| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Wu, Shuang Li, Shulan Pang, Bo Zhang, Jierui Wang, Bin He, Linyi Lv, Weixuan Wang, Na Zhao, Yanshu Zhan. Effects of lead exposure on the activation of microglia in mice fed with high-fat diets. Environmental toxicology. vol 36. issue 9. 2021-08-12. PMID:34156151. |
our finding suggested that pb exposure may aggravate cns damage by promoting m1 polarization and inhibiting m2 polarization of hippocampal microglia in hfd mice. |
2021-08-12 |
2023-08-13 |
mouse |
| Kelly M Bakulski, John F Dou, Robert C Thompson, Christopher Lee, Lauren Y Middleton, Bambarendage P U Perera, Sean P Ferris, Tamara R Jones, Kari Neier, Xiang Zhou, Maureen A Sartor, Saher S Hammoud, Dana C Dolinoy, Justin A Colacin. Single-Cell Analysis of the Gene Expression Effects of Developmental Lead (Pb) Exposure on the Mouse Hippocampus. Toxicological sciences : an official journal of the Society of Toxicology. vol 176. issue 2. 2021-08-11. PMID:32458983. |
gene expression patterns revealed 12 hippocampus cell clusters, mapping to major expected cell types (eg, microglia, astrocytes, neurons, and oligodendrocytes). |
2021-08-11 |
2023-08-13 |
mouse |
| Guangwei Zhang, Yujiao Lu, Luodan Yang, Yan Dong, Jin Wen, Jianguo Xu, Quanguang Zhan. Methylene blue post-treatment improves hypoxia-ischemic recovery in a neonatal rat model. Neurochemistry international. vol 139. 2021-08-11. PMID:32628986. |
in addition, mb profoundly inhibited microglia and astrocyte activation and the pro-inflammatory cytokines production in neonatal cortex and hippocampus after hi. |
2021-08-11 |
2023-08-13 |
rat |
| Qingmei Sun, Hongdan Yan, Falong Chen, Fen Jiang, Wenjuan Chen, Dongliang Li, Yongmin Gu. Restoration of Proresolution Pathway with Exogenous Resolvin D1 Prevents Sevoflurane-Induced Cognitive Decline by Attenuating Neuroinflammation in the Hippocampus in Rats with Type 2 Diabetes Mellitus. Frontiers in pharmacology. vol 12. 2021-08-10. PMID:34366871. |
compared with gk control rats, gk rats received sev exhibited shorter freezing times in trace fear conditioning task, which was accompanied by increased microglia activity and pro-inflammatory cytokine expression in the hippocampus. |
2021-08-10 |
2023-08-13 |
rat |
| Qingmei Sun, Hongdan Yan, Falong Chen, Fen Jiang, Wenjuan Chen, Dongliang Li, Yongmin Gu. Restoration of Proresolution Pathway with Exogenous Resolvin D1 Prevents Sevoflurane-Induced Cognitive Decline by Attenuating Neuroinflammation in the Hippocampus in Rats with Type 2 Diabetes Mellitus. Frontiers in pharmacology. vol 12. 2021-08-10. PMID:34366871. |
rvd1 administration attenuated sev-induced increases in microglia activity and pro-inflammatory cytokine expression in the hippocampus, preventing cognitive decline in gk rats. |
2021-08-10 |
2023-08-13 |
rat |
| Simone Schilling, Bruno Chausse, Hasan Onur Dikmen, Fadi Almouhanna, Jan-Oliver Hollnagel, Andrea Lewen, Oliver Kan. TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34015428. |
we explored the effects of tlr ligands on microglia and neuronal network function in rat organotypic hippocampal slice cultures (in situ), i.e., postnatal cortical tissue lacking adaptive immunity. |
2021-08-06 |
2023-08-13 |
rat |
| Ling Yan, Min-Qing Gu, Zhi-You Yang, Juan Xia, Peng Li, Eero Vasar, Li Tian, Cai Son. Endogenous n-3 PUFAs attenuated olfactory bulbectomy-induced behavioral and metabolomic abnormalities in Fat-1 mice. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34052364. |
ob also increased microglia activation marker cd11b and pro-inflammatory cytokines in the hippocampus. |
2021-08-06 |
2023-08-13 |
mouse |
| Carla Garza-Lombó, Morrent Thang, Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Chandrama Ahmed, Emily Quinn, Kimberly Sullivan, Michelle L Bloc. Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice. Translational psychiatry. vol 11. issue 1. 2021-08-02. PMID:34253711. |
using the lps model of the persistent microglial pro-inflammatory response, male c57bl/6j mice injected with lps (5 mg/kg ip) exhibited persistent changes in microglia morphology and elevated pro-inflammatory markers in the hippocampus, cortex, and midbrain 7 days after lps injection, while the peripheral immune response had resolved. |
2021-08-02 |
2023-08-13 |
mouse |
| Molly A May, Nicolas Barré, Kai K Kummer, Michaela Kress, Monika Ritsch-Marte, Alexander Jesache. Fast holographic scattering compensation for deep tissue biological imaging. Nature communications. vol 12. issue 1. 2021-07-30. PMID:34267207. |
using dash, we demonstrate two-photon fluorescence imaging of microglia cells in highly turbid mouse hippocampal tissue down to a depth of 530 μm. |
2021-07-30 |
2023-08-13 |
mouse |
