| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiying Zhou, Xiang Wu, Luying Ye, Yujing Bai, Hui Zhang, Zhenquan Xuan, Yi Feng, Panpan Zhang, Yi Chen, Yushan Yan, Binbin Zhu, Wei Cu. Edaravone at high concentrations attenuates cognitive dysfunctions induced by abdominal surgery under general anesthesia in aged mice. Metabolic brain disease. vol 35. issue 2. 2021-01-29. PMID:31916204. |
edaravone could also decrease glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule-1 (iba-1) positive areas in the hippocampal regions of surgery mice, suggesting that edaravone might inhibit surgery-induced over-activation of microglia and astrocytes. |
2021-01-29 |
2023-08-13 |
mouse |
| Yangmin Zhao, Yunxiao Gan, Gewei Xu, Guoli Yin, Dandan Li. MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32112178. |
the production of pro-inflammatory factors decreased, while the anti-inflammatory cytokines and neurotrophic factors increased both in the cortex and hippocampus of ischemic hemisphere as well as in the culture supernatant of microglia treated with ogd and nmltc4. |
2021-01-29 |
2023-08-13 |
rat |
| Bruno Pinto, Giovanni Morelli, Mohit Rastogi, Annalisa Savardi, Amos Fumagalli, Andrea Petretto, Martina Bartolucci, Emilio Varea, Tiziano Catelani, Andrea Contestabile, Laura E Perlini, Laura Cancedd. Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome. Neuron. vol 108. issue 5. 2021-01-27. PMID:33027640. |
in the hippocampus of the dp(16) mouse model of ds and ds individuals, we found activated microglia, as assessed by their morphology; activation markers; and, for ds mice, electrophysiological profile. |
2021-01-27 |
2023-08-13 |
mouse |
| Giorgi Lobzhanidze, Nadezhda Japaridze, Tamar Lordkipanidze, Fuad Rzayev, Derrick MacFabe, Mzia Zhvani. Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 2. 2021-01-25. PMID:31997401. |
both transient and enduring ultrastructural alterations in synapses, astro- and microglia were detected in the ca1 hippocampal area. |
2021-01-25 |
2023-08-13 |
rat |
| John F Bowyer, Sumit Sarkar, Susan M Burks, Jade N Hess, Serena Tolani, James P O'Callaghan, Joseph P Hani. Microglial activation and responses to vasculature that result from an acute LPS exposure. Neurotoxicology. vol 77. 2021-01-22. PMID:32014511. |
at 24 h, almost all the microglia soma and proximal processes in the hippocampus, parietal cortex, and thalamus were closely associated with the vasculature and had increased almost 2.0-fold in size. |
2021-01-22 |
2023-08-13 |
mouse |
| Jixiang Wang, Baijuan Yue, Xuhua Zhang, Xin Guo, Zilong Sun, Ruiyan Ni. Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice. The Science of the total environment. vol 760. 2021-01-19. PMID:33172640. |
we discovered that the number of m1-type microglia in fluorosis-mice hippocampus was significantly increased when compared to group c; group f + e showed a decrease in the number of m1-type microglia with the comparison to group f. in addition, the hippocampal transcriptome analysis showed that 576 differential expression genes (deg) were confirmed in group f, compared to group c, and 670 deg were differently expressed in group f + e when compared to group f. gene ontology (go) analysis showed that changed genes were implicated in regulation of transcription, dna-templated, integral component of membrane and adenosine triphosphate (atp) binding. |
2021-01-19 |
2023-08-13 |
mouse |
| Jixiang Wang, Baijuan Yue, Xuhua Zhang, Xin Guo, Zilong Sun, Ruiyan Ni. Effect of exercise on microglial activation and transcriptome of hippocampus in fluorosis mice. The Science of the total environment. vol 760. 2021-01-19. PMID:33172640. |
in conclusion, these results indicate that treadmill running inhibits the excessive activation of microglia in hippocampus of the fluoride-toxic mice, accompanied with the alteration of neuroactive ligand-receptor interaction pathway. |
2021-01-19 |
2023-08-13 |
mouse |
| Rui Guo, Wei-Shuai Qin, Shuang-Yong Zhang, Shu-Ling Zhan. [Effects of modified Xiaoyao San on TLR4/NF-κB pathway in hippocampal microglia of LPS-induced depression model rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 36. issue 4. 2021-01-18. PMID:33167098. |
[effects of modified xiaoyao san on tlr4/nf-κb pathway in hippocampal microglia of lps-induced depression model rats]. |
2021-01-18 |
2023-08-13 |
rat |
| Rui Guo, Wei-Shuai Qin, Shuang-Yong Zhang, Shu-Ling Zhan. [Effects of modified Xiaoyao San on TLR4/NF-κB pathway in hippocampal microglia of LPS-induced depression model rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 36. issue 4. 2021-01-18. PMID:33167098. |
to investigate the effects of modified xiaoyao san on tlr4/nf-κb pathway in hippocampal microglia of lps-induced depression model rats, and to explore its antidepressant mechanism. |
2021-01-18 |
2023-08-13 |
rat |
| YunLei Wang, YuGe Zhang, WenZhu Wang, Xu Liu, YaFei Chi, JianFeng Lei, BaoGui Zhang, Tong Zhan. Effects of circadian rhythm disorder on the hippocampus of SHR and WKY rats. Neurobiology of learning and memory. vol 168. 2021-01-13. PMID:31857218. |
crd and hypertension decreased fractional anisotropy values, the number of neurons and astrocytes in the hippocampus, and the expression of brain-derived neurotrophic factor and synapsin 1; it also enhanced the degeneration of neurons and microglia and reduced blood flow in the hippocampus, and increased nuclear factor κb, caspase, neuron-specific enolase, and interleukin-6 levels. |
