| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jürg Gertsch, Stefan Raduner, Karl-Heinz Altman. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of receptor and signal transduction research. vol 26. issue 5-6. 2007-03-06. PMID:17118807. |
since the discovery that delta 9-tetrahydrocannabinol and related cannabinoids from cannabis sativa l. act on specific physiological receptors in the human body and the subsequent elucidation of the mammalian endogenous cannabinoid system, no other natural product class has been reported to mimic the effects of cannabinoids. |
2007-03-06 |
2023-08-12 |
human |
| Antonio Waldo Zuard. History of cannabis as a medicine: a review. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 28. issue 2. 2007-02-08. PMID:16810401. |
this interest was renewed in the 1990's with the description of cannabinoid receptors and the identification of an endogenous cannabinoid system in the brain. |
2007-02-08 |
2023-08-12 |
Not clear |
| Mark R Wade, Aldemar Degroot, George G Nomiko. Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents. European journal of pharmacology. vol 551. issue 1-3. 2007-02-08. PMID:17030030. |
although the involvement of cannabinoids and the endogenous cannabinoid system in the regulation of the hypothalamo-pituitary-adrenal axis in rodents is well documented, the precise role played by the cannabinoid type one (cb(1)) receptor in this effect has not been fully elucidated. |
2007-02-08 |
2023-08-12 |
mouse |
| Isabel Lastres-Becker, Javier Fernández-Rui. An overview of Parkinson's disease and the cannabinoid system and possible benefits of cannabinoid-based treatments. Current medicinal chemistry. vol 13. issue 30. 2007-01-23. PMID:17168732. |
the present article will review all data about the relationship between pd and the cannabinoid system including: i) the usefulness of cannabinoid-related compounds to alleviate some pd symptoms; ii) that cannabinoid-based compounds might provide protection against the progression of neuronal injury characteristic of this disease; iii) the influence of cannabinoids on local inflammatory events associated with the pathogenesis in pd. |
2007-01-23 |
2023-08-12 |
Not clear |
| Eva De Lago, Sofia B Gustafsson, Javier Fernández-Ruiz, Jonas Nilsson, Stig O P Jacobsson, Christopher J Fowle. Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations. Journal of neurochemistry. vol 99. issue 2. 2007-01-08. PMID:16899063. |
compounds blocking the uptake of the endogenous cannabinoid anandamide (aea) have been used to explore the functions of the endogenous cannabinoid system in the cns both in vivo and in vitro. |
2007-01-08 |
2023-08-12 |
Not clear |
| Roger G Pertwe. Cannabinoid pharmacology: the first 66 years. British journal of pharmacology. vol 147 Suppl 1. 2006-12-27. PMID:16402100. |
also described is how this pharmacological research led to the discovery of cannabinoid cb(1) and cb(2) receptors and of endogenous ligands for these receptors, to the development of cb(1)- and cb(2)-selective agonists and antagonists and to the realization that the endogenous cannabinoid system has significant roles in both health and disease, and that drugs which mimic, augment or block the actions of endogenously released cannabinoids must have important therapeutic applications. |
2006-12-27 |
2023-08-12 |
Not clear |
| P Massi, A Vaccani, D Parolar. Cannabinoids, immune system and cytokine network. Current pharmaceutical design. vol 12. issue 24. 2006-09-25. PMID:16918439. |
nevertheless, their identification provides a specific mechanism of action in the attempting to find out how exogenous cannabinoids and endogenous cannabinoid system affect the immune apparatus, strengthen the hypothesis of cannabinoids as immunomodulators. |
2006-09-25 |
2023-08-12 |
Not clear |
| Shahnaz Christina Azad, Gerhard Ramme. Cannabinoids in anaesthesia and pain therapy. Current opinion in anaesthesiology. vol 18. issue 4. 2006-04-24. PMID:16534269. |
since an endogenous cannabinoid system has been identified in the past two decades, cannabinoids have also become the focus of interest in western medicine. |
2006-04-24 |
2023-08-12 |
Not clear |
| b' M R Elphick, M Egertov\\xc3\\xa. The phylogenetic distribution and evolutionary origins of endocannabinoid signalling. Handbook of experimental pharmacology. issue 168. 2006-04-19. PMID:16596778.' |
the endocannabinoid signalling system in mammals comprises several molecular components, including cannabinoid receptors (e.g. |
2006-04-19 |
2023-08-12 |
caenorhabditis_elegans |
| M Storr, B Yüce, B Gök. [Perspectives of cannabinoids in gastroenterology]. Zeitschrift fur Gastroenterologie. vol 44. issue 2. 2006-03-31. PMID:16456761. |
the characterisation of an endogenous cannabinoid system consisting of receptors, endogenous agonists, antagonists and degrading enzymes opens the door for a comeback of cannabinoids in medicine. |
