| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haas. Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Science translational medicine. vol 8. issue 369. 2017-12-29. PMID:27974666. |
trem2 is a transmembrane protein involved in innate immunity and is selectively expressed by microglia and genetically linked to ad and other neurodegenerative disorders. |
2017-12-29 |
2023-08-13 |
human |
| Peter J Amos, Susan Fung, Amanda Case, Jerusalem Kifelew, Leah Osnis, Carole L Smith, Kevin Green, Alipi Naydenov, Macarena Aloi, Jesse J Hubbard, Aravind Ramakrishnan, Gwenn A Garden, Suman Jayade. Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells. ASN neuro. vol 9. issue 4. 2017-12-08. PMID:28683563. |
using immunofluorescence microscopy, flow cytometry, and reverse transcription polymerase chain reaction, we observed cells with microglia morphology expressing a repertoire of markers associated with microglia: iba1, cx3cr1, cd11b, trem2, hexb, and p2ry12. |
2017-12-08 |
2023-08-13 |
human |
| Daniel W Sirkis, Renan E Aparicio, Randy Schekma. Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. Molecular biology of the cell. vol 28. issue 20. 2017-11-29. PMID:28768830. |
triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane protein expressed on microglia within the brain. |
2017-11-29 |
2023-08-13 |
Not clear |
| Sara Belloli, Maria Pannese, Cecilia Buonsanti, Chiara Maiorino, Giuseppe Di Grigoli, Assunta Carpinelli, Cristina Monterisi, Rosa Maria Moresco, Paola Panina-Bordigno. Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice. Neurobiology of aging. vol 53. 2017-11-16. PMID:28189343. |
we evaluated the effect of trem2 deletion in a 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse model, measuring neurodegeneration and microglia activation using a combined in vivo imaging and postmortem molecular approach. |
2017-11-16 |
2023-08-13 |
mouse |
| Sami Piirainen, Andrew Youssef, Cai Song, Allan V Kalueff, Gary E Landreth, Tarja Malm, Li Tia. Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia? Neuroscience and biobehavioral reviews. vol 77. 2017-10-26. PMID:28185874. |
moreover, genome-wide association studies have linked variants in several immune genes, such as trem2 and cd33, the expression of which in the brain is restricted to microglia, with cognitive dysfunctions in load. |
2017-10-26 |
2023-08-13 |
Not clear |
| Daniel W Sirkis, Luke W Bonham, Renan E Aparicio, Ethan G Geier, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Zachary A Miller, Bruce L Miller, Giovanni Coppola, Jennifer S Yokoyam. Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27589997. |
trem2 encodes a cell surface receptor expressed on microglia and related cells, and the r47h variant associated with ad appears to affect the ability of trem2 to bind extracellular ligands. |
2017-10-25 |
2023-08-13 |
Not clear |
| Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O'Loughlin, Yang Xu, Zain Fanek, David J Greco, Scott T Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L Heppner, Vladimir Litvak, David M Holtzman, Hans Lassmann, Howard L Weiner, Jordi Ochando, Christian Haass, Oleg Butovsk. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. vol 47. issue 3. 2017-10-18. PMID:28930663. |
trem2 (triggering receptor expressed on myeloid cells 2) induced apoe signaling, and targeting the trem2-apoe pathway restored the homeostatic signature of microglia in als and ad mouse models and prevented neuronal loss in an acute model of neurodegeneration. |
2017-10-18 |
2023-08-13 |
mouse |
| Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K Ulland, Yaming Wang, Rudolph E Tanzi, Marco Colonn. Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 4. 2017-10-06. PMID:27520774. |
trem2 is a lipid-sensing activating receptor on microglia known to be important for alzheimer's disease (ad), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial. |
2017-10-06 |
2023-08-13 |
Not clear |
| Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haas. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO molecular medicine. vol 8. issue 9. 2017-09-25. PMID:27402340. |
