| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Naonobu Futamura, Michio Kobayashi, Itaru Toyoshima, Toshiaki Yoshioka, Katsuhiko Enomoto, Nobutaka Arai, Kunimasa Arim. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 4. 2011-12-12. PMID:21118401. |
unexpectedly, trem2 was not expressed on microglia but expressed on a small subset of intravascular monocytes/macrophages in control and nhd brains. |
2011-12-12 |
2023-08-12 |
mouse |
| Jun-Ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Naonobu Futamura, Michio Kobayashi, Itaru Toyoshima, Toshiaki Yoshioka, Katsuhiko Enomoto, Nobutaka Arai, Kunimasa Arim. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 4. 2011-12-12. PMID:21118401. |
these observations indicate that human microglia in brain tissues do not express trem2 and dap12-deficient microglia are preserved in nhd brains, suggesting that the loss of dap2/trem2 function in microglia might not be primarily responsible for the neuropathological phenotype of nhd. |
2011-12-12 |
2023-08-12 |
mouse |
| Benoit Melchior, Angie E Garcia, Bor-Kai Hsiung, Katherine M Lo, Jonathan M Doose, J Cameron Thrash, Anna K Stalder, Matthias Staufenbiel, Harald Neumann, Monica J Carso. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN neuro. vol 2. issue 3. 2011-12-06. PMID:20640189. |
transfection studies revealed that expression of trem2 correlated negatively with motility, but correlated positively with the ability of microglia to stimulate cd4(+) t-cell proliferation, tnf (tumour necrosis factor) and ccl2 (chemokine ligand 2) production, but not ifngamma (interferon gamma) production. |
2011-12-06 |
2023-08-12 |
mouse |
| Benoit Melchior, Angie E Garcia, Bor-Kai Hsiung, Katherine M Lo, Jonathan M Doose, J Cameron Thrash, Anna K Stalder, Matthias Staufenbiel, Harald Neumann, Monica J Carso. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN neuro. vol 2. issue 3. 2011-12-06. PMID:20640189. |
conversely, the phagocytic trem2(+) microglia on the plaque outer zones are positioned to capture and present self-antigens to cns (central nervous system)-infiltrating lymphocytes without promoting pro-inflammatory lymphocyte responses. |
2011-12-06 |
2023-08-12 |
mouse |
| Benoit Melchior, Angie E Garcia, Bor-Kai Hsiung, Katherine M Lo, Jonathan M Doose, J Cameron Thrash, Anna K Stalder, Matthias Staufenbiel, Harald Neumann, Monica J Carso. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN neuro. vol 2. issue 3. 2011-12-06. PMID:20640189. |
instead, plaque-associated trem2(+) microglia have the potential to evoke neuroprotective immune responses that may serve to support cns function during pro-inflammatory anti-amyloid immune therapies. |
2011-12-06 |
2023-08-12 |
mouse |
| Bettina Linnartz, Yiner Wang, Harald Neuman. Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation. International journal of Alzheimer's disease. vol 2010. 2011-07-14. PMID:20721346. |
microglial triggering receptor expressed on myeloid cells-2 (trem2), signal regulatory protein-beta1, and complement receptor-3 (cd11b/cd18) signal via the adaptor protein dap12 and activate phagocytic activity of microglia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Luisa Stefano, Gabriella Racchetti, Fabio Bianco, Nadia Passini, Radhey S Gupta, Paola Panina Bordignon, Jacopo Meldoles. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. Journal of neurochemistry. vol 110. issue 1. 2009-08-21. PMID:19457124. |
it might in contrast be appropriate for the binding of trem2 to hsp60 exposed at the surface of cells closely interacting with microglia. |
2009-08-21 |
2023-08-12 |
Not clear |
| Christine L Hsieh, Maya Koike, Steve C Spusta, Erene C Niemi, Midori Yenari, Mary C Nakamura, William E Seama. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302484. |
a role for trem2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. |
2009-07-16 |
2023-08-12 |
Not clear |
| Christine L Hsieh, Maya Koike, Steve C Spusta, Erene C Niemi, Midori Yenari, Mary C Nakamura, William E Seama. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302484. |
however, evidence that microglia and neurons directly interact through trem2 to orchestrate microglial function is lacking. |
