| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
various immunohistochemical techniques and western blot analyses were applied to examine expressions of trem2, microglia, aβ, neuronal migration protein doublecortin (dcx) and bdnf in the hippocampus of mice. |
2020-06-26 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
in the present study, we found the plaques-associated microglia lowly expressed trem2 and bdnf in aβ1-42 intra-hippocampal injected mice. |
2020-06-26 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
this means that up-regulation of trem2 might induce the microglia to express the bdnf. |
2020-06-26 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
these findings further indicate that the level of trem2 may affect the microglia response to pathological process induced by aβ. |
2020-06-26 |
2023-08-13 |
mouse |
| Eyiyemisi C Damisah, Anupama Rai, Jaime Grutzendle. TREM2: Modulator of Lipid Metabolism in Microglia. Neuron. vol 105. issue 5. 2020-06-18. PMID:32135085. |
trem2: modulator of lipid metabolism in microglia. |
2020-06-18 |
2023-08-13 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Jaime Grutzendle. TREM2: Modulator of Lipid Metabolism in Microglia. Neuron. vol 105. issue 5. 2020-06-18. PMID:32135085. |
(2020) show by cell-specific lipidomics that trem2 deficiency leads to cholesterol ester (ce) overload in microglia. |
2020-06-18 |
2023-08-13 |
Not clear |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
triggering receptor expressed on myeloid cells-2 (trem2) is an innate immune receptor that promotes phagocytosis by myeloid cells such as microglia and macrophages. |
2020-05-18 |
2023-08-13 |
mouse |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
we now clarify whether trem2 on brain microglia or circulating macrophages contribute to its beneficial role in ischemic stroke by generating bone marrow (bm) chimeric mice. |
2020-05-18 |
2023-08-13 |
mouse |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
mice with intact trem2 in brain microglia showed better neurological recovery and reduced infarct volumes, compared with mice lacking microglial trem2. |
2020-05-18 |
2023-08-13 |
mouse |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
these results suggest that trem2 expression is important for post-stroke recovery, and that trem2 expression on brain resident microglia is more essential to this recovery, than that of circulating macrophages. |
2020-05-18 |
2023-08-13 |
mouse |
| Christel Claes, Johanna Van Den Daele, Ruben Boon, Sarah Schouteden, Alessio Colombo, Laura Sebastian Monasor, Mark Fiers, Laura Ordovás, FatemehArefeh Nami, Bernd Bohrmann, Sabina Tahirovic, Bart De Strooper, Catherine M Verfailli. Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 3. 2020-05-05. PMID:30442540. |
murine microglia expressing the alzheimer's disease-linked trem2 |
2020-05-05 |
2023-08-13 |
human |
| Yingyue Zhou, Wilbur M Song, Prabhakar S Andhey, Amanda Swain, Tyler Levy, Kelly R Miller, Pietro L Poliani, Manuela Cominelli, Shikha Grover, Susan Gilfillan, Marina Cella, Tyler K Ulland, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Makoto Sainouchi, Akiyoshi Kakita, David A Bennett, Julie A Schneider, Michael R Nichols, Sean A Beausoleil, Jason D Ulrich, David M Holtzman, Maxim N Artyomov, Marco Colonn. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nature medicine. vol 26. issue 1. 2020-04-13. PMID:31932797. |
variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (trem2) increase ad risk, and activation of disease-associated microglia (dam) is dependent on trem2 in mouse models of ad. |
2020-04-13 |
2023-08-13 |
mouse |
| Taylor R Jay, Victoria E von Saucken, Braulio Muñoz, Juan F Codocedo, Brady K Atwood, Bruce T Lamb, Gary E Landret. TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia. vol 67. issue 10. 2020-03-16. PMID:31265185. |
to understand the role of trem2 on microglia more generally, we investigated changes in microglial function in trem2 |
2020-03-16 |
2023-08-13 |
Not clear |
| Gregory A Elder, Michelle E Ehrlich, Sam Gand. Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans. Neuroscience letters. vol 707. 2020-03-11. PMID:31141716. |
at the molecular level, recent studies have identified trem2 and tyrobp/dap12 as components of a key molecular hub linking inflammation and microglia to the pathophysiology of ad and possibly tbi. |
2020-03-11 |
2023-08-13 |
Not clear |
| Huiping Long, Gang Zhong, Chengzhi Wang, Jian Zhang, Yueling Zhang, Jinglian Luo, Shengliang Sh. TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling. Neurochemical research. vol 44. issue 8. 2020-01-06. PMID:31134514. |
the triggering receptor expressed on myeloid cells 2 (trem2) gene is associated with the pathogenesis of load and plays important roles in mediating the phagocytosis of aβ by microglia and regulating inflammation in central nervous system. |
2020-01-06 |
2023-08-13 |
Not clear |
| Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Panagiotis Alexopoulos, Robert Perneczk. CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum. Neurobiology of aging. vol 74. 2019-11-26. PMID:30458365. |
trem2 was suggested to be an important regulator of microglia during neurodegeneration, but previous studies report conflicting results in relation to soluble trem2 (strem2) in cerebrospinal fluid (csf) when using clinical criteria to classify alzheimer's disease (ad). |
2019-11-26 |
2023-08-13 |
human |
| Beata Peplonska, Mariusz Berdynski, Monika Mandecka, Anna Barczak, Magdalena Kuzma-Kozakiewicz, Maria Barcikowska, Cezary Zekanowsk. TREM2 variants in neurodegenerative disorders in the Polish population. Homozygosity and compound heterozygosity in FTD patients. Amyotrophic lateral sclerosis & frontotemporal degeneration. vol 19. issue 5-6. 2019-10-21. PMID:29557178. |
activation of the trem2 receptor on microglia stimulates phagocytosis and decreases the microglial proinflammatory response. |
2019-10-21 |
2023-08-13 |
human |
| Jerel Adam Fields, Brian Spencer, Mary Swinton, Emma Martine Qvale, María J Marquine, Arina Alexeeva, Sarah Gough, Benchawanna Soontornniyomkij, Elvira Valera, Eliezer Masliah, Cristian L Achim, Paula Desplat. Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. Journal of neurochemistry. vol 147. issue 6. 2019-09-27. PMID:30152135. |
in this retrospective study, we investigated trem2 expression levels and localization to microglia, aβ protein levels, and tumor necrosis factor (tnf)-α transcript levels in the frontal cortices of 52 hiv+ decedents. |
2019-09-27 |
2023-08-13 |
Not clear |
| Lihang Zhang, Juan Xu, Jinchao Gao, Yuncheng Wu, Ming Yin, Wenjuan Zha. CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer's disease. Reviews in the neurosciences. vol 29. issue 8. 2019-08-29. PMID:29729150. |
accumulating studies have revealed that in the cns, cluster of differentiation-200 (cd200) and fractalkine (cx3cl1) expressed mainly on neurons and triggering receptor expressed on myeloid cells 2 (trem2) expressed mainly on microglia. |
2019-08-29 |
2023-08-13 |
Not clear |
| Tyler K Ulland, Marco Colonn. TREM2 - a key player in microglial biology and Alzheimer disease. Nature reviews. Neurology. vol 14. issue 11. 2019-08-29. PMID:30266932. |
variations in triggering receptor expressed on myeloid cells 2 (trem2), one of several genes for which expression is restricted to microglia in the brain, have now been shown to increase the risk of developing late-onset ad. |
2019-08-29 |
2023-08-13 |
mouse |