| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Che. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28680398. |
trem2 has also been shown to stimulate the phagocytosis of apoptotic neurons and define the barrier function in microglia. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hiroyuki Konishi, Hiroshi Kiyam. Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30127720. |
plasma membrane receptors play primary roles as activators of microglia and in this review, we focus on a receptor complex involving triggering receptor expressed on myeloid cells 2 (trem2) and dnax-activating protein of 12 kda (dap12), both of which are causative genes for nasu-hakola disease, a dementia with bone cysts. |
2020-09-30 |
2023-08-13 |
Not clear |
| Honghua Zheng, Baoying Cheng, Yanfang Li, Xin Li, Xiaofen Chen, Yun-Wu Zhan. TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30532704. |
trem2 is specifically expressed in brain microglia and modulates microglial functions in response to key ad pathologies such as amyloid-β (aβ) plaques and tau tangles. |
2020-09-30 |
2023-08-13 |
Not clear |
| Honghua Zheng, Baoying Cheng, Yanfang Li, Xin Li, Xiaofen Chen, Yun-Wu Zhan. TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30532704. |
in this review article, we discuss recent research progress in our understanding on the role of trem2 in microglia and its relevance to ad pathologies. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hailan Yao, Kyle Coppola, Jonas Elias Schweig, Fiona Crawford, Michael Mullan, Daniel Pari. Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31649511. |
several genetic variants of the triggering receptor expressed on myeloid cells-2 (trem2) have been shown to increase the risk of developing alzheimer's disease (ad) supporting a role of microglia and immune cells in the pathobiology of ad. |
2020-09-30 |
2023-08-13 |
Not clear |
| Pascal Gervois, Ivo Lambricht. The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke. Frontiers in immunology. vol 10. 2020-09-28. PMID:31379859. |
triggering receptor expressed on myeloid cells 2 (trem2) is a cell surface receptor which in the central nervous system is mainly expressed on microglia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Juan García-Revilla, Isabel M Alonso-Bellido, Miguel A Burguillos, Antonio J Herrera, Ana M Espinosa-Oliva, Rocío Ruiz, Luis Cruz-Hernández, Irene García-Domínguez, María A Roca-Ceballos, Marti Santiago, José A Rodríguez-Gómez, Manuel Sarmiento Soto, Rocío M de Pablos, José L Vener. Reformulating Pro-Oxidant Microglia in Neurodegeneration. Journal of clinical medicine. vol 8. issue 10. 2020-09-28. PMID:31627485. |
however, the recent identification of endogenous disease-related ligands, which bind to and activate both tlrs and trem2, anticipates the existence of rather complex microglia responses. |
2020-09-28 |
2023-08-13 |
Not clear |
| Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M Pococ. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-28. PMID:31907987. |
a locked immunometabolic switch underlies trem2 r47h loss of function in human ipsc-derived microglia. |
2020-09-28 |
2023-08-13 |
human |
| Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M Pococ. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-28. PMID:31907987. |
microglia, the resident immune cell of the brain, express trem2, and microglial responses are implicated in dementia pathways. |
2020-09-28 |
2023-08-13 |
human |
| Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M Pococ. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-28. PMID:31907987. |
we investigated the role of trem2 on the microglial metabolic function in human patient ipsc-derived microglia expressing loss of function variants in trem2. |
2020-09-28 |
2023-08-13 |
human |
| Gen-Lin He, Zhen Luo, Ting-Ting Shen, Ze-Ze Wang, Ping Li, Xue Luo, Ju Yang, Yu-Long Tan, Yuan Wang, Peng Gao, Xue-Sen Yan. TREM2 Regulates Heat Acclimation-Induced Microglial M2 Polarization Involving the PI3K-Akt Pathway Following EMF Exposure. Frontiers in cellular neuroscience. vol 13. 2020-09-28. PMID:32009907. |
the function of triggering receptor expressed on myeloid cells-2 (trem2) has been described within microglia with a beneficial activated phenotype. |
2020-09-28 |
2023-08-13 |
