| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Chih Jin, Bruno A Benitez, Celeste M Karch, Breanna Cooper, Tara Skorupa, David Carrell, Joanne B Norton, Simon Hsu, Oscar Harari, Yefei Cai, Sarah Bertelsen, Alison M Goate, Carlos Cruchag. Coding variants in TREM2 increase risk for Alzheimer's disease. Human molecular genetics. vol 23. issue 21. 2015-06-10. PMID:24899047. |
the triggering receptor expressed on myeloid 2 (trem2) is an immune phagocytic receptor expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory response. |
2015-06-10 |
2023-08-13 |
human |
| Yaming Wang, Marina Cella, Kaitlin Mallinson, Jason D Ulrich, Katherine L Young, Michelle L Robinette, Susan Gilfillan, Gokul M Krishnan, Shwetha Sudhakar, Bernd H Zinselmeyer, David M Holtzman, John R Cirrito, Marco Colonn. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. vol 160. issue 6. 2015-05-12. PMID:25728668. |
we found that trem2 deficiency and haploinsufficiency augment β-amyloid (aβ) accumulation due to a dysfunctional response of microglia, which fail to cluster around aβ plaques and become apoptotic. |
2015-05-12 |
2023-08-13 |
mouse |
| Gernot Kleinberger, Yoshinori Yamanishi, Marc Suárez-Calvet, Eva Czirr, Ebba Lohmann, Elise Cuyvers, Hanne Struyfs, Nadine Pettkus, Andrea Wenninger-Weinzierl, Fargol Mazaheri, Sabina Tahirovic, Alberto Lleó, Daniel Alcolea, Juan Fortea, Michael Willem, Sven Lammich, José L Molinuevo, Raquel Sánchez-Valle, Anna Antonell, Alfredo Ramirez, Michael T Heneka, Kristel Sleegers, Julie van der Zee, Jean-Jacques Martin, Sebastiaan Engelborghs, Asli Demirtas-Tatlidede, Henrik Zetterberg, Christine Van Broeckhoven, Hakan Gurvit, Tony Wyss-Coray, John Hardy, Marco Colonna, Christian Haas. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science translational medicine. vol 6. issue 243. 2015-02-23. PMID:24990881. |
trem2 is an innate immune receptor preferentially expressed by microglia and is involved in inflammation and phagocytosis. |
2015-02-23 |
2023-08-13 |
Not clear |
| Jun-Ichi Satoh, Nobutaka Motohashi, Yoshihiro Kino, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Nobutaka Arai, Kiyotaka Nakamagoe, Akira Tamaoka, Yuko Saito, Kunimasa Arim. LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains. Orphanet journal of rare diseases. vol 9. 2014-11-12. PMID:24886140. |
trem2 and dap12 constitute a receptor/adaptor signaling complex expressed exclusively on osteoclasts, dendritic cells, macrophages, and microglia. |
2014-11-12 |
2023-08-13 |
Not clear |
| Jason D Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E Mahan, Hong Jiang, Floy R Stewart, Laura Piccio, Marco Colonna, David M Holtzma. Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Molecular neurodegeneration. vol 9. 2014-09-12. PMID:24893973. |
trem2 is expressed by microglia and is thought to regulate phagocytic and inflammatory microglial responses to brain pathology. |
2014-09-12 |
2023-08-13 |
mouse |
| Allal Boutajangout, Thomas Wisniewsk. The innate immune system in Alzheimer's disease. International journal of cell biology. vol 2013. 2014-06-24. PMID:24223593. |
trem2 is expressed on myeloid cells including microglia, macrophages, and dendritic cells, as well as osteoclasts. |
2014-06-24 |
2023-08-12 |
Not clear |
| Todd E Golde, Wolfgang J Streit, Paramita Chakrabart. Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease. Alzheimer's research & therapy. vol 5. issue 3. 2014-06-19. PMID:23692967. |
trem2 is a type 1 membrane receptor protein primarily expressed on microglia in the central nervous system that has been shown to regulate phagocytosis and activation of monocytes. |
2014-06-19 |
2023-08-12 |
Not clear |
| Peter N Alexandrov, Yuhai Zhao, Brandon M Jones, Surjyadipta Bhattacharjee, Walter J Luki. Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line. Journal of inorganic biochemistry. vol 128. 2014-06-07. PMID:23778113. |
expression of the phagocytosis-essential protein trem2 is down-regulated by an aluminum-induced mirna-34a in a murine microglial cell line. |
2014-06-07 |
2023-08-12 |
Not clear |
| Dorit Trudler, Orly Weinreb, Silvia A Mandel, Moussa B H Youdim, Dan Frenke. DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24355073. |
moreover, we discovered that dj-1-deficient microglia have reduced expression of triggering receptor expressed on myeloid cells 2 (trem2), previously suggested as a risk factor for pro-inflammation in neurodegenerative diseases. |
2014-06-04 |
2023-08-12 |
Not clear |
| Suzanne E Hickman, Joseph El Khour. TREM2 and the neuroimmunology of Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24355566. |
using a novel technology called direct rna sequencing wedetermined the quantitative transcriptome of microglia, the principal innate neuroimmune cells and confirmed that trem2 is a major microglia-specific gene in the central nervous system. |
2014-05-19 |
2023-08-12 |
Not clear |
| Suzanne E Hickman, Joseph El Khour. TREM2 and the neuroimmunology of Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24355566. |