| James Morgan, Mariana Alves, Giorgia Conte, Aida Menéndez-Méndez, Laura de Diego-Garcia, Gioacchino de Leo, Edward Beamer, Jonathon Smith, Annette Nicke, Tobias Enge. Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse. Neuroscience bulletin. vol 36. issue 11. 2021-07-28. PMID:32895896. |
the results showed increased p2x7-egfp expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus, cortex, striatum, thalamus and cerebellum, and this was most evident in microglia and oligodendrocytes. |
2021-07-28 |
2023-08-13 |
mouse |
| Jie Meng, Yicong Liu, Zhen Xie, Hong Qing, Peng Lei, Junjun N. Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins. Neurobiology of aging. vol 96. 2021-07-23. PMID:33049518. |
in the present study, increased catb was found in the nucleus of catb-overexpressed microglia followed by l-leucyl-l-leucine methyl ester, a lysosome-destabilizing reagent, and in the nuclear fraction of the cortex and hippocampus from aged mice. |
2021-07-23 |
2023-08-13 |
mouse |
| Yanan Shen, Lihai Chen, Yuan Zhang, Jiayue Du, Jing Hu, Hongguang Bao, Yan Xing, Yanna S. Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder. Neuroscience. vol 468. 2021-07-21. PMID:34166762. |
surgically treated mice had increased expression of pten, ampk, bax, il-1β, and tnf-α, as well as increasing number of activated microglia and apoptosis neurons in the hippocampus. |
2021-07-21 |
2023-08-13 |
mouse |
| Wenjie Su, Min Xie, Yao Li, Xinran Gong, Jiacen L. Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31758388. |
in vitro, hippocampal microglia was treated with lipopolysaccharide or tpm to validate the tpm's anti-inflammatory action. |
2021-07-19 |
2023-08-13 |
rat |
| Svetlana Altamentova, Prakasham Rumajogee, James Hong, Stephanie R Beldick, Sei Joon Park, Albert Yee, Michael G Fehling. Methylprednisolone Reduces Persistent Post-ischemic Inflammation in a Rat Hypoxia-Ischemia Model of Perinatal Stroke. Translational stroke research. vol 11. issue 5. 2021-07-19. PMID:32140998. |
administration of mpss resulted in reduced structural damage (corpus callosum, cortex, hippocampus, striatum), gliosis and reactive microglia and partial restoration of the oligodendrocyte population. |
2021-07-19 |
2023-08-13 |
human |
| Ping-An Zhang, Qian Sun, Yong-Chang Li, Rui-Xia Weng, Rui Wu, Hong-Hong Zhang, Guang-Yin X. Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes. Neuroscience bulletin. vol 36. issue 7. 2021-07-19. PMID:32198702. |
microglia positive for p2x purinoceptor 4 (p2x4r) in the hippocampus were reduced and activated microglia were increased in t2dm rats. |
2021-07-19 |
2023-08-13 |
rat |
| Ping-An Zhang, Qian Sun, Yong-Chang Li, Rui-Xia Weng, Rui Wu, Hong-Hong Zhang, Guang-Yin X. Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes. Neuroscience bulletin. vol 36. issue 7. 2021-07-19. PMID:32198702. |
overall, t2dm led to excessive activation of microglia in the hippocampus, partly through the dna damage-mediated downregulation of p2x4rs, thus contributing to memory impairment. |
2021-07-19 |
2023-08-13 |
rat |
| Judith Leyh, Sabine Paeschke, Bianca Mages, Dominik Michalski, Marcin Nowicki, Ingo Bechmann, Karsten Winte. Classification of Microglial Morphological Phenotypes Using Machine Learning. Frontiers in cellular neuroscience. vol 15. 2021-07-17. PMID:34267628. |
we focused on four microglial morphologies, ramified, rod-like, activated and amoeboid microglia within the murine hippocampus and cortex. |
2021-07-17 |
2023-08-13 |
mouse |
| S Alex Marshall, Justin A McClain, Jessica I Wooden, Kimberly Nixo. Microglia Dystrophy Following Binge-Like Alcohol Exposure in Adolescent and Adult Male Rats. Frontiers in neuroanatomy. vol 14. 2021-07-15. PMID:32903737. |
following 2- and 4-day binge ethanol exposure, the number of microglia was decreased in the hippocampus and the perirhinal and entorhinal cortices of both adult and adolescent rats. |
2021-07-15 |
2023-08-13 |
rat |
| S Alex Marshall, Justin A McClain, Jessica I Wooden, Kimberly Nixo. Microglia Dystrophy Following Binge-Like Alcohol Exposure in Adolescent and Adult Male Rats. Frontiers in neuroanatomy. vol 14. 2021-07-15. PMID:32903737. |
furthermore, a significant number of microglia with a dystrophic morphology were observed in ethanol-exposed tissue, accompanied by a significant decrease in brain-derived neurotrophic factor (bdnf) expression in the hippocampus. |
2021-07-15 |
2023-08-13 |
rat |
| Ji-Hye Kwak, Kyungmin Le. Forebrain glutamatergic neuron-specific Ctcf deletion induces reactive microgliosis and astrogliosis with neuronal loss in adult mouse hippocampus. BMB reports. vol 54. issue 6. 2021-07-13. PMID:33612151. |
however, little is known about the long-term effect of ctcf deficiency on postnatal neurons, astrocytes, or microglia in the hippocampus of adult mice. |
2021-07-13 |
2023-08-13 |
mouse |