| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
this function of apoe is likely linked to triggering receptor expressed on myeloid cells 2 (trem2), which is expressed by microglia in the cns. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
here, we review the rapidly growing literature on the role of disease-associated microglia, trem2 and apoe in the pathogenesis of alzheimer disease and present an integrated view of innate immune function in alzheimer disease. |
2019-08-15 |
2023-08-13 |
Not clear |
| Min Wang, Xiaoping Gao, Kai Zhao, Hemu Chen, Mei Xu, Kai Wan. Effect of TREM2 on Release of Inflammatory Factor from LPS-stimulated Microglia and Its Possible Mechanism. Annals of clinical and laboratory science. vol 49. issue 2. 2019-08-13. PMID:31028072. |
effect of trem2 on release of inflammatory factor from lps-stimulated microglia and its possible mechanism. |
2019-08-13 |
2023-08-13 |
Not clear |
| Min Wang, Xiaoping Gao, Kai Zhao, Hemu Chen, Mei Xu, Kai Wan. Effect of TREM2 on Release of Inflammatory Factor from LPS-stimulated Microglia and Its Possible Mechanism. Annals of clinical and laboratory science. vol 49. issue 2. 2019-08-13. PMID:31028072. |
this study aims to explore the effect of triggering a receptor expressed on myeloid cells 2 (trem2) in lipopolysaccharide (lps)-stimulated primary microglia cells and its mechanisms. |
2019-08-13 |
2023-08-13 |
Not clear |
| Sho Takatori, Wenbo Wang, Akihiro Iguchi, Taisuke Tomit. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms. Advances in experimental medicine and biology. vol 1118. 2019-08-02. PMID:30747419. |
interestingly, trem2 and many genes associated with disease risk are predominantly expressed in microglia, suggesting that these risk factors are involved in pathogenicity through common mechanisms involving microglia. |
2019-08-02 |
2023-08-13 |
Not clear |
| S Loppi, N Kolosowska, O Kärkkäinen, P Korhonen, M Huuskonen, A Grubman, H Dhungana, S Wojciechowski, Y Pomeshchik, M Giordano, H Kagechika, A White, S Auriola, J Koistinaho, G Landreth, K Hanhineva, K Kanninen, T Mal. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:30063972. |
along with the anti-inflammatory capacity of hx600 in vitro, treatment of ischemic mice with hx600 reduced ischemia induced iba-1, p38 and trem2 immunoreactivities, protected endogenous microglia from ischemia induced death and prevented leukocyte infiltration. |
2019-07-31 |
2023-08-13 |
mouse |
| Tomoko Sao, Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Yoko Mori, Shinichiro Ochi, Taku Yoshida, Takaaki Mori, Jun-Ichi Iga, Shu-Ichi Uen. TREM1 mRNA Expression in Leukocytes and Cognitive Function in Japanese Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 64. issue 4. 2019-07-26. PMID:30010135. |
triggering receptor expressed on myeloid cells 2 (trem2) activates the innate immune system, promotes phagocytosis by microglia, and is associated with alzheimer's disease (ad). |
2019-07-26 |
2023-08-13 |
Not clear |
| C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper, Isabella Ferando, Istvan Mody, Giovanni Coppola, Huaxi Xu, X William Yan. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. vol 97. issue 5. 2019-07-15. PMID:29518357. |
elevated trem2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in alzheimer's disease models. |
2019-07-15 |
2023-08-13 |
mouse |
| C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper, Isabella Ferando, Istvan Mody, Giovanni Coppola, Huaxi Xu, X William Yan. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. vol 97. issue 5. 2019-07-15. PMID:29518357. |
to study whether increasing trem2 gene dosage could modify the disease pathogenesis, we developed bac transgenic mice expressing human trem2 (bac-trem2) in microglia. |
2019-07-15 |
2023-08-13 |
mouse |
| C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper, Isabella Ferando, Istvan Mody, Giovanni Coppola, Huaxi Xu, X William Yan. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. vol 97. issue 5. 2019-07-15. PMID:29518357. |
