| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donna M Platt, Annemarie Duggan, Roger D Spealman, James M Cook, Xiaoyan Li, Wenyuan Yin, James K Rowlet. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 313. issue 2. 2005-07-05. PMID:15650112. |
in contrast, pretreatment with the alpha(5)gaba(a) inverse agonist l-655,708 (ethyl[s]-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9h-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxlate) dose-dependently attenuated the ds effects of ethanol and the ethanol-like effects of qh-ii-066. |
2005-07-05 |
2023-08-12 |
monkey |
| Donna M Platt, Annemarie Duggan, Roger D Spealman, James M Cook, Xiaoyan Li, Wenyuan Yin, James K Rowlet. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 313. issue 2. 2005-07-05. PMID:15650112. |
ry-23 (tert-butyl 8-[(trimethylsilyl)ethynyl]-5,6-dihydro-5-methyl-6-oxo-4h-imidazo[1,5a]-[1,4]benzodiazepine-3-carboxylate), another alpha(5)gaba(a) inverse agonist, similarly attenuated the ethanol-like ds effects of qh-ii-066. |
2005-07-05 |
2023-08-12 |
monkey |
| Donna M Platt, Annemarie Duggan, Roger D Spealman, James M Cook, Xiaoyan Li, Wenyuan Yin, James K Rowlet. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. The Journal of pharmacology and experimental therapeutics. vol 313. issue 2. 2005-07-05. PMID:15650112. |
these findings suggest a key role for alpha(5)gaba(a), but not alpha(1)gaba(a), receptor mechanisms in the ds effects of ethanol and the ethanol-like ds effects of benzodiazepine agonists. |
2005-07-05 |
2023-08-12 |
monkey |
| M Tonacchera, A Perri, G De Marco, P Agretti, L Montanelli, M E Banco, A Corrias, J Bellone, M T Tosi, P Vitti, E Martino, A Pinchera, L Chiovat. TSH receptor and Gs(alpha) genetic analysis in children with Down's syndrome and subclinical hypothyroidism. Journal of endocrinological investigation. vol 26. issue 10. 2004-09-07. PMID:14759073. |
in conclusion, our results seem to exclude the role of tshr or gs(alpha) gene mutations in the pathogenesis of the non-autoimmune sh observed in some children with ds. |
2004-09-07 |
2023-08-12 |
Not clear |
| M Christiansen, S O Larsen, C Oxvig, Q-P Qin, J M Wagner, M T Overgaard, G J Gleich, L Sottrup-Jensen, B Nørgaard-Pederse. Screening for Down's syndrome in early and late first and second trimester using six maternal serum markers. Clinical genetics. vol 65. issue 1. 2004-08-31. PMID:15032969. |
the efficiency of six maternal serum markers for down's syndrome (ds), alpha fetoprotein (afp), human chorionic gonadotropin (hcg), free beta-hcg, pregnancy-associated plasma protein-a (papp-a), the proform of eosinophil major basic protein (prombp), pregnancy-specific-beta-1-glycoprotein (sp(1)), and combinations thereof, was examined. |
2004-08-31 |
2023-08-12 |
human |
| Iris Hecht, Rami Hershkoviz, Shoham Shivtiel, Tzvi Lapidot, Irun R Cohen, Ofer Lider, Liora Cahalo. Heparin-disaccharide affects T cells: inhibition of NF-kappaB activation, cell migration, and modulation of intracellular signaling. Journal of leukocyte biology. vol 75. issue 6. 2004-07-12. PMID:15020655. |
we previously reported that disaccharides (ds), generated by enzymatic degradation of heparin or heparan sulfate, inhibit t cell-mediated immune reactions in rodents and regulate cytokine [tumor necrosis factor alpha (tnf-alpha), interleukin (il)-8, and il-1beta] secretion by t cells, macrophages, or intestinal epithelial cells. |
2004-07-12 |
2023-08-12 |
Not clear |
| M S Cheon, K S Shim, S H Kim, A Hara, G Lube. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV). Amino acids. vol 25. issue 1. 2004-05-06. PMID:12836057. |
we therefore evaluated the levels of six proteins whose genes are encoded on chromosome 21 (trefoil factor 1, trefoil factor 2, trefoil factor 3, coxsackie virus and adenovirus receptor, carbonyl reductase 1 and interferon- alpha receptor) in fetal cerebral cortex from ds and controls at the early second trimester using western blot analysis. |
2004-05-06 |
2023-08-12 |
human |
| Wojciech Kułak, Wojciech Sobanie. [Spectral analysis and EEG coherence in children with cerebral palsy: spastic diplegia]. Przeglad lekarski. vol 60 Suppl 1. 2003-10-07. PMID:12945157. |
significant decrease of power alpha at occipital derivations demonstrated in children with ds. |
2003-10-07 |
2023-08-12 |
human |
| Wojciech Kułak, Wojciech Sobanie. [Spectral analysis and EEG coherence in children with cerebral palsy: spastic diplegia]. Przeglad lekarski. vol 60 Suppl 1. 2003-10-07. PMID:12945157. |
significant decrease of interhemispheric coherence values in children with ds for the alpha and theta band frequencies and in a few cases decrease of delta and beta bands were observed. |
2003-10-07 |
2023-08-12 |
human |
| Haiyan Li, Leif Groop, Anita Nilsson, Jianping Weng, Tiinamaija Tuom. A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes. The Journal of clinical endocrinology and metabolism. vol 88. issue 6. 2003-07-01. PMID:12788886. |
