| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pascale Vergne-Salle, Philippe Berti. Chronic pain and neuroinflammation. Joint bone spine. vol 88. issue 6. 2021-11-22. PMID:34022418. |
these afferent fibers release neurotransmitters in the dorsal root ganglion and dorsal horn of the spinal cord, capable of activating microglia, which are the local immune cells. |
2021-11-22 |
2023-08-13 |
Not clear |
| Sungkun Chun, Jun-Ho Lee, Seo-Yeon Yoon, Young-Bae Kwo. The Peripheral Role of CCL2 in the Anti-Nociceptive Effect of Sigma-1 Receptor Antagonist BD1047 on Inflammatory Hyperalgesia in Rats. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769165. |
single treatment of bd1047 before intraplantar injection of zymosan in rats significantly reduced thermal hyperalgesia and mechanical hyperalgesia, as well as ccl2 expression in drg neurons and microglia activation in the spinal dorsal horn. |
2021-11-18 |
2023-08-13 |
rat |
| M Carmen Ruiz-Cantero, Rafael González-Cano, Miguel Á Tejada, Miriam Santos-Caballero, Gloria Perazzoli, Francisco R Nieto, Enrique J Cobo. Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain. Pharmacological research. vol 163. 2021-11-17. PMID:33276102. |
sigma-1 receptor inhibition prevents peripheral (macrophage infiltration into the dorsal root ganglion) and central (activation of microglia and astrocytes) neuroinflammation in several pain models, and enhances immune-driven peripheral opioid analgesia during painful inflammation, maximizing the analgesic potential of peripheral immune cells. |
2021-11-17 |
2023-08-13 |
Not clear |
| Svetlana Gushchina, Ping K Yip, Glesni A Parry, Haripriya Sivakumar, Jie Li, Min Liu, Xuenong B. Alleviation of neuropathic pain by over-expressing a soluble colony-stimulating factor 1 receptor to suppress microgliosis and macrophage accumulation. Glia. vol 69. issue 12. 2021-10-11. PMID:34472629. |
a significant increase in microglia densities in the dorsal and ventral horns of lumbar spinal cords and macrophage densities in drg and sciatic nerves were observed in the mice with either ligation alone or pre-treated with aav9/gfp. |
2021-10-11 |
2023-08-13 |
mouse |
| Svetlana Gushchina, Ping K Yip, Glesni A Parry, Haripriya Sivakumar, Jie Li, Min Liu, Xuenong B. Alleviation of neuropathic pain by over-expressing a soluble colony-stimulating factor 1 receptor to suppress microgliosis and macrophage accumulation. Glia. vol 69. issue 12. 2021-10-11. PMID:34472629. |
in nerve-ligated mice pre-treated with aav9/scsf1r the microglia densities in the dorsal and ventral horns and macrophage densities in drg and sciatic nerves were significantly lower compared to nerve-ligated mice pre-treated with aav9/gfp. |
2021-10-11 |
2023-08-13 |
mouse |
| Xiaobing Yu, Allan Basbaum, Zhonghui Gua. Contribution of colony-stimulating factor 1 to neuropathic pain. Pain reports. vol 6. issue 1. 2021-09-29. PMID:33981926. |
we previously reported that sensory neuron-derived colony-stimulating factor 1 (csf1), by engaging the csf1 receptor (csf1r) that is expressed by both microglia and macrophages, triggers the nerve injury-induced expansion of both resident microglia in the spinal cord and macrophages in the dorsal root ganglion and induces their respective contributions to the neuropathic pain phenotype. |
2021-09-29 |
2023-08-13 |
Not clear |
| Lital Livni, Brooke A Keating, Nathan T Fiore, Justin G Lees, David Goldstein, Gila Moalem-Taylo. Effects of combined chemotherapy and anti-programmed cell death protein 1 treatment on peripheral neuropathy and neuroinflammation in mice. Pain. 2021-08-18. PMID:34224494. |
mice treated with paclitaxel or cotherapy had increased macrophage presence in the drg, and all treated groups presented an altered expression of microglia markers in the dorsal horn of the spinal cord. |
2021-08-18 |
2023-08-13 |
mouse |
| Johannes Leuchtweis, Gisela Segond von Banchet, Annett Eitner, Matthias Ebbinghaus, Hans-Georg Schaibl. Pain-related behaviors associated with persistence of mechanical hyperalgesia after antigen-induced arthritis in rats. Pain. vol 161. issue 7. 2021-05-14. PMID:32149861. |
however, none of the rats showed an expression of atf3 in dorsal root ganglion neurons, nor morphological spinal microglia activation thus not suggesting development of neuropathic pain. |
2021-05-14 |
2023-08-13 |
rat |
| Yasmine Rabah, Bruna Rubino, Elsie Moukarzel, Cendra Agulho. Characterization of transgenic mouse lines for selectively targeting satellite glial cells and macrophages in dorsal root ganglia. PloS one. vol 15. issue 9. 2020-10-27. PMID:32915783. |
here, we characterized in dorsal root ganglia (drgs), different genetically-modified mouse lines previously used for studying astrocytes and microglia, with the goal to implement them for investigating drg sgc and macrophage functions. |
2020-10-27 |
2023-08-13 |
mouse |
| Melissa Jones, Jie Wen, Prabhuanand Selvaraj, Mikiei Tanaka, Sean Moran, Yumin Zhan. Therapeutic Effect of the Substrate-Selective COX-2 Inhibitor IMMA in the Animal Model of Chronic Constriction Injury. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30618769. |
