| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joon Young Chang, Hyun Jung Hong, Seul Gi Kang, Jung Tae Kim, Ben Yuan Zhang, Minho Shon. The Role of Growth Differentiation Factor 15 in Energy Metabolism. Diabetes & metabolism journal. vol 44. issue 3. 2021-06-04. PMID:32613776. |
recent discovery of its receptor, glial cell line-derived neurotrophic factor (gdnf) family receptor α-like (gfral), suggests a central role in appetite regulation. |
2021-06-04 |
2023-08-13 |
Not clear |
| Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo, Dianshuai Ga. Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells. Clinical epigenetics. vol 12. issue 1. 2021-06-03. PMID:32183903. |
glial cell line-derived neurotrophic factor (gdnf) is highly expressed in glioblastoma (gbm) and blocking its expression can inhibit the initiation and development of gbm. |
2021-06-03 |
2023-08-13 |
Not clear |
| Sara Di Persio, Donatella Starace, Chiara Capponi, Rossana Saracino, Stefania Fera, Antonio Filippini, Elena Vicin. TNF-α inhibits GDNF levels in Sertoli cells, through a NF-κB-dependent, HES1-dependent mechanism. Andrology. vol 9. issue 3. 2021-06-03. PMID:33314792. |
glial cell line-derived neurotrophic factor (gdnf) is a soluble molecule crucial for the regulation of the spermatogonial stem cells (ssc) of the testis. |
2021-06-03 |
2023-08-13 |
Not clear |
| Ankur Sharma, Syed Mohmad Shah, Manish Tiwari, Mayank Roshan, Manoj Kumar Singh, Suresh Kumar Singla, Prabhat Palta, Radhay Sham Manik, Manmohan Singh Chauha. Propagation of goat putative spermatogonial stem cells under growth factors defined serum-free culture conditions. Cytotechnology. vol 72. issue 3. 2021-06-02. PMID:32124159. |
after 15 days of subculture, the relative mrna expression study revealed that 40 ng/ml concentration of glial cell line-derived neurotrophic factor (gdnf) upregulated the expression of bcl6b, id4, plzf, and uchl1. |
2021-06-02 |
2023-08-13 |
Not clear |
| Yuanxiang Zhang, Di Luan, Yanhao Liu, Hongjin Li, Jian Dong, Xiaotong Zhang, Lili Yuan, Zhengling Zhong, Lan Jiang, Xuyi Li, Mingquan Ye, Jiucui Ton. Helicid Reverses Lipopolysaccharide-Induced Inflammation and Promotes GDNF Levels in C6 Glioma Cells through Modulation of Prepronociceptin. Chemistry & biodiversity. vol 17. issue 7. 2021-05-25. PMID:32329965. |
collective data from western blots, elisa, immunofluorescence and flow cytometry experiments showed that pnoc silencing or administration of helicid led to reduced inflammatory factor levels, oxidative stress and expression of glial fibrillary acidic protein (gfap), along with increased glial cell lines-derived neurotrophic factor (gdnf) expression. |
2021-05-25 |
2023-08-13 |
rat |
| Lu Chen, Yanping Wang, Shulin Li, Bangjie Zuo, Xiangyu Zhang, Fengzhen Wang, Dong Su. Exosomes derived from GDNF-modified human adipose mesenchymal stem cells ameliorate peritubular capillary loss in tubulointerstitial fibrosis by activating the SIRT1/eNOS signaling pathway. Theranostics. vol 10. issue 20. 2021-05-24. PMID:32802201. |
glial cell line-derived neurotrophic factor (gdnf) has been demonstrated to promote the therapeutic effect of mscs on ameliorating renal injury. |
2021-05-24 |
2023-08-13 |
human |
| Rossana Saracino, Chiara Capponi, Sara Di Persio, Carla Boitani, Silvia Masciarelli, Francesco Fazi, Stefania Fera, Elena Vicin. Regulation of Gdnf expression by retinoic acid in Sertoli cells. Molecular reproduction and development. vol 87. issue 4. 2021-05-20. PMID:32020743. |
glial cell line-derived neurotrophic factor (gdnf) and retinoic acid (ra) are two molecules crucial for the regulation of the spermatogonial compartment of the testis. |
2021-05-20 |
2023-08-13 |
Not clear |