here we propose that the mechanism(s) by which trem2 variants cause alzheimer's disease are via down regulation of the aβ phagocytic ability of microglia and by dysregulation of the pro-inflammatory response of these cells. |
2014-05-19 |
2023-08-12 |
Not clear |
| Mariela Chertoff, Kalpana Shrivastava, Berta Gonzalez, Laia Acarin, Lydia Giménez-Llor. Differential modulation of TREM2 protein during postnatal brain development in mice. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977213. |
furthermore, the spatiotemporal expression pattern and characterization of trem2 indicate towards its other plausible roles in phagocytosis, progenitor's fate determination or microglia phenotype modulation during postnatal development. |
2014-04-08 |
2023-08-12 |
mouse |
| Paola Forabosco, Adaikalavan Ramasamy, Daniah Trabzuni, Robert Walker, Colin Smith, Jose Bras, Adam P Levine, John Hardy, Jennifer M Pocock, Rita Guerreiro, Michael E Weale, Mina Ryte. Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855984. |
using network analysis, we detect a highly preserved trem2-containing module in human brain, show that it relates to microglia, and demonstrate that trem2 is a hub gene in 5 brain regions, including the hippocampus, suggesting that it can drive module function. |
2014-04-02 |
2023-08-12 |
human |
| Patrick Wunderlich, Konstantin Glebov, Nadja Kemmerling, Nguyen T Tien, Harald Neumann, Jochen Walte. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage. The Journal of biological chemistry. vol 288. issue 46. 2014-01-23. PMID:24078628. |
triggering receptor expressed on myeloid cells-2 (trem2) and its signaling adaptor protein tyrobp/dap12 play important roles in signal transduction in dendritic cells, osteoclasts, tissue macrophages, and microglia. |
2014-01-23 |
2023-08-12 |
Not clear |
| Margarita Giraldo, Francisco Lopera, Ashley L Siniard, Jason J Corneveaux, Isabelle Schrauwen, Julian Carvajal, Claudia Muñoz, Manuel Ramirez-Restrepo, Chris Gaiteri, Amanda J Myers, Richard J Caselli, Kenneth S Kosik, Eric M Reiman, Matthew J Huentelma. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiology of aging. vol 34. issue 8. 2013-11-04. PMID:23582655. |
trem2 is important in the phagocytosis of apoptotic neuronal cells by microglia in the brain. |
2013-11-04 |
2023-08-12 |
Not clear |
| Sruti Rayaprolu, Bianca Mullen, Matt Baker, Timothy Lynch, Elizabeth Finger, William W Seeley, Kimmo J Hatanpaa, Catherine Lomen-Hoerth, Andrew Kertesz, Eileen H Bigio, Carol Lippa, Keith A Josephs, David S Knopman, Charles L White, Richard Caselli, Ian R Mackenzie, Bruce L Miller, Magdalena Boczarska-Jedynak, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Steven G Younkin, Ronald C Petersen, Nilüfer Ertekin-Taner, Ryan J Uitti, James F Meschia, Kevin B Boylan, Bradley F Boeve, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson, Rosa Rademakers, Owen A Ros. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Molecular neurodegeneration. vol 8. 2013-09-20. PMID:23800361. |
given the key role of trem2 in the effective phagocytosis of apoptotic neuronal cells by microglia, we hypothesized that dysfunction of trem2 may play a more generalized role in neurodegeneration. |
2013-09-20 |
2023-08-12 |
Not clear |
| Jun-Ichi Satoh, Yoshihiro Shimamura, Hiroko Tabunok. Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease. Cellular and molecular neurobiology. vol 32. issue 3. 2012-12-20. PMID:22080356. |
trem2 and dap12 constitute a receptor/adaptor complex expressed on osteoclasts, dendritic cells, macrophages, monocytes, and microglia. |
2012-12-20 |
2023-08-12 |
human |
| Karel Otero, Masahiro Shinohara, Haibo Zhao, Marina Cella, Susan Gilfillan, Angela Colucci, Roberta Faccio, F Patrick Ross, Steve L Teitelbaum, Hiroshi Takayanagi, Marco Colonn. TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 6. 2012-04-19. PMID:22312126. |
trem2 is an immunoreceptor expressed on osteoclasts (oc) and microglia that transmits intracellular signals through the adaptor dap12. |
2012-04-19 |
2023-08-12 |
mouse |
| Y Numasawa, C Yamaura, S Ishihara, S Shintani, M Yamazaki, H Tabunoki, J-I Sato. Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family. European journal of neurology. vol 18. issue 9. 2012-04-03. PMID:21834902. |
nasu-hakola disease (nhd) is a rare autosomal recessive disorder, characterized by a combination of progressive presenile dementia and formation of multifocal bone cysts, caused by genetic mutations of dap12 and trem2, which constitute a receptor/adapter signaling complex expressed on osteoclasts, dendritic cells, macrophages, and microglia. |
2012-04-03 |
2023-08-12 |
Not clear |
| Jun-Ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Naonobu Futamura, Michio Kobayashi, Itaru Toyoshima, Toshiaki Yoshioka, Katsuhiko Enomoto, Nobutaka Arai, Kunimasa Arim. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 4. 2011-12-12. PMID:21118401. |
trem2 and dap12 constitute a receptor/adapter signaling complex expressed on osteoclasts, dendritic cells (dc), macrophages and microglia. |
2011-12-12 |
2023-08-12 |
mouse |