| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tonia Luca, Giulia Di Benedetto, Mariagrazia Rita Scuderi, Marco Palumbo, Silvia Clementi, Renato Bernardini, Giuseppina Cantarell. The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi's sarcoma cells in vitro. European journal of pharmacology. vol 616. issue 1-3. 2009-10-19. PMID:19539619. |
in view of the antiproliferative effects of cannabinoids on ks-imm cells, one could envision the cannabinoid system as a potential target for pharmacological treatment of kaposi's sarcoma. |
2009-10-19 |
2023-08-12 |
human |
| Zdenek Fisa. Phytocannabinoids and endocannabinoids. Current drug abuse reviews. vol 2. issue 1. 2009-10-12. PMID:19630737. |
discovery of endogenous cannabinoids and studies of the physiological functions of the cannabinoid system in the brain and body are producing a number of important findings about the role of membrane lipids and fatty acids in nerve signal transduction. |
2009-10-12 |
2023-08-12 |
Not clear |
| Zdenek Fisa. Phytocannabinoids and endocannabinoids. Current drug abuse reviews. vol 2. issue 1. 2009-10-12. PMID:19630737. |
the role of lipid membranes in the cannabinoid system follows from the fact that the source and supply of endogenous cannabinoids are derived from arachidonic acid, an important membrane constituent. |
2009-10-12 |
2023-08-12 |
Not clear |
| Alessia Ligresti, Stefania Petrosino, Vincenzo Di Marz. From endocannabinoid profiling to 'endocannabinoid therapeutics'. Current opinion in chemical biology. vol 13. issue 3. 2009-09-30. PMID:19497779. |
the discovery of the endocannabinoid signalling system, that is, of cannabinoid receptors, their endogenous ligands, known as endocannabinoids, and of endocannabinoid anabolic and catabolic enzymes, raised several questions regarding the physiopathological role of these mediators. |
2009-09-30 |
2023-08-12 |
human |
| Vincenzo Di Marz. The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacological research. vol 60. issue 2. 2009-09-02. PMID:19559360. |
the endocannabinoid signalling system includes: (1) at least two g-protein-coupled receptors, known as the cannabinoid cb(1) and cb(2) receptors and discovered following studies on the mechanism of action of delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant cannabis sativa; (2) the endogenous agonists at these receptors, known as endocannabinoids, of which anandamide and 2-arachidonoylglycerol are the best known; and (3) proteins and enzymes for the regulation of endocannabinoid levels and action at receptors. |
2009-09-02 |
2023-08-12 |
Not clear |
| N Realini, T Rubino, D Parolar. Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids. Pharmacological research. vol 60. issue 2. 2009-09-02. PMID:19559364. |
the endocannabinoid system plays an important role in this critical phase for cerebral development, therefore a strong stimulation by the psychoactive component of marijuana, delta-9-tetrahydrocanabinol, that acts through the cannabinoid system, might lead to subtle but lasting neurobiological changes that can affect adult brain functions and behaviour. |
2009-09-02 |
2023-08-12 |
Not clear |
| Zdenek Fisa. Cannabinoids and atherosclerosis. Prague medical report. vol 110. issue 1. 2009-08-18. PMID:19591373. |
discovery of endogenous cannabinoids and studies of the physiological functions of the cannabinoid system in the brain and body are producing a number of important findings about the role of membrane lipids and fatty acids. |
2009-08-18 |
2023-08-12 |
Not clear |
| Zdenek Fisa. Cannabinoids and atherosclerosis. Prague medical report. vol 110. issue 1. 2009-08-18. PMID:19591373. |
the role of lipid membranes in the cannabinoid system follows from the fact that the source and supply of endogenous cannabinoids are derived from arachidonic acid. |
2009-08-18 |
2023-08-12 |
Not clear |
| David R Janero, Subramanian K Vadivel, Alexandros Makriyanni. Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies. International review of psychiatry (Abingdon, England). vol 21. issue 2. 2009-08-04. PMID:19367506. |
two cannabinoid (cb) receptors (cb1 and cb2) currently represent prime endocannabinoid-system therapeutic targets for ligands that either mimic endocannabinoid signalling processes and/or potentiate endocannabinoid-system activity (agonists) or attenuate pathologically heightened endocannabinoid-system transmission (antagonists). |
2009-08-04 |
2023-08-12 |
Not clear |
| Danai Dima, Jonathan P Roiser, Detlef E Dietrich, Catharina Bonnemann, Heinrich Lanfermann, Hinderk M Emrich, Wolfgang Dill. Understanding why patients with schizophrenia do not perceive the hollow-mask illusion using dynamic causal modelling. NeuroImage. vol 46. issue 4. 2009-07-29. PMID:19327402. |
towards a cannabinoid hypothesis of schizophrenia: cognitive impairments due to a dysregulation of the endogenous cannabinoid system. |
2009-07-29 |
2023-08-12 |
human |
| Arash Bahremand, Sara Ebrahimi Nasrabady, Hamed Shafaroodi, Mehdi Ghasemi, Ahmad Reza Dehpou. Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. Epilepsy research. vol 84. issue 2-3. 2009-07-24. PMID:19223154. |