accumulation of astrocytes and microglia in spinal cord dorsal horn and infiltration of macrophages into the dorsal root ganglion and sciatic nerve were reduced by drug treatment. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiaobing Yu, Hongju Liu, Katherine A Hamel, Maelig G Morvan, Stephen Yu, Jacqueline Leff, Zhonghui Guan, Joao M Braz, Allan I Basbau. Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nature communications. vol 11. issue 1. 2020-04-23. PMID:31937758. |
paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (drg). |
2020-04-23 |
2023-08-13 |
mouse |
| Yul Huh, Ru-Rong Ji, Gang Che. Neuroinflammation, Bone Marrow Stem Cells, and Chronic Pain. Frontiers in immunology. vol 8. 2019-11-20. PMID:28871264. |
characteristic features of neuroinflammation in chronic pain conditions include infiltration of immune cells into the pns [e.g., the sciatic nerve and dorsal root ganglion (drg)], activation of glial cells such as microglia and astrocytes in the cns (spinal cord and brain), and production and secretion of pro-inflammatory cytokines and chemokines [tnf, interleukin (il)-1β, il-6, ccl2, and cxcl1]. |
2019-11-20 |
2023-08-13 |
Not clear |
| Koichi Isami, Satoshi Imai, Asami Sukeishi, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30171890. |
c3h/heslc mice exhibited a significant increase in cd206-immunoreactivity (anti-inflammatory macrophages) in the dorsal root ganglia (drg) at 3 and 7 days, and lower iba1-immunoreactivity (microglia) in the spinal cord from 3 to 14 days after psnl than c57bl/6j mice. |
2019-09-10 |
2023-08-13 |
mouse |
| Koichi Isami, Satoshi Imai, Asami Sukeishi, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30171890. |
these phenomena might be associated with a decrease in the production of inflammatory factors (interleukin-1β, interleukin-6, and cx3cl1) in the drg and the poor responsiveness of spinal microglia (i.e. |
2019-09-10 |
2023-08-13 |
mouse |
| Koichi Isami, Satoshi Imai, Asami Sukeishi, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. The impact of mouse strain-specific spatial and temporal immune responses on the progression of neuropathic pain. Brain, behavior, and immunity. vol 74. 2019-09-10. PMID:30171890. |
these findings suggest that the strain-specific aspects of drg macrophages and spinal microglia might be related to the early and late phases of psnl-induced mechanical hypersensitivity, respectively. |
2019-09-10 |
2023-08-13 |
mouse |
| Dekun Yin, Yonglin Chen, Yao Li, Rongxiang Lu, Binbin Wang, Shunxing Zhu, Bingbing Fan, Zhongling X. Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats. Neurochemical research. vol 44. issue 5. 2019-06-11. PMID:30859436. |
the staining further confirmed that irak1 was mainly co-located in the drg astrocytes or sc neurons, but less in the drg microglia or sc astrocytes. |
2019-06-11 |
2023-08-13 |
rat |
| Yuya Kawarai, Sumihisa Orita, Junichi Nakamura, Shuichi Miyamoto, Miyako Suzuki, Kazuhide Inage, Shigeo Hagiwara, Takane Suzuki, Takayuki Nakajima, Tsutomu Akazawa, Seiji Ohtor. Changes in proinflammatory cytokines, neuropeptides, and microglia in an animal model of monosodium iodoacetate-induced hip osteoarthritis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 36. issue 11. 2019-05-09. PMID:29888808. |
mia rats also presented significantly more fg-labeled gap-43-ir drg neurons than the sham group on post-induction days 28, 42, and 56 (p < 0.05), and a significantly higher number of iba-1-ir microglia in the ipsilateral dorsal horn than the other groups, on post-induction days 28, 42, and 56. |
2019-05-09 |
2023-08-13 |
rat |
| Monara Kaélle Sérvulo Cruz Angelim, Luciana Maria Silva de Seixas Maia, Christine Mouffle, Florent Ginhoux, Donovan Low, Angela Amancio-Dos-Santos, Jennifer Makhoul, Hervé Le Corronc, Jean-Marie Mangin, Pascal Legendr. Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. Glia. vol 66. issue 11. 2019-03-26. PMID:30252950. |
embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. |
2019-03-26 |
2023-08-13 |
mouse |
| Monara Kaélle Sérvulo Cruz Angelim, Luciana Maria Silva de Seixas Maia, Christine Mouffle, Florent Ginhoux, Donovan Low, Angela Amancio-Dos-Santos, Jennifer Makhoul, Hervé Le Corronc, Jean-Marie Mangin, Pascal Legendr. Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. Glia. vol 66. issue 11. 2019-03-26. PMID:30252950. |
when microglia colonize the spinal cord, from e11.5 in the mouse embryo, they interact with growing central axons of dorsal root ganglion sensory neurons (sns), which suggests that they may have some functions in sn development. |
2019-03-26 |
2023-08-13 |
mouse |
| Rongguo Liu, Xueru Xu, Yunlu Xu, Xiangyu Fang, Xingwu Li. Pulsed Radiofrequency on Dorsal Root Ganglion Relieved Neuropathic Pain Associated with Downregulation of the Spinal Interferon Regulatory Factor 8, Microglia, p38MAPK Expression in a CCI Rat Model. Pain physician. vol 21. issue 4. 2019-02-27. PMID:30045596. |
pulsed radiofrequency on dorsal root ganglion relieved neuropathic pain associated with downregulation of the spinal interferon regulatory factor 8, microglia, p38mapk expression in a cci rat model. |
2019-02-27 |
2023-08-13 |
rat |