| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zetang Wu, Shiyong Wang, Sandy Gruber, Marina Mata, David J Fin. Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons. Pain. vol 154. issue 9. 2014-03-21. PMID:23711481. |
we undertook the current study to test the hypothesis that mtnfα expressed in microglia might also affect the phenotype of primary sensory afferents, by determining the effect of crtnfα expressed from cos-7 cells on gene expression in primary dorsal root ganglia (drg) neurons. |
2014-03-21 |
2023-08-12 |
Not clear |
| Zetang Wu, Shiyong Wang, Sandy Gruber, Marina Mata, David J Fin. Full-length membrane-bound tumor necrosis factor-α acts through tumor necrosis factor receptor 2 to modify phenotype of sensory neurons. Pain. vol 154. issue 9. 2014-03-21. PMID:23711481. |
taken together, the results of this study suggest that mtnfα expressed in spinal microglia can facilitate pain signaling by up-regulating the expression of cation channels and ccl2 in drg neurons in a tnfr2-dependent manner. |
2014-03-21 |
2023-08-12 |
Not clear |
| Hee Kyung Cho, Yun Woo Cho, Eun Hyuk Kim, Menno E Sluijter, Se Jin Hwang, Sang Ho Ah. Changes in pain behavior and glial activation in the spinal dorsal horn after pulsed radiofrequency current administration to the dorsal root ganglion in a rat model of lumbar disc herniation: laboratory investigation. Journal of neurosurgery. Spine. vol 19. issue 2. 2013-10-17. PMID:23746090. |
using immunohistochemistry methods in the dorsal horn of a rat model of lumbar disc herniation, the authors investigated the effects of pulsed radiofrequency (prf) current administration to the dorsal root ganglion (drg) on pain-related behavior and activation of microglia, astrocytes, and mitogen-activated protein kinase. |
2013-10-17 |
2023-08-12 |
rat |
| Guihua Chen, Kumiko Tanabe, Fumi Yanagidate, Yasuhiko Kawasaki, Lianxi Zhang, Shuji Dohi, Hiroki Iid. Intrathecal endothelin-1 has antinociceptive effects in rat model of postoperative pain. European journal of pharmacology. vol 697. issue 1-3. 2013-05-02. PMID:23041152. |
endothelin-1 decreased the incision-induced increase in the numbers of phosphorylated erk-positive neurons in drg and activated microglia in the dorsal horn, without affecting the numbers of phosphorylated erk-positive neurons in the dorsal horn. |
2013-05-02 |
2023-08-12 |
rat |
| Guihua Chen, Kumiko Tanabe, Fumi Yanagidate, Yasuhiko Kawasaki, Lianxi Zhang, Shuji Dohi, Hiroki Iid. Intrathecal endothelin-1 has antinociceptive effects in rat model of postoperative pain. European journal of pharmacology. vol 697. issue 1-3. 2013-05-02. PMID:23041152. |
our results show that the pain threshold, which is decreased by surgical stimuli, is partially restored by intrathecal endothelin-1 through both endothelin et(a)- and et(b)- receptors in drg neurons and microglia in the spinal cord. |
2013-05-02 |
2023-08-12 |
rat |
| Donghoon Kim, Byunghyun You, Hyoungsub Lim, Sung Joong Le. Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury. Molecular pain. vol 7. 2012-05-11. PMID:21951975. |
in these mice, inflammatory gene expression and spinal cord microglia actvation is compromised, whereas the effects in the dorsal root ganglia (drg) have not been tested. |
2012-05-11 |
2023-08-12 |
mouse |
| Eun Hyun Kim, Da Hye Ryu, Sejin Hwan. The expression of corticotropin-releasing factor and its receptors in the spinal cord and dorsal root ganglion in a rat model of neuropathic pain. Anatomy & cell biology. vol 44. issue 1. 2011-07-14. PMID:21519550. |
after sni, crfr1 was expressed in the activated microglia in the ipsilateral dorsal horn, and immunoreaction for crfr2 was increased in the contralateral drg following sni. |
2011-07-14 |
2023-08-12 |
rat |
| Eun Hyun Kim, Da Hye Ryu, Sejin Hwan. The expression of corticotropin-releasing factor and its receptors in the spinal cord and dorsal root ganglion in a rat model of neuropathic pain. Anatomy & cell biology. vol 44. issue 1. 2011-07-14. PMID:21519550. |
consequently, it has been suggested that the increased expression of crf and crfr2 in drg neurons and primary afferent fibers in dorsal horn, and crfr1 in the activated microglia, may be involved in the mediation of stress responses as well as in microglial activation in the neuropathic pain state following sni. |
2011-07-14 |
2023-08-12 |
rat |
| Louis Doré-Savard, Valérie Otis, Karine Belleville, Myriam Lemire, Mélanie Archambault, Luc Tremblay, Jean-François Beaudoin, Nicolas Beaudet, Roger Lecomte, Martin Lepage, Louis Gendron, Philippe Sarre. Behavioral, medical imaging and histopathological features of a new rat model of bone cancer pain. PloS one. vol 5. issue 10. 2011-03-07. PMID:21048940. |
bone remodeling was accompanied by c-fos (spinal) and atf3 (drg) neuronal activation, sustained by astrocyte (gfap) and microglia (iba1) reactivity in lumbar spinal cord. |