| Chung-Yin Lin, Yu-Chien Lin, Ching-Yun Huang, Shang-Rung Wu, Chiung-Mei Chen, Hao-Li Li. Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome complex: Preclinical investigation for Parkinson's disease treatment. Journal of controlled release : official journal of the Controlled Release Society. vol 321. 2021-05-17. PMID:32112852. |
since both glia cell line-derived neurotrophic factor (gdnf) and brain-derived neurotrophic factor (bdnf) can protect dopaminergic neurons from neurotoxicity demonstrated in parkinson's disease (pd) animal models, the present study seeks (1) to develop a novel gene-nanocarrier mb complex carrying bdnf or gdnf gene and (2) to protect dopaminergic neurons in a mouse model of pd via the proposed utmd system. |
2021-05-17 |
2023-08-13 |
mouse |
| Honghe Xiao, Yuying Wang, Yutong Wu, Hongyan Li, Xicai Liang, Yin Lin, Liang Kong, Yingnan Ni, Yan Deng, Yan Li, Wanyi Li, Jingxian Yan. Osthole ameliorates cognitive impairments via augmenting neuronal population in APP / PS1 transgenic mice. Neuroscience research. vol 164. 2021-05-14. PMID:32302734. |
in this study, by using morris water maze (mwm) test, hematoxylin-eosin (he) staining, nissl staining, immunofluorescence analysis and western blot, we demonstrated that oral administration of ost could improve the learning and memory function, inhibit neuronal apoptosis, elevate the expression of glial cell line derived neurotrophic factor (gdnf), synaptophysin (syp) and postsynaptic density protein 95 (psd95). |
2021-05-14 |
2023-08-13 |
mouse |
| Xiao-Yu Zhu, Bo Xia, Ting Ye, Ming-Zhu Dai, Hua Yang, Chun-Qi Li, Ping L. Ponatinib-induced ischemic stroke in larval zebrafish for drug screening. European journal of pharmacology. vol 889. 2021-05-14. PMID:32668288. |
the mrna levels of the neovascularization-related gene (vegfaa) and vascular endothelial growth factor receptor gene (vegfr), neurodevelopment related genes (mbp and α1-tubulin), brain-derived neurotrophic factor (bdnf) and glial cell derived neurotrophic factor (gdnf) were significantly downregulated; whereas apoptosis-related genes (caspase-3, caspase-7, caspase-9 and bax/bcl-2), and inflammatory factor genes (il-1β, il-6, il-10, tnf-α and nf-κb) were remarkably upregulated in the model. |
2021-05-14 |
2023-08-13 |
human |
| Buket Ucar, Janko Kajtez, Bettina M Foidl, Dimitri Eigel, Carsten Werner, Katherine R Long, Jenny Emnéus, Joëlle Bizeau, Mihai Lomora, Abhay Pandit, Ben Newland, Christian Humpe. Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures. Acta biomaterialia. vol 121. 2021-05-14. PMID:33242639. |
glial cell line-derived neurotrophic factor (gdnf) holds great therapeutic potential for pd, but its efficacious delivery remains difficult. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chee Ern David Wong, Khang Hua, Simon Monis, Vishal Saxena, Anwar Norazit, Suzita Mohd Noor, Marc Ekke. gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish. Journal of neurochemistry. vol 156. issue 4. 2021-05-04. PMID:32583440. |
glial cell line-derived neurotrophic factor (gdnf) has been reported to enhance dopaminergic neuron survival and differentiation in vitro and in vivo, although those results are still being debated. |
2021-05-04 |
2023-08-13 |
zebrafish |
| Chee Ern David Wong, Khang Hua, Simon Monis, Vishal Saxena, Anwar Norazit, Suzita Mohd Noor, Marc Ekke. gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish. Journal of neurochemistry. vol 156. issue 4. 2021-05-04. PMID:32583440. |
glial cell line-derived neurotrophic factor (gdnf) is highly conserved in zebrafish and plays a role in enteric nervous system function. |
2021-05-04 |
2023-08-13 |
zebrafish |