2021-01-13 |
2023-08-13 |
rat |
| Alexander Levit, Sonny Cheng, Olivia Hough, Qingfan Liu, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn N Whitehea. Hypertension and Pathogenic hAPP Independently Induce White Matter Astrocytosis and Cognitive Impairment in the Rat. Frontiers in aging neuroscience. vol 12. 2021-01-10. PMID:32351378. |
angiotensin ii infusion did not affect activation of microglia, which were elevated in the white matter and hippocampus of transgenic rats. |
2021-01-10 |
2023-08-13 |
human |
| Kanako Nozaki, Hikaru Ito, Masahiro Ohgidani, Yosuke Yamawaki, Ezgi Hatice Sahin, Takashi Kitajima, Seishi Katsumata, Shigeto Yamawaki, Takahiro A Kato, Hidenori Aizaw. Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress. Neuropharmacology. vol 162. 2021-01-06. PMID:31682855. |
in mice submitted to chronic social defeat stress, microglia predominantly expressed tspo in limbic areas implicated in depressive-like behaviors, including the amygdala, ventral hippocampus and nucleus accumbens, in which an increase in the production of pro-inflammatory cytokines in vivo were associated. |
2021-01-06 |
2023-08-13 |
mouse |
| Sarah M Smith, Erich Giedzinski, Maria C Angulo, Tiffany Lui, Celine Lu, Audrey L Park, Sharon Tang, Vahan Martirosian, Ning Ru, Nicole N Chmielewski, Yaxuan Liang, Janet E Baulch, Munjal M Acharya, Charles L Limol. Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain. Stem cells translational medicine. vol 9. issue 1. 2021-01-04. PMID:31568685. |
these morphometric improvements were accompanied by increased levels of glial cell-derived growth factor and significant attenuation of radiation-induced increases in postsynaptic density protein 95 and activated microglia were found ipsi- and contra-lateral to the transplantation sites of the irradiated hippocampus treated with hnscs or hnsc-derived evs. |
2021-01-04 |
2023-08-13 |
human |
| Jing Su, Yi-Wei Pan, Si-Qi Wang, Xue-Zhen Li, Fang Huang, Shi-Ping M. Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation. International immunopharmacology. vol 80. 2021-01-04. PMID:31926446. |
furthermore, immunostaining results showed that ssd pretreatment inhibited lps-induced microglia activation in the hippocampus of mice and primary microglia cells. |
2021-01-04 |
2023-08-13 |
mouse |
| Weixu Luo, Yuanshan Han, Pan Meng, Qin Yang, Hongqing Zhao, Jia Ling, Yuhong Wan. Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway. Cancer management and research. vol 12. 2020-12-31. PMID:33376394. |
resatorvid relieves breast cancer complicated with depression by inactivating hippocampal microglia through tlr4/nf-κb/nlrp3 signaling pathway. |
2020-12-31 |
2023-08-13 |
Not clear |
| Weixu Luo, Yuanshan Han, Pan Meng, Qin Yang, Hongqing Zhao, Jia Ling, Yuhong Wan. Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway. Cancer management and research. vol 12. 2020-12-31. PMID:33376394. |
we aim to identify a new drug and identify its functional mechanism in the regulation of hippocampal microglia (mg) in breast cancer complicated with depression (bccd). |
2020-12-31 |
2023-08-13 |
Not clear |
| De-Huang Guo, Masaki Yamamoto, Caterina M Hernandez, Hesam Khodadadi, Babak Baban, Alexis M Stranaha. Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells. The Journal of clinical investigation. vol 130. issue 4. 2020-12-30. PMID:31935195. |
flow cytometric and gene expression analyses revealed that vat transplantation recapitulated the effects of obesity on microglial activation and il-1β gene expression, and visualization of hippocampal microglia revealed similar effects in vivo. |
2020-12-30 |
2023-08-13 |
mouse |
| De-Huang Guo, Masaki Yamamoto, Caterina M Hernandez, Hesam Khodadadi, Babak Baban, Alexis M Stranaha. Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells. The Journal of clinical investigation. vol 130. issue 4. 2020-12-30. PMID:31935195. |
inducible ablation of il-1r1 in cx3cr1-expressing cells eliminated cognitive impairment in mice with dietary obesity and in transplant recipients and restored immunoquiescence in hippocampal microglia. |
2020-12-30 |
2023-08-13 |
mouse |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
[effect of xiaoyao san on ovx combined with cus anxiety and depression model rats based on hippocampal microglia m1 polarization]. |
2020-12-23 |
2023-08-13 |
rat |
| Yang Hao-Ran, Liu Li-Na, G E Fei, Yan Jing, Chen Qin-Lei, L U Wei-Ting, Qiao Fe. [Effect of Xiaoyao San on OVX combined with CUS anxiety and depression model rats based on hippocampal microglia M1 polarization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350270. |
the model of perimenopausal depression was established by ovx and cus; the level of anxiety and depression was evaluated by open field test; the levels of interleukin-1β(il-1β) and interleukin-6(il-6) mrna in rat hippocampus were detected by real-time qpcr; double staining immunofluorescence was used to detect the expression of ionized calcium binding adaptor molecule-1(iba-1) and inducible nitric oxide synthase(inos) in microglia of rat dentate gyrus(dg); western blot was used to detect the protein expression of iba-1 and inos of microglia in dg region of rat hippocampus. |
2020-12-23 |
2023-08-13 |
rat |