| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaodong Huang, Weiheng Wang, Xilin Liu, Yanhai Xi, Jiangming Yu, Xiangqun Yang, Xiaojian Y. Bone mesenchymal stem cells attenuate radicular pain by inhibiting microglial activation in a rat noncompressive disk herniation model. Cell and tissue research. vol 374. issue 1. 2018-12-18. PMID:29858667. |
the study found that the use of np in the drg can induce abnormal mechanical pain, increase the contents of the proinflammatory factors tnf-α and il-1β, decrease the content of the anti-inflammatory cytokine tgf-β1 and activate microglia in the spinal dorsal horns (l5) (p < 0.05). |
2018-12-18 |
2023-08-13 |
rat |
| Binbin Wang, Bingbing Fan, Qijun Dai, Xingguo Xu, Peipei Jiang, Lin Zhu, Haifeng Dai, Zhigang Yao, Zhongling Xu, Xiaojuan Li. Fascin-1 Contributes to Neuropathic Pain by Promoting Inflammation in Rat Spinal Cord. Neurochemical research. vol 43. issue 2. 2018-08-16. PMID:29052088. |
the increased fascin-1 widely expressed in drg, however, it localized predominantly in microglia, seldom in neuron, and hardly in astrocyte in the sc. |
2018-08-16 |
2023-08-13 |
rat |
| Lilian Basso, Tamia K Lapointe, Mircea Iftinca, Candace Marsters, Morley D Hollenberg, Deborah M Kurrasch, Christophe Altie. Granulocyte-colony-stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 42. 2018-06-18. PMID:28973941. |
when cocultured with microglia bv-2 cells exposed to g-csf, dorsal root ganglion (drg) nociceptors become hyperexcitable. |
2018-06-18 |
2023-08-13 |
mouse |
| Xing-Jun Liu, Tong Liu, Gang Chen, Bing Wang, Xiao-Lu Yu, Cui Yin, Ru-Rong J. TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation. Scientific reports. vol 6. 2018-05-18. PMID:27312666. |
cci induced up-regulation of myd88 and chemokine c-c motif ligand 2 expression in drg neurons and macrophage infiltration into drgs, and microglia activation in spinal dorsal horns in wild-type mice, but all these changes were compromised in cko mice. |
2018-05-18 |
2023-08-13 |
mouse |
| Hyoungsub Lim, Hyunkyoung Lee, Kyungchul Noh, Sung Joong Le. IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury. Pain. vol 158. issue 9. 2018-05-02. PMID:28722693. |
however, macrophages recruited into the drg had minimal effects on spinal cord microglia activation, suggesting a causal effect for sgc activation on spinal cord microglia activation. |
2018-05-02 |
2023-08-13 |
mouse |
| Hyoungsub Lim, Hyunkyoung Lee, Kyungchul Noh, Sung Joong Le. IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury. Pain. vol 158. issue 9. 2018-05-02. PMID:28722693. |
in an effort to elucidate the molecular mechanisms, we measured csf1 expression in the drg, which is implicated in spinal cord microglia activation after nerve injury. |
2018-05-02 |
2023-08-13 |
mouse |
| Lu Chang, Fang Ye, Quehua Luo, Yuanxiang Tao, Haihua Sh. Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats. Anesthesia and analgesia. vol 126. issue 1. 2018-01-02. PMID:29135586. |
in this study, we tried to investigate behavioral hyperalgesia, the expression of proinflammatory cytokines, such as interleukin-1β (il-1β), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α), and the activation of microglia in the spinal cord and dorsal root ganglion (drg) in a rat model of surgical plantar incision with or without perioperative fentanyl. |
2018-01-02 |
2023-08-13 |
rat |
| Wenjie Tang, Bing Li, Sheng Chen, Ying Lu, Ning Han, Xia Li, Zengchun Li, Youzhen We. Increased GSK-3β expression in DRG microglia in response to sciatic nerve crush. Acta biochimica et biophysica Sinica. vol 48. issue 6. 2017-02-27. PMID:27125978. |
increased gsk-3β expression in drg microglia in response to sciatic nerve crush. |
2017-02-27 |
2023-08-13 |
Not clear |
| J Jung, N Uesugi, N Y Jeong, B S Park, H Konishi, H Kiyam. Increase of transcription factor EB (TFEB) and lysosomes in rat DRG neurons and their transportation to the central nerve terminal in dorsal horn after nerve injury. Neuroscience. vol 313. 2016-09-30. PMID:26601776. |
these findings suggest that activation of lysosome synthesis including atp packaging in drg, the central transportation of the lysosome, and subsequent its exocytosis from the central nerve terminal of drg neurons in response to nerve injury could be a partial mechanism for activation of microglia in dh. |
2016-09-30 |
2023-08-13 |
rat |
| Dongmei Wang, Yaping Xue, Yajuan Chen, Liqin Ruan, Yanguo Hon. Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats. Neuroscience letters. vol 618. 2016-08-22. PMID:26952974. |
these results suggest that the activation of mrgc receptors can relieve pain hypersensitivity by the inhibition of nnos increase in drg neurons and microglia activation in the spinal dorsal horn in the early time following peripheral nerve injury. |
2016-08-22 |
2023-08-13 |
rat |
| Li-Wen Chu, Jun-Yih Chen, Pao-Chu Wu, Bin-Nan W. Atorvastatin prevents neuroinflammation in chronic constriction injury rats through nuclear NFκB downregulation in the dorsal root ganglion and spinal cord. ACS chemical neuroscience. vol 6. issue 6. 2016-03-15. PMID:25874913. |
