| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shoutang Wang, Meer Mustafa, Carla M Yuede, Santiago Viveros Salazar, Philip Kong, Hua Long, Michael Ward, Omer Siddiqui, Robert Paul, Susan Gilfillan, Adiljan Ibrahim, Hervé Rhinn, Ilaria Tassi, Arnon Rosenthal, Tina Schwabe, Marco Colonn. Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model. The Journal of experimental medicine. vol 217. issue 9. 2021-03-02. PMID:32579671. |
trem2 is a receptor for lipids expressed in microglia. |
2021-03-02 |
2023-08-13 |
mouse |
| Zhouyi Rong, Baoying Cheng, Li Zhong, Xiaowen Ye, Xin Li, Lin Jia, Yanfang Li, Francis Shue, Na Wang, Yiyun Cheng, Xiaohua Huang, Chia-Chen Liu, John D Fryer, Xin Wang, Yun-Wu Zhang, Honghua Zhen. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32613609. |
activation of fak/rac1/cdc42-gtpase signaling ameliorates impaired microglial migration response to aβ mutation of triggering receptor expressed on myeloid cells 2 (trem2) impairs the response of microglia to amyloid-β (aβ) pathology in alzheimer's disease (ad), although the mechanism governing trem2-regulated microglia recruitment to aβ plaques remains unresolved. |
2021-02-25 |
2023-08-13 |
Not clear |
| Siqiang Ren, Wen Yao, Marc D Tambini, Tao Yin, Kelly A Norris, Luciano D'Adami. Microglia eLife. vol 9. 2021-02-22. PMID:32579116. |
microglia to study the mechanisms by which the p.r47h variant of the microglia gene and alzheimer's disease (ad) risk factor trem2 increases dementia risk, we created |
2021-02-22 |
2023-08-13 |
Not clear |
| Juan Kong, Zhigang Du, Li Don. Pinitol Prevents Lipopolysaccharide (LPS)-Induced Inflammatory Responses in BV2 Microglia Mediated by TREM2. Neurotoxicity research. vol 38. issue 1. 2021-02-18. PMID:32198705. |
pinitol prevents lipopolysaccharide (lps)-induced inflammatory responses in bv2 microglia mediated by trem2. |
2021-02-18 |
2023-08-13 |
Not clear |
| Xiao-Yan Li, Hong-Mei Wang, Ya Zhao, Chen Li, Jun Lu, Ji-Hong Wu, Ya T. [Effect of acupuncture on microglia activation in prefrontal cortex of chronic stress-induced depression rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 1. 2021-02-10. PMID:33559426. |
to observe the effect of acupuncture on the expression of proinflammatory cytokines interleukin-1β (il-1β), interleukin-6 (il-6), microglia marker ion calcium adaptor protein (iba-1) and triggering receptor expressed on myeloid cells 2 (trem2) in the prefrontal cortex of chronic stress-induced depression rats, so as to explore its antidepressant mechanism. |
2021-02-10 |
2023-08-13 |
rat |
| Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzma. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544086. |
it is likely that these trem2 variants increase ad risk by decreasing the response of microglia to aβ and its local toxicity. |
2021-02-08 |
2023-08-13 |
mouse |
| Mar Puigdellívol, David H Allendorf, Guy C Brow. Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration. Frontiers in cellular neuroscience. vol 14. 2021-02-03. PMID:32581723. |
activated microglia also release galectin-3 (gal-3), which: (i) further activates microglia via binding to tlr4 and trem2, (ii) binds to desialylated neurons opsonizing them for phagocytosis via mer tyrosine kinase, and (iii) promotes aβ aggregation and toxicity |
2021-02-03 |
2023-08-13 |
Not clear |
| Anne-Brita Knapskog, Kristi Henjum, Ane-Victoria Idland, Rannveig Sakshaug Eldholm, Karin Persson, Ingvild Saltvedt, Leiv Otto Watne, Knut Engedal, Lars N G Nilsso. Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification. Scientific reports. vol 10. issue 1. 2020-12-24. PMID:32985583. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor expressed by microglia. |
2020-12-24 |
2023-08-13 |
Not clear |
| Gemma Manich, Ariadna Regina Gómez-López, Beatriz Almolda, Nàdia Villacampa, Mireia Recasens, Kalpana Shrivastava, Berta González, Bernardo Castellan. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Frontiers in cellular neuroscience. vol 14. 2020-12-18. PMID:33328887. |
in the last years, the microglial receptor triggering receptor expressed on myeloid cells-2 (trem2) has been defined to mediate several microglial functions, including phagocytosis, survival, proliferation, and migration, and to be a key regulator of a new common microglial signature induced under neurodegenerative conditions and aging, also known as disease-associated microglia (dam). |
