| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Romain Fol, Jerome Braudeau, Susann Ludewig, Tobias Abel, Sascha W Weyer, Jan-Peter Roederer, Florian Brod, Mickael Audrain, Alexis-Pierre Bemelmans, Christian J Buchholz, Martin Korte, Nathalie Cartier, Ulrike C Mülle. Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. Acta neuropathologica. vol 131. issue 2. 2016-10-17. PMID:26538149. |
in addition, appsα induced the recruitment of microglia with a ramified morphology into the vicinity of plaques and upregulated ide and trem2 expression suggesting enhanced plaque clearance. |
2016-10-17 |
2023-08-13 |
mouse |
| Konstantin Glebov, Patrick Wunderlich, Ilker Karaca, Jochen Walte. Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2). Journal of neuroinflammation. vol 13. 2016-10-06. PMID:26792193. |
triggering receptor expressed on myeloid cells-2 (trem2) exerts important functions in the regulation of monocytes, like dendritic cells, osteoclasts, tissue macrophages, and microglia. |
2016-10-06 |
2023-08-13 |
Not clear |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
as a novel susceptibility gene for these 2 diseases, triggering receptor expressed on myeloid cells 2 (trem2) gene encodes an immune receptor that is uniquely expressed by microglia. |
2016-08-15 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
herein, using p301s mice, we showed that trem2 was upregulated in microglia during disease progression. |
2016-08-15 |
2023-08-13 |
mouse |
| Marco Colonna, Yaming Wan. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nature reviews. Neuroscience. vol 17. issue 4. 2016-07-21. PMID:26911435. |
genome-wide association studies have identified rare variants of the gene that encodes triggering receptor expressed on myeloid cells 2 (trem2) - an immune receptor that is found in brain microglia - as risk factors for non-familial alzheimer disease (ad). |
2016-07-21 |
2023-08-13 |
Not clear |
| Marco Colonna, Yaming Wan. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nature reviews. Neuroscience. vol 17. issue 4. 2016-07-21. PMID:26911435. |
furthermore, animal studies have indicated that microglia have an important role in the brain response to amyloid-β (aβ) plaques and that trem2 variants may have an impact on such a function. |
2016-07-21 |
2023-08-13 |
Not clear |
| L-F Lue, C Schmitz, D G Walke. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic? Neuroscience. vol 302. 2016-04-26. PMID:25281879. |
although ligands for trem2 are largely unknown, the mitochondrial heat shock protein 60, expressed on cell surface of apoptotic neurons, is a specific ligand that activates trem2-mediated phagocytosis by microglia. |
2016-04-26 |
2023-08-13 |
human |
| L-F Lue, C Schmitz, D G Walke. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic? Neuroscience. vol 302. 2016-04-26. PMID:25281879. |
the association of trem2 mutations with neurodegenerative disease also calls for the understanding of the biology and pathological role of non-mutated trem2 on human brains and microglia. |
2016-04-26 |
2023-08-13 |
human |
| L-F Lue, C Schmitz, D G Walke. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic? Neuroscience. vol 302. 2016-04-26. PMID:25281879. |
this review provides a summary of current literature in trem2 and dap12 from several aspects, and proposes a theory that loss of trem2 functions might contribute to the immunopathogenic role of microglia in alzheimer's disease. |
2016-04-26 |
2023-08-13 |
human |
| Lih-Fen Lue, Christopher T Schmitz, Geidy Serrano, Lucia I Sue, Thomas G Beach, Douglas G Walke. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices. Brain pathology (Zurich, Switzerland). vol 25. issue 4. 2016-03-15. PMID:25186950. |
strong intensities of trem2 immunoreactivity were observed in the microglia associated with amyloid plaques and in neuritic pathology-enriched areas. |
2016-03-15 |
2023-08-13 |
human |
| Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzz. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of aging. vol 36. issue 5. 2016-02-29. PMID:25816748. |
we report that trem2 expression by microglia is significantly up-regulated upon prion infection. |
2016-02-29 |
2023-08-13 |
mouse |
| Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzz. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of aging. vol 36. issue 5. 2016-02-29. PMID:25816748. |
further phenotype profiling of microglia revealed that trem2 deficiency did not change microglial phenotypes. |
2016-02-29 |
2023-08-13 |
mouse |
| Yuka Atagi, Chia-Chen Liu, Meghan M Painter, Xiao-Fen Chen, Christophe Verbeeck, Honghua Zheng, Xia Li, Rosa Rademakers, Silvia S Kang, Huaxi Xu, Steven Younkin, Pritam Das, John D Fryer, Guojun B. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of biological chemistry. vol 290. issue 43. 2016-02-16. PMID:26374899. |
trem2 is highly expressed in microglia, the resident immune cells of the central nervous system. |
2016-02-16 |
2023-08-13 |
human |
| Yuka Atagi, Chia-Chen Liu, Meghan M Painter, Xiao-Fen Chen, Christophe Verbeeck, Honghua Zheng, Xia Li, Rosa Rademakers, Silvia S Kang, Huaxi Xu, Steven Younkin, Pritam Das, John D Fryer, Guojun B. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of biological chemistry. vol 290. issue 43. 2016-02-16. PMID:26374899. |
the functional significance of this binding was highlighted by increased phagocytosis of apoe-bound apoptotic n2a cells by primary microglia in a manner that depends on trem2 expression. |
2016-02-16 |
2023-08-13 |
human |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
trem2 regulates microglial cell activation in response to demyelination in vivo. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
however, it is unknown how trem2 contributes to microglia function in vivo. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
here, we identify a critical role for trem2 in the activation and function of microglia during cuprizone (cpz)-induced demyelination. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
trem2(-/-) microglia proliferated less in areas of demyelination and were less activated, displaying a more resting morphology and decreased expression of the activation markers mhc ii and inducible nitric oxide synthase as compared to wt. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
mechanistically, gene expression and ultrastructural analysis of microglia suggested a defect in myelin degradation and phagosome processing during cpz intoxication in trem2(-/-) microglia. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
these findings place trem2 as a key regulator of microglia activation in vivo in response to tissue damage. |
2015-12-01 |
2023-08-13 |
mouse |