Not clear |
| Bailey A Loving, Kimberley D Bruc. Lipid and Lipoprotein Metabolism in Microglia. Frontiers in physiology. vol 11. 2020-09-28. PMID:32411016. |
increased expression of genes such as apolipoprotein e (apoe), triggering receptor expressed on myeloid cells 2 (trem2) and lipoprotein lipase (lpl) in microglia during development, damage, and disease, suggest that increased lipid metabolism is needed to fuel protective cellular functions such as phagocytosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qiming Xu, Wei Xu, Hao Cheng, Hong Yuan, Xiangshi Ta. Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31283973. |
additionally, trem2 regulates microglia polarization from m1 towards m2 phenotype thereby achieves reduction of neuroinflammation in ad. |
2020-08-14 |
2023-08-13 |
mouse |
| Daria Bortolotti, Valentina Gentili, Antonella Rotola, Elisabetta Caselli, Roberta Rizz. HHV-6A infection induces amyloid-beta expression and activation of microglial cells. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31831060. |
we evaluated the effect of hhv-6a infection on microglial cell expression aβ and the activation status, determined by trem2, apoe, cytokines, and tau expression. |
2020-08-06 |
2023-08-13 |
Not clear |
| Stefan Prokop, Kelly R Miller, Sergio R Labra, Rose M Pitkin, Kevt'her Hoxha, Sneha Narasimhan, Lakshmi Changolkar, Alyssa Rosenbloom, Virginia M-Y Lee, John Q Trojanowsk. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31350575. |
carriers of ad-associated risk variants in trem2 (triggering receptor expressed on myeloid cells 2) showed a reduction of plaque-associated microglia and a substantial increase in dystrophic neurites and overall pathological tau compared with age and disease stage matched ad patients without trem2 risk variants. |
2020-08-04 |
2023-08-13 |
human |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
furthermore, ad risk genes such as triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. |
2020-07-30 |
2023-08-13 |
Not clear |
| Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, Christian Haas. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science translational medicine. vol 11. issue 507. 2020-07-27. PMID:31462511. |
loss of function of trem2, a key receptor selectively expressed by microglia in the brain, contributes to the development of alzheimer's disease (ad). |
2020-07-27 |
2023-08-13 |
human |
| Francesca Grassivaro, Ramesh Menon, Massimo Acquaviva, Linda Ottoboni, Francesca Ruffini, Andrea Bergamaschi, Luca Muzio, Cinthia Farina, Gianvito Martin. Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 4. 2020-07-23. PMID:31818979. |
this comprehensive approach demonstrated that the phenotypic differentiation between microglia and peripheral macrophages is age-dependent and that peripheral macrophages do express some of the most commonly described microglia-specific markers early during development, such as fcrls, p2ry12, tmem119, and trem2. |
2020-07-23 |
2023-08-13 |
mouse |
| Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C G Haddick, Melina Lenser, Timothy K Earr, Ju Shi, Jason C Dugas, Benjamin J Andreone, Todd Logan, Hilda O Solanoy, Hang Chen, Ankita Srivastava, Suresh B Poda, Pascal E Sanchez, Ryan J Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W Lewcock, Kathryn M Monroe, Gilbert Di Paol. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. vol 105. issue 5. 2020-07-07. PMID:31902528. |
loss-of-function (lof) variants of trem2, an immune receptor expressed in microglia, increase alzheimer's disease risk. |
2020-07-07 |
2023-08-13 |
human |
| Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C G Haddick, Melina Lenser, Timothy K Earr, Ju Shi, Jason C Dugas, Benjamin J Andreone, Todd Logan, Hilda O Solanoy, Hang Chen, Ankita Srivastava, Suresh B Poda, Pascal E Sanchez, Ryan J Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W Lewcock, Kathryn M Monroe, Gilbert Di Paol. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. vol 105. issue 5. 2020-07-07. PMID:31902528. |
our studies identify trem2 as a key transcriptional regulator of cholesterol transport and metabolism under conditions of chronic myelin phagocytic activity, as trem2 lof causes pathogenic lipid accumulation in microglia. |
2020-07-07 |
2023-08-13 |
human |