double immunofluorescent staining further demonstrated that pnfκb proteins were decreased by atorvastatin in drg satellite cells and spinal microglia. |
2016-03-15 |
2023-08-13 |
rat |
| Toru Taguchi, Kimiaki Katanosaka, Masaya Yasui, Koei Hayashi, Mai Yamashita, Koji Wakatsuki, Hiroshi Kiyama, Akihiro Yamanaka, Kazue Mizumur. Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. Pain. vol 156. issue 3. 2015-11-02. PMID:25599239. |
these results suggest that the increase in asic3 in the drg facilitated mechanical response of the remaining c-nociceptors and that activated spinal microglia may direct to intensify pain in this model. |
2015-11-02 |
2023-08-13 |
rat |
| Xuehai Guan, Qiaochu Fu, Bingrui Xiong, Zhenpeng Song, Bin Shu, Huilian Bu, Bing Xu, Anne Manyande, Fei Cao, Yuke Tia. Activation of PI3Kγ/Akt pathway mediates bone cancer pain in rats. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25919859. |
our results showed that pi3kγ and its downstream target pakt were up-regulated in a time-dependent manner and distributed predominately in the superficial layers of the spinal dorsal horn neurons, astrocytes and a minority of microglia, and were colocalized with non-peptidergic, calcitonin gene-related peptide-peptidergic, and a-type neurons in dorsal root ganglion ipsilateral to tumor cell inoculation in rats. |
2015-10-09 |
2023-08-13 |
rat |
| Bin Pan, Hongwei Yu, John Park, Yanhui Peter Yu, Z David Luo, Quinn H Hoga. Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia. Journal of neuroscience research. vol 93. issue 3. 2015-09-10. PMID:25327416. |
there is substantial additional tsp4 in the nonneuronal compartment of the l5 drg that does not costain for markers of satellite glia, microglia, or schwann cells and appears to be in the interstitial space. |
2015-09-10 |
2023-08-13 |
rat |
| Jun Pan, Xiang-Jin Lin, Zhi-Heng Ling, You-Zhi Ca. Effect of down-regulation of voltage-gated sodium channel Nav1.7 on activation of astrocytes and microglia in DRG in rats with cancer pain. Asian Pacific journal of tropical medicine. vol 8. issue 5. 2015-05-25. PMID:26003602. |
effect of down-regulation of voltage-gated sodium channel nav1.7 on activation of astrocytes and microglia in drg in rats with cancer pain. |
2015-05-25 |
2023-08-13 |
rat |
| Jun Pan, Xiang-Jin Lin, Zhi-Heng Ling, You-Zhi Ca. Effect of down-regulation of voltage-gated sodium channel Nav1.7 on activation of astrocytes and microglia in DRG in rats with cancer pain. Asian Pacific journal of tropical medicine. vol 8. issue 5. 2015-05-25. PMID:26003602. |
to evaluate the effect of down-regulation of nav1.7 on the activation of astrocytes and microglia in drg of rats with cancer pain, and explore the transmission of the nociceptive information. |
2015-05-25 |
2023-08-13 |
rat |
| Xue-Hai Guan, Qiao-Chu Fu, Dai Shi, Hui-Lian Bu, Zhen-Peng Song, Bing-Rui Xiong, Bin Shu, Hong-Bing Xiang, Bing Xu, Anne Manyande, Fei Cao, Yu-Ke Tia. Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats. Experimental neurology. vol 263. 2015-02-09. PMID:25281485. |
here, we found that the activated cxcr3 was co-localized with either neurons, microglia, and astrocytes in the spinal cord, or non-peptidergic-, peptidergic-, and a-type neurons in the dorsal root ganglion. |
2015-02-09 |
2023-08-13 |
rat |
| Bich-Hoai Thi Ton, Qingmin Chen, Gisela Gaina, Catalin Tucureanu, Adriana Georgescu, Carmen Strungaru, Maria-Luiza Flonta, Dinah Sah, Violeta Ristoi. Activation profile of dorsal root ganglia Iba-1 (+) macrophages varies with the type of lesion in rats. Acta histochemica. vol 115. issue 8. 2014-12-05. PMID:23701965. |
these responses suggest that depending on the type of lesion drg iba-1 (+) resident macrophages have different activation mechanisms, which are dissimilar to those in microglia. |
2014-12-05 |
2023-08-12 |
rat |
| K-I Cheng, H-C Wang, Y-T Chuang, C-W Chou, H-P Tu, Y-C Yu, L-L Chang, C-S La. Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase activation in streptozotocin-induced diabetic rats. European journal of pain (London, England). vol 18. issue 2. 2014-09-04. PMID:23868758. |
in experimental early painful diabetic neuropathy, persistent hyperglycaemia induces dys-regulated sodium channel (navs) expression in the dorsal root ganglion (drg) and activates microglia in the spinal dorsal horn (sdh). |
2014-09-04 |
2023-08-12 |
rat |
| Louis-Philippe Bernier, Ariel R Ase, Philippe Séguél. Post-translational regulation of P2X receptor channels: modulation by phospholipids. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24324400. |
furthermore, the physiological impact of the regulation of ionotropic purinergic responses by phospholipids on pain pathways was recently revealed in the context of native crosstalks between phospholipase c (plc)-linked metabotropic receptors and p2x receptor channels in dorsal root ganglion sensory neurons and microglia. |
2014-03-25 |
2023-08-12 |
Not clear |