2020-12-18 |
2023-08-13 |
Not clear |
| Gemma Manich, Ariadna Regina Gómez-López, Beatriz Almolda, Nàdia Villacampa, Mireia Recasens, Kalpana Shrivastava, Berta González, Bernardo Castellan. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Frontiers in cellular neuroscience. vol 14. 2020-12-18. PMID:33328887. |
our results indicate the appearance of a subpopulation of microglia expressing trem2 after both anterograde and retrograde axonal injury. |
2020-12-18 |
2023-08-13 |
Not clear |
| Jing Li, Runtian Zhao, Yuhan Jiang, Yi Xu, Huan Zhao, Xiaoling Lyu, Tao W. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Food & function. vol 11. issue 2. 2020-11-23. PMID:32003387. |
immunofluorescence and rt-pcr analysis results showed that ba fully activates the microglia and astrocytes, downregulates the expression of inflammatory factors (tnf-α, nf-kβ, il-1β, il-6, cox-2, inos and cd33) and chemokine receptor cx3cr1, and upregulates the expression of microglia homeostatic factors (trem2 and tyrobp) and toll-like receptors (tlr2 and tlr4). |
2020-11-23 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
the discovery of trem2 as a myeloid-specific alzheimer's disease (ad) risk gene has accelerated research into the role of microglia in ad. |
2020-11-09 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
while trem2 mouse models have provided critical insight, the normal and disease-associated functions of trem2 in human microglia remain unclear. |
2020-11-09 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
single-cell sequencing of xenotransplanted human microglia further highlights a loss of disease-associated microglial (dam) responses in human trem2 knockout microglia that we validate by flow cytometry and immunohistochemistry. |
2020-11-09 |
2023-08-13 |
mouse |
| Benjamin J Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M Monroe, Joseph W Lewcoc. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature neuroscience. vol 23. issue 8. 2020-11-05. PMID:32514138. |
alzheimer's-associated plcγ2 is a signaling node required for both trem2 function and the inflammatory response in human microglia. |
2020-11-05 |
2023-08-13 |
mouse |
| Benjamin J Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M Monroe, Joseph W Lewcoc. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature neuroscience. vol 23. issue 8. 2020-11-05. PMID:32514138. |
human genetic data indicate that microglial dysfunction contributes to the pathology of alzheimer's disease (ad), exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2 (trem2) and, more recently, in plcg2, a phospholipase-encoding gene expressed in microglia. |
2020-11-05 |
2023-08-13 |
mouse |
| Anurag K Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj T Kulkarni, Santosh Kumar Sing. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles. Current Alzheimer research. vol 16. issue 13. 2020-10-06. PMID:31481003. |
however, whether decrease level of trem2 assists pathology of tau through changed clearance and pathological escalation of tau or through direct contact between microglia and neuron and any alternative possible mechanisms need to examine. |
2020-10-06 |
2023-08-13 |
Not clear |
| Yingyue Zhou, Tyler K Ulland, Marco Colonn. TREM2-Dependent Effects on Microglia in Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30038567. |
trem2 is an immunoreceptor primarily present on microglia in the cns that binds to polyanionic molecules. |
2020-10-01 |
2023-08-13 |
mouse |
| Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillo. Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30297984. |
we demonstrate that this protocol successfully decreases the expression of two key genes associated with ad, the triggering receptor expressed in myeloid cells 2 (trem2) and cd33, in primary microglia cell cultures. |
2020-10-01 |
2023-08-13 |
Not clear |
| Matthias Brendel, Gernot Kleinberger, Federico Probst, Anna Jaworska, Felix Overhoff, Tanja Blume, Nathalie L Albert, Janette Carlsen, Simon Lindner, Franz Josef Gildehaus, Laurence Ozmen, Marc Suárez-Calvet, Peter Bartenstein, Karlheinz Baumann, Michael Ewers, Jochen Herms, Christian Haass, Axel Rominge. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28197095. |
since trem2 is specifically expressed by microglia in the brain, we hypothesized that soluble trem2 (strem2) levels may increase together with |
2020-09-30 |
2023-08-13 |
mouse |