| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olena Korvatska, James B Leverenz, Suman Jayadev, Pamela McMillan, Irina Kurtz, Xindi Guo, Malia Rumbaugh, Mark Matsushita, Santhosh Girirajan, Michael O Dorschner, Kostantin Kiianitsa, Chang-En Yu, Zoran Brkanac, Gwenn A Garden, Wendy H Raskind, Thomas D Bir. R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study. JAMA neurology. vol 72. issue 8. 2015-11-05. PMID:26076170. |
the r47h variant in the triggering receptor expressed on myeloid cells 2 gene (trem2), a modulator of the immune response of microglia, is a strong genetic risk factor for alzheimer disease (ad) and possibly other neurodegenerative disorders. |
2015-11-05 |
2023-08-13 |
Not clear |
| Li Zhong, Xiao-Fen Chen, Zhen-Lian Zhang, Zhe Wang, Xin-Zhen Shi, Kai Xu, Yun-Wu Zhang, Huaxi Xu, Guojun B. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. The Journal of biological chemistry. vol 290. issue 25. 2015-08-28. PMID:25957402. |
triggering receptor expressed on myeloid cells 2 (trem2) is a dap12-associated receptor expressed in microglia, macrophages, and other myeloid-derived cells. |
2015-08-28 |
2023-08-13 |
Not clear |
| Kazuya Takahash. [Neurodegenerative disease and TREM2]. Rinsho shinkeigaku = Clinical neurology. vol 54. issue 12. 2015-08-17. PMID:25519966. |
a murine in vitro study revealed that the absence of trem2 expression on microglia impaired phagocytosis for tissue debris clearance and increased pro-inflammatory cytokine production; these are necessary to maintain the microenvironmental homeostasis of the central nervous system. |
2015-08-17 |
2023-08-13 |
human |
| Pietro Luigi Poliani, Yaming Wang, Elena Fontana, Michelle L Robinette, Yoshinori Yamanishi, Susan Gilfillan, Marco Colonn. TREM2 sustains microglial expansion during aging and response to demyelination. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25893602. |
like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (trem2), which binds polyanions, such as dextran sulphate and bacterial lps, and activates downstream signaling cascades through the adapter dap12. |
2015-08-17 |
2023-08-13 |
mouse |
| Pietro Luigi Poliani, Yaming Wang, Elena Fontana, Michelle L Robinette, Yoshinori Yamanishi, Susan Gilfillan, Marco Colonn. TREM2 sustains microglial expansion during aging and response to demyelination. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25893602. |
in wt mice, microglia expanded in the corpus callosum with age, whereas aged trem2(-/-) mice had fewer microglia with an abnormal morphology. |
2015-08-17 |
2023-08-13 |
mouse |
| Pietro Luigi Poliani, Yaming Wang, Elena Fontana, Michelle L Robinette, Yoshinori Yamanishi, Susan Gilfillan, Marco Colonn. TREM2 sustains microglial expansion during aging and response to demyelination. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25893602. |
in the cuprizone model of oligodendrocyte degeneration and demyelination, trem2(-/-) microglia failed to amplify transcripts indicative of activation, phagocytosis, and lipid catabolism in response to myelin damage. |
2015-08-17 |
2023-08-13 |
mouse |
| Xianwu Li, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25593125. |
different mechanisms of apolipoprotein e isoform-dependent modulation of prostaglandin e2 production and triggering receptor expressed on myeloid cells 2 (trem2) expression after innate immune activation of microglia. |
2015-07-30 |
2023-08-13 |
mouse |
| Xianwu Li, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25593125. |
we tested the hypothesis that apoe ε4 inheritance modulates both the pge2 pathway and trem2 expression using primary murine microglia from targeted replacement (tr) apoe3/3 and apoe4/4 mice. |
2015-07-30 |
2023-08-13 |
mouse |
| Xianwu Li, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25593125. |
microglial trem2 expression was reduced approximately 85% by all tlr activators; this reduction was approximately one-third greater in microglia from tr apoe4/4 mice. |
2015-07-30 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
using appswe/ps1de9 mice, a transgenic model of ad, we showed that trem2 was upregulated in microglia during disease progression. |
2015-07-07 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
by knockdown and overexpression of trem2 in cultured primary microglia, we revealed that trem2 modulated microglial functions under ad context, as it facilitated aβ(1-42) phagocytosis and inhibited aβ(1-42)-triggered proinflammatory responses. |
2015-07-07 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
taken together, our data suggest that the upregulation of trem2 serves as a compensatory response to aβ(1-42) and subsequently protects against ad progression by modulation of microglia functions. |
2015-07-07 |
2023-08-13 |
mouse |
| Serge Rives. TREM2 enables amyloid β clearance by microglia. Cell research. vol 25. issue 5. 2015-07-02. PMID:25828532. |
trem2 enables amyloid β clearance by microglia. |
2015-07-02 |
2023-08-13 |
mouse |
| Serge Rives. TREM2 enables amyloid β clearance by microglia. Cell research. vol 25. issue 5. 2015-07-02. PMID:25828532. |
trem2 acts as a signaling receptor involved in innate immunity for the natural clearance of this toxic protein by microglia. |
2015-07-02 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
triggering receptor expressed on myeloid cells 2 (trem2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
triggering receptor expressed on myeloid cells-2 (trem2) is a newly identified receptor expressed on microglia and is thought to phagocytose damaged brain cells. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
trem2 knockdown in microglia reduced microglial activation to an amoeboid phenotype and decreased the phagocytosis of injured neurons. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
the numbers of activated microglia and phagocytes in trem2 ko mice were decreased compared with wt mice, and foamy macrophages were nearly absent in the trem2 ko mice. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
postischemia, trem2 was highly expressed on microglia and trem2-fc fusion protein (used as a probe to identify potential trem2 binding partners) bound to an unknown trem2 ligand that colocalized to neurons. |
2015-06-29 |
2023-08-13 |
mouse |
| Taylor R Jay, Crystal M Miller, Paul J Cheng, Leah C Graham, Shane Bemiller, Margaret L Broihier, Guixiang Xu, Daniel Margevicius, J Colleen Karlo, Gregory L Sousa, Anne C Cotleur, Oleg Butovsky, Lynn Bekris, Susan M Staugaitis, James B Leverenz, Sanjay W Pimplikar, Gary E Landreth, Gareth R Howell, Richard M Ransohoff, Bruce T Lam. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. The Journal of experimental medicine. vol 212. issue 3. 2015-06-23. PMID:25732305. |
trem2 was detected on cd45(hi)ly6c(+) myeloid cells, but not on p2ry12(+) parenchymal microglia. |
2015-06-23 |
2023-08-13 |
mouse |