the tnf alpha(308) a and dqb1*02 alleles were in linkage disequilibrium in type 1 patients (ds = 0.81; p < 0.001 vs. ds = 0.25 in controls) and type 2 patients from type 1/2 families (ds = 0.59, p < 0.05 vs. controls) but not in common type 2 patients (ds = 0.39). |
2003-07-01 |
2023-08-12 |
human |
| David A Pan, D Grahame Hardi. A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion. The Biochemical journal. vol 367. issue Pt 1. 2003-06-17. PMID:12093363. |
expression of double stranded (ds) rnas targeted at any of the putative alpha, beta or gamma subunits ablated this activity, and abolished expression of the alpha subunit. |
2003-06-17 |
2023-08-12 |
drosophila_melanogaster |
| E Engidawork, J F Juranville, M Fountoulakis, M Dierssen, G Lube. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome. Journal of neural transmission. Supplementum. issue 61. 2002-06-10. PMID:11771738. |
proteasome zeta chain, an alpha subunit of the 20s proteasome (p < 0.05) and ubiquitin carboxy-terminal hydrolase t (isopeptidase t), a deubiquitinating enzyme (p < 0.001) were significantly increased in fetal ds compared to controls. |
2002-06-10 |
2023-08-12 |
Not clear |
| E Engidawork, T Gulesserian, N Balic, N Cairns, G Lube. Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease. Journal of neural transmission. Supplementum. issue 61. 2002-06-10. PMID:11771745. |
the protein levels of neuronal nachr alpha and beta subunits in human postmortem brain samples (frontal cortex and cerebellum) of control, adult ds, and ad were investigated by making use of western blot analysis. |
2002-06-10 |
2023-08-12 |
human |
| B C Yoo, M Fountoulakis, M Dierssen, G Lube. Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1. Journal of neural transmission. Supplementum. issue 61. 2002-06-10. PMID:11771755. |
however, chaperonin protein tcp-1 alpha and beta subunits showed a significant decrease (p < 0.05) in second trimester brain with ds. |
2002-06-10 |
2023-08-12 |
Not clear |
| R Weitzdoerfer, M Dierssen, M Fountoulakis, G Lube. Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure. Journal of neural transmission. Supplementum. issue 61. 2002-06-10. PMID:11771761. |
quantification of snap 25 revealed significantly reduced values in ds cortex and alpha snap was only present in half of the ds individuals. |
2002-06-10 |
2023-08-12 |
Not clear |
| K Schuchter, E Hafner, G Stangl, M Metzenbauer, D Höfinger, K Philip. The first trimester 'combined test' for the detection of Down syndrome pregnancies in 4939 unselected pregnancies. Prenatal diagnosis. vol 22. issue 3. 2002-04-30. PMID:11920896. |
the specific ds risk was calculated using the computer program alpha version 5aa (logical medical systems, london, uk). |
2002-04-30 |
2023-08-12 |
Not clear |
| Olga V Fedorova, Mark I Talan, Natalia I Agalakova, Edward G Lakatta, Alexei Y Bagro. Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension. Circulation. vol 105. issue 9. 2002-03-18. PMID:11877366. |
the present study investigated the potential roles of 2 putative endogenous spls, an ouabain-like compound (olc) and an alpha(1) na(+),k(+)-atpase inhibitor, marinobufagenin (mbg), in regulating natriuresis and blood pressure (bp) responses to sustained and acute nacl loading in dahl salt-sensitive rats (ds). |
2002-03-18 |
2023-08-12 |
rat |
| M Z Berkman, A C Iplikçioğlu, M K Berkman, T Erbengi, T San, A Sa. The effect of tizanidine on chronic vasospasm in rats. Acta neurochirurgica. vol 142. issue 9. 2001-05-31. PMID:11086815. |
tizanidine (sandoz compound ds 103-282, 5-chloro-4,2 (2-imidazolin-2-yl-amino)-2,1,3-benzothiazol hydrochloride) is a centrally-acting muscle relaxant and a selective alpha 2 adrenoreceptor agonist which shows its effect by stimulating presynaptic alpha 2 adrenoreceptors in central aspergic and gluergic system by inhibiting aspartic acid and glutamic acid release. |
2001-05-31 |
2023-08-12 |
rat |
| T Ishii, H Kwon, J Hiscott, G Mosialos, A E Koromila. Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR. Oncogene. vol 20. issue 15. 2001-05-03. PMID:11313938. |
the interferon (ifn)-inducible double stranded (ds) rna-activated protein kinase pkr plays an important role in protein synthesis by modulating the phosphorylation of the alpha-subunit of eukaryotic initiation fact 2 (eif-2 alpha). |
2001-05-03 |
2023-08-12 |
Not clear |
| J K Pietruski, M D Pietruska, E Jabłońska, P Sacha, M Zaremba, W Stokowsk. Interleukin 6, tumor necrosis factor alpha and their soluble receptors in the blood serum of patients with denture stomatitis and fungal infection. Archivum immunologiae et therapiae experimentalis. vol 48. issue 2. 2000-07-19. PMID:10807050. |
determinations of the blood serum levels of interleukin 6 (il-6), tumor necrosis factor alpha (tnf-alpha) and their soluble receptors (sil-6r, stnfr) in denture stomatitis patients (ds) were performed. |
2000-07-19 |
2023-08-12 |
Not clear |