01. PMID:17239445. |
absence of trem2 expression on microglia impairs their capacity to phagocytose cell membrane debris and increases their gene transcription of pro-inflammatory cytokines. |
2007-06-01 |
2023-08-12 |
Not clear |
| Harald Neumann, Kazuya Takahash. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. Journal of neuroimmunology. vol 184. issue 1-2. 2007-06-01. PMID:17239445. |
the disease plosl and the finding that trem2 of microglia is required for tissue debris clearance provide prototypic molecular evidence that dysfunctional innate immunity can be disease causative leading to a chronic neurodegenerative process. |
2007-06-01 |
2023-08-12 |
Not clear |
| Kazuya Takahashi, Christian D P Rochford, Harald Neuman. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. The Journal of experimental medicine. vol 201. issue 4. 2005-04-11. PMID:15728241. |
here, we show expression of trem2 in microglia. |
2005-04-11 |
2023-08-12 |
Not clear |
| Kazuya Takahashi, Christian D P Rochford, Harald Neuman. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. The Journal of experimental medicine. vol 201. issue 4. 2005-04-11. PMID:15728241. |
knockdown of trem2 in microglia inhibited phagocytosis of apoptotic neurons and increased gene transcription of tumor necrosis factor alpha and nitric oxide synthase-2, whereas overexpression of trem2 increased phagocytosis and decreased microglial proinflammatory responses. |
2005-04-11 |
2023-08-12 |
Not clear |
| Giuseppina Sessa, Paola Podini, Margherita Mariani, Alessandra Meroni, Roberto Spreafico, Francesco Sinigaglia, Marco Colonna, Paola Panina, Jacopo Meldoles. Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. The European journal of neuroscience. vol 20. issue 10. 2005-03-01. PMID:15548205. |
in living human microglia chme-5 and glioblastoma t98g cells, activation of trem2 by its specific antibody induced [ca2+]i responses, documenting its surface expression and functioning. |
2005-03-01 |
2023-08-12 |
mouse |