| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Che. Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29587871. |
trem2 is an innate immune receptor specifically expressed in microglia. |
2018-11-09 |
2023-08-13 |
Not clear |
| Yingjun Zhao, Xiaoguang Li, Timothy Huang, Lu-Lin Jiang, Zhenqiu Tan, Muxian Zhang, Irene Han-Juo Cheng, Xin Wang, Guojun Bu, Yun-Wu Zhang, Qi Wang, Huaxi X. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & molecular medicine. vol 49. issue 12. 2018-10-26. PMID:29611543. |
in the brain, trem2 is highly expressed on the cell surface of microglia, where it can transduce signals to regulate microglial functions such as phagocytosis. |
2018-10-26 |
2023-08-13 |
Not clear |
| Yingjun Zhao, Xiaoguang Li, Timothy Huang, Lu-Lin Jiang, Zhenqiu Tan, Muxian Zhang, Irene Han-Juo Cheng, Xin Wang, Guojun Bu, Yun-Wu Zhang, Qi Wang, Huaxi X. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & molecular medicine. vol 49. issue 12. 2018-10-26. PMID:29611543. |
furthermore, ps1 overexpression results in attenuated phagocytic uptake of aβ by microglia, which is reversed by trem2 overexpression. |
2018-10-26 |
2023-08-13 |
Not clear |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
as a recently identified susceptibility gene for alzheimer's disease (ad), triggering receptor expressed on myeloid cells 2 (trem2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
more importantly, by manipulating trem2 levels in microglia with a lentiviral-mediated strategy, we demonstrated that trem2 ameliorated the pathological effects of activated microglia on neuronal tau hyperphosphorylation via suppression of microglial inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
trem2 modulates microglia phenotypes in the neuroinflammation of parkinson's disease. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
triggering receptor expressed on myeloid cells-2 (trem2) is a recently identified immune receptor expressed by the microglia in the brain. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
emerging evidence indicates that trem2 enhances the phagocytosis function of microglia and suppress inflammation. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
based on these evidence, we hypothesized that trem2 might play a protective role through regulating microglia polarization. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
here, we employ a lentiviral strategy to overexpress or suppress trem2 on microglia and found that trem2 was essential for m2 microglia polarization. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
knockdown of trem2 in bv2 microglia inhibited m2 polarization and lead to exaggeration of m1 microglial inflammatory responses, whereas overexpression of trem2 promoted m2 polarization and alleviated microglial inflammation. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
we also observed that the trem2 level was higher in the midbrain of pd mice, which was accompanied by an elevated level of arginase-1 and increased proinflammatory cytokines, suggesting that trem2 is an important factor in switching the microglia phenotypes. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
taken together, these findings indicate that trem2 plays a crucial role in altering the proinflammatory m1 microglia to m2 phenotype and has beneficial effects in the immune pathogenesis of pd. |
2018-10-09 |
2023-08-13 |
mouse |
| Carmen Mecca, Ileana Giambanco, Rosario Donato, Cataldo Arcur. Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361745. |
as a microglial surface receptor, trem2 interacts with dap12 to initiate signal transduction pathways that promote microglial cell activation, phagocytosis, and microglial cell survival. |
2018-08-03 |
2023-08-13 |
human |
| Xiaobao Zhang, Fang Yan, Jizheng Cui, Yong Wu, Hengfei Luan, Miaomiao Yin, Zhibin Zhao, Jiying Feng, Jinwei Zhan. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia. Mediators of inflammation. vol 2017. 2018-07-09. PMID:29180839. |
this study was designed to elucidate the effect of trem2 on microglia. |
2018-07-09 |
2023-08-13 |
Not clear |
| Xiaobao Zhang, Fang Yan, Jizheng Cui, Yong Wu, Hengfei Luan, Miaomiao Yin, Zhibin Zhao, Jiying Feng, Jinwei Zhan. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia. Mediators of inflammation. vol 2017. 2018-07-09. PMID:29180839. |
we showed that lipopolysaccharide (lps) stimulation significantly increases proinflammatory cytokines and suppressed trem2 in microglia. |
2018-07-09 |
2023-08-13 |
Not clear |
| Xiaobao Zhang, Fang Yan, Jizheng Cui, Yong Wu, Hengfei Luan, Miaomiao Yin, Zhibin Zhao, Jiying Feng, Jinwei Zhan. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia. Mediators of inflammation. vol 2017. 2018-07-09. PMID:29180839. |
in addition, trem2 overexpression inhibited lps-induced microglia activation and elevated m2 phenotype of microglia. |
2018-07-09 |
2023-08-13 |
Not clear |
| Xiaobao Zhang, Fang Yan, Jizheng Cui, Yong Wu, Hengfei Luan, Miaomiao Yin, Zhibin Zhao, Jiying Feng, Jinwei Zhan. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia. Mediators of inflammation. vol 2017. 2018-07-09. PMID:29180839. |
together, our results demonstrate that trem2 overexpression reduced lps-induced proinflammatory cytokine release in microglia and increased m2 phenotype of microglia. |
2018-07-09 |
2023-08-13 |
Not clear |
| Cheryl E G Leyns, Jason D Ulrich, Mary B Finn, Floy R Stewart, Lauren J Koscal, Javier Remolina Serrano, Grace O Robinson, Elise Anderson, Marco Colonna, David M Holtzma. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 43. 2018-06-26. PMID:29073081. |
in the brain, trem2 is predominately expressed on microglia, and its association with ad adds to increasing evidence implicating a role for the innate immune system in ad initiation and progression. |
2018-06-26 |
2023-08-13 |
mouse |
| Dominik Feuerbach, Patrick Schindler, Carmen Barske, Stefanie Joller, Edwige Beng-Louka, Katie A Worringer, Sravya Kommineni, Ajamete Kaykas, Daniel J Ho, Chaoyang Ye, Karl Welzenbach, Gaelle Elain, Laurent Klein, Irena Brzak, Anis K Mir, Christopher J Farady, Reiner Aichholz, Simone Popp, Nathalie George, Ulf Neuman. ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. Neuroscience letters. vol 660. 2018-06-11. PMID:28923481. |
triggering receptor expressed in myeloid cells (trem2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. |
2018-06-11 |
2023-08-13 |
human |