2009-07-16 |
2023-08-12 |
Not clear |
| Christine L Hsieh, Maya Koike, Steve C Spusta, Erene C Niemi, Midori Yenari, Mary C Nakamura, William E Seama. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302484. |
finally, while trem2-l are expressed on neurons, trem2 is not; in the brain, it is found on microglia. |
2009-07-16 |
2023-08-12 |
Not clear |
| Christine L Hsieh, Maya Koike, Steve C Spusta, Erene C Niemi, Midori Yenari, Mary C Nakamura, William E Seama. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302484. |
trem2 and trem2-l form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. |
2009-07-16 |
2023-08-12 |
Not clear |
| Christoph D Schmid, Benoit Melchior, Kokoechat Masek, Shweta S Puntambekar, Patria E Danielson, David D Lo, J Gregor Sutcliffe, Monica J Carso. Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo. Journal of neurochemistry. vol 109 Suppl 1. 2009-05-21. PMID:19393017. |
only three of these molecules (c1qa, trem2, and cxcl14) were found by qpcr to be also enriched in adult microglia isolated from lps/ifngamma-injected cns when compared with infiltrating peripheral macrophages from the same cns. |
2009-05-21 |
2023-08-12 |
Not clear |
| Christoph D Schmid, Benoit Melchior, Kokoechat Masek, Shweta S Puntambekar, Patria E Danielson, David D Lo, J Gregor Sutcliffe, Monica J Carso. Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo. Journal of neurochemistry. vol 109 Suppl 1. 2009-05-21. PMID:19393017. |
in situ hybridization analysis revealed that nearly all microglia expressed high levels of c1qa, while subsets of microglia expressed trem2 and cxcl14. |
2009-05-21 |
2023-08-12 |
Not clear |
| Christoph D Schmid, Benoit Melchior, Kokoechat Masek, Shweta S Puntambekar, Patria E Danielson, David D Lo, J Gregor Sutcliffe, Monica J Carso. Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo. Journal of neurochemistry. vol 109 Suppl 1. 2009-05-21. PMID:19393017. |
expression of c1qa and trem2 was limited to microglia, while large numbers of gaba+ neurons expressed cxcl14. |
2009-05-21 |
2023-08-12 |
Not clear |
| J Cameron Thrash, Bruce E Torbett, Monica J Carso. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18404378. |
trem2 is an orphan, dap12 associated receptor constitutively expressed in vivo by subsets of microglia in the healthy adult murine cns and in vitro by subsets of oligodendrocytes in neonatal mixed glial cultures. |
2009-02-23 |
2023-08-12 |
Not clear |
| J Cameron Thrash, Bruce E Torbett, Monica J Carso. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18404378. |
whether the early onset cognitive dementia and myelin-pallor associated with this disorder are due to deficits in functional trem2 signaling in microglia and/or oligodendrocytes is still being debated. |
2009-02-23 |
2023-08-12 |
Not clear |
| J Cameron Thrash, Bruce E Torbett, Monica J Carso. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18404378. |
in addition, cns expression of trem2 and dap12 are not detected in pu.1ko which lack microglia and macrophages. |
2009-02-23 |
2023-08-12 |
Not clear |
| Stefanie Frank, Guido J Burbach, Michael Bonin, Michael Walter, Wolfgang Streit, Ingo Bechmann, Thomas Delle. TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia. vol 56. issue 13. 2009-01-13. PMID:18551625. |
trem2 is upregulated in amyloid plaque-associated microglia in aged app23 transgenic mice. |
2009-01-13 |
2023-08-12 |
mouse |
| Stefanie Frank, Guido J Burbach, Michael Bonin, Michael Walter, Wolfgang Streit, Ingo Bechmann, Thomas Delle. TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia. vol 56. issue 13. 2009-01-13. PMID:18551625. |
confocal imaging studies, furthermore, confirmed colocalization of trem2 protein with microglia. |
2009-01-13 |
2023-08-12 |
mouse |
| Stefanie Frank, Guido J Burbach, Michael Bonin, Michael Walter, Wolfgang Streit, Ingo Bechmann, Thomas Delle. TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia. vol 56. issue 13. 2009-01-13. PMID:18551625. |
thus, when trem2 is induced on microglia in plaque-loaded brain areas the respective signaling may prevent inflammation-induced bystander damage of neurons. |
2009-01-13 |
2023-08-12 |
mouse |