| Carlos W Gantner, Isabelle R de Luzy, Jessica A Kauhausen, Niamh Moriarty, Jonathan C Niclis, Christopher R Bye, Vanessa Penna, Cameron P J Hunt, Charlotte M Ermine, Colin W Pouton, Deniz Kirik, Lachlan H Thompson, Clare L Paris. Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease. Cell stem cell. vol 26. issue 4. 2021-04-27. PMID:32059808. |
here, we examined whether delivery of a developmentally critical protein, glial cell line-derived neurotrophic factor (gdnf), could improve graft outcomes. |
2021-04-27 |
2023-08-13 |
human |
| Piotr Chmielarz, Şafak Er, Julia Konovalova, Laura Bandres, Irena Hlushchuk, Katrina Albert, Anne Panhelainen, Kelvin Luk, Mikko Airavaara, Andrii Domansky. GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. Movement disorders : official journal of the Movement Disorder Society. vol 35. issue 12. 2021-04-27. PMID:32964492. |
glial cell line-derived neurotrophic factor (gdnf) promotes survival of mature dopamine (da) neurons in vitro and in vivo. |
2021-04-27 |
2023-08-13 |
Not clear |
| Guozhen Qiu, Chunyan Xu, Qiwen Guo, Fei-Qi Zh. SORL1 mutations are associated with parkinsonian and psychiatric features in Alzheimer disease: Case reports. Medicine. vol 100. issue 16. 2021-04-26. PMID:33879716. |
sorla also mediates a trophic pathway that acts through glial cell line-derived neurotrophic factor (gdnf), a critical survival factor for the midbrain dopaminergic (da) neurons. |
2021-04-26 |
2023-08-13 |
Not clear |
| Simon Dulz, Mahmoud Bassal, Kai Flachsbarth, Kristoffer Riecken, Boris Fehse, Stefanie Schlichting, Susanne Bartsch, Udo Bartsc. Intravitreal Co-Administration of GDNF and CNTF Confers Synergistic and Long-Lasting Protection against Injury-Induced Cell Death of Retinal Ganglion Cells in Mice. Cells. vol 9. issue 9. 2021-04-20. PMID:32932933. |
we have recently demonstrated that neural stem cell-based intravitreal co-administration of glial cell line-derived neurotrophic factor (gdnf) and ciliary neurotrophic factor (cntf) confers profound protection to injured retinal ganglion cells (rgcs) in a mouse optic nerve crush model, resulting in the survival of ~38% rgcs two months after the nerve lesion. |
2021-04-20 |
2023-08-13 |
mouse |
| Shiori Murase, Kimiko Kobayashi, Teruaki Nasu, Chiaki Kihara, Toru Taguchi, Kazue Mizumur. Synergistic interaction of nerve growth factor and glial cell-line derived neurotrophic factor in muscular mechanical hyperalgesia in rats. The Journal of physiology. vol 599. issue 6. 2021-04-20. PMID:33476055. |
nerve growth factor (ngf) and glial cell line-derived neurotrophic factor (gdnf) are essential for neuronal development and survival in embryo. |
2021-04-20 |
2023-08-13 |
rat |
| Shiori Murase, Kimiko Kobayashi, Teruaki Nasu, Chiaki Kihara, Toru Taguchi, Kazue Mizumur. Synergistic interaction of nerve growth factor and glial cell-line derived neurotrophic factor in muscular mechanical hyperalgesia in rats. The Journal of physiology. vol 599. issue 6. 2021-04-20. PMID:33476055. |
in some inflammatory conditions both nerve growth factor (ngf) and glial cell line-derived neurotrophic factor (gdnf) are upregulated and play pivotal roles in inducing hyperalgesia. |
2021-04-20 |
2023-08-13 |
rat |
| Michael Meir, Felix Kannapin, Markus Diefenbacher, Yalda Ghoreishi, Catherine Kollmann, Sven Flemming, Christoph-Thomas Germer, Jens Waschke, Patrick Leven, Reiner Schneider, Sven Wehner, Natalie Burkard, Nicolas Schlege. Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent. International journal of molecular sciences. vol 22. issue 4. 2021-04-19. PMID:33672854. |
glial cell line-derived neurotrophic factor (gdnf) contributes to ieb maturation and may therefore be the predominant mediator of this process by egcs. |
2021-04-19 |
2023-08-13 |
Not clear |