| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W Ryder, Eva Wozniak, Kristie Wood, Charles A Mein, Richard J B Dobson, David A Collier, Michael J O'Neill, Angela K Hodges, Stephen J Newhous. Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain. Neurobiology of aging. vol 69. 2019-05-21. PMID:29906661. |
loss of trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain. |
2019-05-21 |
2023-08-13 |
mouse |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
functional studies of missense trem2 mutations in human stem cell-derived microglia. |
2019-04-23 |
2023-08-13 |
human |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
we used stem cell-derived microglia to study the consequences of missense mutations in the microglial-expressed protein triggering receptor expressed on myeloid cells 2 (trem2), which are causal for frontotemporal dementia-like syndrome and nasu-hakola disease. |
2019-04-23 |
2023-08-13 |
human |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
however, in the absence of plasma membrane trem2, microglia differentiate normally, respond to stimulation with lipopolysaccharide, and are phagocytically competent. |
2019-04-23 |
2023-08-13 |
human |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
these data indicate that dementia-associated trem2 mutations have subtle effects on microglia biology, consistent with the adult onset of disease in individuals with these mutations. |
2019-04-23 |
2023-08-13 |
human |
| Maud Gratuze, Cheryl E G Leyns, David M Holtzma. New insights into the role of TREM2 in Alzheimer's disease. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30572908. |
genetic factors such as rare variants of trem2 (triggering receptor expressed on myeloid cells-2) strongly increase the risk of developing ad, confirming the role of microglia in ad pathogenesis. |
2019-04-12 |
2023-08-13 |
human |
| Maud Gratuze, Cheryl E G Leyns, David M Holtzma. New insights into the role of TREM2 in Alzheimer's disease. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30572908. |
in this review, we summarize increases in our understanding of the involvement of trem2 and microglia in ad development that may open new therapeutic strategies targeting the immune system to influence ad pathogenesis. |
2019-04-12 |
2023-08-13 |
human |
| Jiang-Tao Li, Ying Zhan. TREM2 regulates innate immunity in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29655369. |
recent research has shown that the triggering receptor expressed on myeloid cells 2 (trem2) in microglia is closely related to the pathogenesis of alzheimer's disease (ad). |
2019-04-08 |
2023-08-13 |
Not clear |
| Jiang-Tao Li, Ying Zhan. TREM2 regulates innate immunity in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29655369. |
trem2 is part of the trem family of receptors, which are expressed primarily in myeloid cells, including monocytes, dendritic cells, and microglia. |
2019-04-08 |
2023-08-13 |
Not clear |
| Li Yang, Peiyu Jin, Xiaoyan Wang, Qing Zhou, Xiaoli Lin, Shuhua X. Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats. Neurotoxicology. vol 69. 2019-03-15. PMID:30273629. |
we found that fluoride exposure activated microglia and increased the expression of dap12 and trem2, as well as promoted pro-inflammatory cytokines secretion via erk/mapk and p38/mapk signal pathways. |
2019-03-15 |
2023-08-13 |
rat |
| Lang-Yue Hu, Yang Zhou, Wen-Qiang Cui, Xue-Ming Hu, Li-Xia Du, Wen-Li Mi, Yu-Xia Chu, Gen-Cheng Wu, Yan-Qing Wang, Qi-Liang Mao-Yin. Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29051087. |
furthermore, cisplatin enhanced triggering receptor expressed on myeloid cells 2 (trem2) /dnax-activating protein of 12 kda (dap12) signaling in the spinal cord microglia. |
2019-03-12 |
2023-08-13 |
mouse |
| Lang-Yue Hu, Yang Zhou, Wen-Qiang Cui, Xue-Ming Hu, Li-Xia Du, Wen-Li Mi, Yu-Xia Chu, Gen-Cheng Wu, Yan-Qing Wang, Qi-Liang Mao-Yin. Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29051087. |
functional blockage of trem2 or inhibition of microglia both benefited for cisplatin-induced peripheral neuropathy. |
2019-03-12 |
2023-08-13 |
mouse |
| Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boch. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:28987033. |
as part of investigations of microglia using post-mortem resources provided by the medical research council cognitive function and ageing studies (mrc-cfas), we immunostained the cerebral cortex of 299 participants for trem2 using the sigma antibody hpa010917 and compared with the macrophage/microglial markers iba1 and cd68. |
2019-03-05 |
2023-08-13 |
human |
| Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boch. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:28987033. |
however, in most cases (284/299), the trem2 antibody labelled monocytes within vascular lumens, but not microglia or perivascular macrophages. |
2019-03-05 |
2023-08-13 |
human |
| Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boch. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:28987033. |
our observations, using the hpa010917 anti-trem2 antibody, suggest that trem2 is not expressed by microglia but instead seems to be a marker of recruited monocytes in the human brain. |
2019-03-05 |
2023-08-13 |
human |
| Aleksandra Deczkowska, Hadas Keren-Shaul, Assaf Weiner, Marco Colonna, Michal Schwartz, Ido Ami. Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration. Cell. vol 173. issue 5. 2019-02-27. PMID:29775591. |
here, we propose that microglia are endowed with a dedicated sensory mechanism, which includes the trem2 signaling pathway, to detect damage within the cns in the form of neurodegeneration-associated molecular patterns (namps). |
2019-02-27 |
2023-08-13 |
human |
| Qingwen Cheng, Jean Danao, Santosh Talreja, Paul Wen, Jun Yin, Ning Sun, Chi-Ming Li, Danny Chui, David Tran, Samir Koirala, Hang Chen, Ian N Foltz, Songli Wang, Shilpa Sambashiva. TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant The Journal of biological chemistry. vol 293. issue 32. 2019-02-15. PMID:29599291. |
trem2-activating antibodies abrogate the negative pleiotropic effects of the alzheimer's disease variant triggering receptor expressed on myeloid cells 2 (trem2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. |
2019-02-15 |
2023-08-13 |
Not clear |
| Athena Sudom, Santosh Talreja, Jean Danao, Eric Bragg, Rob Kegel, Xiaoshan Min, Jason Richardson, Zhongqi Zhang, Nikolai Sharkov, Edoardo Marcora, Steve Thibault, Jodi Bradley, Steve Wood, Ai-Ching Lim, Hang Chen, Songli Wang, Ian N Foltz, Shilpa Sambashivan, Zhulun Wan. Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. The Journal of biological chemistry. vol 293. issue 32. 2019-02-07. PMID:29794134. |
triggering receptor expressed on myeloid cells 2 (trem2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. |
2019-02-07 |
2023-08-13 |
Not clear |
| Hongbei Xu, Song Mu, Wenyi Qi. Microglia TREM2 is required for electroacupuncture to attenuate neuroinflammation in focal cerebral ischemia/reperfusion rats. Biochemical and biophysical research communications. vol 503. issue 4. 2019-01-15. PMID:30149915. |
microglia trem2 is required for electroacupuncture to attenuate neuroinflammation in focal cerebral ischemia/reperfusion rats. |
2019-01-15 |
2023-08-13 |
rat |
| Manru Ren, Ying Guo, Xinbing Wei, Shaoqi Yan, Yue Qin, Xiumei Zhang, Fan Jiang, Haiyan Lo. TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease. Experimental neurology. vol 302. 2018-12-11. PMID:29407460. |
triggering receptor expressed on myeloid cells-2 (trem2) was a newly identified receptor expressed on microglia. |
2018-12-11 |
2023-08-13 |
mouse |