| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the results showed that in the model group, the number of horizontal movement, the number of vertical movement and central residence time were significantly reduced, and the grooming time was significantly prolonged(p<0.05 or p<0.01); the levels of il-1β and il-6 in hippocampus increased significantly(p<0.05); the number of positive cells with co-expression of iba-1/inos of microglia cells in dg region of hippocampus increased; the expression levels of iba-1 and inos protein in hippocampus were significantly increased(p<0.01), suggesting that microglia in dg region of hippocampus was activated and polarized toward m1 type in rats with stress. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
meanwhile, it reversed the activation and quantity change of microglia in hippocampus. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
low dose xiaoyao san significantly decreased inos protein level(p<0.05), and high dose xiaoyao san significantly down-regulated the protein expression of iba-1 and inos in hippocampus microglia(p<0.05 or p<0.01). |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
in conclusion, xiaoyao san can improve anxiety and depression-like behavior in ovx combined with cus model rats, and its mechanism is related to its anti-inflammatory effect by inhibiting m1 polarization of hippocampal microglia. |
2020-12-23 |
2023-08-13 |
rat |
| Suman K Guha, Ishita Sarkar, Mandar Patgaonkar, Souvik Banerjee, Siuli Mukhopadhyay, Shobhona Sharma, Sulabha Pathak, Vidita A Vaidy. A history of juvenile mild malaria exacerbates chronic stress-evoked anxiety-like behavior, neuroinflammation, and decline of adult hippocampal neurogenesis in mice. Journal of neuroimmunology. vol 348. 2020-12-14. PMID:32919145. |
at baseline, a-h/jmal mice showed increased activated microglia within the hippocampal dentate gyrus subfield. |
2020-12-14 |
2023-08-13 |
mouse |
| Megan K Lowther, Jarrod P Tunnell, Jayme M Palka, Darlene R King, Damilola C Salako, Dimitri G Macris, Jay B Italiya, Justin L Grodin, Carol S North, E Sherwood Brow. Relationship between inflammatory biomarker galectin-3 and hippocampal volume in a community study. Journal of neuroimmunology. vol 348. 2020-12-14. PMID:32927397. |
galectin-3 (gal3) is expressed by microglia and performs functions including adhesion; activation of macrophages and fibroblasts, and mediates inflammatory responses in the hippocampus. |
2020-12-14 |
2023-08-13 |
human |
| Adriel Barrios-Anderson, Xiaodi Chen, Sakura Nakada, Ray Chen, Yow-Pin Lim, Barbara S Stonestree. Inter-alpha Inhibitor Proteins Modulate Neuroinflammatory Biomarkers After Hypoxia-Ischemia in Neonatal Rats. Journal of neuropathology and experimental neurology. 2020-12-08. PMID:31274164. |
hiaips reduced quantities of cortical gfap, hippocampal iba-1-positive microglia, corpus callosum mpo, and cortical mmp9-mpo cells and the percent of neutrophils in peripheral blood after hi in male, but not female rats. |
2020-12-08 |
2023-08-13 |
human |
| Berkley Luck, Melinda A Engevik, Bhanu Priya Ganesh, Elizabeth P Lackey, Tao Lin, Miriam Balderas, Angela Major, Jessica Runge, Ruth Ann Luna, Roy V Sillitoe, James Versalovi. Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial function. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32385412. |
at postnatal day 4 (p4), conventionalized mice and bifidobacterium-colonized mice exhibited decreased expression of synapse-promoting genes and increased markers indicative of reactive microglia in the cerebellum, cortex and hippocampus relative to germ-free mice. |
2020-12-04 |
2023-08-13 |
mouse |
| Ying Zhou, Jiayu Wang, Xiaofeng Li, Ke Li, Lei Chen, Zongze Zhang, Mian Pen. Neuroprotectin D1 Protects Against Postoperative Delirium-Like Behavior in Aged Mice. Frontiers in aging neuroscience. vol 12. 2020-12-01. PMID:33250764. |
npd1 also abolished the activation of microglia and astrocytes in the hippocampus and prefrontal cortex, which is associated with improved general and memory function after surgery. |
2020-12-01 |
2023-08-13 |
mouse |
| Geng Lin, Xinlu Li, Xiaofeng Cheng, Ning Zhao, Wei Zhen. Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation. Frontiers in aging neuroscience. vol 12. 2020-11-28. PMID:33244298. |
using the transgenic app/ps1/tau triple transgenic ad (3×tg-ad) mouse model and mouse-derived microglia and neuroblastoma cell lines, we found that chronic 5-month mn treatment increased beta amyloid peptide (aβ) expression and aβ plaques in the cerebral cortex and hippocampus in these 3×tg-ad mice. |
2020-11-28 |
2023-08-13 |
mouse |
| Rongcan Luo, Ling-Yan Su, Guiyu Li, Jing Yang, Qianjin Liu, Lu-Xiu Yang, Deng-Feng Zhang, Hejiang Zhou, Min Xu, Yu Fan, Jiali Li, Yong-Gang Ya. Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy. vol 16. issue 1. 2020-11-24. PMID:30898012. |
