| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tyler K Ulland, Wilbur M Song, Stanley Ching-Cheng Huang, Jason D Ulrich, Alexey Sergushichev, Wandy L Beatty, Alexander A Loboda, Yingyue Zhou, Nigel J Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W Virgin, Emil R Unanue, Yaming Wang, Maxim N Artyomov, David M Holtzman, Marco Colonn. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. vol 170. issue 4. 2017-08-16. PMID:28802038. |
here, we find that microglia in ad patients carrying trem2 risk variants and trem2-deficient mice with ad-like pathology have abundant autophagic vesicles, as do trem2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (er) stress. combined metabolomics and rna sequencing (rna-seq) linked this anomalous autophagy to defective mammalian target of rapamycin (mtor) signaling, which affects atp levels and biosynthetic pathways. |
2017-08-16 |
2023-08-13 |
mouse |
| Li Zhong, Xiao-Fen Chen, Tingting Wang, Zhe Wang, Chunyan Liao, Zongqi Wang, Ruizhi Huang, Daxin Wang, Xinxiu Li, Linbei Wu, Lin Jia, Honghua Zheng, Meghan Painter, Yuka Atagi, Chia-Chen Liu, Yun-Wu Zhang, John D Fryer, Huaxi Xu, Guojun B. Soluble TREM2 induces inflammatory responses and enhances microglial survival. The Journal of experimental medicine. vol 214. issue 3. 2017-08-14. PMID:28209725. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor expressed in microglia in the brain. |
2017-08-14 |
2023-08-13 |
Not clear |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
trem2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
haplodeficiency of the microglia gene trem2 increases risk for late-onset alzheimer's disease (ad) but the mechanisms remain uncertain. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
we found that microglia processes, rich in trem2, tightly surround early amyloid fibrils and plaques promoting their compaction and insulation. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
in trem2- or dap12-haplodeficient mice and in humans with r47h trem2 mutations, microglia had a markedly reduced ability to envelop amyloid deposits. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
thus, trem2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 92. issue 1. 2017-07-24. PMID:27710785. |
trem2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. |
2017-07-24 |
2023-08-13 |
mouse |
| Yaming Wang, Tyler K Ulland, Jason D Ulrich, Wilbur Song, John A Tzaferis, Justin T Hole, Peng Yuan, Thomas E Mahan, Yang Shi, Susan Gilfillan, Marina Cella, Jaime Grutzendler, Ronald B DeMattos, John R Cirrito, David M Holtzman, Marco Colonn. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. The Journal of experimental medicine. vol 213. issue 5. 2017-07-21. PMID:27091843. |
however, in the absence of trem2, aβ plaques were not fully enclosed by microglia; they were more diffuse, less dense, and were associated with significantly greater neuritic damage. |
2017-07-21 |
2023-08-13 |
mouse |
| Yaming Wang, Tyler K Ulland, Jason D Ulrich, Wilbur Song, John A Tzaferis, Justin T Hole, Peng Yuan, Thomas E Mahan, Yang Shi, Susan Gilfillan, Marina Cella, Jaime Grutzendler, Ronald B DeMattos, John R Cirrito, David M Holtzman, Marco Colonn. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. The Journal of experimental medicine. vol 213. issue 5. 2017-07-21. PMID:27091843. |
thus, trem2 protects from ad by enabling microglia to surround and alter aβ plaque structure, thereby limiting neuritic damage. |
2017-07-21 |
2023-08-13 |
mouse |
| Masaaki Kobayashi, Hiroyuki Konishi, Akira Sayo, Toshiyuki Takai, Hiroshi Kiyam. TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 43. 2017-07-14. PMID:27798193. |
the present study showed that the dnax-activating protein of 12 kda (dap12) and its associated "triggering receptor expressed on myeloid cells 2" (trem2) were predominantly expressed by microglia in the dorsal horn after spinal nerve injury, revealing a role for trem2/dap12 signaling in neuropathic pain. |
2017-07-14 |
2023-08-13 |
mouse |
| Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haas. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The EMBO journal. vol 36. issue 13. 2017-07-14. PMID:28559417. |
the ftd-like syndrome causing trem2 t66m mutation impairs microglia function, brain perfusion, and glucose metabolism. |
2017-07-14 |
2023-08-13 |
mouse |
| Megan M Varnum, Kevin A Clayton, Asuka Yoshii-Kitahara, Grant Yonemoto, Lacin Koro, Seiko Ikezu, Tsuneya Ikez. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. The Journal of biological chemistry. vol 292. issue 25. 2017-07-05. PMID:28490631. |
triggering receptor expressed on myeloid cells 2 (trem2) is a single transmembrane molecule uniquely expressed in microglia. |
2017-07-05 |
2023-08-13 |
Not clear |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of trem2 signaling, and the cytokine paradox in alzheimer's disease are further contributions to this article. |
2017-06-14 |
2023-08-13 |
Not clear |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of trem2 signaling, and the cytokine paradox in alzheimer's disease are further contributions to this article. |
2017-06-14 |
2023-08-13 |
Not clear |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
as a novel risk gene for alzheimer's disease (ad), triggering receptor expressed on myeloid cells 2 (trem2) gene encodes a type i transmembrane receptor that is uniquely expressed by the microglia in the brain. |
2017-06-13 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
in the present study, to test this hypothesis, a lentiviral-mediated strategy was employed to selectively overexpress trem2 on microglia in the brain of p301s mice. |
2017-06-13 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
additionally, the suppressed neuroinflammation might be ascribed to the m2 activation of microglia induced by trem2, as the expression of m2 phenotype makers including arg1, retnla, il4 and il10 was markedly increased. |
2017-06-13 |
2023-08-13 |
mouse |
| Jun-ichi Satoh, Yoshihiro Kino, Nobutaka Motohashi, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Nobutaka Arai, Kiyotaka Nakamagoe, Akira Tamaoka, Yuko Saito, Kunimasa Arim. Immunohistochemical characterization of CD33 expression on microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 35. issue 6. 2016-12-13. PMID:26087043. |
trem2, by transmitting signals via the immunoreceptor tyrosine-based activation motif (itam) of dap12, stimulates phagocytic activity of microglia, and itam signaling is counterbalanced by sialic acid-binding immunoglobulin (ig)-like lectins (siglecs)-mediated immunoreceptor tyrosine-based inhibitory motif (itim) signaling. |
2016-12-13 |
2023-08-13 |
Not clear |
| Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott, Kevin Mills, Henrik Zetterber. Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26754172. |
trem2 is expressed on microglia, the resident immune cells of the brain and has been linked to phagocytotic clearance of amyloid β (aβ) plaques. |
2016-11-08 |
2023-08-13 |
Not clear |