| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Baker, Gareth Pryc. The endocannabinoid system and multiple sclerosis. Current pharmaceutical design. vol 14. issue 23. 2008-11-17. PMID:18781983. |
recent advances in cannabinoid biology are beginning to support these anecdotal observations, notably the demonstration that spasticity is tonically regulated by the endogenous cannabinoid system. |
2008-11-17 |
2023-08-12 |
Not clear |
| David Baker, Gareth Pryc. The endocannabinoid system and multiple sclerosis. Current pharmaceutical design. vol 14. issue 23. 2008-11-17. PMID:18781983. |
stimulation of endocannabinoid activity in these areas either through increase of synthesis or inhibition of endocannabinoid degradation offers the positive therapeutic potential of the cannabinoid system whilst limiting adverse events by locally targeting the lesion. |
2008-11-17 |
2023-08-12 |
Not clear |
| Martin Cohen, Nadia Solowij, Vaughan Car. Cannabis, cannabinoids and schizophrenia: integration of the evidence. The Australian and New Zealand journal of psychiatry. vol 42. issue 5. 2008-08-14. PMID:18473254. |
exogenous cannabinoids alter the normative functioning of the endogenous cannabinoid system. |
2008-08-14 |
2023-08-12 |
Not clear |
| F Teixeira-Clerc, B Julien, P Grenard, J Tran Van Nhieu, V Deveaux, C Hezode, A Mallat, S Lotersztaj. [The endocannabinoid system as a novel target for the treatment of liver fibrosis]. Pathologie-biologie. vol 56. issue 1. 2008-04-18. PMID:17412522. |
the cannabinoid system comprises specific g protein-coupled receptors (cb1 and cb2), exogenous (marijuana-derived cannabinoids) and endogenous (endocannabinoids) ligands, and a machinery dedicated to endocannabinoid synthesis and degradation. |
2008-04-18 |
2023-08-12 |
Not clear |
| Laura Lamota, Francisco Javier Bermudez-Silva, Eva-María Marco, Ricardo Llorente, Araceli Gallego, Fernando Rodríguez de Fonseca, María-Paz Vivero. Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17720206. |
the present results indicate that the endogenous cannabinoid system is active as a metabolic modulator during adolescence and that nicotine exposure can induce long-lasting effects on metabolic regulation, altering cannabinoid modulation of energy expenditure and metabolism. |
2008-04-18 |
2023-08-12 |
rat |
| Marcello Solinas, Sevil Yasar, Steven R Goldber. Endocannabinoid system involvement in brain reward processes related to drug abuse. Pharmacological research. vol 56. issue 5. 2008-04-08. PMID:17936009. |
in addition to reward functions, the endocannabinoid cannabinoid system appears to be involved in the ability of drugs and drug-related cues to reinstate drug-seeking behavior in animal models of relapse. |
2008-04-08 |
2023-08-12 |
Not clear |
| Gianluigi Tand. Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence. Pharmacological research. vol 56. issue 5. 2008-04-08. PMID:17945506. |
recent studies have shown that the endocannabinoid system participates in specific stages and aspects of drug dependence in general, and some of this evidence suggests an involvement of the cannabinoid system in cocaine effects. |
2008-04-08 |
2023-08-12 |
human |
| K Luan Phan, Mike Angstadt, Jamie Golden, Ikechukwu Onyewuenyi, Ana Popovska, Harriet de Wi. Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 10. 2008-04-07. PMID:18322078. |
the current findings fit well with the notion that thc and other cannabinoids may have an anxiolytic role in central mechanisms of fear behaviors and provide a rationale for exploring novel therapeutic strategies that target the cannabinoid system for disorders of anxiety and social fear. |
2008-04-07 |
2023-08-12 |
Not clear |
| M Maccarron. CB2 receptors in reproduction. British journal of pharmacology. vol 153. issue 2. 2008-04-02. PMID:17828289. |
the discovery of the 'endocannabinoid system (ecs)', composed of bioactive lipids (endocannabinoids), their receptors and their metabolic enzymes, and the generation of mouse models missing cannabinoid receptors or other elements of the ecs, has enabled a wealth of information on the significance of endocannabinoid signalling in multiple reproductive events: sertoli cell survival, spermatogenesis, placentation, fertilization, preimplantation embryo development, implantation and postimplantation embryonic growth. |
2008-04-02 |
2023-08-12 |
mouse |
| Fernando Correa, Fabian Docagne, Leyre Mestre, Frida Loría, Miriam Hernangómez, José Borrell, Carmen Guaz. Cannabinoid system and neuroinflammation: implications for multiple sclerosis. Neuroimmunomodulation. vol 14. issue 3-4. 2008-03-31. PMID:18073512. |