2011-03-07 |
2023-08-12 |
human |
| Nisha Patro, Aarti Nagayach, I K Patr. Iba1 expressing microglia in the dorsal root ganglia become activated following peripheral nerve injury in rats. Indian journal of experimental biology. vol 48. issue 2. 2010-06-01. PMID:20455319. |
the presence of microglia in dorsal root ganglia (drg) has not been reported earlier. |
2010-06-01 |
2023-08-12 |
rat |
| Richard J Miller, Hosung Jung, Sonia K Bhangoo, Fletcher A Whit. Cytokine and chemokine regulation of sensory neuron function. Handbook of experimental pharmacology. issue 194. 2009-10-15. PMID:19655114. |
the actions of inflammatory cytokines synthesized by drg neurons and associated glial cells, as well as by astrocytes and microglia in the spinal cord, can produce changes in the excitability of nociceptive sensory neurons. |
2009-10-15 |
2023-08-12 |
Not clear |
| H Yamanaka, K Obata, K Kobayashi, Y Dai, T Fukuoka, K Noguch. Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain. Neuroscience. vol 150. issue 1. 2008-03-28. PMID:17905520. |
continuous intrathecal infusion of the fgfr1 inhibitor, 3-[3-(2-carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone, reduced p38 mapk phosphorylation in the drg and pain-related behaviors in the partial sciatic nerve model rat without affecting on the activation of spinal glia cells (microglia and astrocyte). |
2008-03-28 |
2023-08-12 |
rat |
| Koichi Obata, Hirokazu Katsura, Toshiyuki Mizushima, Jun Sakurai, Kimiko Kobayashi, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Koichi Noguch. Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17509087. |
nerve injury increased erk5 phosphorylation in spinal microglia and in both damaged and undamaged dorsal root ganglion (drg) neurons. |
2007-11-06 |
2023-08-12 |
Not clear |
| Koichi Obata, Hirokazu Katsura, Toshiyuki Mizushima, Jun Sakurai, Kimiko Kobayashi, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Koichi Noguch. Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17509087. |
our results show that erk5 activated in spinal microglia and drg neurons contributes to the development of neuropathic pain. |
2007-11-06 |
2023-08-12 |
Not clear |
| Weiya Ma, Remi Quirio. The ERK/MAPK pathway, as a target for the treatment of neuropathic pain. Expert opinion on therapeutic targets. vol 9. issue 4. 2007-01-25. PMID:16083338. |
following nerve injury, phosphorylation of extracellular signal-regulated protein kinase (erk), an important member of this family, is sequentially increased in neurons, microglia and astrocytes of the dorsal horn and gracile nucleus, and in injured large drg neurons. |
2007-01-25 |
2023-08-12 |
Not clear |
| Ji Zhang, Yves De Koninc. Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. Journal of neurochemistry. vol 97. issue 3. 2006-06-22. PMID:16524371. |
in an attempt to understand the potential role of monocyte chemoattractant protein-1 (mcp-1) in triggering spinal glial activation and its contribution to the development of neuropathic pain, we investigated the effect of peripheral nerve injury on mcp-1 expression in dorsal root ganglia (drg) and the spinal cord, and established its temporal relationship with activation of spinal microglia and astrocytes. |
2006-06-22 |
2023-08-12 |
Not clear |
| Camilla I Svensson, Maria Schäfers, Toni L Jones, Henry Powell, Linda S Sorki. Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neuroscience letters. vol 379. issue 3. 2005-06-24. PMID:15843065. |
spinal nerve ligation (snl) results in a profound long lasting allodynia and increases in phosphorylated p38 in dorsal root ganglia (drg) neurons and spinal cord microglia. |
2005-06-24 |
2023-08-12 |
Not clear |
| Camilla I Svensson, Maria Schäfers, Toni L Jones, Henry Powell, Linda S Sorki. Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neuroscience letters. vol 379. issue 3. 2005-06-24. PMID:15843065. |
these data imply that tnf provides the trigger for phosphorylation of p38 in both drg neurons and spinal microglia. |
2005-06-24 |
2023-08-12 |
Not clear |
| Dianna L Hynds, Nagarathnamma Rangappa, Julia Ter Beest, Diane M Snow, Alexander G Rabchevsk. Microglia enhance dorsal root ganglion outgrowth in Schwann cell cultures. Glia. vol 46. issue 2. 2004-05-28. PMID:15042588. |
microglia enhance dorsal root ganglion outgrowth in schwann cell cultures. |
2004-05-28 |
2023-08-12 |
rat |
| Dianna L Hynds, Nagarathnamma Rangappa, Julia Ter Beest, Diane M Snow, Alexander G Rabchevsk. Microglia enhance dorsal root ganglion outgrowth in Schwann cell cultures. Glia. vol 46. issue 2. 2004-05-28. PMID:15042588. |
schwann cells (sc) or microglia grafted into injury sites can promote axonal regrowth of central projections of dorsal root ganglion (drg) sensory neurons. |
2004-05-28 |
2023-08-12 |
rat |