in summary, our study shows that a genomic transgene-driven increase in trem2 expression reprograms microglia responsivity and ameliorates neuropathological and behavioral deficits in ad mouse models. |
2019-07-15 |
2023-08-13 |
mouse |
| Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia A. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. Cell biology international. vol 43. issue 4. 2019-07-15. PMID:29663649. |
trem2 inhibits inflammatory responses in mouse microglia by suppressing the pi3k/nf-κb signaling. |
2019-07-15 |
2023-08-13 |
mouse |
| Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia A. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. Cell biology international. vol 43. issue 4. 2019-07-15. PMID:29663649. |
this study aimed to investigate the effects of triggering receptor expressed on myeloid cell-2 (trem2) on the production of pro-inflammatory mediators and cytokines induced by lipopolysaccharide (lps) in bv2 microglia. |
2019-07-15 |
2023-08-13 |
mouse |
| Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia A. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. Cell biology international. vol 43. issue 4. 2019-07-15. PMID:29663649. |
thus, we concluded that trem2 inhibited neuroinflammation by down-regulating pi3 k/akt and nf-kb signaling in bv2 microglia. |
2019-07-15 |
2023-08-13 |
mouse |
| Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haas. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30630532. |
trem2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. |
2019-07-05 |
2023-08-13 |
Not clear |
| Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haas. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30630532. |
soluble trem2 (strem2) resulting from shedding of the trem2 ectodomain can be detected in the cerebrospinal fluid (csf) and is a surrogate measure of trem2-mediated microglia function. |
2019-07-05 |
2023-08-13 |
Not clear |
| C Gussago, M Casati, E Ferri, B Arosi. The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore. The Journal of frailty & aging. vol 8. issue 2. 2019-06-27. PMID:30997915. |
it has been reported that genetic variants of the triggering receptor expressed on myeloid cells-2 (trem2), a cell-surface receptor expressed in microglial cells, greatly increase the risk of ad, thus suggesting an involvement of the microglia in the ad pathogenesis. |
2019-06-27 |
2023-08-13 |
Not clear |
| Bettina Linnartz-Gerlach, Liviu-Gabriel Bodea, Christine Klaus, Aurélien Ginolhac, Rashi Halder, Lasse Sinkkonen, Jochen Walter, Marco Colonna, Harald Neuman. TREM2 triggers microglial density and age-related neuronal loss. Glia. vol 67. issue 3. 2019-06-13. PMID:30548312. |
cultured microglia of trem2 knock-out mice showed reduced phagocytosis and oxidative burst. |
2019-06-13 |
2023-08-13 |
mouse |
| Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirth. Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia. Acta neuropathologica communications. vol 6. issue 1. 2019-06-12. PMID:30340518. |
our data further indicate that gpnmb is part of a microglia activation state that is only present under neurodegenerative conditions and that is characterized by the up-regulation of a subset of genes including trem2, apoe and cst7. |
2019-06-12 |
2023-08-13 |
mouse |
| Su-Man Kim, Bo-Ram Mun, Sun-Jun Lee, Yechan Joh, Hwa-Youn Lee, Kon-Young Ji, Ha-Rim Choi, Eun-Hee Lee, Eun-Mi Kim, Ji-Hye Jang, Hyeong-Woo Song, Inhee Mook-Jung, Won-Seok Choi, Hyung-Sik Kan. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28894284. |
trem2 promotes aβ phagocytosis by upregulating c/ebpα-dependent cd36 expression in microglia. |
2019-06-11 |
2023-08-13 |
mouse |
| Su-Man Kim, Bo-Ram Mun, Sun-Jun Lee, Yechan Joh, Hwa-Youn Lee, Kon-Young Ji, Ha-Rim Choi, Eun-Hee Lee, Eun-Mi Kim, Ji-Hye Jang, Hyeong-Woo Song, Inhee Mook-Jung, Won-Seok Choi, Hyung-Sik Kan. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28894284. |
trem2 plays a critical role in the alleviation of alzheimer's disease by promoting aβ phagocytosis by microglia, but the detailed molecular mechanism underlying trem2-induced direct phagocytic activity of aβ remains to be revealed. |
2019-06-11 |
2023-08-13 |
mouse |