| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beat Lut. Molecular biology of cannabinoid receptors. Prostaglandins, leukotrienes, and essential fatty acids. vol 66. issue 2-3. 2002-12-06. PMID:12052031. |
many recent studies using genetically modified mouse lines which lack cb(1) and/or cb(2) finally could show the importance of cannabinoid receptors in animal physiology and will contribute to unravel the full complexity of the cannabinoid system. |
2002-12-06 |
2023-08-12 |
mouse |
| Basalingappa L Hungund, Balapal S Basavarajappa, Csaba Vadasz, George Kunos, Fernando Rodriguez de Fonseca, Giancarlo Colombo, Salvatore Serra, Loren Parsons, George F Koo. Ethanol, endocannabinoids, and the cannabinoidergic signaling system. Alcoholism, clinical and experimental research. vol 26. issue 4. 2002-08-16. PMID:11981134. |
the presentations were (1) role of endocannabinoids in ethanol tolerance, by appa hungund; (2) modulation of cannabinoid receptor and its signal transduction in chronic alcoholism, by b. s. basavarajappa; (3) endocannabinoid involvement in the control of appetitive behavior, by george kunos; (4) regulation of voluntary ethanol intake by cannabinoid receptor agonists and antagonists in alcohol-preferring sp rats, by giancarlo colombo; (5) role of endogenous cannabinoid system in alcoholism, by fernado rodriguez de fonseca; and (6) endocannabinoids and dopamine interactions in vivo, by loren parsons and george koob. |
2002-08-16 |
2023-08-12 |
rat |
| W Paul Farquhar-Smith, Sian I Jaggar, Andrew S C Ric. Attenuation of nerve growth factor-induced visceral hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors. Pain. vol 97. issue 1-2. 2002-08-12. PMID:12031775. |
these data add to the growing evidence of a therapeutic potential for cannabinoids, and support the hypothesis that the endogenous cannabinoid system modulates the ngf-mediated components of inflammatory processes. |
2002-08-12 |
2023-08-12 |
Not clear |
| D Braida, M Pozzi, R Cavallini, M Sal. Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system. Neuroscience. vol 104. issue 4. 2001-09-13. PMID:11457579. |
taken together these findings are important for understanding how the cannabinoids produce reward and the interconnection of the opioid and cannabinoid system in the motivation. |
2001-09-13 |
2023-08-12 |
Not clear |
| E Murillo-Rodríguez, R Cabeza, M Méndez-Díaz, L Navarro, O Prospéro-Garcí. Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor. Neuroreport. vol 12. issue 10. 2001-09-06. PMID:11447321. |
the present results suggest that a cannabinoid system in the pptg may be involved in sleep regulation and that the cannabinoid effect is mediated by the cb1 receptor coupled to a plc second messenger system. |
2001-09-06 |
2023-08-12 |
rat |
| C J Fowler, O Nilsson, M Andersson, G Disney, S O Jacobsson, G Tige. Pharmacological properties of cannabinoid receptors in the avian brain: similarity of rat and chicken cannabinoid1 receptor recognition sites and expression of cannabinoid2 receptor-like immunoreactivity in the embryonic chick brain. Pharmacology & toxicology. vol 88. issue 4. 2001-08-23. PMID:11322181. |
the pharmacological properties of brain cannabinoid receptors were investigated in brains of 35 day-old chickens, since little is known about the avian cannabinoid system. |
2001-08-23 |
2023-08-12 |
human |
| T Yamamoto, K Takad. Role of cannabinoid receptor in the brain as it relates to drug reward. Japanese journal of pharmacology. vol 84. issue 3. 2001-03-01. PMID:11138722. |
however, the discriminative stimulus effects of cannabinoids have been reported to be highly specific in that the effects were not substituted by other classes of compounds including opioidergic and dopaminergic agents nor were they antagonized by antagonists of various neurotransmission systems, suggesting that the discriminative stimulus effects only involve the cannabinoid system. |
2001-03-01 |
2023-08-12 |
Not clear |
| M Salzet, C Breton, T Bisogno, V Di Marz. Comparative biology of the endocannabinoid system possible role in the immune response. European journal of biochemistry. vol 267. issue 16. 2000-10-18. PMID:10931174. |
in this review we discuss data showing that the endogenous cannabinoid system, represented by cannabinoid receptors, endogenous cannabinoid receptor ligands and enzymes for the biosynthesis and degradation of these ligands, is conserved throughout evolution from coelenterates to man. |
2000-10-18 |
2023-08-12 |
Not clear |
| N E Buckley, K L McCoy, E Mezey, T Bonner, A Zimmer, C C Felder, M Glass, A Zimme. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. European journal of pharmacology. vol 396. issue 2-3. 2000-07-06. PMID:10822068. |
furthermore, we conclude that the cannabinoid cb(2) receptor knockout mouse is a useful animal model in which to study the role of the cannabinoid system in immunoregulation. |
2000-07-06 |
2023-08-12 |
mouse |