there is a reduced level of soluble aβ and insoluble aβ in hippocampus and cortex tissues from app-psen1Δe9 mice after treatment with either gemfibrozil or wy14643, which promoted the recruitment of microglia and astrocytes to the vicinity of aβ plaques and enhanced autophagosome biogenesis. |
2020-11-24 |
2023-08-13 |
mouse |
| Jing Li, Runtian Zhao, Yuhan Jiang, Yi Xu, Huan Zhao, Xiaoling Lyu, Tao W. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Food & function. vol 11. issue 2. 2020-11-23. PMID:32003387. |
altogether, we show for the first time that ba consumption reverses alzheimer's disease-induced cognitive disfunction, decreases hippocampal neuroinflammatory responses, and induces phagocytosis of microglia to beta-amyloid protein plaques by regulating the cd33/trem2/tyrobp signaling pathway in microglia. |
2020-11-23 |
2023-08-13 |
mouse |
| Huimin Kong, Huaili Wang, Zhihong Zhuo, Zhenbiao Li, Peichao Tian, Jing Wu, Jian Liu, Zheng Chen, Jiyao Zhang, Qiang Lu. Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy. Laboratory investigation; a journal of technical methods and pathology. vol 100. issue 9. 2020-11-23. PMID:32461588. |
inhibition of mir-181a-5p protected the hippocampus against epilepsy, including hippocampal insults, neuronal apoptosis, astrocyte and microglia activation, neuroinflammation, oxidative stress, mitochondrial function, and cognitive dysfunction. |
2020-11-23 |
2023-08-13 |
rat |
| Genevieve Saw, Kumar Krishna, Neelima Gupta, Tuck Wah Soong, Karthik Mallilankaraman, Sreedharan Sajikumar, S Thameem Dhee. Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Glia. vol 68. issue 3. 2020-11-19. PMID:31702864. |
whole-cell voltage-clamp showed the involvement of microglia in neuronal ltp, as selective ablation or disruption of microglia with clodronate in rat hippocampal slices abolished ltp. |
2020-11-19 |
2023-08-13 |
rat |
| Chin Wai Hui, Haley A Vecchiarelli, Étienne Gervais, Xiao Luo, Félix Michaud, Lisa Scheefhals, Kanchan Bisht, Kaushik Sharma, Lisa Topolnik, Marie-Ève Trembla. Sex Differences of Microglia and Synapses in the Hippocampal Dentate Gyrus of Adult Mouse Offspring Exposed to Maternal Immune Activation. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192308. |
sex differences of microglia and synapses in the hippocampal dentate gyrus of adult mouse offspring exposed to maternal immune activation. |
2020-11-17 |
2023-08-13 |
mouse |
| Nayara A Sousa, Guilherme A L Oliveira, Ana Patrícia de Oliveira, André Luís F Lopes, Bruno Iles, Kerolayne M Nogueira, Thiago S L Araújo, Luan K M Souza, Alyne R Araújo, Joilson Ramos-Jesus, Alexandra Plácido, Constança Amaral, Yuri D M Campelo, Eder Alves Barbosa, Camila C Portugal, Renato Socodato, Andrea Lobo, Joao Relvas, Marcelo Bemquerer, Peter Eaton, José Roberto S A Leite, Jand Venes R Medeiro. Novel Ocellatin Peptides Mitigate LPS-induced ROS Formation and NF-kB Activation in Microglia and Hippocampal Neurons. Scientific reports. vol 10. issue 1. 2020-11-13. PMID:32060388. |
novel ocellatin peptides mitigate lps-induced ros formation and nf-kb activation in microglia and hippocampal neurons. |
2020-11-13 |
2023-08-13 |
Not clear |
| Dharani Manickavasagam, Li Lin, Moses O Oyewum. Nose-to-brain co-delivery of repurposed simvastatin and BDNF synergistically attenuates LPS-induced neuroinflammation. Nanomedicine : nanotechnology, biology, and medicine. vol 23. 2020-11-11. PMID:31655202. |
we found out that the efficiency of the combination drug-loaded polymersomes to suppress microglia activation in brain regions followed the order: frontal cortex > striatum > hippocampus. |
2020-11-11 |
2023-08-13 |
Not clear |
| Megumi Andoh, Yuji Ikegaya, Ryuta Koyam. Microglia modulate the structure and function of the hippocampus after early-life seizures. Journal of pharmacological sciences. vol 144. issue 4. 2020-11-02. PMID:33070840. |
microglia modulate the structure and function of the hippocampus after early-life seizures. |
2020-11-02 |
2023-08-13 |
Not clear |
| Megumi Andoh, Yuji Ikegaya, Ryuta Koyam. Microglia modulate the structure and function of the hippocampus after early-life seizures. Journal of pharmacological sciences. vol 144. issue 4. 2020-11-02. PMID:33070840. |
studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. |
2020-11-02 |
2023-08-13 |
Not clear |
| Caitlin E Bromberg, Andrew M Condon, Samantha W Ridgway, Gokul Krishna, Pamela C Garcia-Filion, P David Adelson, Rachel K Rowe, Theresa Currier Thoma. Sex-Dependent Pathology in the HPA Axis at a Sub-acute Period After Experimental Traumatic Brain Injury. Frontiers in neurology. vol 11. 2020-10-28. PMID:33101162. |
evidence of microglia activation in the dentate gyrus of the hippocampus was robust in both sexes compared with uninjured shams and there was evidence of a significant interaction between sex and injury regarding microglial cell count. |
2020-10-28 |
2023-08-13 |
rat |