advances in the understanding of the physiology and pharmacology of the cannabinoid system have potentiated the interest in cannabinoids as potential therapeutic targets. |
2008-03-31 |
2023-08-12 |
Not clear |
| M Paola Castelli, A Paola Piras, Antonella D'Agostino, Fabio Pibiri, Simona Perra, Gian Luigi Gessa, Mauro Maccarrone, Marco Pisti. Dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist WIN 55,212-2. European journal of pharmacology. vol 573. issue 1-3. 2008-03-13. PMID:17644084. |
dysregulation of the endogenous cannabinoid system in adult rats prenatally treated with the cannabinoid agonist win 55,212-2. |
2008-03-13 |
2023-08-12 |
rat |
| Karin Woelkart, Outi M H Salo-Ahen, Rudolf Baue. CB receptor ligands from plants. Current topics in medicinal chemistry. vol 8. issue 3. 2008-03-07. PMID:18289087. |
advances in understanding the physiology and pharmacology of the endogenous cannabinoid system have potentiated the interest of cannabinoid receptors as potential therapeutic targets. |
2008-03-07 |
2023-08-12 |
Not clear |
| Yossi Dagon, Yosefa Avraham, Yaron Ilan, Raphael Mechoulam, Elliot M Berr. Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 10. 2007-11-05. PMID:17431095. |
the cannabinoid system controls systemic energy balance via the cannabinoid receptors cb-1 and cb-2. |
2007-11-05 |
2023-08-12 |
mouse |
| Andrea Cippitelli, Ainhoa Bilbao, Miguel Angel Gorriti, Miguel Navarro, Maurizio Massi, Daniele Piomelli, Roberto Ciccocioppo, Fernando Rodríguez de Fonsec. The anandamide transport inhibitor AM404 reduces ethanol self-administration. The European journal of neuroscience. vol 26. issue 2. 2007-10-25. PMID:17650118. |
to avoid this problem, a novel pharmacological approach to the study of the contribution of the cannabinoid system in alcoholism may be to use drugs that locally amplify the effects of alcohol on endogenous cannabinoids. |
2007-10-25 |
2023-08-12 |
rat |
| Maurice R Elphic. BfCBR: a cannabinoid receptor ortholog in the cephalochordate Branchiostoma floridae (Amphioxus). Gene. vol 399. issue 1. 2007-09-24. PMID:17553639. |
the invertebrate ancestry of endocannabinoid signalling: an orthologue of vertebrate cannabinoid receptors in the urochordate ciona intestinalis. |
2007-09-24 |
2023-08-12 |
human |
| Stéphanie Caillé, Lily Alvarez-Jaimes, Ilham Polis, David G Stouffer, Loren H Parson. Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 14. 2007-05-02. PMID:17409233. |
ethanol and opiate self-administration are sensitive to manipulations of cannabinoid cb1 receptor function and, from this, a role for the endogenous cannabinoid system in the modulation of drug reward has been hypothesized. |
2007-05-02 |
2023-08-12 |
Not clear |
| Ivan Rodriguez-Martin, Ezequiel Marron Fernandez de Velasco, Raquel E Rodrigue. Characterization of cannabinoid-binding sites in zebrafish brain. Neuroscience letters. vol 413. issue 3. 2007-04-24. PMID:17178193. |
our results provide evidence that, although some of the typical cannabinoid ligands for mammalian receptors do not fully recognize the cannabinoid-binding sites in zebrafish brain, the activity of the endogenous zebrafish cannabinoid system might not significantly differ from that displayed by the cannabinoid system described in other species. |
2007-04-24 |
2023-08-12 |
zebrafish |
| Ivan Rodriguez-Martin, Ezequiel Marron Fernandez de Velasco, Raquel E Rodrigue. Characterization of cannabinoid-binding sites in zebrafish brain. Neuroscience letters. vol 413. issue 3. 2007-04-24. PMID:17178193. |
hence the study of zebrafish cannabinoid activity may contribute to an understanding of the endogenous cannabinoid system in higher vertebrates. |
2007-04-24 |
2023-08-12 |
zebrafish |
| Styliani Vlachou, George G Nomikos, George Panagi. Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. Psychopharmacology. vol 188. issue 3. 2007-03-13. PMID:16953388. |
the endogenous cannabinoid system is responsive to the neurobiological actions of delta9-tetrahydrocannabinol (thc) and other cannabinoid ligands. |
2007-03-13 |
2023-08-12 |
Not clear |
| Ioannis Kyrou, George Valsamakis, Constantine Tsigo. The endocannabinoid system as a target for the treatment of visceral obesity and metabolic syndrome. Annals of the New York Academy of Sciences. vol 1083. 2007-03-07. PMID:17148745. |
the endogenous cannabinoid system is a novel, remarkably elaborate physiological signaling system, comprising the recently identified endogenous cannabinoid ligands, their corresponding selective receptors, and the machinery of proteins and enzymes that is involved in their biosynthesis, release, transport, and degradation. |
2007-03-07 |
2023-08-12 |
Not clear |