cannabinoid system plays a pivotal role in the seizure threshold modulation which is mainly mediated through activation of the cannabinoid cb(1) receptor. |
2009-07-24 |
2023-08-12 |
mouse |
| Patrik Roser, Jürgen Gallinat, Gordon Weinberg, Georg Juckel, Inge Gorynia, Andreas M Stadelman. Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects. European archives of psychiatry and clinical neuroscience. vol 259. issue 5. 2009-07-01. PMID:19224107. |
based on the close relationship between cannabis use, the endogenous cannabinoid system and motor disturbances found in schizophrenia, we expected that administration of cannabinoids may change pattern of psychomotor activity like in schizophrenic patients. |
2009-07-01 |
2023-08-12 |
human |
| Sarada Krishnan, Ruth Cairns, Robert Howar. Cannabinoids for the treatment of dementia. The Cochrane database of systematic reviews. issue 2. 2009-06-23. PMID:19370677. |
following the discovery of an endogenous cannabinoid system and the identification of specific cannabinoid receptors in the central nervous system, much work has been done to investigate the main effects of these compounds. |
2009-06-23 |
2023-08-12 |
Not clear |
| Luciano De Petrocellis, Vincenzo Di Marz. An introduction to the endocannabinoid system: from the early to the latest concepts. Best practice & research. Clinical endocrinology & metabolism. vol 23. issue 1. 2009-05-26. PMID:19285257. |
the number of the members of this endocannabinoid signalling system seems to be ever increasing as new non-cb(1) non-cb(2) receptors for endocannabinoids, endocannabinoid-related molecules with little activity at cb(1) and cb(2) receptors, and new enzymes for endocannabinoid biosynthesis and degradation are being identified every year. |
2009-05-26 |
2023-08-12 |
Not clear |
| Laura Orio, Scott Edwards, Olivier George, Loren H Parsons, George F Koo. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 15. 2009-05-12. PMID:19369553. |
although emerging evidence implicates the endogenous cannabinoid system in aspects of opioid and ethanol addiction, a role of the endocannabinoid system in cocaine addiction remains widely inconclusive. |
2009-05-12 |
2023-08-12 |
human |
| Tiziana Rubino, Daniela Vigano', Natalia Realini, Cinzia Guidali, Daniela Braida, Valeria Capurro, Chiara Castiglioni, Francesca Cherubino, Patrizia Romualdi, Sanzio Candeletti, Mariaelvina Sala, Daniela Parolar. Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 11. 2009-04-22. PMID:18172430. |
this study tested whether long-lasting interference by cannabinoids with the developing endogenous cannabinoid system during adolescence caused persistent behavioral alterations in adult rats. |
2009-04-22 |
2023-08-12 |
rat |
| Chad R Edwards, Patrick D Skosni. Cerebellar-dependent learning as a neurobehavioral index of the cannabinoid system. Critical reviews in neurobiology. vol 19. issue 1. 2009-04-14. PMID:19166390. |
thus, there is a demand in contemporary clinical neuroscience for methods sensitive to cannabinoid system function, not only for assessing how cannabis use influences human information processing, but also to assess the involvement of the endocannabinoid system (ecs) in clinical disease and evaluate the effects of cb1-based drug therapies. |
2009-04-14 |
2023-08-12 |
mouse |
| R Capasso, F Borrelli, M G Cascio, G Aviello, K Huben, J K Zjawiony, P Marini, B Romano, V Di Marzo, F Capasso, A A Izz. Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors. British journal of pharmacology. vol 155. issue 5. 2009-01-16. PMID:18622408. |
because intestinal inflammation upregulates cannabinoid receptors and endogenous cannabinoids, in the present study we investigated the possible involvement of the endogenous cannabinoid system in salvinorin a-induced delay in motility in the inflamed gut. |
2009-01-16 |
2023-08-12 |
Not clear |
| Styliani Vlachou, Fygaleia Stamatopoulou, George G Nomikos, George Panagi. Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine. The international journal of neuropsychopharmacology. vol 11. issue 7. 2008-12-08. PMID:18377702. |
these results indicate that cannabinoids may interfere with brain reward systems responsible for the expression of acute reinforcing/rewarding properties of cocaine, and provide further evidence that the cannabinoid system could be explored as a potential drug discovery target for the treatment of psychostimulant addiction and pathological states associated with psychomotor overexcitability. |
2008-12-08 |
2023-08-12 |
Not clear |
| Nico Wegener, Sybille Kuhnert, Annika Thüns, Rasmus Roese, Michael Koc. Effects of acute systemic and intra-cerebral stimulation of cannabinoid receptors on sensorimotor gating, locomotion and spatial memory in rats. Psychopharmacology. vol 198. issue 3. 2008-11-17. PMID:18446326. |
cannabinoid cb(1) receptors in the brain are targets of both endocannabinoid signalling and the psychoactive compounds of the hemp plant. |
2008-11-17 |
2023-08-12 |
rat |