| F M Leweke, U Schneider, M Radwan, E Schmidt, H M Emric. Different effects of nabilone and cannabidiol on binocular depth inversion in Man. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837858. |
the influence of psychoactive cannabinoids on this perceptual model and the role of the endogenous cannabinoid system in visual information processing are discussed. |
2000-07-06 |
2023-08-12 |
human |
| J Fernández-Ruiz, F Berrendero, M L Hernández, J A Ramo. The endogenous cannabinoid system and brain development. Trends in neurosciences. vol 23. issue 1. 2000-02-15. PMID:10631784. |
studies have used a variety of techniques to elucidate the effects of cannabinoids during development, as well as to characterize the presence of elements of the endogenous cannabinoid system (receptors and ligands) in the developing brain. |
2000-02-15 |
2023-08-12 |
Not clear |
| G Marsicano, B Lut. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594647. |
therefore, we suggest that a putative cross-talk between cannabinoids and cck might exist and will be relevant to better understanding of physiology and pharmacology of the cannabinoid system. |
2000-02-10 |
2023-08-12 |
mouse |
| A A Izzo, N Mascolo, L Pinto, R Capasso, F Capass. The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats. European journal of pharmacology. vol 384. issue 1. 2000-01-18. PMID:10611417. |
these results suggest that (i) intestinal motility and defaecation could be tonically inhibited by the endogenous cannabinoid system, (ii) exogenous activation of cannabinoid cb(1) receptors produces a reduction in intestinal motility in the upper gastrointestinal tract but not in defaecation, (iii) endogenous or exogenous activation of cannabinoid cb(2) receptors does not affect defaecation or intestinal motility and (iv) the cannabinoid receptor agonist, cp 55, 940, possesses a weak and transient antidiarrhoeal effect while the cannabinoid receptor agonist, win 55,212-2, does not possess antidiarrhoeal activity. |
2000-01-18 |
2023-08-12 |
rat |
| R G Pertwe. Cannabis and cannabinoids: pharmacology and rationale for clinical use. Forschende Komplementarmedizin. vol 6 Suppl 3. 2000-01-05. PMID:10575283. |
the discovery of this 'endogenous cannabinoid system' has led to the development of selective cb1 and cb2 receptor ligands and fueled renewed interest in the clinical potential of cannabinoids. |
2000-01-05 |
2023-08-12 |
Not clear |
| K R Müller-Vahl, H Kolbe, U Schneider, H M Emric. Cannabis in movement disorders. Forschende Komplementarmedizin. vol 6 Suppl 3. 2000-01-05. PMID:10627163. |
it has been suggested that an endogenous cannabinoid tone participates in the control of movements and, therefore, the central cannabinoid system might play a role in the pathophysiology of these diseases. |
2000-01-05 |
2023-08-12 |
Not clear |
| A A Izzo, N Mascolo, R Capasso, M P Germanò, R De Pasquale, F Capass. Inhibitory effect of cannabinoid agonists on gastric emptying in the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494894. |
these results suggest that cannabinoid agonists delay gastric emptying through activation of cannabinoid cb1 receptors, while the endogenous cannabinoid system does not seem to modulate gastric motility. |
1999-11-08 |
2023-08-12 |
rat |
| B E Akinshola, A Chakrabarti, E S Onaiv. In-vitro and in-vivo action of cannabinoids. Neurochemical research. vol 24. issue 10. 1999-10-18. PMID:10492518. |
the discovery of endocannabinoids such as anandamide and the wide spread localization of cannabinoid receptors in the brain and peripheral tissues, suggests that the cannabinoid system represents a previously unrecognized ubiquitous net work in the nervous system, whose physiology and function is unfolding. |
1999-10-18 |
2023-08-12 |
mouse |
| R G Pertwe. Pharmacology of cannabinoid receptor ligands. Current medicinal chemistry. vol 6. issue 8. 1999-10-07. PMID:10469884. |
the discovery of this endogenous cannabinoid system has been paralleled by a renewed interest in possible therapeutic applications of cannabinoids, for example in the management of pain and in the suppression of muscle spasticity/spasm associated with multiple sclerosis or spinal cord injury. |
1999-10-07 |
2023-08-12 |
Not clear |
| b' M Poncelet, M C Barnouin, J C Breli\\xc3\\xa8re, G Le Fur, P Soubri\\xc3\\xa. Blockade of cannabinoid (CB1) receptors by 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils. Psychopharmacology. vol 144. issue 2. 1999-08-17. PMID:10394995.' |
a cannabinoid hypothesis of schizophrenia has been proposed according to which cognitive dysfunction could be associated with dysregulation of an endogenous cannabinoid system. |
1999-08-17 |
2023-08-12 |
Not clear |
| V Di Marzo, D Melck, T Bisogno, L De Petrocelli. Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends in neurosciences. vol 21. issue 12. 1999-05-24. PMID:9881850. |
the existence of an endogenous cannabinoid system was demonstrated conclusively with the discovery of endogenous brain constituents capable of activating the cannabinoid receptors functionally. |
1999-05-24 |
2023-08-12 |
Not clear |