2006-03-31 |
2023-08-12 |
Not clear |
| Mohammad Javad Khodayar, Bijan Shafaghi, Nima Naderi, Mohammad-Reza Zarrindas. Antinociceptive effect of spinally administered cannabinergic and 2-adrenoceptor drugs on the formalin test in rat: possible interactions. Journal of psychopharmacology (Oxford, England). vol 20. issue 1. 2006-03-29. PMID:16174681. |
in conclusion, our findings may suggest that: (1) spinal cannabinoid and 2-adrenoceptor systems are able to induce antinociception in both phases of formalin test, and (2) the cannabinoid system may be involved in the antinociception induced by adrenoceptors in the early phase. |
2006-03-29 |
2023-08-12 |
rat |
| Attila Köfalvi, Ricardo J Rodrigues, Catherine Ledent, Ken Mackie, E Sylvester Vizi, Rodrigo A Cunha, Beáta Sperlág. Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 11. 2006-03-13. PMID:15772347. |
our results indicate distinct modulation of striatal gabaergic and glutamatergic transmission by cannabinoids and will facilitate the understanding of the role and importance of the cannabinoid system in normal and pathological motor function. |
2006-03-13 |
2023-08-12 |
mouse |
| Silvia Ortega-Gutiérrez, Eduardo Molina-Holgado, Angel Arévalo-Martín, Fernando Correa, Alma Viso, María L López-Rodríguez, Vincenzo Di Marzo, Carmen Guaz. Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 10. 2006-03-06. PMID:15941768. |
recent studies have described the involvement of the cannabinoid system in the progression of the disease and the benefits associated with the administration of cannabinoid agonists. |
2006-03-06 |
2023-08-12 |
mouse |
| Franjo Grotenherme. Cannabinoids. Current drug targets. CNS and neurological disorders. vol 4. issue 5. 2006-01-23. PMID:16266285. |
since the discovery of an endogenous cannabinoid system, research into the pharmacology and therapeutic potential of cannabinoids has steadily increased. |
2006-01-23 |
2023-08-12 |
Not clear |
| Franjo Grotenherme. Cannabinoids. Current drug targets. CNS and neurological disorders. vol 4. issue 5. 2006-01-23. PMID:16266285. |
besides phytocannabinoids of the cannabis plant, modulators of the cannabinoid system comprise synthetic agonists and antagonists at the cb receptors and inhibitors of endocannabinoid degradation. |
2006-01-23 |
2023-08-12 |
Not clear |
| Olga Valverd. Participation of the cannabinoid system in the regulation of emotional-like behaviour. Current pharmaceutical design. vol 11. issue 26. 2005-12-20. PMID:16250845. |
all this recent information has further clarified the role played by the endogenous cannabinoid system in the control of emotional behaviour and provides data to support a new possible therapeutic use of cannabinoid compounds. |
2005-12-20 |
2023-08-12 |
mouse |
| Fernando Correa, Leyre Mestre, Eduardo Molina-Holgado, Angel Arévalo-Martín, Fabian Docagne, Eva Romero, Francisco Molina-Holgado, José Borrell, Carmen Guaz. The role of cannabinoid system on immune modulation: therapeutic implications on CNS inflammation. Mini reviews in medicinal chemistry. vol 5. issue 7. 2005-09-01. PMID:16026313. |
advances in the understanding of the physiology and pharmacology of the cannabinoid system have increased the interest of cannabinoids as potential therapeutic targets. |
2005-09-01 |
2023-08-12 |
Not clear |
| Jorge Manzanares, Sergio Ortiz, José M Oliva, Sandra Pérez-Rial, Tomás Palom. Interactions between cannabinoid and opioid receptor systems in the mediation of ethanol effects. Alcohol and alcoholism (Oxford, Oxfordshire). vol 40. issue 1. 2005-08-31. PMID:15550451. |
however, little is known about the effects of ethanol on the endogenous cannabinoid system, the vulnerability of cannabinoid receptors to alcohol intake or their neurochemical implications in reducing consumption of alcohol. |
2005-08-31 |
2023-08-12 |
Not clear |
| Heidi M B Lesscher, Emily Hoogveld, J Peter H Burbach, Jan M van Ree, Mirjam A F M Gerrit. Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 15. issue 1. 2005-03-29. PMID:15572271. |
the endogenous cannabinoid system is a relatively novel discovered system consisting of cannabinoid cb1 receptors, which are expressed both in the periphery and in the central nervous system, peripheral cannabinoid cb2 receptors and endogenous cannabinoids, which are anandamide and 2-arachidonyl glycerol. |
2005-03-29 |
2023-08-12 |
Not clear |
| F Markus Leweke, Christoph W Gerth, Joachim Klosterkötte. Cannabis-associated psychosis: current status of research. CNS drugs. vol 18. issue 13. 2005-02-04. PMID:15521792. |
interestingly, the recently suggested role of the endogenous cannabinoid system in schizophrenia not related to previous cannabinoid consumption introduces an additional perspective on the mechanism underlying cannabis-associated schizophrenia-like disorders, as well as on the effects of cannabis consumption in schizophrenia. |
2005-02-04 |
2023-08-12 |
Not clear |