recently, heterozygous mutations in the triggering receptor expressed on myeloid cells 2 (trem2), a microglial gene involved in phagocytosis, were genetically linked to late onset ad loss of trem2 reduces the ability of microglia to engulf aβ. |
2017-09-25 |
2023-08-13 |
Not clear |
| Honghua Zheng, Chia-Chen Liu, Yuka Atagi, Xiao-Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S Kang, Terrone L Rosenberry, John D Fryer, Yun-Wu Zhang, Huaxi Xu, Guojun B. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143430. |
consistent with this in vivo result, lps or oligomeric amyloid-β treatment down regulated trem2 but up-regulated treml2 expression in primary microglia. |
2017-09-19 |
2023-08-13 |
mouse |
| Honghua Zheng, Chia-Chen Liu, Yuka Atagi, Xiao-Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S Kang, Terrone L Rosenberry, John D Fryer, Yun-Wu Zhang, Huaxi Xu, Guojun B. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143430. |
in addition, the proliferation of primary microglia was significantly decreased when trem2 was down regulated, whereas it was increased on treml2 knockdown. |
2017-09-19 |
2023-08-13 |
mouse |
| Honghua Zheng, Chia-Chen Liu, Yuka Atagi, Xiao-Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S Kang, Terrone L Rosenberry, John D Fryer, Yun-Wu Zhang, Huaxi Xu, Guojun B. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143430. |
our findings provide novel mechanistic insights into the functions of trem2 and treml2 in microglia and have implications on designing new therapeutic strategies to treat ad. |
2017-09-19 |
2023-08-13 |
mouse |
| Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez-Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haas. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO molecular medicine. vol 8. issue 5. 2017-09-13. PMID:26941262. |
trem2 is an innate immune receptor expressed on the surface of microglia. |
2017-09-13 |
2023-08-13 |
Not clear |
| Jie Yin, Xiaocui Liu, Qing He, Lujun Zhou, Zengqiang Yuan, Siqi Zha. Vps35-dependent recycling of Trem2 regulates microglial function. Traffic (Copenhagen, Denmark). vol 17. issue 12. 2017-09-04. PMID:27717139. |
triggering receptor expressed on myeloid cells 2 (trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. |
2017-09-04 |
2023-08-13 |
Not clear |
| Jie Yin, Xiaocui Liu, Qing He, Lujun Zhou, Zengqiang Yuan, Siqi Zha. Vps35-dependent recycling of Trem2 regulates microglial function. Traffic (Copenhagen, Denmark). vol 17. issue 12. 2017-09-04. PMID:27717139. |
trem2 might be involved in the development of alzheimer's disease (ad) through regulating the inflammatory responses and phagocytosis of microglia. |
2017-09-04 |
2023-08-13 |
Not clear |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
trem2 binds to apolipoproteins, including apoe and clu/apoj, and thereby facilitates uptake of amyloid-beta by microglia. |
2017-08-22 |
2023-08-13 |
human |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
genetic variants of trem2, a protein expressed selectively by microglia in the brain, are associated with alzheimer's disease (ad). |
2017-08-22 |
2023-08-13 |
human |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
trem2 knockout microglia showed reduced internalization of ldl and clu. |
2017-08-22 |
2023-08-13 |
human |
| Honghua Zheng, Lin Jia, Chia-Chen Liu, Zhouyi Rong, Li Zhong, Longyu Yang, Xiao-Fen Chen, John D Fryer, Xin Wang, Yun-Wu Zhang, Huaxi Xu, Guojun B. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28077724. |
triggering receptor expressed on myeloid cells 2 (trem2), which is expressed on myeloid cells including microglia in the cns, has recently been identified as a risk factor for alzheimer's disease (ad). |
2017-08-18 |
2023-08-13 |
Not clear |
| Honghua Zheng, Lin Jia, Chia-Chen Liu, Zhouyi Rong, Li Zhong, Longyu Yang, Xiao-Fen Chen, John D Fryer, Xin Wang, Yun-Wu Zhang, Huaxi Xu, Guojun B. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28077724. |
to elucidate the signaling pathways underlying reduced trem2 expression or loss of function in microglia, we respectively knocked down and knocked out the expression of trem2 in |
2017-08-18 |
2023-08-13 |
Not clear |